• 1
    U.S. Department of Health and Human Services 2004 The frequency of bone disease. In: Bone Health and Osteoporosis: A Report of the Surgeon General. U.S. Department of Health and Human Services, Office of the Surgeon General, Rockville, MD, USA, 6887.
  • 2
    Raisz LG 1988 Local and systemic factors in the pathogenesis of osteoporosis. N Engl J Med 318: 818828.
  • 3
    Riggs BL, Khosla S, Melton LJ 2002 Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 23: 279302.
  • 4
    Seeman E 2002 Pathogenesis of bone fragility in women and men. Lancet 359: 18411850.
  • 5
    1999 The evaluation of osteoporosis dual energy X-ray absorptiometry and ultrasound in clinical practice BlakeGM, WahnerHW, FogelmanI (eds.) 2nd ed. Martin Dunitz, London, UK.
  • 6
    Riggs BL, Wahner HW, Melton LJ III, Richelson LS, Judd HL, Offord KP 1986 Rates of bone loss in the appendicular and axial skeletons of women: Evidence of substantial vertebral bone loss before menopause. J Clin Invest 77: 14871491.
  • 7
    Slemenda C, Longcope C, Peacock M, Hui S, Johnston CC 1996 Sex steroids, bone mass and bone loss. A prospective study of pre-, peri-, and postmenopausal women. J Clin Invest 97: 1421.
  • 8
    Eastell R, Mosekilde L, Hodgson SF, Riggs BL 1990 Proportion of human vertebral body bone that is cancellous. J Bone Miner Res 5: 12371241.
  • 9
    Nordstrom P, Neovius M, Nordstrom A 2007 Early and rapid bone mineral density loss of the proximal femur in men. J Clin Endocrinol Metab 92: 19021908.
  • 10
    Aaron JE, Makins NB, Sagreiya K 1987 The microanatomy of trabecular bone loss in normal aging men and women. Clin Orthop 215: 260271.
  • 11
    Riggs BL, Melton LJI, Robb RA, Camp JJ, Atkinson EJ, Peterson JM, Rouleau PA, McCollough CH, Bouxsein ML, Khosla S 2004 Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites. J Bone Miner Res 19: 19451954.
    Direct Link:
  • 12
    Kalender WA, Felsenberg D, Louis O, Lopez P, Klotz E, Osteaux M, Fraga J 1989 Reference values for trabecular and cortical vertebral bone density in single and dual-energy quantitative computed tomography. Eur J Radiol 9: 7580.
  • 13
    Meier DE, Orwoll ES, Jones JM 1984 Marked disparity between trabecular and cortical bone loss with age in healthy men. Ann Intern Med 101: 605612.
  • 14
    Ruegsegger P, Durand EP, Dambacher MA 1991 Differential effects of aging and disease on trabecular and compact bone density of the radius. Bone 12: 99105.
  • 15
    Dambacher MA, Neff M, Kissling R, Qin L 1998 Highly precise peripheral quantitative computed tomography for the evaluation of bone density, loss of bone density and structures. Drugs Aging 12(Suppl 1): 1524.
  • 16
    Khosla S, Melton LJI, Atkinson EJ, O'Fallon WM, Klee GG, Riggs BL 1998 Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: A key role for bioavailable estrogen. J Clin Endocrinol Metab 83: 22662274.
  • 17
    Cummings SR, Browner WS, Bauer D, Stone K, Ensrud K, Jamal S, Ettinger B 1998 Endogenous hormones and the risk of hip and vertebral fractures among older women. N Engl J Med 339: 733738.
  • 18
    Riggs BL, Khosla S, Melton LJI 1998 A unitary model for involutional osteoporosis: Estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J Bone Miner Res 13: 763773.
  • 19
    Slemenda CW, Longcope C, Zhou L, Hui SL, Peacock M, Johnston C 1997 Sex steroids and bone mass in older men: Positive associations with serum estrogens and negative associations with androgens. J Clin Invest 100: 17551759.
  • 20
    Greendale GA, Edelstein S, Barrett-Connor E 1997 Endogenous sex steroids and bone mineral density in older women and men: The Rancho Bernardo study. J Bone Miner Res 12: 18331843.
  • 21
    Khosla S, Melton LJ, Atkinson EJ, O'Fallon WM 2001 Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men. J Clin Endocrinol Metab 86: 35553561.
  • 22
    Khosla S, Melton LJ III, Robb RA, Camp JJ, Atkinson EJ, Oberg AL, Rouleau PA, Riggs BL 2005 Relationship of volumetric BMD and structural parameters at different skeletal sites to sex steroid levels in men. J Bone Miner Res 20: 730740.
  • 23
    Genant HK, Cann CE, Ettinger B, Gordan GS 1982 Quantitative computed tomography of vertebral spongiosa: A sensitive method for detecting early bone loss after oophorectomy. Ann Intern Med 97: 699705.
  • 24
    Khosla S, Riggs BL, Atkinson EJ, Oberg AL, McDaniel LJ, Holets M, Peterson JM, Melton LJ III 2006 Effects of sex and age on bone microstructure at the ultradistal radius: A population-based noninvasive in vivo assessment. J Bone Miner Res 21: 124131.
  • 25
    Sowers M-FR, Jannausch M, McConnell D, Little RD, Greendale GA, Finkelstein JS, Neer RM, Johnston J, Ettinger B 2006 Hormone predictors of bone mineral density changes during the menopausal transition. J Clin Endocrinol Metab 91: 12611267.
  • 26
    Sun L, Peng Y, Sharrow AC, Iqbal J, Zhang Z, Papachristou DJ, Zaidi S, Zhu L-L, Yaroslavskiy BB, Zhou H, Zallone AZ, Sairam MR, Kumar TR, Bo W, Braun JJ, Cardoso-Landa L, Schaffler MB, Moonga BS, Blair HC, Zaidi M 2006 FSH directly regulates bone mass. Cell 125: 247260.
  • 27
    Gao J, Tiwari-Pandey R, Samadfam R, Yang Y, Miao D, Karaplis AC, Sairam MR, Goltzman D 2007 Altered ovarian function affects skeletal homeostasis independent of the action of follicle-stimulating hormone (FSH). Endocrinology 148: 26132621.
  • 28
    Ohlsson C, Bengtsson B-A, Isaksson OGP, Andreassen TT, Slootweg MC 1998 Growth hormone and bone. Endocr Rev 19: 5579.
  • 29
    Veldhuis JD, Roemmich JN, Richmond EJ, Bowers CY 2006 Somatotropic and gonadotropic axes linkages in infancy, childhood, and the puberty-adult transition. (Review). Endocr Rev 27: 101140.
  • 30
    Jones JI, Clemmons DR 1995 Insulin-like growth factors and their binding proteins: Biological actions. Endocr Rev 16: 334.
  • 31
    Mohan S, Jennings JC, Linkhart TA, Baylink DJ 1988 Primary structure of human skeletal growth factor: Homology with human insulin-like growth factor-II. Biochim Biophys Acta 966: 4455.
  • 32
    Kanzaki S, Baxter R, Knutsen R, Baylink D, Mohan S 1995 Evidence that human bone cells in culture secrete insulin-like growth factor (IGF)-II and IGF binding protein-3 but not acid-labile subunit both under basal and regulated conditions. J Bone Miner Res 10: 854858.
  • 33
    Kassem M, Okazaki R, Harris SA, Spelsberg TC, Conover CA, Riggs BL 1998 Estrogen effects on insulin-like growth factor gene expression in a human osteoblastic cell line with high levels of estrogen receptor. Calcif Tissue Int 62: 6066.
  • 34
    Genant HK, Boyd D 1977 Quantitative bone mineral analysis using dual energy computed tomography. Invest Radiol 12: 545551.
  • 35
    Kricun ME 1985 Red-yellow marrow conversion: Its effect on the location of some solitary bone lesions. Skeletal Radiol 14: 1019.