Development of high endothelial venule-like characteristics in the spiral modiolar vein induced by viral labyrinthitis
Article first published online: 4 JAN 2009
Copyright © 1993 The Triological Society
Volume 103, Issue 8, pages 890–898, August 1993
How to Cite
Stearns, G. S., Keithley, E. M. and Harris, J. P. (1993), Development of high endothelial venule-like characteristics in the spiral modiolar vein induced by viral labyrinthitis. The Laryngoscope, 103: 890–898. doi: 10.1288/00005537-199308000-00010
- Issue published online: 4 JAN 2009
- Article first published online: 4 JAN 2009
- Manuscript Accepted: 20 JUL 1992
- NIH. Grant Numbers: DC00193, DC00386
- The Research Service of The Veterans Affairs.
The postcapillary venule is known to be the preferred site of lymphocyte migration into the extravascular compartment. In this study, induction of these high endothelial venule (HEV)-like vessels has been investigated by inoculation of live cytomegalovirus or inactivated virus into scala tympani of guinea pig cochleas. Endothelial cells of the spiral modiolar vein (SMV) were evaluated histologically 2 to 6 days following inoculation. The experimental group endothelial cells had larger nuclei and increased amounts of cytoplasm. In addition, many lymphocytes were adherent to and present within the vascular wall. Control SMV endothelia showed normal structure and morphology throughout the study. These findings reiterate that nonlymphoid tissues may develop HEV-like characteristics and suggest that HEV-like morphology may be acquired during an acute inflammatory condition in the cochlea.