• 1
    Gordon CL, Webber CE, Nicholson PS 1998 Relation between image-based assessment of distal radius trabecular structure and compressive strength. Can Assoc Radiol J 49: 390397.
  • 2
    Bousson V, Le Bras A, Roqueplan F, Kang Y, Mitton D, Kolta S, Bergot C, Skalli W, Vicaut E, Kalender W, Engelke K, Laredo JD 2006 Volumetric quantitative computed tomography of the proximal femur: Relationships linking geometric and densitometric variables to bone strength. Role for compact bone. Osteoporos Int 17: 855864.
  • 3
    Siris ES, Brenneman SK, Barrett-Connor E, Miller PD, Sajjan S, Berger ML, Chen YT 2006 The effect of age and bone mineral density on the absolute, excess, and relative risk of fracture in postmenopausal women aged 50-99: Results from the National Osteoporosis Risk Assessment (NORA). Osteoporos Int 17: 565574.
  • 4
    Recker RR, Barger-Lux MJ 2004 The elusive concept of bone quality. Curr Osteopor Rep 2: 97100.
  • 5
    Paschalis EP, Boskey AL, Kassem M, Eriksen EF 2003 Effect of hormone replacement therapy on bone quality in early postmenopausal women. J Bone Miner Res 18: 955959.
  • 6
    Kleerekoper M, Villanueva AR, Stanciu J, Sudhaker Rao D, Parfitt AM 1985 The Role of Three-Dimensional Trabecular Microstructure in the Pathogenesis of Vertebral Compression Fractures. Calcif Tissue Int 37: 594597.
  • 7
    Recker RR 1993 Architecture and vertebral fracture. Calcif Tissue Int 53(Suppl 1): S139S142.
  • 8
    Amling M, Posl M, Ritzel H, Hahn M, Vogel M, Wening VJ, Delling G 1996 Architecture and distribution of cancellous bone yield vertebral fracture clues. A histomorphometric analysis of the complete spinal column from 40 autopsy specimens. Arch Orthop Trauma Surg 115: 262269.
  • 9
    Legrand E, Chappard D, Pascaretti C, Duquenne M, Krebs S, Rohmer V, Basle MF, Audran M 2000 Trabecular bone microarchitecture, bone mineral density and vertebral fractures in male osteoporosis. J Bone Miner Res 15: 1319.
  • 10
    Wehrli FW, Hwang SN, Ma J, Song HK, Ford JC, Haddad JG 1998 Cancellous bone volume and structure in the forearm: Noninvasive assessment with MR microimaging and image processing. Radiology 206: 347357.
  • 11
    Wehrli FW, Gomberg BR, Saha PK, Song HK, Hwang SN, Snyder PJ 2001 Digital topological analysis of in vivo magnetic resonance microimages of trabecular bone reveals structural implications of osteoporosis. J Bone Miner Res 16: 15201531.
  • 12
    Majumdar S, Link TM, Augat P, Lin JC, Newitt D, Lane NE, Genant HK 1999 Trabecular bone architecture in the distal radius using magnetic resonance imaging in subjects with fractures of the proximal femur. Magnetic Resonance Science Center and Osteoporosis and Arthritis Research Group. Osteoporos Int 10: 231239.
  • 13
    Link TM, Saborowski S, Kisters K, Kempkes M, Kosch M, Newitt D, Lu Y, Waldt S, Majumdar S 2002 Changes in calcaneal trabecular bone structure assessed with high-resolution MR imaging in patients with kidney transplantation. Osteoporos Int 13: 119129.
  • 14
    Link TM, Vieth V, Matheis J, Newitt D, Lu Y, Rummeny EJ, Majumdar S 2002 Bone structure of the distal radius and the calcaneus vs BMD of the spine and proximal femur in the prediction of osteoporotic spine fractures. Eur Radiol 12: 401408.
  • 15
    Boutry N, Cortet B, Dubois P, Marchandise X, Cotten A 2003 Trabecular bone structure of the calcaneus: Preliminary in vivo MR imaging assessment in men with osteoporosis. Radiology 227: 708717.
  • 16
    Link TM, Bauer J, Kollstedt A, Stumpf I, Hudelmaier M, Settles M, Majumdar S, Lochmuller EM, Eckstein F 2004 Trabecular bone structure of the distal radius, the calcaneus, and the spine: Which site predicts fracture status of the spine best? Invest Radiol 39: 487497.
  • 17
    Slade JM, Bickel CS, Modlesky CM, Majumdar S, Dudley GA 2005 Trabecular bone is more deteriorated in spinal cord injured versus estrogen-free postmenopausal women. Osteoporos Int 16: 263272.
  • 18
    Boutroy S, Bouxsein ML, Munoz F, Delmas PD 2005 In Vivo Assessment of Trabecular Bone Microarchitecture by High-Resolution Peripheral Quantitative Computed Tomography. J Clin Endocrinol Metab 90: 68056815.
  • 19
    Sornay-Rendu E, Boutroy S, Munoz F, Delmas PD 2007 Alterations of cortical and trabecular architecture are associated with fractures in postmenopausal women, partially independent of decreased BMD measured by DXA: The OFELY study. J Bone Miner Res 22: 425433.
  • 20
    Chevalier F, Laval-Jeantet AM, Laval-Jeantet M, Bergot C 1992 CT image analysis of the vertebral trabecular network in vivo. Calcif Tissue Int 51: 813.
  • 21
    Mundinger A, Wiesmeier B, Dinkel E, Helwig A, Beck A, Schulte Moenting J 1993 Quantitative image analysis of vertebral body architecture–improved diagnosis in osteoporosis based on high-resolution computed tomography. Br J Radiol 66: 209213.
  • 22
    Ito M, Ikeda K, Nishiguchi M, Shindo H, Uetani M, Hosoi T, Orimo H 2005 Multi-detector row CT imaging of vertebral microstructure for evaluation of fracture risk. J Bone Miner Res 20: 18281836.
  • 23
    Wehrli FW, Saha PK, Gomberg BR, Song HK 2003 Noninvasive assessment of bone architecture by magnetic resonance micro-imaging-based virtual bone biopsy. Proc IEEE 91: 15201542.
  • 24
    Song HK, Wehrli FW 1999 In vivo micro-imaging using alternating navigator echoes with applications to cancellous bone structural analysis. Magn Reson Med 41: 947953.
  • 25
    Hwang SN, Wehrli FW 1999 Estimating voxel volume fractions of trabecular bone on the basis of magnetic resonance images acquired in vivo. Int J Imaging Syst Technol 10: 186198.
  • 26
    Hwang SN, Wehrli FW 2002 Subvoxel processing: A Method for reducing partial volume blurring with application to in vivo MR images of trabecular bone. Magn Reson Med 47: 948957.
  • 27
    Saha PK, Wehrli FW 2004 Measurement of trabecular bone thickness in the limited resolution regime of in vivo MRI by fuzzy distance transform. IEEE Trans Med Imaging 23: 5362.
  • 28
    Hwang SN, Wehrli FW, Williams JL 1997 Probability-based structural parameters from 3D NMR images as predictors of trabecular bone strength. Med Phys 24: 12551261.
  • 29
    Saha PK, Gomberg BR, Wehrli FW 2000 Three-dimensional digital topological characterization of cancellous bone architecture. Int J Imaging Syst Technol 11: 8190.
  • 30
    Gomberg BG, Saha PK, Song HK, Hwang SN, Wehrli FW 2000 Application of topological analysis to magnetic resonance images of human trabecular bone. IEEE Trans Med Imaging 19: 166174.
  • 31
    Gomberg BR, Wehrli FW, Vasilic B, Weening RH, Saha PK, Song HK, Wright AC 2004 Reproducibility and error sources of micro-MRI-based trabecular bone structural parameters of the distal radius and tibia. Bone 35: 266276.
  • 32
    Eastell R, Cedel SL, Wahner HW, Riggs BL, Melton LJ III 1991 Classification of vertebral fractures. J Bone Miner Res 6: 207215.
  • 33
    Steiner E, Jergas M, Genant HK 1996 Radiology of osteoporosis. MarcusR, FeldmanD, KelseyJ (eds.) Osteoporosis. Academic Press, San Diego, CA, USA, 10191050.
  • 34
    Benito M, Vasilic B, Wehrli FW, Bunker B, Wald M, Gomberg B, Wright AC, Zemel B, Cucchiara A, Snyder PJ 2005 Effect of testosterone replacement on bone architecture in hypogonadal men. J Bone Miner Res 20: 1785.
  • 35
    Liu XS, Sajda P, Saha PK, Wehrli FW, Guo XE 2006 Quantification of the roles of trabecular microarchitecture and trabecular type in determining the elastic modulus of human trabecular bone. J Bone Miner Res 21: 16081617.
  • 36
    Hahn M, Vogel M, Pompesius-Kempa M, Delling G 1992 Trabecular bone pattern factor–a new parameter for simple quantification of bone microarchitecture. Bone 13: 327330.
  • 37
    Feldkamp LA, Goldstein SA, Parfitt AM, Jesion G, Kleerekoper M 1989 The direct examination of three-dimensional bone architecture in vitro by computed tomography. J Bone Miner Res 4: 311.
  • 38
    Cortet B, Dubois P, Boutry N, Palos G, Cotten A, Marchandise X 2002 Computed tomography image analysis of the calcaneus in male osteoporosis. Osteoporos Int 13: 3341.
  • 39
    Hildebrand T, Laib A, Muller R, Dequeker J, Ruegsegger P 1999 Direct three-dimensional morphometric analysis of human cancellous bone: Microstructural data from spine, femur, iliac crest, and calcaneus. J Bone Miner Res 14: 11671174.
  • 40
    Vasilic B, Ladinsky GA, Saha PK, Wehrli FW 2006 Micro-MRI-based image acquisition and processing system for assessing the response to therapeutic intervention. Proceedings of the SPIE: The International Society for Optical Engineering. International Society for Optical Engineering, San Diego, CA, USA, February 11–16, 2006.
  • 41
    Lin W, Ladinsky GA, Wehrli FW, Song HK 2007 Image metric-based correction (autofocusing) of motion artifacts in high-resolution trabecular bone imaging. J Magn Reson Imaging 26: 191197.
  • 42
    Newitt DC, van Rietbergen B, Majumdar S 2002 Processing and analysis of in vivo high-resolution MR images of trabecular bone for longitudinal studies: Reproducibility of structural measures and micro-finite element analysis derived mechanical properties. Osteoporos Int 13: 278287.