• 1
    Aubin JE, Heersche JNM 1997 Vitamin D and osteoblasts. In: FeldmanD, GlorieuxFH, PikeJW (eds.) Vitamin D. Academic Press, San Diego, CA, USA, 313328.
  • 2
    Sambrook PN, Eisman JA 2000 Osteoporosis prevention and treatment. Med J Aust 172: 226229.
  • 3
    Li YC, Amling M, Pirro AE, Priemel M, Meuse J, Baron R, Delling G, Demay MB 1998 Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice. Endocrinology 139: 43914396.
  • 4
    Boivin G, Mesguich P, Pike JW, Bouillon R, Meunier PJ, Haussler MR, Dubois PM, Morel G 1987 Ultrastructural immunocytochemical localization of endogenous 1α,25-dihydroxyvitamin D3 and its receptors in osteoblasts and osteocytes from neonatal mouse and rat calvaria. J Bone Miner Res 3: 125136.
  • 5
    Kraichely DM, MacDonald PN 1998 Transcriptional activation through the vitamin D receptor in osteoblasts. Front Biosci 3: D821D833.
  • 6
    Bellows CG, Reimers SM, Heersche JN 1999 Expression of mRNAs for type-I collagen, bone sialoprotein, osteocalcin, and osteopontin at different stages of osteoblastic differentiation and their regulation by 1α,25 dihydroxyvitamin D3. Cell Tissue Res 297: 249259.
  • 7
    Meszaros JG, Karin NJ, Farach-Carson MC 1996 Voltage-sensitive calcium channels in osteoblasts: Mediators of plasma membrane signalling events. Connect Tissue Res 34–5: 161165.
  • 8
    Zanello LP, Norman AW 2004 Rapid modulation of osteoblast ion channel responses by 1α,25-dihydroxyvitamin D3 requires the presence of a functional vitamin D nuclear receptor. Proc Natl Acad Sci USA 101: 15891594.
  • 9
    Zanello LP, Norman AW 2004 Electrical responses to 1α,25-dihydroxyvitamin D3 and their physiological significance in osteoblasts. Steroids 69: 561565.
  • 10
    Zhang X, Biswas P, Owraghi M, Zanello LP 2007 1α,25-dihydroxyvitamin D3 membrane-initiated calcium signaling modulates exocytosis and cell survival. J Steroid Biochem Mol Biol 103: 457461.
  • 11
    Wu W, Zhang X, Zanello LP 2007 1α,25-dihydroxyvitamin D3 antiproliferative actions involve vitamin D receptor-mediated activation of MAPK pathways and AP-1/p21waf1 upregulation in human osteosarcoma. Cancer Lett 254: 7586.
  • 12
    Le Mellay V, Lasmoles F, Lieberherr M 1999 Gαq/11 and Gγ proteins and membrane signaling of calcitriol and estradiol. J Cell Biochem 75: 138146.
  • 13
    Vertino AM, Bula CM, Chen JR, Almeida M, Han L, Bellido T, Kousteni S, Norman AW, Manolagas SC 2005 Nongenotropic, anti-apoptotic signaling of 1α,25-dihydroxyvitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases. J Biol Chem 280: 1413014137.
  • 14
    Duque G, El Abdaimi K, Henderson JE, Lomri A, Kremer R 2004 Vitamin D inhibits Fas ligand-induced apoptosis in human osteoblasts by regulating components of both the mitochondrial and Fas-related pathways. Bone 35: 5764.
  • 15
    Morales O, Samuelsson MK, Lindgren U, Haldosen LA 2004 Effects of 1α,25-dihydroxyvitamin D3 and growth hormone on apoptosis and proliferation in UMR 106 osteoblast-like cells. Endocrinology 145: 8794.
  • 16
    Prince RL 2007 Calcium and vitamin D: For whom and when. Menopause Int 13: 3537.
  • 17
    Kaye EK 2007 Bone health and oral health. J Am Dent Assoc 138: 616619.
  • 18
    Boonen S, Rizzoli R, Meunier PJ, Stone M, Nuki G, Syversen U, Lehtonen M, Lips P, Johnell O, Reginster JY 2004 The need for clinical guidance in the use of calcium and vitamin D in the management of osteoporosis: A consensus report. Osteoporos Int 15: 511519.
  • 19
    Vanhaesebroeck B, Alessi DR 2000 The PI3K-PDK1 connection: More than just a road to PKB. Biochem J 346: 561576.
  • 20
    Song G, Ouyang G, Bao S 2005 The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med 9: 5971.
  • 21
    Datta SR, Brunet A, Greenberg ME 1999 Cellular survival: A play in three Akts. Genes Dev 13: 29052927.
  • 22
    Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME 1997 Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91: 231241.
  • 23
    Lamkanfi M, Declercq W, Depuydt B, Kalai M, Salens X, Vandenabeele P 2003 The caspase family. In: LossM, WalczakH (eds.) Caspases: Their Role in Cell Death and Survival. Landes Biosciences & Kluwer Academic, New York, NY, USA, 140.
  • 24
    Tafani M, Minchenko DA, Serroni A, Farber JL 2001 Induction of the mitochondrial permeability transition mediates the killing of HeLa cells by staurosporine. Cancer Res 61: 24592466.
  • 25
    Zhang XD, Gillespie SK, Hersey P 2004 Staurosporine induces apoptosis of melanoma by both caspase-dependent and -independent apoptotic pathways. Molec Cancer Ther 3: 187197.
  • 26
    Mizwicki MT, Keidel D, Bula CM, Bishop JE, Zanello LP, Wurtz JM, Moras D, Norman AW 2004 Identification of an alternative ligand-binding pocket in the nuclear vitamin D receptor and its functional importance in 1α,25(OH)2-vitamin D3 signaling. Proc Natl Acad Sci USA 101: 1287612881.
  • 27
    Huhtakangas JA, Olivera CJ, Bishop JE, Zanello LP, Norman AW 2004 The vitamin D receptor is present in caveolae-enriched plasma membranes and binds 1α,25-dihydroxyvitamin D3 in vivo and in vitro. Mol Endocrinol 18: 26602671.
  • 28
    Gidley J, Openshaw S, Pring ET, Sale S, Mansell JP 2006 Lysophosphatidic acid cooperates with 1α,25-dihydroxyvitamin D3 in stimulating human MG63 osteoblast maturation. Prostaglandins Other Lipid Mediat 80: 4661.
  • 29
    Zanello LP, Norman AW 1997 Stimulation by 1α,25-dihydroxyvitamin D3 of whole cell chloride currents in osteoblastic ROS 17/2.8 cells: A structure-function study. J Biol Chem 272: 2261722622.
  • 30
    Perlman H, Sata M, Le Roux A, Sedlak TW, Branellec D, Walsh K 1998 Bax-mediated cell death by the Gax homeoprotein requires mitogen activation but is independent of cell cycle activity. EMBO J 17: 35763586.
  • 31
    Lamkanfi M, Festjens N, Declercq W, Vanden Berghe T, Vandenabeele P 2007 Caspases in cell survival, proliferation and differentiation. Cell Death Differ 14: 4455.
  • 32
    Tafani M, Michenko DA, Serroni A, Farber JL 2001 Induction of the mitochondrial permeability transition mediates the killing of HeLa cells by staurosporine. Cancer Res 61: 24592466.
  • 33
    Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JC 1998 Regulation of cell death protease caspase-9 by phosphorylation. Science 282: 13181321.
  • 34
    Zhang XD, Gillespie SK, Hersey P 2003 Staurosporine induces apoptosis of melanoma by both caspase-dependent and -independent apoptotic pathways. Mol Cancer Ther 3: 187197.
  • 35
    Nemere I, Farach-Carson MC, Rohe B, Sterling TM, Norman AW, Boyan BD, Safford SE 2004 Ribozyme knockdown functionally links a 1α,25-dihydroxyvitamin D3 membrane binding protein (1,25D3-MARRS) and phosphate uptake in intestinal cells. Proc Natl Acad Sci USA 101: 73927397.
  • 36
    Boyan BD, Bonewald LF, Sylvia VL, Nemere I, Larsson D, Norman AW, Rosser J, Dean DD, Schwartz Z 2002 Evidence for distinct membrane receptors for 1α,25-dihydroxyvitamin D3 and 24R,25-(OH)2 vitamin D3 in osteoblasts. Steroids 67: 235246.
  • 37
    Capiati D, Benassati S, Boland RL 2002 1α,25(OH)2-vitamin D3 induces translocation of the vitamin D receptor (VDR) to the plasma membrane in skeletal muscle cells. J Cell Biochem 86: 128135.
  • 38
    Erben RG, Soegiarto DW, Weber K, Zeitz U, Lieberherr M, Gniadecki R, Moller G, Adamski J, Balling R 2002 Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D. Mol Endocrinol 16: 15241537.
  • 39
    Wyckoff MH, Chambliss KL, Mineo C, Yuhanna IS, Mendelsohn ME, Mumby SM, Shaul PW 2001 Plasma membrane estrogen receptors are coupled to endothelial nitric-oxide synthase through Gai. J Biol Chem 276: 2707127076.
  • 40
    Razandi M, Pedram A, Park ST, Levin ER 2003 Proximal events in signaling by plasma membrane estrogen receptors. J Biol Chem 278: 27012712.
  • 41
    Vanhaesebroeck B, Alessi DR 2000 The PI3K-PDK1 connection: More than just a road to PKB. Exp Cell Res 346: 561576.
  • 42
    Chen YJ, Wang CJ, Yang KD, Chang PR, Huang HC, Huang YT, Sun YC, Wang FS 2003 Pertussis toxin-sensitive Gαi protein and ERK-dependent pathways mediate ultrasound promotion of osteogenic transcription in human osteoblasts. FEBS Lett 554: 154158.
  • 43
    De Haes P, Garmyn M, Carmeliet G, Degreef H, Vantieghem K, Bouillon R, Segaert S 2004 Molecular pathways involved in the anti-apoptotic effect of 1α,25-dihydroxyvitamin D3 in primary human keratinocytes. J Cell Biochem 93: 951967.
  • 44
    Ma Y, Yu WD, Kong RX, Trump D, Johnson CS 2006 Role of nongenomic activation of phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase 1/2 pathways in 1,25D3-mediated apoptosis in squamous cell carcinoma cells. Cancer Res 66: 81318138.
  • 45
    Diaz GD, Paraskeva C, Thomas MG, Binderup L, Hague A 2000 Apoptosis is induced by the active metabolite of vitamin D3 and its analogue EB1089 in colorectal adenoma and carcinoma cells: Possible implications for prevention and therapy. Cancer Res 60: 23042312.
  • 46
    Manggau M, Kim DS, Ruwisch L, Vogler R, Korting HC, Schafer-Korting M, Kleuser B 2001 1α,25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingosine-1-phosphate. J Invest Dermatol 117: 12411249.
  • 47
    Thomas P, Pang Y, Filardo EJ, Dong J 2005 Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology 146: 624632.
  • 48
    Srivastava DP, Ju EJ, Kennedy K, Chatwin H, Reale V, Hamon M, Smith T, Evans PD 2005 Rapid, nongenomic responses to ecdysteroids and catecholamines mediated by a novel Drosophila G-protein-coupled receptor. J Neurosci 25: 61456155.