• 1
    Anderson HC 1995 Molecular biology of matrix vesicles. Clin Orthop Res 314: 266280.
  • 2
    Anderson HC 1969 Vesicles associated with calcification in the matrix of epiphyseal cartilage. J Cell Biol 41: 5972.
  • 3
    Ali SY, Sajdera SW, Anderson HC 1970 Isolation and characterization of calcifying matrix vesicles from epiphyseal cartilage. Proc Natl Acad Sci USA 67: 15131520.
  • 4
    Akisaka T, Gay CV 1985 The plasma membrane and matrix vesicles of mouse growth plate chondrocytes during differentiation as revealed in freeze-fracture replicas. Am J Anat 173: 269286.
  • 5
    Terkeltaub R 2001 Inorganic pyrophosphate generation and disposition in pathophysiology. Am J Physiol Cell Physiol 281: C1C11.
  • 6
    Moss DW, Eaton RH, Smith JK, Whitby LG 1967 Association of inorganic-pyrophosphatase activity with human alkaline-phosphatase preparations. Biochem J 1 102: 5357.
  • 7
    Majeska RJ, Wuthier RE 1975 Studies on matrix vesicles isolated from chick epiphyseal cartilage. Association of pyrophosphatase and ATPase activities with alkaline phosphatase. Biochim Biophys Acta 391: 5160.
  • 8
    Meyer JL 1984 Studies on matrix vesicles isolated from chick epiphyseal cartilage. Association of pyrophosphatase and ATPase activities with alkaline phosphatase. Arch Biochem Biophys 231: 18.
  • 9
    Rezende A, Pizauro J, Ciancaglini P, Leone F 1994 Phosphodiesterase activity is a novel property of alkaline phosphatase from osseous plate. Biochem J 1 301: 517522.
  • 10
    Hessle L, Johnsson KA, Anderson HC, Narisawa S, Sali A, Goding JW, Terkeltaub R, Millán JL 2002 Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. Proc Natl Acad Sci USA 99: 94459449.
  • 11
    Terkeltaub R, Rosenbach M, Fong F, Goding J 1994 Causal link between nucleotide pyrophosphohydrolase overactivity and increased intracellular inorganic pyrophosphate generation demonstrated by transfection of cultured fibroblasts and osteoblasts with plasma cell membrane glycoprotein-1. Arthritis Rheum 37: 934941.
  • 12
    Johnson K, Vaingankar S, Chen Y, Moffa A, Goldring M, Sano K, Jin-Hua P, Sali A, Goding J, Terkeltaub R 1999 Differential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytes. Arthritis Rheum 42: 19861997.
  • 13
    Johnson K, Moffa A, Chen Y, Pritzker K, Goding J, Terkeltaub R 1999 Matrix vesicle plasma membrane glycoprotein-1 regulates mineralization by murine osteoblastic MC3T3 cells. J Bone Miner Res 14: 883892.
  • 14
    Hakim FT, Cranley R, Brown KS, Eanes ED, Harne L, Oppenheim JJ 1994 Hereditary joint disorder in progressive ankylosis (ank/ank) mice. I. Association of calcium hydroxyapatite deposition with inflammatory arthropathy. Arthritis Rheum 27: 14111420.
  • 15
    Ho AM, Johnson MD, Kingsley DM 2000 Role of mouse ank gene in control of tissue calcification and arthritis. Science 289: 265269.
  • 16
    Henthorn PS, Whyte MP 1992 Missense mutations of the tissue-nonspecific alkaline phosphatase gene in hypophosphatasia. Clin Chem 38: 25012505.
  • 17
    Whyte MP 1994 Hypophosphatasia and the role of alkaline phosphatase in skeletal mineralization. Endocr Rev 15: 439461.
  • 18
    Waymire KG, Mahuren JD, Jaje JM, Guilarte TR, Coburn SP, McGregor GR 1995 Mice lacking tissue non-specific alkaline phophatase die from seizures die to defective metabolism of vitamin B-6. Nat Genet 11: 4551.
  • 19
    Narisawa N, Fröhlander N, Millán JL 1997 Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia. Dev Dyn 208: 432446.
  • 20
    Fedde KN, Blair L, Silverstein J, Coburn SP, Ryan LM, Weinstein RS, Waymire K, Narisawa S, Millán JL, McGregor GR, Whyte MP 1999 Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia. J Bone Miner Res 14: 20152026.
  • 21
    Whyte MP 2001 The Metabolic and Molecular Bases of Inherited Disease. McGraw-Hill, New York, NY, USA.
  • 22
    Hashimoto S, Ochs RL, Komiya S, Lotz M 1998 Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis. Arthritis Rheum 41: 16321638.
  • 23
    Okawa A, Nakamura I, Goto S, Moriya H, Nakamura Y, Ikegawa S 1998 Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nat Genet 19: 271273.
  • 24
    Sali A, Favaloro JM, Terkeltaub R, Goding JW 1999 Germline deletion of the nucleoside triphosphate pyrophosphohydrolase (NTPPPH) plasma cell membrane glycoprotein-1 (PC-1) produces abnormal calcification of periarticular tissues. VanduffelL, LemmemsR (eds.) Maastrich, The Netherlands, Ecto-ATPases and Related Ectoenzymes. Shaker Publishing, 267282.
  • 25
    Johnson K, Pritzker K, Goding J, Terkeltaub R 2001 The nucleoside triphosphate pyrophosphohydrolase isozyme PC-1 directly promotes cartilage calcification through chondrocyte apoptosis and increased calcium precipitation by mineralizing vesicles. J Rheumatol 28: 26812691.
  • 26
    Johnson K, Hashimoto S, Lotz M, Pritzker K, Goding J, Terkeltaub R 2001 Up-regulated expression of the phosphodiesterase nucleotide pyrophosphatase family member PC-1 is a marker and pathogenic factor for knee meniscal cartilage matrix calcification. Arthritis Rheum 44: 10711081.
  • 27
    Johnson K, Goding J, Van Etten D, Sali A, Hu SI, Farley D, Krug H, Hessle L, Millán JL, Terkeltaub R 2003 Linked deficiencies in extracellular inorganic pyrophosphate (PPi) and osteopontin expression mediate pathologic ossification in PC-1 null mice. J Bone Miner Res 18: 9941004.
  • 28
    Nürnberg P, Theile H, Chandler D, Höhne W, Cunningham ML, Ritter H, Leschik G, Uhlmann K, Mischung C, Harrop K, Goldblatt J, Borochowitz ZU, Kotzot D, Westermann F, Mundlos S, Braun HS, Laing N, Tinschert S 2001 Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia. Nat Genet 28: 3741.
  • 29
    Boskey AL, Maresca M, Ulrich W, Doty SB, Butler WT, Prince CW 1993 Osteopontin hydroxyapatite interactions in vitro. Inhibition of hydroxyapatite formation and growth in a gelatin gel. Bone Miner 22: 147159.
  • 30
    Hunter GK, Kyle CL, Goldberg HA 1994 Modulation of crystal formation by bone phosphoproteins; structural specificity of the osteopontin-mediated inhibition of hydroxyapatite formation. Biochem J 300: 723728.
  • 31
    Sodek J, Ganss B, McKee MD 2000 Osteopontin. Crit Rev Oral Biol Med 11: 279303.
  • 32
    Harmey D, Hessle L, Narisawa S, Johnson KA, Terkeltaub R, Millán JL 2004 Concerted regulation of inorganic pyrophosphate and osteopontin by Akp2, Enpp1 and Ank. An integrated model of the pathogenesis of mineralization disorders. Am J Pathol 164: 11991209.
  • 33
    Tesch W, Vandenbos T, Roschgr P, Fratzl-Zelman N, Klaushofer K, Beertsen W, Fratzl P 2003 Orientation of mineral crystallites and mineral density during skeletal development in mice deficient in tissue nonspecific alkaline phosphatase. J Bone Miner Res 18: 117125.
  • 34
    Denhardt DT, Noda M, O'Regan AW, Pavlin D, Bergman JS 2001 Osteopontin as a means to cope with environmental insults: Regulation of inflammation, tissue remodeling, and cell survival. J Clin Invest 107: 10551061.
  • 35
    Rittling SR, Matsumoto HN, McKee MD, Nanci A, An XR, Novick KE, Kowalski AJ, Noda M, Denhardt DT 1998 Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro. J Bone Miner Res 13: 11011111.
  • 36
    Kozlenkov A, Du Le MH, Cuniasse P, Ny T, Hoylaerts MF, Millan JL 2004 Residues determining the binding specificity of uncompetitive inhibitors to tissue-nonspecific alkaline phosphatase. J Bone Miner Res 19: 18621872.
  • 37
    Murshed M, Harmey D, Millán JL, McKee M, Karsenty G 2005 Co-expression of broadly expressed genes accounts for the spatial restriction of ECM to bone. Genes Dev 19: 10931104.
  • 38
    Boskey AL, Spevak L, Paschalis E, Doty SB, McKee MD 2002 Osteopontin deficiency increases mineral content and mineral crystallinity in mouse bone. Calcif Tissue Int 71: 145154.
  • 39
    Shapses SA, Cifuentes M, Spevak L, Chowdhury H, Brittingham J, Boskey AL, Denhardt DT 2003 Osteopontin facilitates bone resorption, decreasing bone mineral crystallinity and content during calcium deficiency. Calc Tissue Int 73: 8692.
  • 40
    Sodek J, Zhu B, Huynh MH, Brown TJ, Ringuette M 2002 Novel functions of the matricellular proteins osteopontin and osteonectin/SPARC. Connect Tissue Res 43: 308319.
  • 41
    Liu YK, Uemura T, Nemoto A, Yabe T, Fujii N, Ushida T, Tateishi T 1997 Osteopontin involvement in integrin-mediated cell signaling and regulation of expression of alkaline phosphatase during early differentiation of UMR cells. FEBS Lett 420: 112116.
  • 42
    Anderson HC, Harmey D, Camacho NP, Garimella R, Sipe JB, Tague S, Bi X, Johnson K, Terkeltaub R, Millán JL 2005 Sustained osteomalacia of long bones despite major improvement in other hypophosphatasia-related mineral deficits in TNALP/NPP1 double deficient mice. Am J Pathol 166: 17111720.