1523-4681/asset/cover.gif?v=1&s=a8419ff5f302b0d9fefec557d81c0aa9776c60e3 "Journal of Bone and Mineral Research")
The authors state that they have no conflicts of interest.
1523-4681/asset/olbannerleft.gif?v=1&s=d7e4c0e37904a489128d3a4e58ba94214db307a9)
1523-4681/asset/olbannerright.gif?v=1&s=854ee0e4d351ead9faaca8bfab3e50b1c7c9d03d)
Research Article
You have free access to this content
Association Between Physical Activity and BMD in Young Men Is Modulated by Catechol-O-Methyltransferase (COMT) Genotype: The GOOD Study†
Article first published online: 23 APR 2007
DOI: 10.1359/jbmr.070416
Copyright © 2007 ASBMR
Additional Information
How to Cite
Lorentzon, M., Eriksson, A. L., Nilsson, S., Mellström, D. and Ohlsson, C. (2007), Association Between Physical Activity and BMD in Young Men Is Modulated by Catechol-O-Methyltransferase (COMT) Genotype: The GOOD Study. J Bone Miner Res, 22: 1165–1172. doi: 10.1359/jbmr.070416
- †
Publication History
- Issue published online: 4 DEC 2009
- Article first published online: 23 APR 2007
- Manuscript Accepted: 17 APR 2007
- Manuscript Revised: 19 MAR 2007
- Manuscript Received: 5 DEC 2006
References
- 1
- 2, , , , 1995 Genetic influences on bone turnover, bone density and fracture. Eur J Endocrinol 133: 265–271.
- 3, , , , , , , , , , , , , , , , 2005 Predictive value of BMD for hip and other fractures. J Bone Miner Res 20: 1185–1194.
- 4, , , , , , , , 1995 Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med 332: 767–773.
- 5, , , , , , 1989 Reduced bone mass in daughters of women with osteoporosis. N Engl J Med 320: 554–558.
- 6, , , , , 1987 Genetic determinants of bone mass in adults. A twin study. J Clin Invest 80: 706–710.
- 7, , , , 1998 Genetic and environmental contributions to the association between quantitative ultrasound and bone mineral density measurements: A twin study. J Bone Miner Res 13: 1318–1327.
- 8
- 9, , , , , , 2000 Peak bone mass. Osteoporos Int 11: 985–1009.
- 10, , , 2007 Smoking in young men is associated with lower bone mineral density and reduced cortical thickness. J Clin Endocrinol Metab. J Clin Endocrinol Metab 92: 497–503.
- 112002 Genetic control of susceptibility to osteoporosis. J Clin Endocrinol Metab 87: 2460–2466.
- 12, , , , , , , 2003 Aerobic exercise and bone mineral density in middle-aged finnish men: A controlled randomized trial with reference to androgen receptor, aromatase, and estrogen receptor alpha gene polymorphisms small star, filled. Bone 32: 412–420.
- 13, , , , , , , 2004 Association between exercise and pubertal BMD is modulated by estrogen receptor alpha genotype. J Bone Miner Res 19: 1758–1765.
- 142003 Men, bone and estrogen: Unresolved issues. Osteoporos Int 14: 93–98.
- 15, , 1998 A unitary model for involutional osteoporosis: Estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J Bone Miner Res 13: 763–773.
- 16, , , 2004 Estrogens are essential for male pubertal periosteal bone expansion. J Clin Endocrinol Metab 89: 6025–6029.
- 17, , , , , 2004 Androgens and bone. Endocr Rev 25: 389–425.
- 18, , , , , , , , 2000 Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice. Proc Natl Acad Sci USA 97: 5474–5479.
- 19, , 1998 The estrogen receptor's involvement in osteoblasts' adaptive response to mechanical strain. J Bone Miner Res 13: 1275–1282.
- 20, , 2000 Mechanical strain stimulates osteoblast proliferation through the estrogen receptor in males as well as females. J Bone Miner Res 15: 2169–2177.
- 211996 Using functional loading to influence bone mass and architecture: Objectives, mechanisms, and relationship with estrogen of the mechanically adaptive process in bone. Bone 18(1 Suppl): 37S–43S.
- 22, , , , , 2001 Mechanical strain and estrogen activate estrogen receptor alpha in bone cells. J Bone Miner Res 16: 1045–1055.
- 23, , , 2004 The COMT val158met polymorphism is associated with peak BMD in men. J Bone Miner Res 19: 2005–2011.Direct Link:
- 24, , 2005 Association of amount of physical activity with cortical bone size and trabecular volumetric BMD in young adult men: The GOOD Study. J Bone Miner Res 20: 1936–1943.
- 25, , , , , 1996 Human catechol-O-methyltransferase pharmacogenetics: Description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 6: 243–250.
- 26, , , , 2005 Free testosterone is a positive, whereas free estradiol is a negative, predictor of cortical bone size in young Swedish men:The GOOD Study. J Bone Miner Res 20: 1334–1341.
- 27, , 1999 A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 84: 3666–3672.
- 28, , , , 2000 Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. J Clin Endocrinol Metab 85: 3276–3282.
- 29, , , , , , 2007 CYP17 and COMT gene polymorphisms can influence bone directly, or indirectly through their effects on endogenous sex steroids, in postmenopausal Japanese women. Bone. Bone 40: 28–36.
- 30, , , , , , , , , 2004 Two single nucleotide polymorphisms in the CYP17 and COMT Genes–relation to bone mass and longitudinal bone changes in postmenopausal women with or without hormone replacement therapy. The Danish Osteoporosis Prevention Study. Calcif Tissue Int 75: 123–132.
- 31, , , , , , 1997 Estrogen regulates the rate of bone turnover but bone balance in ovariectomized rats is modulated by prevailing mechanical strain. Proc Natl Acad Sci USA 94: 4199–4204.
- 321999 On the estrogen-bone relationship and postmenopausal bone loss: A new model. J Bone Miner Res 14: 1473–1477.
- 33, , 2002 Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 23: 279–302.
- 34, , , , 2003 Endocrinology: Bone adaptation requires oestrogen receptor-alpha. Nature 424: 389.
- 35, , , , , , 2004 Association between the low activity genotype of catechol-O-methyltransferase and myocardial infarction in a hypertensive population. Eur Heart J 25: 386–391.
- 36, , , , , 2003 Influence of the catechol-O-methyltransferase (COMT) codon 158 polymorphism on estrogen levels in women. Hum Reprod 18: 262–266.
- 37, , , , 1998 Differential effects of estrogen metabolites on bone and reproductive tissues of ovariectomized rats. J Bone Miner Res 13: 1023–1031.
- 38, , , , , 2003 Dose-response effects of 2-methoxyestradiol on estrogen target tissues in the ovariectomized rat. Endocrinology 144: 785–792.
- 39, , , , , , , , 2002 Leptin regulates bone formation via the sympathetic nervous system. Cell 111: 305–317.