Drs Burge and King are employees of Procter & Gamble. Dr Tosteson has served as a consultant to Procter & Gamble and Amgen. All other authors state that they have no conflicts of interest.
Incidence and Economic Burden of Osteoporosis-Related Fractures in the United States, 2005–2025†
Article first published online: 4 DEC 2006
Copyright © 2007 ASBMR
Journal of Bone and Mineral Research
Volume 22, Issue 3, pages 465–475, March 2007
How to Cite
Burge, R., Dawson-Hughes, B., Solomon, D. H., Wong, J. B., King, A. and Tosteson, A. (2007), Incidence and Economic Burden of Osteoporosis-Related Fractures in the United States, 2005–2025. J Bone Miner Res, 22: 465–475. doi: 10.1359/jbmr.061113
- Issue published online: 4 DEC 2009
- Article first published online: 4 DEC 2006
- Manuscript Accepted: 29 NOV 2006
- Manuscript Revised: 26 SEP 2006
- Manuscript Received: 26 APR 2006
- health services and economics;
This study predicts the burden of incident osteoporosis-related fractures and costs in the United States, by sex, age group, race/ethnicity, and fracture type, from 2005 to 2025. Total fractures were >2 million, costing nearly $17 billion in 2005. Men account for >25% of the burden. Rapid growth in the disease burden is projected among nonwhite populations.
Introduction: The aging of the U.S. population will likely lead to greater prevalence of osteoporosis. Policy makers require precise projections of the disease burden by demographic subgroups and skeletal sites to effectively target osteoporosis intervention and treatment programs.
Materials and Methods: A state transition Markov decision model was used to estimate total incident fractures and costs by age, sex, race/ethnicity, and skeletal site for the U.S. population ≥50 years of age for 2005–2025.
Results: More than 2 million incident fractures at a cost of $17 billion are predicted for 2005. Total costs including prevalent fractures are more than $19 billion. Men account for 29% of fractures and 25% of costs. Total incident fractures by skeletal site were vertebral (27%), wrist (19%), hip (14%), pelvic (7%), and other (33%). Total costs by fracture type were vertebral (6%), hip (72%), wrist (3%), pelvic (5%), and other (14%). By 2025, annual fractures and costs are projected to rise by almost 50%. The most rapid growth is estimated for people 65–74 years of age, with an increase >87%. An increase of nearly 175% is projected for Hispanic and other subpopulations.
Conclusions: Osteoporosis prevention, treatment, and education efforts should address all skeletal sites, not just hip and vertebral, and appropriate attention is warranted for men and diverse race/ethnicity subgroups.