Objective: The incidence of prostate cancer has risen sharply in the last decade, yet knowledge about the psychological health of men with this disease is still limited. A study was therefore undertaken to identify (1) the prevalence of psychological distress in these males, and (2) factors predicting psychological distress.

Design: Retrospective cross-sectional survey design by means of a self-administered questionnaire.

Method: A sample of 94 men with various stages of prostate cancer completed the Functional Assessment of Cancer Therapy—Prostate Instrument (FACT-P), the Hospital Anxiety Depression Scale (HADS) and items measuring satisfaction with medical care.

Results: We detected a prevalence rate of 38% of participants reporting psychological distress corresponding to a HADS cut-off score at or above 15. A standard multivariate regression analysis revealed social/family well-being, physical well-being and functional well-being as significant inverse predictors of psychological distress.

Conclusions: Health professionals should be aware of the potential for psychological distress in patients exhibiting poor physical functioning and those with apparent deficits in social or family support in this under-studied group of patients. Strategies for psychosocial intervention are implied.