The authors state that they have no conflicts of interest.
Association Between Physical Activity and BMD in Young Men Is Modulated by Catechol-O-Methyltransferase (COMT) Genotype: The GOOD Study†
Article first published online: 23 APR 2007
Copyright © 2007 ASBMR
Journal of Bone and Mineral Research
Volume 22, Issue 8, pages 1165–1172, August 2007
How to Cite
Lorentzon, M., Eriksson, A. L., Nilsson, S., Mellström, D. and Ohlsson, C. (2007), Association Between Physical Activity and BMD in Young Men Is Modulated by Catechol-O-Methyltransferase (COMT) Genotype: The GOOD Study. J Bone Miner Res, 22: 1165–1172. doi: 10.1359/jbmr.070416
- Issue published online: 4 DEC 2009
- Article first published online: 23 APR 2007
- Manuscript Accepted: 17 APR 2007
- Manuscript Revised: 19 MAR 2007
- Manuscript Received: 5 DEC 2006
- physical activity;
In this large population-based study in young men, we show that the COMT val158met polymorphism modulates the association between physical activity, aBMD (DXA), and trabecular vBMD (pQCT).
Introduction: Peak BMD is an important predictor of future risk of osteoporosis and is largely determined by genetic factors but also by environmental factors, among which physical activity (PA) is a strong contributor. Estrogens are believed to influence the mechanical strain signal generated by bones subjected to mechanical loading. Catechol-O-methyltransferase (COMT) is involved in the degradation of estrogens. A functional polymorphism in the COMT gene (val158met), results in a 60–75% difference in enzyme activity between the val (high activity = H) and met (low activity = L) variants. The aim of this study was to determine if the COMT val158met polymorphism modulates the association between PA and BMD in young men.
Materials and Methods: The Gothenburg Osteoporosis and Obesity Determinants (GOOD) study consists of 1068 men (age, 18.9 ± 0.6 yr). Areal BMD (aBMD) was measured by DXA, whereas cortical and trabecular volumetric BMD (vBMD) were measured by pQCT. Study subjects were genotyped and classified as COMTLL, COMTHL, or COMTHH. The amount (h/wk) of PA was determined through questionnaires.
Results: Using a linear regression model (including age, height, weight, smoking, and calcium intake as covariates), significant interactions between the COMT genotype and PA were seen for aBMD at all sites and for trabecular vBMD in both the radius and the tibia. The difference in adjusted aBMD and trabecular vBMD between high (≥4 h/wk) and low PA (<4 h/wk) was greater in COMTLL subjects than in subjects homozygous for the COMTHH (total body aBMD: COMTLL 4.2% versus COMTHH 1.5%, p = 0.02; lumbar spine aBMD: COMTLL 7.8% versus COMTHH 3.9%, p = 0.04; tibia trabecular vBMD: COMTLL 7.1% versus COMTHH 1.0%, p < 0.01). The COMT polymorphism was associated with aBMD, at all sites and with trabecular vBMD in the low-PA subjects, but not in their high-PA counterparts.
Conclusions: We show that the COMT val158met polymorphism modulates the association between PA, aBMD, and trabecular vBMD, suggesting that this polymorphism is of importance for BMD in subjects with a low level of PA.