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Subtrochanteric and Diaphyseal Femur Fractures in Patients Treated With Alendronate: A Register-Based National Cohort Study†‡

  1. Bo Abrahamsen1,*,
  2. Pia Eiken2,
  3. Richard Eastell3

Article first published online: 29 DEC 2008

DOI: 10.1359/jbmr.081247

Issue

Journal of Bone and Mineral Research

Journal of Bone and Mineral Research

Volume 24, Issue 6, pages 1095–1102, June 2009

Additional Information

How to Cite

Abrahamsen, B., Eiken, P. and Eastell, R. (2009), Subtrochanteric and Diaphyseal Femur Fractures in Patients Treated With Alendronate: A Register-Based National Cohort Study. Journal of Bone and Mineral Research, 24: 1095–1102. doi: 10.1359/jbmr.081247

Author Information

  1. 1

    Department of Medicine and Endocrinology F, Copenhagen University Hospital Gentofte, Hellerup, Denmark

  2. 2

    Department of Cardiology and Endocrinology, Hillerød Hospital, Hillerød, Denmark

  3. 3

    Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, United Kingdom

*Address correspondence to: Bo Abrahamsen, MD, PhD, Department of Medicine and Endocrinology F, Copenhagen University Hospital Gentofte, Niels Andersensvej 65, Hellerup DK-2900, Denmark

  1. †

    Dr. Abrahamsen receives consultancy fees from Nycomed and Novartis, research grants from Roche, and speaker's fees from Servier, Eli Lilly, and MSD. Dr. Eiken receives speaker fees from Nycomed, Roche, and Servier. Dr. Eastell receives research funding or consultation honoraria from Amgen, AstraZeneca, Aventis, Eli Lilly, GlaxoSmithKline, Hologic, Interleukin Genetics, Kyphon, Lilly, Maxygen, Nastech Pharmaceuticals, Nestle Research Center, New Zealand Milk Limited, Novartis, Novo-Nordisk, Ono Pharma, Organon, Osteologix, Paraxel, Pfizer, Procter & Gamble, Roche Diagnostics, Sanofi-aventis, Servier, Shire, Transpharma Medical Limited, Unilever, and Unipath.

  2. ‡

    Published online on December 29, 2009

Publication History

  1. Issue published online: 4 DEC 2009
  2. Article first published online: 29 DEC 2008
  3. Manuscript Accepted: 23 DEC 2008
  4. Manuscript Revised: 10 OCT 2008
  5. Manuscript Received: 21 JUL 2008

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REFERENCES

  • 1
    Tonino RP, Meunier PJ, Emkey R, Rodriguez-Portales JA, Menkes CJ, Wasnich RD, Bone HG, Santora AC, Wu M, Desai R, Ross PD 2000 Skeletal benefits of alendronate: 7-year treatment of postmenopausal osteoporotic women. Phase III Osteoporosis Treatment Study Group. J Clin Endocrinol Metab 85: 3109–3115.
  • 2
    Ettinger B, San Martin J, Crans G, Pavo I 2004 Differential effects of teriparatide on BMD after treatment with raloxifene or alendronate. J Bone Miner Res 19: 745–751.
    Direct Link:
  • 3
    Bone HG, Hosking D, Devogelaer JP, Tucci JR, Emkey RD, Tonino RP, Rodriguez-Portales JA, Downs RW, Gupta J, Santora AC, Liberman UA 2004 Ten years' experience with alendronate for osteoporosis in postmenopausal women. N Engl J Med 350: 1189–1199.
  • 4
    Lenart BA, Lorich DG, Lane JM 2008 Atypical fractures of the femoral diaphysis in postmenopausal women taking alendronate. N Engl J Med 358: 1304–1306.
  • 5
    Neviaser AS, Lane JM, Lenart BA, Edobor-Osula F, Lorich DG 2008 Low-energy femoral shaft fractures associated with alendronate use. J Orthop Trauma 22: 346–350.
  • 6
    Goh SK, Yang KY, Koh JS, Wong MK, Chua SY, Chua DT, Howe TS 2007 Subtrochanteric insufficiency fractures in patients on alendronate therapy: A caution. J Bone Joint Surg Br 89: 349–353.
  • 7
    Kwek EB, Goh SK, Koh JS, Png MA, Howe TS 2008 An emerging pattern of subtrochanteric stress fractures: A long-term complication of alendronate therapy ? Injury 39: 224–231.
  • 8
    Wells GA, Cranney A, Peterson J, Boucher M, Shea B, Robinson V, Coyle D, Tugwell P 2008 Alendronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women. Cochrane Database Syst Rev CD001155.
  • 9
    Andersen TF, Madsen M, Jorgensen J, Mellemkjoer L, Olsen JH 1999 The Danish National Hospital Register. A valuable source of data for modern health sciences. Dan Med Bull 46: 263–268.
  • 10
    Concato J, Shah N, Horwitz RI 2000 Randomized, controlled trials, observational studies, and the hierarchy of research designs. N Engl J Med 342: 1887–1892.
  • 11
    Wells GA, Cranney A, Peterson J, Boucher M, Shea B, Robinson V, Coyle D, Tugwell P 2008 Alendronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women. Cochrane Database Syst Rev CD001155.
  • 12
    Odvina CV, Zerwekh JE, Rao DS, Maalouf N, Gottschalk FA, Pak CY 2005 Severely suppressed bone turnover: A potential complication of alendronate therapy. J Clin Endocrinol Metab 90: 1294–1301.
  • 13
    Hundrup YA, Hoidrup S, Obel EB, Rasmussen NK 2004 The validity of self-reported fractures among Danish female nurses: Comparison with fractures registered in the Danish National Hospital Register. Scand J Public Health 32: 136–143.
  • 14
    Neviaser AS, Lane JM, Lenart BA, Edobor-Osula F, Lorich DG 2008 Low-energy femoral shaft fractures associated with alendronate use. J Orthop Trauma 22: 346–350.
  • 15
    Solomon DH, Avorn J, Katz JN, Finkelstein JS, Arnold M, Polinski JM, Brookhart MA 2005 Compliance with osteoporosis medications. Arch Intern Med 165: 2414–2419.
  • 16
    Siris ES, Harris ST, Rosen CJ, Barr CE, Arvesen JN, Abbott TA, Silverman S 2006 Adherence to bisphosphonate therapy and fracture rates in osteoporotic women: Relationship to vertebral and nonvertebral fractures from 2 US claims databases. Mayo Clin Proc 81: 1013–1022.
  • 17
    Quan H, Sundararajan V, Halfon P, Fong A, Burnand B, Luthi JC, Saunders LD, Beck CA, Feasby TE, Ghali WA 2005 Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data. Med Care 43: 1130–1139.
  • 18
    Schneeweiss S, Wang PS, Avorn J, Glynn RJ 2003 Improved comorbidity adjustment for predicting mortality in Medicare populations. Health Serv Res 38: 1103–1120.
    Direct Link:
  • 19
    Vandenbroucke JP, von Elm E, Altman DG, Gotzsche PC, Mulrow CD, Pocock SJ, Poole C, Schlesselman JJ, Egger M 2007 Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and elaboration. Epidemiology 18: 805–835.
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