Correlation of Obesity and Osteoporosis: Effect of Fat Mass on the Determination of Osteoporosis

Authors

  • Lan-Juan Zhao,

    1. Departments of Orthopedic Surgery and Basic Medical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA
    2. These authors contributed equally to this paper
    Search for more papers by this author
  • Hui Jiang,

    1. These authors contributed equally to this paper
    2. Laboratory of Molecular and Statistical Genetics, College of Life Science, Hunan Normal University, Changsha, Hunan, China
    Search for more papers by this author
  • Christopher J Papasian,

    1. Departments of Orthopedic Surgery and Basic Medical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA
    Search for more papers by this author
  • Dev Maulik,

    1. Department of Obstetrics and Gynecology, University of Missouri-Kansas City, Kansas City, Missouri, USA
    Search for more papers by this author
  • Betty Drees,

    1. Departments of Orthopedic Surgery and Basic Medical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA
    Search for more papers by this author
  • James Hamilton,

    1. Departments of Orthopedic Surgery and Basic Medical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA
    Search for more papers by this author
  • Hong-Wen Deng PhD

    Corresponding author
    1. Departments of Orthopedic Surgery and Basic Medical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA
    2. Laboratory of Molecular and Statistical Genetics, College of Life Science, Hunan Normal University, Changsha, Hunan, China
    3. The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China
    • Address reprint requests to: Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri-Kansas City, 2411 Holmes Street, Room M3-C03, Kansas City, MO, 64108-2792, USA
    Search for more papers by this author

  • The authors state that they have no conflicts of interest.

Abstract

It was previously believed that obesity and osteoporosis were two unrelated diseases, but recent studies have shown that both diseases share several common genetic and environmental factors. Body fat mass, a component of body weight, is one of the most important indices of obesity, and a substantial body of evidence indicates that fat mass may have beneficial effects on bone. Contrasting studies, however, suggest that excessive fat mass may not protect against osteoporosis or osteoporotic fracture. Differences in experimental design, sample structure, and even the selection of covariates may account for some of these inconsistent or contradictory results. Despite the lack of a clear consensus regarding the impact of effects of fat on bone, a number of mechanistic explanations have been proposed to support the observed epidemiologic and physiologic associations between fat and bone. The common precursor stem cell that leads to the differentiation of both adipocytes and osteoblasts, as well the secretion of adipocyte-derived hormones that affect bone development, may partially explain these associations. Based on our current state of knowledge, it is unclear whether fat has beneficial effects on bone. We anticipate that this will be an active and fruitful focus of research in the coming years.

Ancillary