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  • 1
    Rubin C, Turner AS, Bain S, Mallinckrodt C, McLeod K 2001 Anabolism. Low mechanical signals strengthen long bones. Nature 412: 603604.
  • 2
    Notomi T, Okimoto N, Okazaki Y, Tanaka Y, Nakamura T, Suzuki M 2001 Effects of tower climbing exercise on bone mass, strength, and turnover in growing rats. J Bone Miner Res 16: 166174.
  • 3
    Notomi T, Lee SJ, Okimoto N, Okazaki Y, Takamoto T, Nakamura T, Suzuki M 2000 Effects of resistance exercise training on mass, strength, and turnover of bone in growing rats. Eur J Appl Physiol 82: 268274.
  • 4
    Iwamoto J, Yeh JK, Aloia JF 1999 Differential effect of treadmill exercise on three cancellous bone sites in the young growing rat. Bone 24: 163169.
  • 5
    Prior BM, Lloyd PG, Yang HT, Terjung RL 2003 Exercise-induced vascular remodelling. Exerc Sport Sci Rev 31: 2633.
  • 6
    Richardson RS, Wagner H, Mudaliar SR, Henry R, Noyszewski EA, Wagner PD 1999 Human VEGF gene expression in skeletal muscle: Effect of acute normoxic and hypoxic exercise. Am J Physiol 277: H2247H2252.
  • 7
    Hiscock N, Fischer CP, Pilegaard H, Pedersen BK 2003 Vascular endothelial growth factor mRNA expression and arteriovenous balance in response to prolonged, submaximal exercise in humans. Am J Physiol Heart Circ Physiol 285: H1759H1763.
  • 8
    Brown MD, Hudlicka O 2003 Modulation of physiological angiogenesis in skeletal muscle by mechanical forces: Involvement of VEGF and metalloproteinases. Angiogenesis 6: 114.
  • 9
    Mujika I, Padilal S 2001 Muscular characteristics of detraining in humans. Med Sci Sports Exerc 33: 12971303.
  • 10
    Gerber HP, Ferrara N 2000 Angiogenesis and bone growth. Trends Cardiovasc Med 10: 223228.
  • 11
    Glowacki J 1998 Angiogenesis in fracture repair. Clin Orthop 355 (Suppl): S82S89.
  • 12
    Fenwick SA, Gregg PJ, Rooney P 1999 Osteoarthritic cartilage loses its ability to remain avascular. Osteoarthritis Cartilage 7: 441452.
  • 13
    Hausman MR, Schaffler MB, Majeska RJ 2001 Prevention of fracture healing in rats by an inhibitor of angiogenesis. Bone 29: 560564.
  • 14
    Vogt MT, Cauley JA, Kuller LH, Nevitt MC 1997 Bone mineral density and blood flow to the lower extremities: The study of osteoporotic fractures. J Bone Miner Res 12: 283289.
  • 15
    Laroche M, Moulinier L, Leger P, Lefebvre D, Mazières B, Boccalon H 2003 Bone mineral decrease in the leg with unilateral occlusive arterial disease. Clin Exp Rheumatol 21: 103106.
  • 16
    Garcia-Ramirez M, Toran N, Andaluz P, Carrascosa A, Audi L 2000 Vascular endothelial growth factor is expressed in human fetal growth cartilage. J Bone Miner Res 15: 534540.
  • 17
    Ornit DM, Marie PJ 2000 FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. Genes Dev 16: 14461465.
  • 18
    Fiorelli G, Orlando C, Benvenuti S, Franceschelli F, Bianchi S, Pioli P, Tanini A, Serio M, Bartucci F, Brandi ML 1994 Characterization, regulation, and function of specific cell membrane receptors for insulin-like growth factor I on bone endothelial cells. J Bone Miner Res 9: 329337.
  • 19
    Horner A, Bord S, Kemp P, Grainger D, Compston JE 1996 Distribution of platelet-derived growth factor (PDGF) A chain mRNA, protein, and PDGF-alpha receptor in rapidly forming human bone. Bone 19: 353362.
  • 20
    Dickson KM, Bergeron JJ, Philip A, O'Connor-McCourt M, Warshawsky H 2001 Localization of specific binding sites for 125I-TGF-beta1 to fenestrated endothelium in bone and anastomosing capillary networks in enamel organ suggests a role for TGF-beta1 in angiogenesis. Calcif Tissue Int 68: 304315.
  • 21
    Ferrara N, Gerber HP, LeCouter J 2003 The biology of VEGF and its receptors. Nat Med 9: 669676.
  • 22
    Zachary I 2001 Signalling mechanisms mediating vascular protective actions of vascular endothelial growth factor. Am J Physiol Cell Physiol 280: C1375C1386.
  • 23
    Tober KL, Cannon RE, Spalding JW, Oberyszyn TM, Parrett ML, Rackoff AI, Oberyszyn AS, Tennant RW, Robertson FM 1998 Comparative expression of novel vascular endothelial growth factor/vascular permeability factor transcripts in skin, papillomas, and carcinomas of v-Ha-ras Tg.AC transgenic mice and FVB/N mice. Biochem Biophys Res Commun 247: 644653.
  • 24
    Zhang L, Conejo-Garcia JR, Yang N, Huang W, Mohamed-Hadley A, Yao W, Benencia F, Coukos G 2002 Different effects of glucose starvation on expression and stability of VEGF mRNA isoforms in murine ovarian cancer cells. Biochem Biophys Res Commun 292: 860868.
  • 25
    Zelzer E, McLean W, Ng YS, Fukai N, Reginato AM, Lovejoy S, D'Amore PA, Olsen BR 2002 Skeletal defects in VEGF (120/120) mice reveal multiple roles for VEGF in skeletogenesis. Development 129: 18931904.
  • 26
    Maes C, Carmeliet P, Moermans K, Stockmans I, Smets N, Collen D, Bouillon R, Carmeliet G 2002 Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF (164) and VEGF (188). Mech Dev 111: 6173.
  • 27
    Gerber HP, Vu TH, Ryan AM, Kowalski J, Werb Z, Ferrara N 1999 VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med 5: 623628.
  • 28
    Hiltunen MO, Ruuskanen M, Huuskonen J, Mahonen AJ, Ahonen M, Rutanen J, Kosma VM, Mahonen A, Kroger H, Yla-Herttuala S 2003 Adenovirus-mediated VEGF-A gene transfer induces bone formation in vivo. FASEB J 17: 11471149.
  • 29
    Barou O, Vico L, Alexandre C, Lafage-Proust MH 2000 Early bone vascular alterations in the rat hindlimb unloading model. J Bone Miner Res 15: S301. (abstract)
  • 30
    Mekraldi S, Lafage-Proust MH, Bloomfield S, Alexandre C, Vico L 2003 Changes in vasoactive factors associated with altered vessel morphology in the tibial metaphysis during ovariectomy-induced bone loss in rats. Bone 32: 630641.
  • 31
    Bourrin S, Palle S, Pupier R, Vico L, Alexandre C 1995 Effect of physical training on bone adaptation in three zones of the rat tibia. J Bone Miner Res 10: 17451752.
  • 32
    Guerrin M, Moukadiri H, Chollet P, Moro F, Dutt K, Malecaze F, Plouët J 1995 Vasculotropin/vascular endothelial growth factor is an autocrine growth factor for human retinal pigment epithelial cells cultured in vitro. J Cell Physiol 164: 385394.
  • 33
    Berard M, Sordello S, Ortega N, Carrier JL, Peyri N, Wassef M, Bertrand N, Enjolras O, Drouet L, Plouet J 1997 Vascular endothelial growth factor confers a growth advantage in vitro and in vivo to stromal cells cultured from neonatal hemangiomas. Am J Pathol 150: 13151326.
  • 34
    Barou O, Mekraldi S, Vico L, Boivin G, Alexandre C, Lafage-Proust MH 2002 Relationships between trabecular bone remodeling and bone vascularization: A quantitative study. Bone 30: 604612.
  • 35
    Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR 1987 Bone histomorphometry: Standarization of nomenclature, symbols and units. J Bone Miner Res 2: 595610.
  • 36
    Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156159.
  • 37
    Zhang L, Bail H, Mittlmeier T, Haas NP, Schaser KD 2003 Immediate microcirculatory derangements in skeletal muscle and periosteum after closed tibial fracture. J Trauma 54: 979985.
  • 38
    Chanavaz M 1995 Anatomy and histophysiology of the periosteum: Quantification of the periosteal blood supply to the adjacent bone with 85Sr and gamma spectrometry. J Oral Implantol 21: 214219.
  • 39
    Milkiewicz M, Hudlicka O, Verhaeg J, Egginton S, Brown MD 2003 Differential expression of Flk-1 and Flt-1 in rat skeletal muscle in response to chronic ischaemia: Favorable effect of muscle activity. Clin Sci (Lond) 105: 473482.
  • 40
    Waltenberger J, Claesson-Welsh L, Siegbahn A, Shibuya M, Heldin CH 1994 Different signal transduction properties of KDR and Flt-1, two receptors for vascular endothelial growth factor. J Biol Chem 269: 2698826995.
  • 41
    Shih SC, Ju M, Liu N, Smith LE 2003 Selective stimulation of VEGFR-1 prevents oxygen-induced retinal vascular degeneration in retinopathy of prematurity. J Clin Invest 112: 5057.
  • 42
    Millauer B, Shawver LK, Plate KH, Risau W, Ullrich A 1994 Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature 367: 576579.
  • 43
    Gerber HP, Vu TH, Ryan AM, Kowalski J, Werb Z, Ferrara N 1999 VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med 5: 623628.
  • 44
    Gavin TP, Wagner PD 2002 Attenuation of the exercise-induced increase in skeletal muscle Flt-1 mRNA by nitric oxide synthase inhibition. Acta Physiol Scand 175: 201209.
  • 45
    Ferguson C, Alpern E, Miclau T, Helms JA 1999 Does adult fracture repair recapitulate embryonic skeletal formation? Mech Dev 87: 5766.
  • 46
    Tatsuyama K, Maezawa Y, Bab H, Imamura Y, Fukuda M 2000 Expression of various growth factors for cell proliferation and cytodifferentiation during fracture repair of bone. Eur J Histochem 44: 269278.
  • 47
    Street J, Bao M, deGuzman L, Bunting S, Peale FV Jr, Ferrara N, Steinmetz H, Hoeffel J, Cleland JL, Daugherty A, van Bruggen N, Redmond HP, Carano RA, Filvaroff EH 2002 Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci USA 99: 96569661.
  • 48
    Deckers MM, Karperien M, van der Bent C, Yamashita T, Papapoulos SE, Lowik CW 2000 Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation. Endocrinology 141: 16671674.
  • 49
    Saadeh PB, Mehrara BJ, Steinbrech DS, Spector JA, Greenwald JA, Chin GS, Ueno H, Gittes GK, Longaker MT 2000 Mechanisms of fibroblast growth factor-2 modulation of vascular endothelial growth factor expression by osteoblastic cells. Endocrinology 141: 20752083.
  • 50
    Wang DS, Miura M, Demura H, Sato K 1997 Anabolic effects of 1,25-dihydroxyvitamin D3 on osteoblasts are enhanced by vascular endothelial growth factor produced by osteoblasts and by growth factors produced by endothelial cells. Endocrinology 138: 29532962.
  • 51
    Mayr-Wohlfart U, Waltenberger J, Hausser H, Kessler S, Gunther KP, Dehio C, Puhl W, Brenner RE 2002 Vascular endothelial growth factor stimulates chemotactic migration of primary human osteoblasts. Bone 30: 472477.
  • 52
    Midy V, Plouet J 1994 Vasculortropin/vascular endothelial growth factor induces differention in cultured osteoblasts. Biochem Biophys Res Commun 199: 380386.
  • 53
    Claffey KP, Abrams K, Shih SC, Brown LF, Mullen A, Keough M 2001 Fibroblast growth factor 2 activation of stromal cell vascular endothelial growth factor expression and angiogenesis. Lab Invest 81: 6175.
  • 54
    Deckers MM, van Bezooijen RL, van der Horst G, Hoogendam J, van Der Bent C, Papapoulos SE, Lowik CW 2002 Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A. Endocrinology 143: 15451553.
  • 55
    Yeh LC, Lee JC 1999 Osteogenic protein-1 increases gene expression of vascular endothelial growth factor in primary cultures of fetal rat calvaria cells. Mol Cell Endocrinol 153: 113124.
  • 56
    Chua CC, Hamdy RC, Chua BH 2000 Mechanism of transforming growth factor-beta1-induced expression of vascular endothelial growth factor in murine osteoblastic MC3T3-E1 cells. Biochem Biophys Acta 1497: 6976.
  • 57
    Kozawa O, Matsuno H, Uematsu TJ 2001 Involvement of p70 S6 kinase in bone morphogenetic protein signaling: Vascular endothelial growth factor synthesis by bone morphogenetic protein-4 in osteoblasts. Cell Biochem 81: 430436.
  • 58
    Kohno S, Kaku M, Tsutsui K, Motokawa M, Ohtani J, Tenjo K, Tohma Y, Tokimasa C, Fujita T, Kawata T, Tanne K 2003 Expression of vascular endothelial growth factor and the effects on bone remodeling during experimental tooth movement. J Dent Res 82: 177182.
  • 59
    Fong KD, Nacamuli RP, Loboa EG, Henderson JH, Fang TD, Song HBM, Cowan CM, Warren SM, Carter DR, Longaker MT 2003 Equibiaxial tensile strain affects calvarial osteoblast biology. J Craniomaxillofac Surg 14: 348355.
  • 60
    Nakagawa M, Kaneda T, Arakawa T, Morita S, Sato T, Yomada T, Hanada K, Kumegawa M, Hakeda Y 2000 Vascular endothelial growth factor (VEGF) directly enhances osteoclastic bone resorption and survival of mature osteoclasts. FEBS Lett 473: 161164.
  • 61
    Engsig MT, Chen QJ, Vu TH, Pedersen AC, Therkidsen B, Lund LR, Henriksen K, Lenhard T, Foged NT, Werb Z, Delaisse JM 2000 Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones. J Cell Biol 151: 879889.
  • 62
    Matsumoto Y, Tanaka K, Hirata G, Hanada M, Matsuda S, Shuto T, Iwamoto Y 2002 Possible involvement of the vascular endothelial growth factor-Flt-1-focal adhesion kinase pathway in chemotaxis and the cell proliferation of osteoclast precursor cells in arthritic joints. J Immunol 168: 58245831.
  • 63
    Chiao JW, Moonga BS, Yang YM, Kancherla R, Mittelman A, Wu-Wong JR, Ahmed T 2000 Endothelin-1 from prostate cancer cells is enhanced by bone contact which blocks osteoclastic bone resorption. Br J Cancer 83: 360365.
  • 64
    Alam AS, Gallagher A, Shankar V, Ghatei MA, Datta HK, Huang CL, Moonga BS, Chambers TJ, Bloom SR, Zaidi M 1992 Endothelin inhibits osteoclastic bone resorption by a direct effect on cell motility: Implications for the vascular control of bone resorption. Endocrinology 130: 36173624.
  • 65
    MacIntyre I, Zaidi M, Alam AS, Datta HK, Moonga BS, Lidbury PS, Hecker M, Vane JR 1991 Osteoclastic inhibition: An action of nitric oxide not mediated by cyclic GMP. Proc Natl Acad Sci USA 88: 29362940.