• Please log in or register to access this feature.

Research Article

You have full text access to this OnlineOpen article

Cadmium Exposure and Distal Forearm Fractures†

  1. Tobias Alfvén1,2,*,
  2. Carl-Gustaf Elinder3,
  3. Lennart Hellström4,
  4. Frédéric Lagarde1,
  5. Lars Järup1,2,5

Article first published online: 2 FEB 2004

DOI: 10.1359/JBMR.040202

Issue

Journal of Bone and Mineral Research

Journal of Bone and Mineral Research

Volume 19, Issue 6, pages 900–905, June 2004

Additional Information

How to Cite

Alfvén, T., Elinder, C.-G., Hellström, L., Lagarde, F. and Järup, L. (2004), Cadmium Exposure and Distal Forearm Fractures. J Bone Miner Res, 19: 900–905. doi: 10.1359/JBMR.040202

Author Information

  1. 1

    Division of Environmental Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

  2. 2

    Department of Environmental Health, Stockholm County Council, Stockholm, Sweden

  3. 3

    Department of Renal Medicine Huddinge University Hospital and Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden

  4. 4

    Department of Public Health, County Council of Kalmar, Oskarshamn, Sweden

  5. 5

    Department of Epidemiology and Public Health, Imperial College, London, United Kingdom

*Address reprint requests to: Tobias Alfvén, PhD, MD, Division of Environmental Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, Stockholm SE-171 77, Sweden

  1. †

    Abstract was presented at the 2002 Annual Meeting of the International Society for Environmental Epidemiology, Vancouver, Canada, August 8, 2002.The authors have no conflict of interest

Publication History

  1. Issue published online: 2 DEC 2009
  2. Article first published online: 2 FEB 2004
  3. Manuscript Accepted: 2 FEB 2004
  4. Manuscript Revised: 1 DEC 2003
  5. Manuscript Received: 8 SEP 2003

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (76K)

REFERENCES

  • 1
    Genant HK, Cooper C, Poor G, Reid I, Ehrlich G, Kanis J, Nordin BE, Barrett-Connor E, Black D, Bonjour JP, Dawson-Hughes B, Delmas PD, Dequeker J, Ragi ES, Gennari C, Johnell O, Johnston CC Jr, Lau EM, Liberman UA, Lindsay R, Martin TJ, Masri B, Mautalen CA, Meunier PJ, Khaltaev N 1999 Interim report and recommendations of the World Health Organization Task-Force for Osteoporosis. Osteoporos Int 10: 259–264.
  • 2
    Cummings SR, Kelsey JL, Nevitt MC, O'Dowd KJ 1985 Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol Rev 7: 178–208.
  • 3
    Dolan P, Torgerson DJ 1998 The cost of treating osteoporotic fractures in the United Kingdom female population. Osteoporos Int 8: 611–617.
  • 4
    Cuddihy MT, Gabriel SE, Crowson CS, O'Fallon WM, Melton LJ III 1999 Forearm fractures as predictors of subsequent osteoporotic fractures. Osteoporos Int 9: 469–475.
  • 5
    Mallmin H, Ljunghall S, Persson I, Naessen T, Krusemo UB, Bergstrom R 1993 Fracture of the distal forearm as a forecaster of subsequent hip fracture: A population-based cohort study with 24 years of follow-up. Calcif Tissue Int 52: 269–272.
  • 6
    Nguyen TV, Center JR, Sambrook PN, Eisman JA 2001 Risk factors for proximal humerus, forearm, and wrist fractures in elderly men and women: The Dubbo Osteoporosis Epidemiology Study. Am J Epidemiol 153: 587–595.
  • 7
    Honkanen RJ, Honkanen K, Kroger H, Alhava E, Tuppurainen M, Saarikoski S 2000 Risk factors for perimenopausal distal forearm fracture. Osteoporos Int 11: 265–270.
  • 8
    Hillier S, Cooper C, Kellingray S, Russell G, Hughes H, Coggon D 2000 Fluoride in drinking water and risk of hip fracture in the UK: A case-control study. Lancet 355: 265–269.
  • 9
    Phipps KR, Orwoll ES, Mason JD, Cauley JA 2000 Community water fluoridation, bone mineral density, and fractures: Prospective study of effects in older women. BMJ 321: 860–864.
  • 10
    Friberg L, Elinder C-G, Kjellström T, Nordberg GF 1986 Cadmium and Health: A Toxicological and Epidemiological Apprasial, vol. II (Effects and Response). CRC Press Inc., Boca Raton, FL, USA.
  • 11
    Staessen JA, Roels HA, Emelianov D, Kuznetsova T, Thijs L, Vangronsveld J, Fagard R 1999 Environmental exposure to cadmium, forearm bone density, and risk of fractures: Prospective population study. Public Health and Environmental Exposure to Cadmium (PheeCad) Study Group. Lancet 353: 1140–1144.
  • 12
    Ogoshi K, Nanzai Y, Moriyama T 1992 Decrease in bone strength of cadmium-treated young and old rats. Arch Toxicol 66: 315–320.
  • 13
    Ogoshi K, Moriyama T, Nanzai Y 1989 Decrease in the mechanical strength of bones of rats administered cadmium. Arch Toxicol 63: 320–324.
  • 14
    Uriu K, Morimoto I, Kai K, Okazaki Y, Okada Y, Qie YL, Okimoto N, Kaizu K, Nakamura T, Eto S 2000 Uncoupling between bone formation and resorption in ovariectomized rats with chronic cadmium exposure. Toxicol Appl Pharmacol 164: 264–272.
  • 15
    Bergbäck B, Carlsson M 1995 Heritage of cadmium and lead. A case study of a Swedish accumulator factory. Sci Total Environ 166: 35–42.
  • 16
    Alfven T, Elinder C-G, Carlsson MD, Grubb A, Hellström L, Persson B, Pettersson C, Spång G, Schütz A, Järup L 2000 Low level cadmium exposure and osteoporosis. J Bone Miner Res 15: 1579–1586.
  • 17
    Alfvén T, Järup L, Elinder CG 2002 Cadmium and lead in blood in relation to low bone mineral density and tubular proteinuria. Environ Health Perspect 110: 699–702.
  • 18
    Huopio J, Kroger H, Honkanen R, Saarikoski S, Alhava E 2000 Risk factors for perimenopausal fractures: A prospective study. Osteoporos Int 11: 219–227.
  • 19
    Elinder C-G, Gerhardsson L, Oberdörster G 1988 Biological monitoring of toxic metals—overview. In: ClarksonTW, FribergL, NordbergGF, SagerPR (eds.) Biological Monitoring of Toxic Metals. Plenum Press, New York, NY, USA, pp. 1–71.
  • 20
    Alfvén T 2002 Bone and kidney effects from cadmium exposure—Dose effect and dose response relationships. Ph.D. thesis, Karolinska Institutet, Stockholm, Sweden.
  • 21
    Jarup L, Berglund M, Elinder CG, Nordberg G, Vahter M 1998 Health effects of cadmium exposure—a review of the literature and a risk estimate. Scand J Work Environ Health 24 (Suppl 1): 1–51.
  • 22
    Friberg L, Elinder C-G, Kjellström T, Nordberg GF 1985 Cadmium and Health: A Toxicological and Epidemiological Apprasial, vol. I (Exposure, Dose, and Metabolism). CRC Press Inc., Boca Raton, FL, USA.
  • 23
    Elinder C-G, Friberg L, Nordberg GF, Kjellström T, Oberdoerster G 1994 Biological Monitoring of Metals. World Health Organization, Geneva, Switzerland.
  • 24
    World Health Organization 1992 Cadmium Environmental Health Criteria 134. World Health Organization, Geneva, Switzerland.
  • 25
    Hollenbach KA, Barrett-Connor E, Edelstein SL, Holbrook T 1993 Cigarette smoking and bone mineral density in older men and women. Am J Public Health 83: 1265–1270.
  • 26
    Egger P, Duggleby S, Hobbs R, Fall C, Cooper C 1996 Cigarette smoking and bone mineral density in the elderly. J Epidemiol Community Health 50: 47–50.
  • 27
    Szulc P, Garnero P, Claustrat B, Marchand F, Duboeuf F, Delmas PD 2002 Increased bone resorption in moderate smokers with low body weight: The Minos study. J Clin Endocrinol Metab 87: 666–674.
  • 28
    Ward KD, Klesges RC 2001 A meta-analysis of the effects of cigarette smoking on bone mineral density. Calcif Tissue Int 68: 259–270.
  • 29
    Kjellstrom T 1992 Mechanism and epidemiology of bone effects of cadmium. In: NordbergG, HerberR, AlessioL (eds.) Cadmium in the Human Environment: Toxicity and Carcinogenicity. IARC Scientific Publications, Lyon, France, pp. 301–310.
  • 30
    Koo WW, Succop PA, Bornschein RL, Krug-Wispe SK, Steinchen JJ, Tsang RC, Berger OG 1991 Serum vitamin D metabolites and bone mineralization in young children with chronic low to moderate lead exposure. Pediatrics 87: 680–687.
  • 31
    Mahaffey KR, Rosen JF, Chesney RW, Peeler JT, Smith CM, DeLuca HF 1982 Association between age, blood lead concentration, and serum 1,25-dihydroxycholecalciferol levels in children. Am J Clin Nutr 35: 1327–1331.
  • 32
    Goyer RA, Epstein S, Bhattacharyya M, Korach KS, Pounds J 1994 Environmental risk factors for osteoporosis. Environ Health Perspect 102: 390–394.
  • 33
    World Health Organization 1995 Inorganic Lead: Environmental Health Criteria 165. World Health Organization, Geneva, Switzerland.
View Full Article (HTML) Get PDF (76K)