• 1
    Aubin JE, Heersche JNM 1997 Vitamin D and Osteoblasts. Academic Press, San Diego, CA, USA.
  • 2
    Kraichely DM, MacDonald PN 1998 Transcriptional activation through the vitamin D receptor in osteoblasts. Front Biosci 3: D821D833.
  • 3
    Huhtakangas JA, Olivera CJ, Bishop JE, Zanello LP, Norman AW 2004 The vitamin D receptor is present in caveolae-enriched plasma membranes and binds 1α,25(OH)2-vitamin D3 in vivo and in vitro. Mol Endocrinol 18: 26602671.
  • 4
    Farach-Carson MC, Sergeev IN, Norman AW 1991 Nongenomic actions of 1α,25(OH)2-vitamin D3 in rat osteosarcoma cells: Structure-function studies using ligand analogs. Endocrinology 129: 18761884.
  • 5
    Boyan BD, Sylvia VL, Dean DD, Pedrozo H, Del Toro F, Nemere I, Posner GH, Schwartz Z 1999 1α,25(OH)2-vitamin D3 modulates growth plate chondrocytes via membrane receptor-mediated protein kinase C by a mechanism that involves changes in phospholipid metabolism and the action of arachidonic acid and PGE2. Steroids 64: 129136.
  • 6
    Lieberherr M 1987 Effects of vitamin-D3 metabolites on cytosolic free calcium in confluent mouse osteoblasts. J Biol Chem 262: 1316813173.
  • 7
    Civitelli R, Kim YS, Gunsten SL, Fujimori A, Huskey M, Avioli LV, Hruska KA 1990 Nongenomic activation of the calcium message system by vitamin D metabolites in osteoblast-like cells. Endocrinology 127: 22532262.
  • 8
    Zanello LP, Norman AW 1997 Stimulation by 1α,25(OH)2-vitamin D3 of whole cell chloride currents in osteoblastic ROS 17/2.8 cells: A structure-function study. J Biol Chem 272: 2261722622.
  • 9
    Zanello LP, Norman AW 2003 Multiple molecular mechanisms of 1α,25(OH)2-vitamin D3 rapid modulation of three ion channel activities in osteoblasts. Bone 33: 7179.
  • 10
    Zanello LP, Norman AW 2004 Rapid modulation of osteoblast ion channel responses by 1α,25(OH)2-vitamin D3 requires the presence of a functional vitamin D nuclear receptor. Proc Natl Acad Sci USA 101: 15891594.
  • 11
    Zanello LP, Norman AW 2004 Electrical responses to 1α,25(OH)2-vitamin D3 and their physiological significance in osteoblasts. Steroids 69: 561565.
  • 12
    Caffrey JM, Farach-Carson MC 1989 Vitamin D3 metabolites modulate dihydropyridine-sensitive calcium currents in clonal rat osteosarcoma cells. J Biol Chem 264: 2026520274.
  • 13
    Xiaoyu Z, Payal B, Melissa O, Zanello LP 2007 1α,25(OH)2-vitamin D3 membrane-initiated calcium signaling modulates exocytosis and cell survival. J Steroid Biochem Mol Biol 103: 457461.
  • 14
    Jorgensen NR, Henriksen Z, Brot C, Eriksen EF, Sorensen OH, Civitelli R, Steinberg TH 2000 Human osteoblastic cells propagate intercellular calcium signals by two different mechanisms. J Bone Miner Res 15: 10241032.
  • 15
    Zanello LP, Norman AW 2004 Steroid hormone-regulated exocytosis in osteoblasts. Steroids 86: 171175.
  • 16
    Genetos DC, Geist DJ, Liu D, Donahue HJ, Duncan RL 2005 Fluid shear-induced ATP secretion mediates prostaglandin release in MC3T3-E1 osteoblasts. Bone 20: 4149.
  • 17
    Bhangu PS, Genever PG, Spencer GJ, Grewal TS, Skerry TM 2001 Evidence for targeted vesicular glutamate exocytosis in osteoblasts. Bone 29: 1623.
  • 18
    Romanello M, Pani B, Bicego M, D'Andrea P 2001 Mechanically induced ATP release from human osteoblastic cells. Biochem Biophys Res Commun 289: 12751281.
  • 19
    Romanello M, Codognotto A, Bicego M, Pines A, Tell G, D'Andrea P 2005 Autocrine/paracrine stimulation of purinergic receptors in osteoblasts: Contribution of vesicular ATP release. Biochem Biophys Res Commun 331: 14291438.
  • 20
    Nakano Y, Addison WN, Kaartinen MT 2007 ATP-mediated mineralization of MC3T3-E1 osteoblast cultures. Bone 41: 549561.
  • 21
    Hoebertz A, Arnett TR, Burnstock G 2003 Regulation of bone resorption and formation by purines and pyrimidines. Trends Pharmacol Sci 24: 290297.
  • 22
    Morrison MS, Turin L, King BF, Burnstock G, Arnett TR 1998 ATP is a potent stimulator of the activation and formation of rodent osteoclasts. J Physiol 511: 495500.
  • 23
    Zimmermann H 2000 Extracellular metabolism of ATP and other nucleotides. Naunyn Schmiedebergs Arch Pharmacol 362: 299309.
  • 24
    Buckley KA, Hipskind RA, Gartland A, Bowler WB, Gallagher JA 2002 Adenosine triphosphate stimulates human osteoclast activity via upregulation of osteoblast-expressed receptor activator of nuclear factor-kappa B ligand. Bone 31: 582590.
  • 25
    Wu W, Zhang X, Zanello LP 2007 1α,25(OH)2-vitamin D3 antiproliferative actions involve vitamin D receptor-mediated activation of MAPK pathways and AP-1/p21(waf1) upregulation in human osteosarcoma. Cancer Lett 254: 7586.
  • 26
    Gosling M, Smith JW, Poyner DR 1995 Characterization of a volume-sensitive chloride current in rat osteoblast-like (ROS 17/2.8) cells. J Physiol 485: 671682.
  • 27
    Mizwicki MT, Keidel D, Bula CM, Bishop JE, Zanello LP, Wurtz JM, Moras D, Norman AW 2004 Identification of an alternative ligand-binding pocket in the nuclear vitamin D receptor and its functional importance in 1α,25(OH)2-vitamin D3 signaling. Proc Natl Acad Sci USA 101: 1287612881.
  • 28
    Knight GE, Bodin P, De Groat WC, Burnstock G 2002 ATP is released from guinea pig ureter epithelium on distension. Am J Physiol Renal Physiol 282: F281F288.
  • 29
    Zhang X, Zanello LP 2008 Vitamin D receptor-dependent 1α,25(OH)2-vitamin D3-induced antiapoptotic PI3K/Akt signaling in osteoblasts. J Bone Miner Res 23: 12381248.
  • 30
    Barg S 2003 Mechanisms of exocytosis in insulin-secreting B-cells and glucagon-secreting A-cells. Pharmacol Toxicol 92: 313.
  • 31
    Becherer U, Moser T, Stuhmer W, Oheim M 2003 Calcium regulates exocytosis at the level of single vesicles. Nat Neurosci 6: 846853.
  • 32
    Levitan ES 2008 Signaling for vesicle mobilization and synaptic plasticity. Mol Neurobiol 37: 3943.
  • 33
    Meszaros JG, Karin NJ, Farach-Carson MC 1996 Voltage-sensitive calcium channels in osteoblasts: Mediators of plasma membrane signalling events. Connect Tissue Res 34-5: 161165.
  • 34
    Liu R, Li W, Karin NJ, Bergh JJ, Adler-Storthz K, Farach-Carson MC 2000 Ribozyme ablation demonstrates that the cardiac subtype of the voltage-sensitive calcium channel is the molecular transducer of 1α,25(OH)2-vitamin D3-stimulated calcium influx in osteoblastic cells. J Biol Chem 275: 87118718.
  • 35
    Le Mellay V, Grosse B, Lieberherr M 1997 Phospholipase C β and membrane action of calcitriol and estradiol. J Biol Chem 272: 1190211907.
  • 36
    Zhang X, Zanello LP 2005 Activation of the PI3K/Akt(PKB)/Bad cascade by 1α,25(OH)2-vitamin D3 in osteoblasts. Mol Biol Cell 16: B522.
  • 37
    Barg S, Huang P, Eliasson L, Nelson DJ, Obermüller S, Rorsman P, Thévenod F, Renström E 2001 Priming of insulin granules for exocytosis by granular Cl uptake and acidification. J Cell Sci 114: 21452154.
  • 38
    Thevenod F 2002 Ion channels in secretory granules of the pancreas and their role in exocytosis and release of secretory proteins. Am J Physiol Cell Physiol 283: C651C672.
  • 39
    Zanello LP, Norman AW 1996 1α,25(OH)2 vitamin D3-mediated stimulation of outward anionic currents in osteoblast-like ROS 17/2.8 cells. Biochem Biophys Res Commun 225: 551556.
  • 40
    Biswas P, Zanello LP 2005 Calcium signals associated with 1α,25(OH)2 vitamin D3–regulated exocytosis in osteoblasts. Mol Biol Cell 16: B428.
  • 41
    Vertino AM, Bula CM, Chen JR, Almeida M, Han L, Bellido T, Kousteni S, Norman AW, Manolagas SC 2005 Nongenotropic, anti-apoptotic signaling of 1α,25(OH)2 vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases. J Biol Chem 280: 1413014137.
  • 42
    Orriss IR, Utting JC, Brandao-Burch A, Colston K, Grubb BR, Burnstock G, Arnett TR 2007 Extracellular nucleotides block bone mineralization in vitro: Evidence for dual inhibitory mechanisms involving both P2Y2 receptors and pyrophosphate. Endocrinology 148: 42084216.