The author states that she has no conflicts of interest
Commentary
You have free access to this content
Vitamin K and Bone: Past, Present, and Future†
Article first published online: 30 MAR 2009
DOI: 10.1359/jbmr.090312
Copyright © 2009 ASBMR
Additional Information
How to Cite
Gundberg, C. M. (2009), Vitamin K and Bone: Past, Present, and Future. J Bone Miner Res, 24: 980–982. doi: 10.1359/jbmr.090312
- †
Publication History
- Issue published online: 4 DEC 2009
- Article first published online: 30 MAR 2009
REFERENCES
- 1, , , , , , , , 2009 Vitamin K Treatment Reduces Undercarboxylated Osteocalcin But Does Not Alter Bone Turnover, Density or Geometry in Healthy Postmenopausal North American Women. J Bone Miner Res 24: 000–000.
- 2
- 3
- 4, , , 1940 Studies on the hemorrhagic sweet clover disease. I. The preparation of hemorrhafic concentrates. J Biol Chem 136: 47–55.
- 5, , , 1974 Vitamin K-dependent modifications of glutamic acid residues in prothrombin. Proc Natl Acad Sci USA 71: 2730–2733.
- 6, , 1974 The mode of action of vitamin K. Identification of gamma-carboxyglutamic acid as a component of prothrombin. J Biol Chem 249: 6347–6350.
- 71993 Synthesis of vitamin K-dependent proteins. FASEB J 7: 445–452.
- 8, 1975 Congenital malformations associated with the administration of oral anticoagulants during pregnancy. J Pediatr 86: 459–462.
- 9, , 1975 Direct identification of the calcium-binding amino acid, gamma-carboxyglutamate, in mineralized tissue. Proc Natl Acad Sci USA 72: 3925–3929.
- 10, , 1983 Matrix Gla protein, a new gamma-carboxyglutamic acid-containing protein which is associated with the organic matrix of bone. Biochem Biophys Res Commun 117: 765–771.
- 11, , , , , 2008 Gla-rich protein (GRP), a new vitamin K–dependent protein identified from sturgeon cartilage and highly conserved in vertebrates. J Biol Chem 283: 36655–36664.
- 12, 2008 Metabolism and cell biology of vitamin K. Thromb Haemost 100: 530–547.
- 131995 The importance of menaquinones in human nutrition. Annu Rev Nutr 15: 399–417.
- 14, 1996 Comparison of biochemical indexes for assessing vitamin K nutritional status in a healthy adult population. Am J Clin Nutr 63: 566–573.
- 15, , , , , 1997 Changes in serum osteocalcin, plasma phylloquinone, and urinary gamma- carboxyglutamic acid in response to altered intakes of dietary phylloquinone in human subjects. Am J Clin Nutr 65: 779–784.
- 16, , , 1993 Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. J Clin Invest 91: 1769–1774.
- 17, , , 1996 Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture: A three year follow-up study. Bone 18: 487–488.
- 18, , , , 1999 Changes in bone density after exposure to oral anticoagulants: A meta-analysis. Osteoporos Int 9: 441–448.
- 192007 Bone health and osteoporosis: The role of vitamin K and potential antagonism by anticoagulants. Nutr Clin Pract 22: 517–544.
- 20, , , , , 1999 Vitamin K intake and hip fractures in women: A prospective study. Am J Clin Nutr 69: 74–79.
- 21, , , , , , , , , 2003 Vitamin K intake and bone mineral density in women and men. Am J Clin Nutr 77: 512–516.
- 22, , , , , 1999 Potassium, magnesium and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr 69: 727–736.
- 23, , , , , , 2006 Intake of fermented soybeans, natto, Is associated with reduced bone loss in postmenopausal women: Japanese population-based Osteoporosis (JPOS) Study. J Nutr 136: 1323–1328.
- 24, , 2005 Geranylgeranylacetone inhibits formation and function of human osteoclasts and prevents bone loss in tail-suspended rats and ovariectomized rats. Calcif Tissue Int 77: 376–385.
- 25, , , , , 2006 vitamin K and the prevention of fractures: Systematic review and meta-analysis of randomized controlled trials. Arch Intern Med 166: 1256–1261.
- 26, , , , , 2008 Effect of vitamin K supplementation on bone loss in elderly men and women. J Clin Endocrinol Metab 93: 1217–1223.
- 27, , 2007 Vitamin K and the prevention of fractures. Arch Intern Med. 167: 94.
- 28, , , , 2007 Prevention of hip fractures: Concern about validity of trials. Arch Intern Med. 167: 513–514.
- 29, , , , , , , , 2007 Two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women. J Bone Miner Res 22: 509–519.
- 30
- 31, , , , 2000 Vitamin K supplementation reduces serum under gamma-carboxylated osteocalcin concentration in healthy adults. Am J Clin Nutr 72: 1523–1528.
- 32, , 2007 Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporos Int 18: 963–972.
- 33Eisai 2005 Eisai announces the intermediate analysis of anti-osteoporosis treatment post-marketing research to investigate the benefits of menatetreone as part of the Ministry of Health, Labor, and Welfare's pharmacoepidemiological drug review program. Available at www.eisai.co.jp/enews/enews200506.html. Accessed October 5, 2007.
- 34, , , , , , , , , , , , , , 2007 Endocrine regulation of energy metabolism by the skeleton. Cell 130: 456–469.
- 35, , , , , , , , 2008 Effect of vitamin K supplementation on insulin resistance in older men and women. Diabetes Care 31: 2092–2096.

1523-4681/asset/olbannerleft.gif?v=1&s=d7e4c0e37904a489128d3a4e58ba94214db307a9)
1523-4681/asset/olbannerright.gif?v=1&s=854ee0e4d351ead9faaca8bfab3e50b1c7c9d03d)
