• 1
    Hassler O 1969 The human intervertebral disc. A micro-angiographical study on its vascular supply at various ages. Acta Orthop Scand 40: 765772.
  • 2
    Rajpurohit R, Risbud MV, Ducheyne P, Vresilovic EJ, Shapiro IM 2002 Phenotypic characteristics of the nucleus pulposus: Expression of hypoxia inducing factor-1, glucose transporter-1 and MMP-2. Cell Tissue Res 308: 401407.
  • 3
    Risbud MV, Guttapalli A, Stokes DG, Hawkins D, Danielson KG, Schaer TP, Albert TJ, Shapiro IM 2006 Nucleus pulposus cells express HIF-1alpha under normoxic culture conditions: A metabolic adaptation to the intervertebral disc microenvironment. J Cell Biochem 98: 152159.
  • 4
    Grunder S, Geissler HS, Bassler EL, Ruppersberg JP 2000 A new member of acid-sensing ion channels from pituitary gland. Neuroreport 11: 16071611.
  • 5
    Garcia-Anoveros J, Derfler B, Neville-Golden J, Hyman BT, Corey DP 1997 BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proc Natl Acad Sci USA 94: 14591464.
  • 6
    Lingueglia E, de Weille Jr, Bassilana F, Heurteaux C, Sakai H, Waldmann R, Lazdunski M 1997 A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells. J Biol Chem 272: 2977829783.
  • 7
    Chen CC, England S, Akopian AN, Wood JN 1998 A sensory neuron-specific, proton-gated ion channel. Proc Natl Acad Sci USA 95: 1024010245.
  • 8
    Waldmann R, Champigny G, Bassilana F, Heurteaux C, Lazdunski M 1997 A proton-gated cation channel involved in acid-sensing. Nature 386: 173177.
  • 9
    Bassilana F, Champigny G, Waldmann R, de Weille Jr, Heurteaux C, Lazdunski M 1997 The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties. J Biol Chem 272: 2881928822.
  • 10
    Reeh PW, Kress M 2001 Molecular physiology of proton transduction in nociceptors. Curr Opin Pharmacol 1: 4551.
  • 11
    Hesselager M, Timmermann DB, Ahring PK 2004 pH Dependency and desensitization kinetics of heterologously expressed combinations of acid-sensing ion channel subunits. J Biol Chem 279: 1100611015.
  • 12
    Sutherland SP, Benson CJ, Adelman JP, McCleskey EW 2001 Acid-sensing ion channel 3 matches the acid gated current in cardiac ischemia-sensing neurons. Proc Natl Acad Sci USA 98: 711716.
  • 13
    Sluka KA, Price MP, Breese NM, Stucky CL, Wemmie JA, Welsh MJ 2003 Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1. Pain 106: 229239.
  • 14
    Sluka KA, Radhakrishnan R, Benson CJ, Eshcol JO, Price MP, Babinski K, Audette KM, Yeomans DC, Wilson SP 2007 ASIC3 in muscle mediates mechanical, but not heat, hyperalgesia associated with muscle inflammation. Pain 129: 102112.
  • 15
    Yagi J, Wenk HN, Naves LA, McCleskey EW 2006 Sustained currents through ASIC3 ion channels at the modest pH changes that occur during myocardial ischemia. Circ Res 99: 501509.
  • 16
    Jones RC III, Xu L, Gebhart GF 2005 The mechanosensitivity of mouse colon afferent fibers and their sensitization by inflammatory mediators require transient receptor potential vanilloid 1 and acid-sensing ion channel 3. J Neurosci 25: 1098110989.
  • 17
    Mamet J, Baron A, Lazdunski M, Voilley N 2002 Proinflammatory mediators, stimulators of sensory neuron excitability via the expression of acid-sensing ion channels. J Neurosci 22: 1066210670.
  • 18
    Suzuki T, Kurahashi H, Ichinose H 2004 Ras/MEK pathway is required for NGF-induced expression of tyrosine hydroxylase gene. Biochem Biophys Res Commun 315: 389396.
  • 19
    Meakin SO, Gryz EA, MacDonald JI 1997 A kinase insert isoform of rat TrkA supports nerve growth factor-dependent cell survival but not neurite outgrowth. J Neurochem 69: 954967.
  • 20
    Vaidya RJ, Ray RM, Johnson LR 2005 MEK1 restores migration of polyamine-depleted cells by retention and activation of Rac1 in the cytoplasm. Am J Physiol Cell Physiol 288: C350C359.
  • 21
    Khwaja F, Allen J, Lynch J, Andrews P, Djakiew D 2004 Ibuprofen inhibits survival of bladder cancer cells by induced expression of the p75NTR tumor suppressor protein. Cancer Res 64: 62076213.
  • 22
    Rankin SL, Guy CS, Mearow KM 2005 TrkA NGF receptor plays a role in the modulation of p75NTR expression. Neurosci Lett 383: 305310.
  • 23
    Jahr H, van Driel M, van Osch GJ, Weinans H, van Leeuwen JP 2005 Identification of acid-sensing ion channels in bone. Biochem Biophys Res Commun 337: 349354.
  • 24
    Alvarez de la Rosa D, Zhang P, Shao D, White F, Canessa CM 2002 Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system. Proc Natl Acad Sci USA 99: 23262331.
  • 25
    Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA, Welsh MJ 2003 cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1. Proc Natl Acad Sci USA 100: 20292034.
  • 26
    Mamet J, Lazdunski M, Voilley N 2003 How nerve growth factor drives physiological and inflammatory expressions of acid-sensing ion channel 3 in sensory neurons. J Biol Chem 278: 4890748913.
  • 27
    Abe Y, Akeda K, An HS, Aoki Y, Pichika R, Muehleman C, Kimura T, Masuda K 2007 Proinflammatory cytokines stimulate the expression of nerve growth factor by human intervertebral disc cells. Spine 32: 635642.
  • 28
    Gigante A, Bevilacqua C, Pagnotta A, Manzotti S, Toesca A, Greco F 2003 Expression of NGF, Trka and p75 in human cartilage. Eur J Histochem 47: 339344.
  • 29
    Lad SP, Neet KE 2003 Activation of the mitogen-activated protein kinase pathway through p75NTR: A common mechanism for the neurotrophin family. J Neurosci Res 73: 614626.
  • 30
    Risbud MV, Fertala J, Vresilovic EJ, Albert TJ, Shapiro IM 2005 Nucleus pulposus cells upregulate PI3K/Akt and MEK/ERK signaling pathways under hypoxic conditions and resist apoptosis induced by serum withdrawal. Spine 30: 882889.
  • 31
    Risbud MV, Di Martino A, Guttapalli A, Seghatoleslami R, Denaro V, Vaccaro AR, Albert TJ, Shapiro IM 2006 Toward an optimum system for intervertebral disc organ culture: TGF-beta 3 enhances nucleus pulposus and annulus fibrosus survival and function through modulation of TGF-beta-R expression and ERK signaling. Spine 31: 884890.
  • 32
    Schneider D, Gerhardt E, Bock J, Muller MM, Wolburg H, Lang F, Schulz JB 2004 Intracellular acidification by inhibition of the Na+/H+-exchanger leads to caspase-independent death of cerebellar granule neurons resembling paraptosis. Cell Death Differ 11: 760770.
  • 33
    Kim KM, Lee YJ 2005 Amiloride augments TRAIL-induced apoptotic death by inhibiting phosphorylation of kinases and phosphatases associated with the P13K-Akt pathway. Oncogene 24: 355366.