This study investigated the dominance of predictive relationships between Sense of Coherence (SOC) and work characteristics (organizational climate and job control) in cross-lagged longitudinal data with two measurement points and a time lag of 3 years. The sample consisted of 615 (587 men and 28 women) managers, aged between 27 and 64 years. The cross-lagged longitudinal analysis was done by the use of Structural Equation Modelling (SEM) within the framework by LISREL. The results of the chi-square difference tests indicated that the model where SOC at Time 1 predicted work characteristics at Time 2 better accounted for the data than the competitive models. However, the only significant path in addition to test-retest stabilities was the path from SOC at Time 1 to organizational climate at Time 2 indicating that high SOC predicts good organizational climate over a 3-year follow-up period. The path from SOC at Time 1 to job control at Time 2 was not significant. Thus, it seems that SOC, as a relatively stable disposition, influences the ability to mobilize and generate social resources in the workplace but not the ability to produce job control.