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  • 1
    Kanis JA, Melton LJ III, Christiansen C, Johnston CC, Khaltaev N 1994 The diagnosis of osteoporosis. J Bone Miner Res 9: 11371141.
  • 2
    Pocock NA, Eisman JA, Hopper JL, Yeates MG, Sambrook PN, Eberl S 1987 Genetic determinants of bone mass in adults. A twin study. J Clin Invest 80: 706710.
  • 3
    Ralston SH 2005 Genetic determinants of osteoporosis. Curr Opin Rheumatol 17: 475479.
  • 4
    Keen RW, Hart DJ, Arden NK, Doyle DV, Spector TD 1999 Family history of appendicular fracture and risk of osteoporosis: A population-based study. Osteoporos Int 10: 161166.
  • 5
    van Meurs JB, Dhonukshe-Rutten RA, Pluijm SM, van der Klift M, de Jonge R, Lindemans J, de Groot LC, Hofman A, Witteman JC, van Leeuwen JP, Breteler MM, Lips P, Pols HA, Uitterlinden AG 2004 Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med 350: 20332041.
  • 6
    McLean RR, Jacques PF, Selhub J, Tucker KL, Samelson EJ, Broe KE, Hannan MT, Cupples LA, Kiel DP 2004 Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med 350: 20422049.
  • 7
    Sato Y, Honda Y, Iwamoto J, Kanoko T, Satoh K 2005 Effect of folate and mecobalamin on hip fractures in patients with stroke: A randomized controlled trial. JAMA 293: 10821088.
  • 8
    van Meurs JB, Uitterlinden AG 2005 Homocysteine and fracture prevention. JAMA 293: 11211122.
  • 9
    Davey Smith G, Ebrahim S 2003 ‘Mendelian randomization’: Can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 32: 122.
  • 10
    Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP, Rozen R 1995 A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase. Nat Genet 10: 111113.
  • 11
    Mills JL, Kirke PN, Molloy AM, Burke H, Conley MR, Lee YJ, Mayne PD, Weir DG, Scott JM 1999 Methylenetetrahydrofolate reductase thermolabile variant and oral clefts. Am J Med Genet 86: 7174.
  • 12
    Casas JP, Bautista LE, Smeeth L, Sharma P, Hingorani AD 2005 Homocysteine and stroke: Evidence on a causal link from mendelian randomisation. Lancet 365: 224232.
  • 13
    Ma J, Stampfer MJ, Giovannucci E, Artigas C, Hunter DJ, Fuchs C, Willett WC, Selhub J, Hennekens CH, Rozen R 1997 Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res 57: 10981102.
  • 14
    Powers RW, Minich LA, Lykins DL, Ness RB, Crombleholme WR, Roberts JM 1999 Methylenetetrahydrofolate reductase polymorphism, folate, and susceptibility to preeclampsia. J Soc Gynecol Investig 6: 7479.
  • 15
    Freeman JM, Finkelstein JD, Mudd SH 1975 Folate-responsive homocystinuria and “schizophrenia”. A defect in methylation due to deficient 5,10-methylenetetrahydrofolate reductase activity. N Engl J Med 292: 491496.
  • 16
    Abrahamsen B, Madsen JS, Tofteng CL, Stilgren L, Bladbjerg EM, Kristensen SR, Brixen K, Mosekilde L 2003 A common methylenetetrahydrofolate reductase (C677T) polymorphism is associated with low bone mineral density and increased fracture incidence after menopause: Longitudinal data from the Danish osteoporosis prevention study. J Bone Miner Res 18: 723729.
  • 17
    Hustad S, Ueland PM, Vollset SE, Zhang Y, Bjorke-Monsen AL, Schneede J 2000 Riboflavin as a determinant of plasma total homocysteine: Effect modification by the methylenetetrahydrofolate reductase C677T polymorphism. Clin Chem 46: 10651071.
  • 18
    Guenther BD, Sheppard CA, Tran P, Rozen R, Matthews RG, Ludwig ML 1999 The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia. Nat Struct Biol 6: 359365.
  • 19
    Jacques PF, Kalmbach R, Bagley PJ, Russo GT, Rogers G, Wilson PW, Rosenberg IH, Selhub J 2002 The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene. J Nutr 132: 283288.
  • 20
    McNulty H, McKinley MC, Wilson B, McPartlin J, Strain JJ, Weir DG, Scott JM 2002 Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: Implications for riboflavin requirements. Am J Clin Nutr 76: 436441.
  • 21
    Miyao M, Morita H, Hosoi T, Kurihara H, Inoue S, Hoshino S, Shiraki M, Yazaki Y, Ouchi Y 2000 Association of methylenetetrahydrofolate reductase (MTHFR) polymorphism with bone mineral density in postmenopausal Japanese women. Calcif Tissue Int 66: 190194.
  • 22
    Macdonald HM, McGuigan FE, Fraser WD, New SA, Ralston SH, Reid DM 2004 Methylenetetrahydrofolate reductase polymorphism interacts with riboflavin intake to influence bone mineral density. Bone 35: 957964.
  • 23
    McLean RR, Karasik D, Selhub J, Tucker KL, Ordovas JM, Russo GT, Cupples LA, Jacques PF, Kiel DP 2004 Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status. J Bone Miner Res 19: 410418.
  • 24
    Abrahamsen B, Madsen JS, Tofteng CL, Stilgren L, Bladbjerg EM, Kristensen SR, Brixen K, Mosekilde L 2005 Are effects of MTHFR (C677T) genotype on BMD confined to women with low folate and riboflavin intake? Analysis of food records from the Danish osteoporosis prevention study. Bone 36: 577583.
  • 25
    Hofman A, Grobbee DE, de Jong PT, van den Ouweland FA 1991 Determinants of disease and disability in the elderly: The Rotterdam Elderly Study. Eur J Epidemiol 7: 403422.
  • 26
    Klipstein-Grobusch K, den Breeijen JH, Goldbohm RA, Geleijnse JM, Hofman A, Grobbee DE, Witteman JC 1998 Dietary assessment in the elderly: Validation of a semiquantitative food frequency questionnaire. Eur J Clin Nutr 52: 588596.
  • 27
    Willett WC, Howe GR, Kushi LH 1997 Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 65: 1220S1228S.
  • 28
    Araki A, Sako Y 1987 Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J Chromatogr 422: 4352.
  • 29
    Ubbink JB, Hayward Vermaak WJ, Bissbort S 1991 Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum. J Chromatogr 565: 441446.
  • 30
    World Health Organization 1992 International Statistical Classification of Diseases and Related Health Problems, 10th ed. World Health Organization, Geneva, Switzerland.
  • 31
    Cooper C 1993 The epidemiology of fragility fractures: Is there a role for bone quality? Calcif Tissue Int 53: S23S26.
  • 32
    Alberti KG, Zimmet PZ 1998 Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15: 539553.
  • 33
    Ott A, Breteler MM, van Harskamp F, Stijnen T, Hofman A 1998 Incidence and risk of dementia. The Rotterdam Study. Am J Epidemiol 147: 574580.
  • 34
    de Bruyne MC, Kors JA, Hoes AW, Kruijssen DA, Deckers JW, Grosfeld M, van Herpen G, Grobbee DE, van Bemmel JH 1997 Diagnostic interpretation of electrocardiograms in population-based research: Computer program research physicians, or cardiologists? J Clin Epidemiol 50: 947952.
  • 35
    Lathrop Stern L, Shane B, Bagley PJ, Nadeau M, Shih V, Selhub J 2003 Combined marginal folate and riboflavin status affect homocysteine methylation in cultured immortalized lymphocytes from persons homozygous for the MTHFR C677T mutation. J Nutr 133: 27162720.
  • 36
    Kimura M, Umegaki K, Higuchi M, Thomas P, Fenech M 2004 Methylenetetrahydrofolate reductase C677T polymorphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes. J Nutr 134: 4856.
  • 37
    Jorgensen HL, Madsen JS, Madsen B, Saleh MM, Abrahamsen B, Fenger M, Lauritzen JB 2002 Association of a common allelic polymorphism (C677T) in the methylene tetrahydrofolate reductase gene with a reduced risk of osteoporotic fractures. A case control study in Danish postmenopausal women. Calcif Tissue Int 71: 386392.
  • 38
    McNulty H, Dowey le RC, Strain JJ, Dunne A, Ward M, Molloy AM, McAnena LB, Hughes JP, Hannon-Fletcher M, Scott JM 2006 Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism. Circulation 113: 7480.
  • 39
    McKusick VA 1966 Heritable Disorders of Connective Tissue, 3rd ed. C.V. Mosby, St Louis, MO, USA.
  • 40
    Dhonukshe-Rutten RA, Pluijm SM, de Groot LC, Lips P, Smit JH, van Staveren WA 2005 Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people. J Bone Miner Res 20: 921929.
  • 41
    Paschalis EP, Shane E, Lyritis G, Skarantavos G, Mendelsohn R, Boskey AL 2004 Bone fragility and collagen cross-links. J Bone Miner Res 19: 20002004.
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  • 42
    Saito M, Fujii K, Marumo K 2006 Degree of mineralization-related collagen crosslinking in the femoral neck cancellous bone in cases of hip fracture and controls. Calcif Tissue Int 79: 160168.
  • 43
    Koh JM, Lee YS, Kim YS, Kim DJ, Kim HH, Park JY, Lee KU, Kim GS 2006 Homocysteine enhances bone resorption by stimulation of osteoclast formation and activity through increased intracellular ROS generation. J Bone Miner Res 21: 10031011.