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REFERENCES

  • 1
    Brown SD Twells RC Hey PJ Cox RD Levy ER Soderman AR Metzker ML Caskey CT Todd JA Hess JF 1998 Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family. Biochem Biophys Res Commun 248: 879888.
  • 2
    Dong Y Lathrop W Weaver D Qiu Q Cini J Bertolini D Chen D 1998 Molecular cloning and characterization of LR3, a novel LDL receptor family protein with mitogenic activity. Biochem Biophys Res Commun 251: 784790.
  • 3
    Hey PJ Twells RC Phillips MS Yusuke N Brown SD Kawaguchi Y Cox R Guochun X Dugan V Hammond H Metzker ML Todd JA Hess JF 1998 Cloning of a novel member of the low-density lipoprotein receptor family. Gene 216: 103111.
  • 4
    Kim DH Inagaki Y Suzuki T Ioka RX Yoshioka SZ Magoori K Kang MJ Cho Y Nakano AZ Liu Q Fujino T Suzuki H Sasano H Yamamoto TT 1998 A new low density lipoprotein receptor related protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein E. J Biochem 124: 10721076.
  • 5
    Polakis P 2007 The many ways of Wnt in cancer. Curr Opin Genet Dev 17: 4551.
  • 6
    de Iongh RU Abud HE Hime GR 2006 WNT/Frizzled signaling in eye development and disease. Front Biosci 11: 24422464.
  • 7
    De Ferrari GV Moon RT 2006 The ups and downs of Wnt signaling in prevalent neurological disorders. Oncogene 25: 75457553.
  • 8
    Tzahor E 2007 Wnt/beta-catenin signaling and cardiogenesis: Timing does matter. Dev Cell 13: 1013.
  • 9
    Kruit JK 2008 LRP6: A link between the multiple disorders of the metabolic syndrome. Clin Genet 73: 228229.
  • 10
    He X Semenov M Tamai K Zeng X 2004 LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: Arrows point the way. Development 131: 16631677.
  • 11
    Bhat BM Allen KM Liu W Graham J Morales A Anisowicz A Lam HS McCauley C Coleburn V Cain M Fortier E Bhat RA Bex FJ Yaworsky PJ 2007 Structure-based mutation analysis shows the importance of LRP5 beta-propeller 1 in modulating Dkk1-mediated inhibition of Wnt signaling. Gene 391: 103112.
  • 12
    Panakova D Sprong H Marois E Thiele C Eaton S 2005 Lipoprotein particles are required for Hedgehog and Wingless signalling. Nature 435: 5865.
  • 13
    Fujino T Asaba H Kang MJ Ikeda Y Sone H Takada S Kim DH Ioka RX Ono M Tomoyori H Okubo M Murase T Kamataki A Yamamoto J Magoori K Takahashi S Miyamoto Y Oishi H Nose M Okazaki M Usui S Imaizumi K Yanagisawa M Sakai J Yamamoto TT 2003 Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc Natl Acad Sci USA 100: 229234.
  • 14
    Magoori K Kang MJ Ito MR Kakuuchi H Ioka RX Kamataki A Kim DH Asaba H Iwasaki S Takei YA Sasaki M Usui S Okazaki M Takahashi S Ono M Nose M Sakai J Fujino T Yamamoto TT 2003 Severe hypercholesterolemia, impaired fat tolerance, and advanced atherosclerosis in mice lacking both low density lipoprotein receptor-related protein 5 and apolipoprotein E. J Biol Chem 278: 1133111336.
  • 15
    Mani A Radhakrishnan J Wang H Mani A Mani MA Nelson-Williams C Carew KS Mane S Najmabadi H Wu D Lifton RP 2007 LRP6 mutation in a family with early coronary disease and metabolic risk factors. Science 315: 12781282.
  • 16
    Inoki K Ouyang H Zhu T Lindvall C Wang Y Zhang X Yang Q Bennett C Harada Y Stankunas K Wang CY He X MacDougald OA You M Williams BO Guan KL 2006 TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126: 955968.
  • 17
    Chen D Lathrop W Dong Y 1999 Molecular cloning of mouse Lrp7(Lr3) cDNA and chromosomal mapping of orthologous genes in mouse and human. Genomics 55: 314321.
  • 18
    Pospisil H Herrmann A Butherus K Pirson S Reich JG Kemmner W 2006 Verification of predicted alternatively spliced Wnt genes reveals two new splice variants (CTNNB1 and LRP5) and altered Axin-1 expression during tumour progression. BMC Genomics 7: 148.
  • 19
    Bjorklund P Akerstrom G Westin G 2007 An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling. PLoS Med 4: e328.
  • 20
    Miller JR 2008 The Wnts. Genome Biol 3:REVIEWS3001
  • 21
    Shitashige M Hirohashi S Yamada T Wnt signaling inside the nucleus. Cancer Sci 99: 631637.
  • 22
    Pan W Choi SC Wang H Qin Y Volpicelli-Daley L Swan L Lucast L Khoo C Zhang X Li L Abrams CS Sokol SY Wu D 2008 Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation. Science 321: 13501353.
  • 23
    Wu X Tu X Joeng KS Hilton MJ Williams DA Long F 2008 Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. Cell 133: 340353.
  • 24
    Veeman MT Axelrod JD Moon RT 2003 A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell 5: 367377.
  • 25
    Takada I Mihara M Suzawa M Ohtake F Kobayashi S Igarashi M Youn MY Takeyama K Nakamura T Mezaki Y Takezawa S Yogiashi Y Kitagawa H Yamada G Takada S Minami Y Shibuya H Matsumoto K Kato S 2007 A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation. Nat Cell Biol 9: 12731285.
  • 26
    Tu X Joeng KS Nakayama KI Nakayama K Rajagopal J Carroll TJ McMahon AP Long F 2007 Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell 12: 113127.
  • 27
    Niehrs C 2006 Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene 25: 74697481.
  • 28
    Nakamura T Nakamura T Matsumoto K 2008 The functions and possible significance of kremen as the gatekeeper of Wnt signaling in development and pathology. J Cell Mol Med 12: 391408.
  • 29
    Cselenyi CS Lee E 2008 Context-dependent activation or inhibition of Wnt-beta-catenin signaling by Kremen. Sci Signal 1: pe10.
  • 30
    Semenov MV Zhang X He X 2008 DKK1 antagonizes Wnt signaling without promotion of LRP6 internalization and degradation. J Biol Chem 283: 2142721432.
  • 31
    Wang K Zhang Y Li X Chen L Wang H Wu J Zheng J Wu D 2008 Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism. J Biol Chem 283: 2337123375.
  • 32
    Hendrickx M Leyns L 2008 Non-conventional Frizzled ligands and Wnt receptors. Dev Growth Differ 50: 229243.
  • 33
    van Bezooijen RL ten Dijke P Papapoulos SE Lowik CW 2005 SOST/sclerostin, an osteocyte-derived negative regulator of bone formation. Cytokine Growth Factor Rev 16: 319327.
  • 34
    de Vernejoul MC 2008 Sclerosing bone disorders. Best Pract Res Clin Rheumatol 22: 7183.
  • 35
    O'Brien CA Plotkin LI Galli C Goellner JJ Gortazar AR Allen MR Robling AG Bouxsein M Schipani E Turner CH Jilka RL Weinstein RS Manolagas SC Bellido T 2008 Control of bone mass and remodeling by PTH receptor signaling in osteocytes. PLoS One 3: e2942.
  • 36
    Hsieh JC Lee L Zhang L Wefer S Brown K DeRossi C Wines ME Rosenquist T Holdener BC 2003 Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity. Cell 112: 355367.
  • 37
    Gong Y Slee RB Fukai N Rawadi G Roman-Roman S Reginato AM Wang H Cundy T Glorieux FH Lev D Zacharin M Oexle K Marcelino J Suwairi W Heeger S Sabatakos G Apte S Adkins WN Allgrove J Arslan-Kirchner M Batch JA Beighton P Black GC Boles RG Boon LM Borrone C Brunner HG Carle GF Dallapiccola B De Paepe A Floege B Halfhide ML Hall B Hennekam RC Hirose T Jans A Juppner H Kim CA Keppler-Noreuil K Kohlschuetter A LaCombe D Lambert M Lemyre E Letteboer T Peltonen L Ramesar RS Romanengo M Somer H Steichen-Gersdorf E Steinmann B Sullivan B Superti-Furga A Swoboda W van den Boogaard MJ Van Hul W Vikkula M Votruba M Zabel B Garcia T Baron R Olsen BR Warman ML 2001 LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107: 513523.
  • 38
    Yadav VK Ryu J-H Suda N Tanaka K Gingrich KA Schutz G Glorieux FH Chiang CY Zajac JD Insogna KL Mann JJ Hen R Ducy P Karsenty G 2008 Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum: An entero-bone endocrine axis. Cell 135: 825837.
  • 39
    Lobov IB Rao S Carroll TJ Vallance JE Ito M Ondr JK Kurup S Glass DA Patel MS Shu W Morrisey EE McMahon AP Karsenty G Lang RA 2005 WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature 437: 417421.
  • 40
    Jiao X Ventruto V Trese MT Shastry BS Hejtmancik JF 2004 Autosomal recessive familial exudative vitreoretinopathy is associated with mutations in LRP5. Am J Hum Genet 75: 878884.
  • 41
    Qin M Hayashi H Oshima K Tahira T Hayashi K Kondo H 2005 Complexity of the genotype-phenotype correlation in familial exudative vitreoretinopathy with mutations in the LRP5 and/or FZD4 genes. Hum Mutat 26: 104112.
  • 42
    Toomes C Bottomley HM Jackson RM Towns KV Scott S Mackey DA Craig JE Jiang L Yang Z Trembath R Woodruff G Gregory-Evans CY Gregory-Evans K Parker MJ Black GC Downey LM Zhang K Inglehearn CF 2004 Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q. Am J Hum Genet 74: 721730.
  • 43
    Xu Q Wang Y Dabdoub A Smallwood PM Williams J Woods C Kelley MW Jiang L Tasman W Zhang K Nathans J 2004 Vascular development in the retina and inner ear: Control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell 116: 883895.
  • 44
    Haines JL Schnetz-Boutaud N Schmidt S Scott WK Agarwal A Postel EA Olson L Kenealy SJ Hauser M Gilbert JR Pericak-Vance MA 2006 Functional candidate genes in age-related macular degeneration: Significant association with VEGF, VLDLR, and LRP6. Invest Ophthalmol Vis Sci 47: 329335.
  • 45
    Boyden LM Mao J Belsky J Mitzner L Farhi A Mitnick MA Wu D Insogna K Lifton RP 2002 High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med 346: 15131521.
  • 46
    Little RD Carulli JP Del Mastro RG Dupuis J Osborne M Folz C Manning SP Swain PM Zhao SC Eustace B Lappe MM Spitzer L Zweier S Braunkschweiger K Benchekroun Y Hu X Adair R Chee L FitzGerald MG Tulig C Caruso A Tzellas N Bawa A Franklin B McGuire S Nogues X Gong G Allen KM Anisowicz A Morales AJ Lomedico PT Recker SM Van Eerdewegh P Recker RR Johnson ML 2002 A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am J Hum Genet 70: 1119.
  • 47
    Belsky JL Hamer JS Hubert JE Insogna K Johns W 2003 Torus palatinus: A new anatomical correlation with bone density in postmenopausal women. J Clin Endocrinol Metab 88: 20812086.
  • 48
    Van Wesenbeeck L Cleiren E Gram J Beals RK Benichou O Scopelliti D Key L Renton T Bartels C Gong Y Warman ML De Vernejoul MC Bollerslev J Van Hul W 2003 Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density. Am J Hum Genet 72: 763771.
  • 49
    Carter M Chen X Slowinska B Minnerath S Glickstein S Shi L Campagne F Weinstein H Ross ME 2005 Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6. Proc Natl Acad Sci USA 102: 1284312848.
  • 50
    Holmen SL Giambernardi TA Zylstra CR Buckner-Berghuis BD Resau JH Hess JF Glatt V Bouxsein ML Ai M Warman ML Williams BO 2004 Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. J Bone Miner Res 19: 20332040.
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  • 51
    Kokubu C Heinzmann U Kokubu T Sakai N Kubota T Kawai M Wahl MB Galceran J Grosschedl R Ozono K Imai K 2004 Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis. Development 131: 54695480.
  • 52
    Kubota T Michigami T Sakaguchi N Kokubu C Suzuki A Namba N Sakai N Nakajima S Imai K Ozono K 2008 Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd. J Bone Miner Res 23: 16611671.
  • 53
    Richards JB Rivadeneira F Inouye M Pastinen TM Soranzo N Wilson SG Andrew T Falchi M Gwilliam R Ahmadi KR Valdes AM Arp P Whittaker P Verlaan DJ Jhamai M Kumanduri V Moorhouse M van Meurs JB Hofman A Pols HA Hart D Zhai G Kato BS Mullin BH Zhang F Deloukas P Uitterlinden AG Spector TD 2008 Bone mineral density, osteoporosis, and osteoporotic fractures: A genome-wide association study. Lancet 371: 15051512.
  • 54
    van Meurs JB Trikalinos TA Ralston SH Balcells S Brandi ML Brixen K Kiel DP Langdahl BL Lips P Ljunggren O Lorenc R Obermayer-Pietsch B Ohlsson C Pettersson U Reid DM Rousseau F Scollen S van Hul W Agueda L Akesson K Benevolenskaya LI Ferriari SL Hallmans G Hofman A Husted LB Kruk M Kaptoge S Karasik D Karlsson MK Lorentzon M Masi L McGuigan FE Mellstrom D Mosekilde L Nogues X Pols HA Reeve J Renner W Rivadeneira F van Schoor NM Weber K, Loannidis JP, Uitterlinden AG 2008 Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis. JAMA 299: 12771290.
  • 55
    Tian E Zhan F Walker R Rasmussen E Ma Y Barlogie B Shaughnessy JD , Jr. 2003 The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med 349: 24832494.
  • 56
    Qiu W Andersen TE Bollerslev J Mandrup S Abdallah BM Kassem M 2007 Patients with high bone mass phenotype exhibit enhanced osteoblast differentiation and inhibition of adipogenesis of human mesenchymal stem cells. J Bone Miner Res 22: 17201731.
  • 57
    Kato M Patel MS Levasseur R Lobov I Chang BH Glass DA , 2nd, Hartmann C Li L Hwang TH Brayton CF Lang RA Karsenty G Chan L 2002 Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol 157: 303314.
  • 58
    Babij P Zhao W Small C Kharode Y Yaworsky PJ Bouxsein ML Reddy PS Bodine PV Robinson JA Bhat B Marzolf J Moran RA Bex F 2003 High bone mass in mice expressing a mutant LRP5 gene. J Bone Miner Res 18: 960974.
  • 59
    Pinson KI Brennan J Monkley S Avery BJ Skarnes WC 2000 An LDL-receptor-related protein mediates Wnt signalling in mice. Nature 407: 535538.
  • 60
    Kelly OG Pinson KI Skarnes WC 2004 The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. Development 131: 28032815.
  • 61
    Albers J Gebauer M Friedrich F Schulze J Priemel M Francke U Amling M Schinke T 2008 Mice lacking the Wnt receptor Frizzled-9 display osteopenia caused by decreased bone formation. J Bone Miner Res 23: S3.
  • 62
    Holmen SL Zylstra CR Mukherjee A Sigler RE Faugere MC Bouxsein ML Deng L Clemens TL Williams BO 2005 Essential role of beta-catenin in postnatal bone acquisition. J Biol Chem 280: 2116221168.
  • 63
    Glass DA , 2nd, Bialek P Ahn JD Starbuck M Patel MS Clevers H Taketo MM Long F McMahon AP Lang RA Karsenty G 2005 Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell 8: 751764.
  • 64
    Day TF Guo X Garrett-Beal L Yang Y 2005 Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev Cell 8: 739750.
  • 65
    Hill TP Spater D Taketo MM Birchmeier W Hartmann C 2005 Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev Cell 8: 727738.
  • 66
    Hu H Hilton MJ Tu X Yu K Ornitz DM Long F 2005 Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development 132: 4960.
  • 67
    Morvan F Boulukos K Clement-Lacroix P Roman Roman S Suc-Royer I Vayssiere B Ammann P Martin P Pinho S Pognonec P Mollat P Niehrs C Baron R Rawadi G 2006 Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J Bone Miner Res 21: 934945.
  • 68
    Li X Liu P Liu W Maye P Zhang J Zhang Y Hurley M Guo C Boskey A Sun L Harris SE Rowe DW Ke HZ Wu D 2005 Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation. Nat Genet 37: 945952.
  • 69
    Nakanishi R Akiyama H Kimura H Otsuki B Shimizu M Tsuboyama T Nakamura T 2008 Osteoblast-targeted expression of Sfrp4 in mice results in low bone mass. J Bone Miner Res 23: 271277.
  • 70
    Schulze J Seitz S Schneebauer M Amling M Schinke T 2008 Transgenic over-expression of the Wnt antagonist kremen-2 in osteoblasts leads to severe impairment of bone formation and increased bone resorption. J Bone Miner Res 23: S2.
  • 71
    Bodine PV Zhao W Kharode YP Bex FJ Lambert AJ Goad MB Gaur T Stein GS Lian JB Komm BS 2004 The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice. Mol Endocrinol 18: 12221237.
  • 72
    Sawakami K Robling AG Ai M Pitner ND Liu D Warden SJ Li J Maye P Rowe DW Duncan RL Warman ML Turner CH 2006 The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment. J Biol Chem 281: 2369823711.
  • 73
    Robling AG Niziolek PJ Baldridge LA Condon KW Allen MR Alam I Mantila SM Gluhak-Heinrich J Bellido TM Harris SE Turner CH 2008 Mechanical stimulation of bone in vivo reduces osteocyte expression of sost/sclerostin. J Biol Chem 283: 58665875.
  • 74
    Diem SJ Blackwell TL Stone KL Yaffe K Haney EM Bliziotes MM Ensrud KE 2007 Use of antidepressants and rates of hip bone loss in older women: The study of osteoporotic fractures. Arch Intern Med 167: 12401245.
  • 75
    Haney EM Chan BK Diem SJ Ensrud KE Cauley JA Barrett-Connor E Orwoll E Bliziotes MM 2007 Association of low bone mineral density with selective serotonin reuptake inhibitor use by older men. Arch Intern Med 167: 12461251.
  • 76
    Richards JB Papaioannou A Adachi JD Joseph L Whitson HE Prior JC Goltzman D 2007 Effect of selective serotonin reuptake inhibitors on the risk of fracture. Arch Intern Med 167: 188194.
  • 77
    Li X Warmington K Niu QT Grisanti M Tan H Dwyer D Stolina M Simonet WS Kostenuik PJ Paszty C Ke HZ 2008 Increases in BMD observed with anti-sclerostin antibody treatment are reversible: A longitudinal ovariectomized rat study. J Bone Miner Res 23: S60.
  • 78
    Padhi D Stouch B Jang G Fang L Darling M Glise H Robinson M Harris S Posvar E 2007 Anti-sclerostin antibody increases markeres of bone formation in healthy postmenopausal women. J Bone Miner Res 22: S1; S37.
  • 79
    Glantschnig H Hampton R Wei N Scott K Nantermet P Zhao J Chen F Fisher J Su Q Pennypacker B Cusick T Sandhu P Reszka A Strohl W Flores O Wang F Kimmel D An Z 2008 Fully human anti-DKK1 antibodies increase bone formation and resolve osteopenia in mouse models of estrogen-deficiency induced bone loss. J Bone Miner Res 23: S60.
  • 80
    Bodine PV Stauffer B Ponce-de-Leon H Bhat RA Mangine A Seestaller-Wehr LM Moran RA Billiard J Fukayama S Komm BS Pitts K Krishnamurthy G Gopalsamy A Shi M Kern JC Commons TJ Wilson MA Welmaker GS Trybulski EJ Moore WJ 2007 A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein (SFRP)-1 stimulates bone formation. J Bone Miner Res 22: S1; S4.
  • 81
    Wan M Yang C Li J Wu X Yuan H Ma H He X Nie S Chang C Cao X 2008 Parathyroid hormone signaling through low-density lipoprotein-related protein 6. Genes Dev 22: 29682979.
  • 82
    Keller H Kneissel M 2005 SOST is a target gene for PTH in bone. Bone 37: 148158.
  • 83
    Lee NK Sowa H Hinoi E Ferron M Ahn JD Confavreux C Dacquin R Mee PJ McKee MD Jung DY Zhang Z Kim JK Mauvais-Jarvis F Ducy P Karsenty G 2007 Endocrine regulation of energy metabolism by the skeleton. Cell 130: 456469.
  • 84
    Lindvall C Bu W Williams BO Li Y 2007 Wnt signaling, stem cells, and the cellular origin of breast cancer. Stem Cell Rev 3: 157168.