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  • 1
    Melton LJ III , Thamer M, Ray NF, Chan JK, Chesnut CH III , Einhorn TA, Johnston CC, Raisz LG, Silverman SL, Siris ES 1997 Fractures attributable to osteoporosis: Report from the National Osteoporosis Foundation. J Bone Miner Res 12: 1623.
  • 2
    Zethraeus N, Borgstrom F, Strom O, Kanis JA, Jonsson B 2007 Cost-effectiveness of the treatment and prevention of osteoporosis: A review of the literature and a reference model. Osteoporos Int 18: 923.
  • 3
    Faulkner KG, Wacker WK, Barden HS, Simonelli C, Burke PK, Ragi S, Del Rio L 2006 Femur strength index predicts hip fracture independent of bone density and hip axis length. Osteoporos Int 17: 593599.
  • 4
    Faulkner KG, Cummings SR, Black D, Palermo L, Gluer CC, Genant HK 1993 Simple measurement of femoral geometry predicts hip fracture: The study of osteoporotic fractures. J Bone Miner Res 8: 12111217.
  • 5
    Kanis JA 2002 Diagnosis of osteoporosis and assessment of fracture risk. Lancet 359: 19291936.
  • 6
    Lauretani F, Bandinelli S, Bartali B, Iorio AD, Giacomini V, Corsi AM, Guralnik JM, Ferrucci L 2006 Axonal degeneration affects muscle density in older men and women. Neurobiol Aging 27: 11451154.
  • 7
    Visser M, Kritchevsky SB, Goodpaster BH, Newman AB, Nevitt M, Stamm E, Harris TB 2002 Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: The health, aging and body composition study. J Am Geriatr Soc 50: 897904.
  • 8
    Broadwin J, Goodman-Gruen D, Slymen D 2001 Ability of fat and fat-free mass percentages to predict functional disability in older men and women. J Am Geriatr Soc 49: 16411645.
  • 9
    Huygens W, Thomis MA, Peeters MW, Vlietinck RF, Beunen GP 2004 Determinants and upper-limit heritabilities of skeletal muscle mass and strength. Can J Appl Physiol 29: 186200.
  • 10
    Visser M, Deeg DJ, Lips P, Harris TB, Bouter LM 2000 Skeletal muscle mass and muscle strength in relation to lower-extremity performance in older men and women. J Am Geriatr Soc 48: 381386.
  • 11
    Zhai G, Ding C, Stankovich J, Cicuttini F, Jones G 2005 The genetic contribution to longitudinal changes in knee structure and muscle strength: A sibpair study. Arthritis Rheum 52: 28302834.
  • 12
    Seeman E, Hopper JL, Young NR, Formica C, Goss P, Tsalamandris C 1996 Do genetic factors explain associations between muscle strength, lean mass, and bone density? A twin study. Am J Physiol 270: E320E327.
  • 13
    Videman T, Levalahti E, Battie MC, Simonen R, Vanninen E, Kaprio J 2007 Heritability of BMD of femoral neck and lumbar spine: A multivariate twin study of Finnish men. J Bone Miner Res 22: 14551462.
  • 14
    Sun X, Lei SF, Deng FY, Wu S, Papacian C, Hamilton J, Recker RR, Deng HW 2006 Genetic and environmental correlations between bone geometric parameters and body compositions. Calcif Tissue Int 79: 4349.
  • 15
    Soria J, Almasy L, Souto J, Buil A, Martlessi;'nez-Sa'nchez E, Mateo J, Borrell M, Stone W 2003 A new locus on chromosome 18 that influences normal variation in activated protein C resistance phenotype and factor VIII activity and its relation to thrombosis susceptibility. Blood 101: 163167.
  • 16
    Demissie S, Dupuis J, Cupples LA, Beck TJ, Kiel DP, Karasik D 2007 Proximal hip geometry is linked to several chromosomal regions: Genome-wide linkage results from the Framingham Osteoporosis Study. Bone 40: 743750.
  • 17
    Karasik D, Cupples LA, Hannan MT, Kiel DP 2004 Genome screen for a combined bone phenotype using principal component analysis: The Framingham study. Bone 34: 547556.
  • 18
    Khoo BC, Beck TJ, Qiao QH, Parakh P, Semanick L, Prince RL, Singer KP, Price RI 2005 In vivo short-term precision of hip structure analysis variables in comparison with bone mineral density using paired dual-energy X-ray absorptiometry scans from multi-center clinical trials. Bone 37: 112121.
  • 19
    Beck TJ, Ruff CB, Scott WW Jr , Plato CC, Tobin JD, Quan CA 1992 Sex differences in geometry of the femoral neck with aging: A structural analysis of bone mineral data. Calcif Tissue Int 50: 2429.
  • 20
    Martin RB, Burr DB 1984 Non-invasive measurement of long bone cross-sectional moment of inertia by photon absorptiometry. J Biomech 17: 195201.
  • 21
    Yuan B, Vaske D, Weber JL, Beck J, Sheffield VC 1997 Improved set of short-tandem-repeat polymorphisms for screening the human genome. Am J Hum Genet 60: 459460.
  • 22
    Levy D, DeStefano AL, Larson MG, O'Donnell CJ, Lifton RP, Gavras H, Cupples LA, Myers RH 2000 Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the framingham heart study. Hypertension 36: 477483.
  • 23
    Michels K, Greenland S, Rosner B 1998 Does body mass index adequately capture the relation of body composition and body size to health outcomes ? Am J Epidemiol 147: 167172.
  • 24
    Heath SC 1997 Markov chain Monte Carlo segregation and linkage analysis for oligogenic models. Am J Hum Genet 61: 748760.
  • 25
    Abecasis GR, Cherny SS, Cookson WO, Cardon LR 2002 Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 30: 97101.
  • 26
    Kong A, Gudbjartsson DF, Sainz J, Jonsdottir GM, Gudjonsson SA, Richardsson B, Sigurdardottir S, Barnard J, Hallbeck B, Masson G, Shlien A, Palsson ST, Frigge ML, Thorgeirsson TE, Gulcher JR, Stefansson K 2002 A high-resolution recombination map of the human genome. Nat Genet 31: 241247.
  • 27
    Almasy L, Blangero J 1998 Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62: 11981211.
  • 28
    Blangero J, Williams JT, Almasy L 2000 Robust LOD scores for variance component-based linkage analysis. Genet Epidemiol 19 (Suppl 1): S8S14.
  • 29
    Goring HH, Terwilliger JD, Blangero J 2001 Large upward bias in estimation of locus-specific effects from genomewide scans. Am J Hum Genet 69: 13571369.
  • 30
    Almasy L, Dyer TD, Blangero J 1997 Bivariate quantitative trait linkage analysis: Pleiotropy versus co- incident linkages. Genet Epidemiol 14: 953958.
  • 31
    Williams JT, Van Eerdewegh P, Almasy L, Blangero J 1999 Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. I. Likelihood formulation and simulation results. Am J Hum Genet 65: 11341147.
  • 32
    Havill LM, Rogers J, Cox LA, Mahaney MC 2006 QTL with pleiotropic effects on serum levels of bone-specific alkaline phosphatase and osteocalcin maps to the baboon ortholog of human chromosome 6p23-21.3. J Bone Miner Res 21: 18881896.
  • 33
    Karasik D, Dupuis J, Cupples LA, Beck TJ, Mahaney MC, Havill LM, Kiel DP, Demissie S 2007 Bivariate linkage study of proximal hip geometry and body size indices: The Framingham study. Calcif Tissue Int 81: 162173.
  • 34
    Camp NJ, Farnham JM 2001 Correcting for multiple analyses in genomewide linkage studies. Ann Hum Genet 65: 577582.
  • 35
    Deng FY, Xiao P, Lei SF, Zhang L, Yang F, Tang ZH, Liu PY, Liu YJ, Recker RR, Deng HW 2007 Bivariate whole genome linkage analysis for femoral neck geometric parameters and total body lean mass. J Bone Miner Res 22: 808816.
  • 36
    Visser M, Harris TB, Langlois J, Hannan MT, Roubenoff R, Felson DT, Wilson PW, Kiel DP 1998 Body fat and skeletal muscle mass in relation to physical disability in very old men and women of the Framingham Heart Study. J Gerontol A Biol Sci Med Sci 53: M214M221.
  • 37
    Kvame T, Vangen O 2007 Selection for lean weight based on ultrasound and CT in a meat line of sheep. Livestock Sci 106: 232242.
  • 38
    Li X, Masinde G, Gu W, Wergedal J, Mohan S, Baylink DJ 2002 Genetic dissection of femur breaking strength in a large population (MRL/MpJ x SJL/J) of F2 mice: Single QTL effects, epistasis, and pleiotropy. Genomics 79: 734740.
  • 39
    Prior SJ, Roth SM, Wang X, Kammerer C, Miljkovic-Gacic I, Bunker CH, Wheeler VW, Patrick AL, Zmuda JM 2007 Genetic and environmental influences on skeletal muscle phenotypes as a function of age and sex in large, multigenerational families of African heritage. J Appl Physiol 103: 11211127.
  • 40
    Beck TJ, Ruff CB, Warden KE, Scott WW Jr , Rao GU 1990 Predicting femoral neck strength from bone mineral data. A structural approach. Invest Radiol 25: 618.
  • 41
    Econs MJ, McEnery PT, Lennon F, Speer MC 1997 Autosomal dominant hypophosphatemic rickets is linked to chromosome 12p13. J Clin Invest 100: 26532657.
  • 42
    Chagnon YC, Rice T, Perusse L, Borecki IB, Ho-Kim MA, Lacaille M, Pare C, Bouchard L, Gagnon J, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C 2001 Genomic scan for genes affecting body composition before and after training in Caucasians from HERITAGE. J Appl Physiol 90: 17771787.
  • 43
    Zhang F, Xiao P, Yang F, Shen H, Xiong DH, Deng HY, Papasian CJ, Drees BM, Hamilton JJ, Recker RR, Deng HW 2008 A whole genome linkage scan for QTLs underlying peak bone mineral density. Osteoporos Int 19: 303310.
  • 44
    Livshits G, Kato BS, Wilson SG, Spector TD 2007 Linkage of genes to total lean body mass in normal women. J Clin Endocrinol Metab 92: 31713176.
  • 45
    De Mars G, Windelinckx A, Huygens W, Peeters MW, Beunen GP, Aerssens J, Vlietinck R, Thomis MA 2008 Genome-wide linkage scan for maximum and length-dependent knee muscle strength in young men: Significant evidence for linkage at chromosome 14q24.3. J Med Genet 45: 275283.
  • 46
    Shore EM, Kaplan FS 2008 Insights from a rare genetic disorder of extraskeletal bone formation, fibrodysplasia ossificans progressiva (FOP). Bone 43: 427433.
  • 47
    Richards JB, Rivadeneira F, Inouye M, Pastinen TM, Soranzo N, Wilson SG, Andrew T, Falchi M, Gwilliam R, Ahmadi KR, Valdes AM, Arp P, Whittaker P, Verlaan DJ, Jhamai M, Kumanduri V, Moorhouse M, van Meurs JB, Hofman A, Pols HA, Hart D, Zhai G, Kato BS, Mullin BH, Zhang F, Deloukas P, Uitterlinden AG, Spector TD 2008 Bone mineral density, osteoporosis, and osteoporotic fractures: A genome-wide association study. Lancet 371: 15051512.
  • 48
    Styrkarsdottir U, Halldorsson BV, Gretarsdottir S, Gudbjartsson DF, Walters GB, Ingvarsson T, Jonsdottir T, Saemundsdottir J, Center JR, Nguyen TV, Bagger Y, Gulcher JR, Eisman JA, Christiansen C, Sigurdsson G, Kong A, Thorsteinsdottir U, Stefansson K 2008 Multiple genetic loci for bone mineral density and fractures. N Engl J Med 358: 23552365.
  • 49
    Liu YZ, Wilson SG, Wang L, Liu XG, Guo YF, Li J, Yan H, Deloukas P, Soranzo N, Chinnapen-Horsley U, Cervino A, Williams FM, Xiong DH, Zhang YP, Jin TB, Levy S, Papasian CJ, Drees BM, Hamilton JJ, Recker RR, Spector TD, Deng HW 2008 Identification of PLCL1 gene for hip bone size variation in females in a genome-wide association study. PLoS One 3: e3160.
  • 50
    Mailman MD, Feolo M, Jin Y, Kimura M, Tryka K, Bagoutdinov R, Hao L, Kiang A, Paschall J, Phan L, Popova N, Pretel S, Ziyabari L, Lee M, Shao Y, Wang ZY, Sirotkin K, Ward M, Kholodov M, Zbicz K, Beck J, Kimelman M, Shevelev S, Preuss D, Yaschenko E, Graeff A, Ostell J, Sherry ST 2007 The NCBI dbGaP database of genotypes and phenotypes. Nat Genet 39: 11811186.
  • 51
    Li R, Tsaih SW, Shockley K, Stylianou IM, Wergedal J, Paigen B, Churchill GA 2006 Structural model analysis of multiple quantitative traits. PLoS Genet 2: e114.
  • 52
    Hamrick MW, Pennington C, Byron CD 2003 Bone architecture and disc degeneration in the lumbar spine of mice lacking GDF-8 (myostatin). J Orthop Res 21: 10251032.
  • 53
    Garland T Jr , Morgan MT, Swallow JG, Rhodes JS, Girard I, Belter JG, Carter PA 2002 Evolution of a small-muscle polymorphism in lines of house mice selected for high activity levels. Evolution Int J Org Evolution 56: 12671275.
  • 54
    Vitarius JA, Sehayek E, Breslow JL 2006 Identification of quantitative trait loci affecting body composition in a mouse intercross. Proc Natl Acad Sci USA 103: 1986019865.
  • 55
    Karamichou E, Richardson RI, Nute GR, Gibson KP, Bishop SC 2006 Genetic analyses and quantitative trait loci detection, using a partial genome scan, for intramuscular fatty acid composition in Scottish Blackface sheep. J Anim Sci 84: 32283238.
  • 56
    Schenkel FS, Miller SP, Ye X, Moore SS, Nkrumah JD, Li C, Yu J, Mandell IB, Wilton JW, Williams JL 2005 Association of single nucleotide polymorphisms in the leptin gene with carcass and meat quality traits of beef cattle. J Anim Sci 83: 20092020.
  • 57
    Karasik D, Kiel DP 2008 Genetics of the musculoskeletal system: A pleiotropic approach. J Bone Miner Res 23: 788802.
  • 58
    Hewitt J, Lu X, Gilbert L, Nanes MS 2008 The muscle transcription factor MyoD promotes osteoblast differentiation by stimulation of the osterix promoter. Endocrinology 149: 36983707.
  • 59
    Ruff CB 2000 Biomechanical analyses of archeological human skeletons. In: KatzenbergM, SaundersS (eds.). Biological Anthropology of the Human Skeleton. Wiley-Liss, New York, NY, USA, 71102.
  • 60
    Samelson EJ, Broe KE, Demissie S, Beck TJ, Karasik D, Kathiresan S, Kiel DP 2008 Increased plasma osteoprotegerin concentrations are associated with indices of bone strength of the hip. J Clin Endocrinol Metab 93: 17891795.
  • 61
    Prendergast P, van der Helm F, Duda G 2005 Analysis of muscle and joint loads. In: MowV, HuiskesR (eds.). Basic Orthopaedic Biomechanics and Mechano-Biology 3rd ed. Lippincott Williams & Wilkins, Philadelphia, PA, USA 2989.