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Growth Hormone Injections Improve Bone Quality in a Mouse Model of Osteogenesis Imperfecta†
Article first published online: 18 JAN 2005
DOI: 10.1359/JBMR.050108
Copyright © 2005 ASBMR
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How to Cite
King, D., Jarjoura, D., McEwen, H. A. and Askew, M. J. (2005), Growth Hormone Injections Improve Bone Quality in a Mouse Model of Osteogenesis Imperfecta. J Bone Miner Res, 20: 987–993. doi: 10.1359/JBMR.050108
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Publication History
- Issue published online: 4 DEC 2009
- Article first published online: 18 JAN 2005
- Manuscript Accepted: 12 JAN 2005
- Manuscript Revised: 5 JAN 2005
- Manuscript Received: 12 OCT 2004
REFERENCES
- 12004 Syndromes with congenital brittle bones. BMC Pediatr 4: 16.
- 2, , , , 1993 Evaluation of growth hormone axis and responsiveness to growth stimulation of short children with osteogenesis imperfecta. Am J Med Genet 45: 261–264.
- 3, , , , , , 2003 Positive linear growth and bone responses to growth hormone treatment in children with types III and IV osteogenesis imperfecta: High predictive value of the carboxyterminal propeptide of type I procollagen. J Bone Miner Res 18: 237–243.
- 4, , , , 1999 Effect of growth hormone treatment on calcium kinetics in patients with osteogenesis imperfecta type III and IV. Bone 25: 501–505.
- 5, , , , , 2000 Calcium kinetics in children with osteogenesis imperfecta type III and IV: Pre- and post-growth hormone therapy. Calcif Tissue Int 67: 97–100.
- 6, , , , , , , , 1993 Defective pro alpha 2(I) collagen synthesis in a recessive mutation in mice: A model of human osteogenesis imperfecta. Proc Natl Acad Sci USA 90: 1701–1705.
- 7, , , , , , 1997 Effect of rhBMP-2 on the osteogenic potential of bone marrow stromal cells from an osteogenesis imperfecta mouse (oim). Bone 21: 7–15.
- 8, , 1996 Mineral changes in a mouse model of osteogenesis imperfecta detected by Fourier transform infrared microscopy. Connect Tissue Res 35: 259–265.
- 9, , , , , , , 1999 The material basis for reduced mechanical properties in oim mice bones. J Bone Miner Res 14: 264–272.
- 10, , , , , , 2001 Age- and genotype-dependence of bone material properties in the osteogenesis imperfecta murine model (oim). Bone 29: 453–457.
- 11, , , , , 1996 Heterozygous oim mice exhibit a mild form of osteogenesis imperfecta. Bone 19: 575–579.
- 12, , , , , , , 2005 Effects of growth hormone transgene expression on vertebrae in a mouse model of osteogenesis imperfecta. Spine (in press)
- 13, 1977 Linear and Nonlinear Models for the Analysis of Repeated Measurements. Marcel Dekker, New York, NY, USA.
- 14, , , , , , , , 2001 Growth inhibition in giant growth hormone transgenic mice by overexpression of insulin-like growth factor-binding protein-2. Endocrinology 142: 1889–1898.
- 15, , , , , , 1997 Actions and interactions of growth hormone and insulin-like growth factor-II: Body and organ growth of transgenic mice. Transgenic Res 6: 213–222.
- 16, , , , 1983 Metallothionein-human GH fusion genes stimulate growth of mice. Science 222: 809–814.
- 17, , , 2003 Evidence that sensitivity to growth hormone (GH) is growth period and tissue type dependent: Studies in GH-deficient lit/lit mice. Endocrinology 144: 3950–3957.
- 18, , , , 2001 Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth. Dev Biol 229: 141–162.
- 19, , , , 2003 Temporal analysis of rat growth plates: Cessation of growth with age despite presence of a physis. J Histochem Cytochem 51: 373–383.
- 20, 1996 PCR genotyping of oim mutant mice. Biotechniques 21: 190–192.
- 21, , 1999 Anthropometry of patients with osteogenesis imperfecta. Arch Dis Child 80: 524–528.
- 22, , 1979 Genetic heterogeneity in osteogenesis imperfecta. J Med Genet 16: 101–116.
- 23, 2002 Physiology of erythropoietin during mammalian development. Acta Paediatr Suppl 91: 17–26.
- 24, 1966 Blood and blood formation. In: GreenEL (ed.) Biology of the Laboratory Mouse. Dover Publications, New York, NY, USA, pp. 351–372.
- 252003 New insights into the molecular mechanisms of action of bisphosphonates. Curr Pharm Des 9: 2643–2658.
- 261991 Growth hormone and bone. Horm Res 36 (Suppl 1): 49–55.
- 27, , 2002 Ultrastructural localization of proteoglycans in bone in osteogenesis imperfecta as demonstrated by cuprolinic blue staining. J Bone Miner Metab 20: 288–293.
- 28, , , , , , 1991 Osteogenesis imperfecta: Changes in noncollagenous proteins in bone. J Bone Miner Res 6: 501–505.
- 29, , , 1994 Ultrastructural studies of bones from patients with osteogenesis imperfecta. Matrix Biol 14: 337–345.
- 30, , , 2000 Static and dynamic bone histomorphometry in children with osteogenesis imperfecta. Bone 26: 581–589.
- 31, , , , , , , 1996 Growth hormone treatment in osteogenesis imperfecta with quantitative defect of type I collagen synthesis. J Pediatr 129: 432–439.
- 32, , , , , , , 1999 Body proportions during long-term growth hormone treatment in girls with Turner syndrome participating in a randomized dose-response trial. J Clin Endocrinol Metab 84: 4622–4628.
- 33, , 2003 Body proportions before and during growth hormone therapy in children with chronic renal failure. Pediatr Nephrol 18: 679–684.
- 34, , , 2000 Does growth hormone therapy harmonize distorted morphology and body composition in chronic renal failure. Pediatr Nephrol 15: 229–235.
- 35, , 2004 Growth hormone treatment in children: Review of safety and efficacy. Paediatr Drugs 6: 93–106.
- 36, , , , 2002 Effects of dose and gender on the growth and growth factor response to GH in GH-deficient children: Implications for efficacy and safety. J Clin Endocrinol Metab 87: 90–98.
- 372004 Lessons from the national cooperative growth study. Eur J Endocrinol 151: S55–S59.
- 38, 2004 Cancer risk following growth hormone use in childhood: Implications for current practice. Drug Saf 27: 369–382.

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