• 1
    Rodan GA, Martin TJ 2000 Therapeutic approaches to bone diseases. Science 289: 15081514.
  • 2
    Teitelbaum SL 2000 Bone resorption by osteoclasts. Science 289: 15041508.
  • 3
    Stenbeck G 2002 Formation and function of the ruffled border in osteoclasts. Semin Cell Dev Biol 13: 285292.
  • 4
    Blair HC, Teitelbaum SL, Ghiselli R, Gluck S 1989 Osteoclastic bone resorption by a polarized vacuolar proton pump. Science 245: 855857.
  • 5
    al Awqati Q 1995 Chloride channels of intracellular organelles. Curr Opin Cell Biol 7: 504508.
  • 6
    Laitala T, Vaananen HK 1994 Inhibition of bone resorption in vitro by antisense RNA and DNA molecules targeted against carbonic anhydrase II or two subunits of vacuolar H(+)-ATPase. J Clin Invest 93: 23112318.
  • 7
    Jentsch TJ, Stein V, Weinreich F, Zdebik AA 2002 Molecular structure and physiological function of chloride channels. Physiol Rev 82: 503568.
  • 8
    Nilius B, Eggermont J, Voets T, Droogmans G 1996 Volume-activated Cl-channels. Gen Pharmacol 27: 11311140.
  • 9
    Kelly ME, Dixon SJ, Sims SM 1994 Outwardly rectifying chloride current in rabbit osteoclasts is activated by hyposmotic stimulation. J Physiol 475: 377389.
  • 10
    Sakai H, Nakamura F, Kuno M 1999 Synergetic activation of outwardly rectifying Cl-currents by hypotonic stress and external Ca2+ in murine osteoclasts. J Physiol 51: 157168.
  • 11
    Weidema AF, Dixon SJ, Sims SM 2000 Electrophysiological characterization of ion channels in osteoclasts isolated from human deciduous teeth. Bone 27: 511.
  • 12
    Campos-Xavier AB, Saraiva JM, Ribeiro LM, Munnich A, Cormier-Daire V 2003 Chloride channel 7 (CLCN7) gene mutations in intermediate autosomal recessive osteopetrosis. Hum Genet 112: 186189.
  • 13
    Benichou O, Cleiren E, Gram J, Bollerslev J, de Vernejoul MC, Van Hul W 2001 Mapping of autosomal dominant osteopetrosis type II (Albers-Schonberg disease) to chromosome 16p13.3. Am J Hum Genet 69: 647654.
  • 14
    Cleiren E, Benichou O, Van Hul E, Gram J, Bollerslev J, Singer FR, Beaverson K, Aledo A, Whyte MP, Yoneyama T, deVernejoul MC, Van Hul W 2001 Albers-Schonberg disease (autosomal dominant osteopetrosis, type II) results from mutations in the ClCN7 chloride channel gene. Hum Mol Genet 10: 28612867.
  • 15
    Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR 2001 Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. Hum Mol Genet 10: 339352.
  • 16
    Kornak U, Kasper D, Bosl MR, Kaiser E, Schweizer M, Schulz A, Friedrich W, Delling G, Jentsch TJ 2001 Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man. Cell 104: 205215.
  • 17
    Bennekou P, de Franceschi L, Pedersen O, Lian L, Asakura T, Evans G, Brugnara C, Christophersen P 2001 Treatment with NS3623, a novel Cl-conductance blocker, ameliorates erythrocyte dehydration in transgenic SAD mice: A possible new therapeutic approach for sickle cell disease. Blood 97: 14511457.
  • 18
    Hélix N, Strøbaek D, Dahl BH, Christophersen P 2003 Inhibition of the volume-regulated anion channel (VRAC) in HEK293 cells by acidic di-aryl-ureas. J Membr Biol 196: 112.
  • 19
    Nicholson GC, Malakellis M, Collier FM, Cameron PU, Holloway WR, Gough TJ, Gregorio-King C, Kirkland MA, Myers DE 2000 Induction of osteoclasts from CD14-positive human peripheral blood mononuclear cells by receptor activator of nuclear factor kappaB ligand (RANKL). Clin Sci (Lond) 99: 133140.
  • 20
    Karsdal MA, Hjorth P, Henriksen K, Kirkegaard T, Nielsen KL, Lou H, Delaisse JM, Foged NT 2003 Transforming growth factor-beta controls human osteoclastogenesis through the p38 MAPK and regulation of RANK expression. J Biol Chem 278: 4497544987.
  • 21
    Blavier L, Delaisse JM 1995 Matrix metalloproteinases are obligatory for the migration of preosteoclasts to the developing marrow cavity of primitive long bones. J Cell Sci 108: 36493659.
  • 22
    Engsig MT, Chen QJ, Vu TH, Pedersen AC, Therkidsen B, Lund LR, Henriksen K, Lenhard T, Foged NT, Werb Z, Delaisse JM 2000 Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones. J Cell Biol 151: 879889.
  • 23
    Baron R, Neff L, Louvard D, Courtoy PJ 1985 Cell-mediated extracellular acidification and bone resorption: Evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border. J Cell Biol 101: 22102222.
  • 24
    Ishii M, Hashimoto S, Tsutsumi S, Wada Y, Matsushima K, Kodama T, Aburatani H 2000 Direct comparison of GeneChip and SAGE on the quantitative accuracy in transcript profiling analysis. Genomics 68: 136143.
  • 25
    Brandt S, Jentsch TJ 1995 ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family. FEBS Lett 377: 1520.
  • 26
    Brockstedt H, Bollerslev J, Melsen F, Mosekilde L 1996 Cortical bone remodeling in autosomal dominant osteopetrosis: A study of two different phenotypes. Bone 18: 6772.
  • 27
    Ravn P, Hosking D, Thompson D, Cizza G, Wasnich RD, McClung M, Yates AJ, Bjarnason NH, Christiansen C 1999 Monitoring of alendronate treatment and prediction of effect on bone mass by biochemical markers in the early postmenopausal intervention cohort study. J Clin Endocrinol Metab 84: 23632368.
  • 28
    Rodan GA, Reszka AA 2002 Bisphosphonate mechanism of action. Curr Mol Med 2: 571577.
  • 29
    Bourrin S, Ammann P, Bonjour JP, Rizzoli R 2002 Recovery of proximal tibia bone mineral density and strength, but not cancellous bone architecture, after long-term bisphosphonate or selective estrogen receptor modulator therapy in aged rats. Bone 30: 195200.
  • 30
    Visentin L, Dodds RA, Valente M, Misiano P, Bradbeer JN, Oneta S, Liang X, Gowen M, Farina C 2000 A selective inhibitor of the osteoclastic V-H(+)-ATPase prevents bone loss in both thyroparathyroidectomized and ovariectomized rats. J Clin Invest 106: 309318.
  • 31
    Taranta A, Migliaccio S, Recchia I, Caniglia M, Luciani M, De Rossi G, Dionisi-Vici C, Pinto RM, Francalanci P, Boldrini R, Lanino E, Dini G, Morreale G, Ralston SH, Villa A, Vezzoni P, Del Principe D, Cassiani F, Palumbo G, Teti A 2003 Genotype-phenotype relationship in human ATP6i-dependent autosomal recessive osteopetrosis. Am J Pathol 162: 5768.
  • 32
    Jaworski ZF 1984 Coupling of bone formation to bone resorption: A broader view. Calcif Tissue Int 36: 531535.