Atypical Femoral Fractures, Bisphosphonates, and Adult Hypophosphatasia


  • Michael P Whyte

    Corresponding author
    1. Division of Bone and Mineral Diseases, Washington University School of Medicine at Barnes-Jewish Hospital, and Center for Metabolic Bone Disease and Molecular Research, Shriners Hospitals for Children, St. Louis, Missouri, USA
    • Address correspondence to: Michael P. Whyte, MD, Division of Bone and Mineral Diseases, Box 8301, Barnes-Jewish Hospital (North Campus), 660 South Euclid Avenue, St. Louis, MO 63110, USA
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  • Dr. Whyte received a grant and served as a consultant for Enobia Pharma, Montreal, Canada. He owns stock in Merck.

  • Published online on December 29, 2008


Lateral subtrochanteric femoral pseudofractures occurring in adults with osteomalacia from hypophosphatasia and X-linked hypophosphatemia support the hypothesis that atypical femoral fractures in osteoporosis treated with bisphosphonates also result from low bone turnover.