• 1
    Adams SL, Cohen AJ, Lassová L 2007 Integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formation. J Cell Physiol 213: 635641.
  • 2
    Gerber HP, Ferrara N 2000 Angiogenesis and bone growth. Trends Cardiovasc Med 10: 223228.
  • 3
    Carano RA, Filvaroff EH 2003 Angiogenesis and bone repair. Drug Discov Today 8: 980989.
  • 4
    Coultas L, Chawengsaksophak K, Rossant J 2005 Endothelial cells and VEGF in vascular development. Nature 438: 937945.
  • 5
    Chen D, Ji X, Harris MA, Feng JQ, Karsenty G, Celeste AJ, Rosen V, Mundy GR, Harris SE 1998 Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages. J Cell Biol 142: 295305.
  • 6
    Ryoo HM, Lee MH, Kim YJ 2006 Critical molecular switches involved in BMP-2-induced osteogenic differentiation of mesenchymal cells. Gene 366: 5157.
  • 7
    Carev D, Saraga M, Saraga-Babic M 2008 Involvement of FGF and BMP family proteins and VEGF in early human kidney development. Histol Histopathol 23: 853862.
  • 8
    van Wijk B, Moorman AF, van den Hoff MJ 2007 Role of bone morphogenetic proteins in cardiac differentiation. Cardiovasc Res 74: 244255.
  • 9
    Langenfeld EM, Langenfeld J 2004 Bone morphogenetic protein-2 stimulates angiogenesis in developing tumors. Mol Cancer Res 2: 141149.
  • 10
    Moser M, Patterson C 2005 Bone morphogenetic proteins and vascular differentiation: BMPing up vasculogenesis. Thromb Haemost 94: 713718.
  • 11
    Yang X, Castilla LH, Xu XL, Li CL, Gotay J, Weinstein M, Liu PP, Deng CX 1999 Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5. Development 126: 15711580.
  • 12
    Suzuki Y, Montagne K, Nishiara A, Watabe T, Miyazono K 2008 BMPs promote proliferation and migration of endothelial cells via stimulation of VEGF-A/VEGFR2 and angiopoietin-1/Tie2 signalling. J Biochem 143: 199206.
  • 13
    Deckers MM, van Bezooijen RL, van der Horst G, Hoogendam J, van Der Bent C, Papapoulos SE, Löwik CW 2002 Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A. Endocrinology 143: 15451553.
  • 14
    Ferrara N, Gerber HP, LeCouter J 2003 The biology of VEGF and its receptor. Nat Med 9: 669676.
  • 15
    Hicklin DJ, Ellis LM 2005 Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23: 10111027.
  • 16
    Samee M, Kasugai S, Kondo H, Ohya K, Shimokawa H, Kuroda S 2008 Bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) transfection to human periosteal cells enhances osteoblast differentiation and bone formation. J Pharmacol Sci 108: 1831.
  • 17
    Peng H, Wright V, Usas A, Gearhart B, Shen HC, Cummins J, Huard J 2002 Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4. J Clin Invest 110: 751759.
  • 18
    Heldin CH, Miyazono K, Tendijke P 1997 TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 390: 465471.
  • 19
    Derynck R, Zhang YE 2003 Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425: 577584.
  • 20
    Attisano L, Wrana JL 2002 Signal transduction by the TGF-beta superfamily. Science 43: 635639.
  • 21
    Knockaert M, Sapkota G, Alarcon C, Massague J, Brivanlou AH 2006 Unique players in the BMP pathway: Small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling. Proc Natl Acad Sci USA 103: 1194011945.
  • 22
    Shi WB, Sun CX, He B, Xiong WC, Shi XM, Yao DC, Cao X 2004 GADD34-PP1c recruited by Smad7 dephosphorylates TGFβ type I receptor. J Cell Biol 164: 291300.
  • 23
    Bennett D, Alphey L 2002 PP1 binds Sara and negatively regulates Dpp signaling in Drosophila melanogaster. Nat Genet 31: 419423.
  • 24
    Shi WB, Chang CB, Nie SY, Xie ST, Wan M, Cao X 2007 Endofin acts as a Smad anchor for receptor activation in BMP signaling. J Cell Sci 120: 12161224.
  • 25
    Zhao M, Harris SE, Horn D, Geng ZP, Nishimura R, Mundy GR, Chen D 2002 Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation. J Cell Biol 157: 10491060.
  • 26
    Grizzle WE, Myers RB, Manne U, Stockard CR, Harkins LE, Srivastava S 1998 Factors affecting immunohistochemical evaluation of biomarker expression in Neoplasia. In: MargaretH, ZbigniewW (eds.) John Walker's Methods in Molecular Medicine—Tumor Marker Protocols. Humana Press, Totoma, NJ, USA, 161179.
  • 27
    Qiu T, Grizzle WE, Oelschlager DK, Shen X, Cao X 2007 Control of prostate cell growth:BMP antagonizes androgen mitogenic activity with incorporation of MAPK signals in Smad1. EMBO J 26: 346357.
  • 28
    Wan C, Gilbert SR, Wang Y, Cao X, Shen X, Ramaswamy G, Jacobsen KA, Alaql ZS, Eberhardt AW, Gerstenfeld LC, Einhorn TA, Deng L, Clemens TL 2008 Activation of the hypoxia-inducible factor-1alpha pathway accelerates bone regeneration. Proc Natl Acad Sci USA 105: 686691.
  • 29
    Wang Y, Wan C, Deng LF, Liu XM, Cao XM, Gilbert SR, Bouxsein ML, Faugere MC, Guldberg RE, Gerstenfeld LC, Haase VH, Johnson RS, Schipani E, Clemens TL 2007 The hypoxia-inducible factor a pathway couples angiogenesis to osteogenesis during skeletal development. J Clin Invest 117: 16161626.
  • 30
    Gerber HP, Vu TH, Ryon AM, Kowalski J, Werb Z, Ferrara N 1999 VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med 5: 623628.
  • 31
    Sena K, Sumner DR, Virdi AS 2007 Modulation of VEGF expression in rat bone marrow stromal cells by GDF-5. Connect Tissue Res 48: 324331.
  • 32
    Dewulf N, Verschueren K, Lonnoy O, Moren A, Grimsby S, Vandespiegle K, Miyazono K, Huylebroeck D, Tendijke P 1995 Distinct spatial and temporal expression patterns of 2 type-I receptors for bone morphogenetic proteins during mouse embryogenesis. Endocrinology 136: 26522663.
  • 33
    Enomoto-Iwamoto M, Iwamoto M, Mukudai Y, Kawakami Y, Nohno T, Higuchi Y, Takemoto S, Ohuchi H, Noji S, Kurisu K 1998 Bone morphogenetic protein signaling is required for maintenance of differentiated phenotype, control of proliferation, and hypertrophy in chondrocytes. J Cell Biol 140: 409418.
  • 34
    Liu D, Wang J, Kinzel B, Mueller M, Mao XH, Valdez R, Liu YX, Li E 2007 Dosage-dependent requirement of BMP type II receptor for maintenance of vascular integrity. Blood 110: 15021510.
  • 35
    Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL 1998 SARA, a FYVE domain protein that recruits Smad2 to the TGF beta receptor. Cell 95: 779791.
  • 36
    Bluteau G, Julien M, Magne D, Mallein-Genin F, Weiss P, Daculsi G, Guicheux J 2007 VEGF and VEGF receptors are differentially expressed in chondrocytes. Bone 40: 568576.
  • 37
    Schipani E, Didrickson S, Kobayashi T, Knight M, Johnson RS 2001 Hypoxia in cartilage: Hif-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev 15: 28652876.
  • 38
    Towler DA 2007 Vascular biology and bone formation: hints from HIF. J Clin Invest 117: 14771480.