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Establishing a Reference Interval for Bone Turnover Markers in 637 Healthy, Young, Premenopausal Women From the United Kingdom, France, Belgium, and the United States†

  1. Sarah J Glover1,
  2. Martin Gall2,
  3. Oliver Schoenborn-Kellenberger3,
  4. Michael Wagener3,
  5. Patrick Garnero4,
  6. Steven Boonen5,
  7. Jane A Cauley6,
  8. Dennis M Black7,
  9. Pierre D Delmas8,
  10. Richard Eastell1,*

Article first published online: 28 JUL 2008

DOI: 10.1359/jbmr.080703

Issue

Journal of Bone and Mineral Research

Journal of Bone and Mineral Research

Volume 24, Issue 3, pages 389–397, March 2009

Additional Information

How to Cite

Glover, S. J., Gall, M., Schoenborn-Kellenberger, O., Wagener, M., Garnero, P., Boonen, S., Cauley, J. A., Black, D. M., Delmas, P. D. and Eastell, R. (2009), Establishing a Reference Interval for Bone Turnover Markers in 637 Healthy, Young, Premenopausal Women From the United Kingdom, France, Belgium, and the United States. J Bone Miner Res, 24: 389–397. doi: 10.1359/jbmr.080703

Author Information

  1. 1

    University of Sheffield, Sheffield, United Kingdom

  2. 2

    Novartis Pharmaceuticals, East Hanover, New Jersey, USA

  3. 3

    Novartis Pharma AG, Basel, Switzerland

  4. 4

    INSERM Unit 664, SYNARC, Lyon, France

  5. 5

    Gerontology and Geriatrics Section and Musculoskeletal Research Unit, Leuven University Department of Experimental Medicine, Katholieke Universiteit Leuven, Leuven, Belgium

  6. 6

    University of Pittsburgh, Pittsburgh, Pennsylvania, USA

  7. 7

    Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA

  8. 8

    INSERM Research Unit 831,University of Lyon, Lyon, France

*Address reprint requests to: Richard Eastell, ND, FRCP, Department of Bone Metabolism, Academic Unit of Bone Metabolism, Metabolic Bone Centre, Sorby Wing, Northern General Hospital, Herries Road, Sheffield, South Yorkshire S5 7AU, UK

  1. †

    The authors state that they have no conflicts of interest.

Publication History

  1. Issue published online: 4 DEC 2009
  2. Article first published online: 28 JUL 2008
  3. Manuscript Accepted: 24 JUL 2008
  4. Manuscript Received: 8 APR 2008
  5. Manuscript Revised: 8 APR 2008

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REFERENCES

  • 1
    Black DM Delmas PD Eastell R Reid IR Boonen S Cauley JA Cosman F Lakatos P Leung PC Man Z Mautalen C Mesenbrink P Hu H Caminis J Tong K Rosario-Jansen T Hue Tf Tong K Sellmeyer D Eriksen EF Cummings SR 2007 Once yearly zoledronic acid for treatment of postmenopausal osteoporsis. N English J Med 356: 1809–1822.
  • 2
    Eastell R Barton I Hannon RA Chines A Garnero P Delmas PD 2003 Relationship of early changes in bone resorption to the reduction in fracture risk with risedronate. J Bone Miner Res 18: 1051–1056.
    Direct Link:
  • 3
    Garnero P Sornay-Rendu E Claustrat B Delmas PD 2000 Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: The OFELY study. J Bone Miner Res 15: 1526–1536.
    Direct Link:
  • 4
    Garnero P Hausherr E Chapuy MC Marcelli C Grandjean H Muller C Cormier C Breart G Meunier PJ Delmas PD 1996 Markers of bone resorption predict hip fracture in elderly women: The EPIDOS Prospective Study. J Bone Miner Res 11: 1531–1538.
    Direct Link:
  • 5
    Dobnig H Sipos A Jiang Y Fahrleitner-Pammer A Ste-Marie LG Gallagher JC Pavo I Wang J Eriksen EF 2005 Early changes in biochemical markers of bone formation correlate with improvements in bone structure during teriparatide therapy. J Clin Endocrinol Metab 90: 3970–3977.
  • 6
    Altman DG 1991 Some common problems in medical research. In: AltmanDG (ed.) practical statistics for medical research, 1st ed. Chapman and Hall, LONDON, UK 396–439.
  • 7
    Delmas PD Eastell R Garnero P Seibel MJ Stepan J 2000 The use of biochemical markers of bone turnover in osteoporosis. Committee of Scientific Advisors of the International Osteoporosis Foundation. Osteoporos Int 11 (Suppl 6): S2–S17.
  • 8
    Garnero P Shih WJ Gineyts E Kalpf D Delmas PD 1994 Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment. J Clin Endocrinol Metab 79: 1693–1700.
  • 9
    Gertz BJ Shao P Hanson DA Quan H Harris ST Genant HK Chesnut CH , III, Eyre DR 1994 Monitoring bone resorption in early postmenopausal women by an immunoassay for cross-linked collagen peptides in urine. J Bone Miner Res 9: 135–142.
    Direct Link:
  • 10
    de Papp AE Bone HG Caulfield MP Kagan R Buinewicz A Chen E Rosenberg E Reitz RE 2007 A cross-sectional study of bone turnover markers in healthy premenopausal women. Bone 40: 1222–1230.
  • 11
    Hannon R Eastell R 2000 Preanalytical variability of biochemical markers of bone turnover. Osteoporos Int 11 (Suppl 6): S30–S44.
  • 12
    Wright EM Royston P 1999 Calculating reference intervals for laboratory measurements. Stat Methods Med Res 8: 93–112.
  • 13
    Royston P Matthews JN 1991 Estimation of reference ranges from normal samples. Stat Med 10: 691–695.
    Direct Link:
  • 14
    Glover SJ Garnero P Naylor K Rogers A Eastell R 2008 Establishing a reference name for bone turnover markers in young, healthy women. Bone 42: 623–630.
  • 15
    Blumsohn A Naylor KE Timm W Eagleton AC Hannon RA Eastell R 2003 Absence of marked seasonal change in bone turnover: A longitudinal and multicenter cross-sectional study. J Bone Miner Res 18: 1274–1281.
    Direct Link:
  • 16
    Cohen FJ Eckert S Mitlak BH 1998 Geoghraphic differences in bone turnover: Data from a multinational study in healthy postmenopausal women. Calcif Tissue Int 63: 277–282.
  • 17
    Garnero P Sornay-Rendu E Delmas PD 1995 Decreased bone turnover in oral contraceptive users. Bone 16: 499–503.
  • 18
    Gorai I Taguchi Y Chaki O Kikuchi R Nakayama M Yang BC Yokota S Minaguchi H 1998 Serum soluble interleukin-6 receptor and biochemical markers of bone metabolism show significant variations during the menstrual cycle. J Clin Endocrinol Metab 83: 326–332.
  • 19
    Bjarnason NH Christiansen C 2000 The influence of thinness and smoking on bone loss and response to hormone replacement therapy in early postmenopausal women. J Clin Endocrinol Metab 85: 590–596.
  • 20
    Woitge HW Friedmann B Suttner S Farahmand I Muller M Schmidt GH Baertsch P Ziegler R Seibel MJ 1998 Changes in bone turnover induced by aerobic and anaerobic exercise in young males. J Bone Miner Res 13: 1797–1804.
    Direct Link:
  • 21
    Hannon R Blumsohn A Naylor K Eastell R 1998 Response of biochemical markers of bone turnover to hormone replacement therapy: Impact of biological variability. J Bone Miner Res 13: 1124–1133.
    Direct Link:
  • 22
    Nielsen HK Lundby L Rasmussen K Charles P Hansen C 1990 Alcohol decreases serum osteocalcin in a dose-dependent way in normal subjects. Calcif Tissue Int 46: 173–178.
  • 23
    Sahota O Masud T San P Hosking DJ 1999 Vitamin D insufficiency increases bone turnover markers and enhances bone loss at the hip in patients with established vertebral osteoporosis. Clin Endocrinol (Oxf) 51: 217–221.
    Direct Link:
  • 24
    Brazier M Kamel S Maamer M Agbomson F Elesper I Garabedien M Desmet G Sebert JL 1995 Markers of bone remodelling in the elderly subject: Effect of vitamin D insufficiency and its correction. J Bone Miner Res 10: 1753–1761.
    Direct Link:
  • 25
    Scharla SH Scheid-Nave C Leidig G Woitge H Wüster C Seibel MJ Ziegter R 2003 1996 Lower serum 25-hydroxyvitamin D is associate with increased bone resorption makers and lower bone density at the proximal femur in normal females: A population-base study. Exp clin endocrinol diabetes 104: 289–292.
  • 26
    Heaney RP 2003 Is the paradigm shifting ? Bone 33: 457–465.
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