Does Low Vitamin D Status Contribute to “Age-Related” Morbidity?


  • Neil Binkley MD

    Corresponding author
    1. University of Wisconsin–Madison Institute on Aging and School of Medicine and Public Health, Madison, Wisconsin, USA
    • Address reprint requests to: 2870 University Avenue, Suite 100, Madison, WI 53705, USA
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    • Dr Binkley received support from Aventis, Deltanoid, GlaxoSmithKline, Merck & Co., Novartis, and Roche. He serves as a speaker for GlaxoSmithKline, Merck & Co., Procter & Gamble, and Roche. He consults for Eli Lilly and Company, Merck & Co., and Novartis.


It is increasingly appreciated that vitamin D plays important physiological roles beyond the musculoskeletal system. As such, it is plausible that endemic vitamin D deficiency contributes to much nonskeletal morbidity that adversely affects quality of life with advancing age among older adults. This overview will explore the evidence for, and potential involvement of, vitamin D deficiency in nonbone conditions that are currently accepted as “age-related” morbidity among older adults.