• 1
    Cummings SR, Melton LJ 2002 Epidemiology and outcomes of osteoporotic fractures. Lancet 359: 17611767.
  • 2
    Lenchik L, Hsu FC, Register TC, Lohman KK, Freedman BI, Langefeld CD, Bowden DW, Carr JJ 2004 Heritability of spinal trabecular volumetric bone mineral density measured by QCT in the Diabetes Heart Study. Calcif Tissue Int 75: 305312.
  • 3
    Yang TL, Zhao LJ, Liu YJ, Liu JF, Recker RR, Deng HW 2006 Genetic and environmental correlations of bone mineral density at different skeletal sites in females and males. Calcif Tissue Int 78: 212217.
  • 4
    Xu H, Long JR, Yang YJ, Deng FY, Deng HW 2006 Genetic determination and correlation of body weight and body mass index (BMI) and cross-sectional geometric parameters of the femoral neck. Osteoporos Int 17: 16021607.
  • 5
    Harris M, Nguyen TV, Howard GM, Kelly PJ, Eisman JA 1998 Genetic and environmental correlations between bone formation and bone mineral density: A twin study. Bone 22: 141145.
  • 6
    Howard GM, Nguyen TV, Harris M, Kelly PJ, Eisman JA 1998 Genetic and environmental contributions to the association between quantitative ultrasound and bone mineral density measurements: A twin study. J Bone Miner Res 13: 13181327.
  • 7
    Nguyen TV, Howard GM, Kelly PJ, Eisman JA 1998 Bone mass, lean mass, and fat mass: Same genes or same environments? Am J Epidemiol 147: 316.
  • 8
    Pocock NA, Eisman JA, Hopper JL, Yeates MG, Sambrook PN, Eberl S 1987 Genetic determinants of bone mass in adults. A twin study. J Clin Invest 80: 706710.
  • 9
    Sun X, Lei SF, Deng FY, Wu S, Papacian C, Hamilton J, Recker RR, Deng HW 2006 Genetic and environmental correlations between bone geometric parameters and body compositions. Calcif Tissue Int 79: 4349.
  • 10
    Jian WX, Long JR, Li MX, Liu XH, Deng HW 2005 Genetic determination of variation and covariation of bone mineral density at the hip and spine in a Chinese population. J Bone Miner Metab 23: 181185.
  • 11
    Brown LB, Streeten EA, Shapiro JR, McBride D, Shuldiner AR, Peyser PA, Mitchell BD 2005 Genetic and environmental influences on bone mineral density in pre- and post-menopausal women. Osteoporos Int 16: 18491856.
  • 12
    Deng FY, Lei SF, Li MX, Jiang C, Dvornyk V, Deng HW 2006 Genetic determination and correlation of body mass index and bone mineral density at the spine and hip in Chinese Han ethnicity. Osteoporos Int 17: 119124.
  • 13
    Livshits G, Deng HW, Nguyen TV, Yakovenko K, Recker RR, Eisman JA 2004 Genetics of bone mineral density: Evidence for a major pleiotropic effect from an intercontinental study. J Bone Miner Res 19: 914923.
  • 14
    Sievänen H 2000 A physical model for dual-energy X-ray absorptiometry–derived bone mineral density. Invest Radiol 35: 325330.
  • 15
    Adami S, Gatti D, Braga V, Bianchini D, Rossini M 1999 Site-specific effects of strength training on bone structure and geometry of ultradistal radius in postmenopausal women. J Bone Miner Res 14: 120124.
  • 16
    Frost HM 2000 The Utah paradigm of skeletal physiology: An overview of its insights for bone, cartilage and collagenous tissue organs. J Bone Miner Metab 18: 305316.
  • 17
    Heinonen A, Sievänen H, Kannus P, Oja P, Vuori I 2002 Site-specific skeletal response to long-term weight training seems to be attributable to principal loading modality: A pQCT study of female weightlifters. Calcif Tissue Int 70: 469474.
  • 18
    Nikander R, Sievänen H, Uusi-Rasi K, Heinonen A, Kannus P 2006 Loading modalities and bone structures at nonweight-bearing upper extremity and weight-bearing lower extremity: A pQCT study of adult female athletes. Bone 39: 886894.
  • 19
    Vico L, Collet P, Guignandon A, Lafage-Proust MH, Thomas T, Rehaillia M, Alexandre C 2000 Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts. Lancet 355: 16071611.
  • 20
    Kaprio J, Koskenvuo M 2002 Genetic and environmental factors in complex diseases: The older Finnish Twin Cohort. Twin Res 5: 358365.
  • 21
    Kaprio J, Sarna S, Koskenvuo M, Rantasalo I 1978 The Finnish Twin Registry: Formation and compilation, questionnaire study, zygosity determination procedures, and research program. Prog Clin Biol Res 24 Pt B: 179184.
  • 22
    Carter DR, Hayes WC 1976 Bone compressive strength: The influence of density and strain rate. Science 194: 11741176.
  • 23
    Martin RB 1991 Determinants of the mechanical properties of bones. J Biomech 24(Suppl 1): 7988.
  • 24
    Grimby G 1986 Physical activity and muscle training in the elderly. Acta Med Scand Suppl 711: 233237.
  • 25
    Posthuma D, Beem AL, de Geus EJ, van Baal GC, von Hjelmborg JB, Iachine I, Boomsma DI 2003 Theory and practice in quantitative genetics. Twin Res 6: 361376.
  • 26
    Rijsdijk FV, Sham PC 2002 Analytic approaches to twin data using structural equation models. Brief Bioinform 3: 119133.
  • 27
    Plomin R, DeFries JC, McClearn GE, McGuffin P 2001 Behavioral Genetics, 4th ed. Worth Publishers, New York, NY, USA.
  • 28
    Neale MC, Cardon LR 1992 Methodology for Genetic Studies of Twins and Families. Kluwer, Dordrecht, The Netherlands.
  • 29
    Neale MC, Boker SM, Xie G, Maes HH 2003 Mx: Statistical Modeling. 6th ed. Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
  • 30
    Hunter DJ, de Lange M, Andrew T, Snieder H, MacGregor AJ, Spector TD 2001 Genetic variation in bone mineral density and calcaneal ultrasound: A study of the influence of menopause using female twins. Osteoporos Int 12: 406411.
  • 31
    Knapp KM, Andrew T, MacGregor AJ, Blake GM, Fogelman I, Spector TD 2003 An investigation of unique and shared gene effects on speed of sound and bone density using axial transmission quantitative ultrasound and DXA in twins. J Bone Miner Res 18: 15251530.
  • 32
    Lei SF, Chen Y, Xiong DH, Li LM, Deng HW 2006 Ethnic difference in osteoporosis-related phenotypes and its potential underlying genetic determination. J Musculoskelet Neuronal Interact 6: 3646.
  • 33
    Havill LM, Mahaney MC, L Binkley T, Specker BL 2007 Effects of genes, sex, age, and activity on BMC, bone size, and areal and volumetric BMD. J Bone Miner Res 22: 737746.
  • 34
    Cranney A, Guyatt G, Griffith L, Wells G, Tugwell P, Rosen C, Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group 2002 Meta-analyses of therapies for postmenopausal osteoporosis. IX: Summary of meta-analyses of therapies for postmenopausal osteoporosis. Endocr Rev 23: 570578.
  • 35
    Christiansen P, Steiniche T, Brixen K, Hessov I, Melsen F, Charles P, Mosekilde L 1997 Primary hyperparathyroidism: Biochemical markers and bone mineral density at multiple skeletal sites in Danish patients. Bone 21: 9399.
  • 36
    Matkovic V, Landoll JD, Badenhop-Stevens NE, Ha EY, Crncevic-Orlic Z, Li B, Goel P 2004 Nutrition influences skeletal development from childhood to adulthood: A study of hip, spine, and forearm in adolescent females. J Nutr 134: 701S705S.
  • 37
    Martin JC, Munro R, Campbell MK, Reid DM 1997 Effects of disease and corticosteroids on appendicular bone mass in postmenopausal women with rheumatoid arthritis: Comparison with axial measurements. Br J Rheumatol 36: 4349.
  • 38
    Ward KD, Klesges RC 2001 A meta-analysis of the effects of cigarette smoking on bone mineral density. Calcif Tissue Int 68: 259270.
  • 39
    Uusi-Rasi K, Sievänen H, Pasanen M, Oja P, Vuori I 2002 Associations of calcium intake and physical activity with bone density and size in premenopausal and postmenopausal women: A peripheral quantitative computed tomography study. J Bone Miner Res 17: 544552.
  • 40
    Shackelford LC, LeBlanc AD, Driscoll TB, Evans HJ, Rianon NJ, Smith SM, Spector E, Feeback DL, Lai D 2004 Resistance exercise as a countermeasure to disuse-induced bone loss. J Appl Physiol 97: 119129.
  • 41
    Hui SL, Koller DL, Foroud TM, Econs MJ, Johnston CC, Peacock M 2006 Heritability of changes in bone size and bone mass with age in premenopausal white sisters. J Bone Miner Res 21: 11211125.
  • 42
    Sievänen H, Koskue V, Rauhio A, Kannus P, Heinonen A, Vuori I 1998 Peripheral quantitative computed tomography in human long bones: Evaluation of in vitro and in vivo precision. J Bone Miner Res 13: 871882.
  • 43
    Schmitz S, Cherny SS, Fulker DW 1998 Increase in power through multivariate analyses. Behav Genet 28: 357363.