• 1
    Cooke AM 1955 Osteoporosis. Lancet 1 : 877882, 929–937.
  • 2
    Hirsch C, Brodetti A 1956 The weight-bearing capacity of structural elements in femoral necks. Acta Orthop Scand 26 : 1524.
  • 3
    Passi N, Gefen A 2005 Trabecular bone contributes to strength of the proximal femur under mediolateral impact in the avian. J Biomech Eng 127 : 198203.
  • 4
    Werner C, Iversen BF, Therkildsen MH 1988 Contribution of the trabecular component to mechanical strength and bone mineral content of the femoral neck. An experimental study on cadaver bones. Scand J Clin Lab Invest 48 : 457460.
  • 5
    Holzer G, von Skrbensky G, Holzer LA, Pichl W 2009 Hip fractures and the contribution of cortical versus trabecular bone to femoral neck strength. J Bone Miner Res 24 : 468474.
  • 6
    Manske SL, Liu-Ambrose T, Cooper DML, Kontulainen S, Guy P, Forster BB, MacKay HA 2009 Cortical and trabecular bone in the femoral neck both contribute to proximal femur failure load prediction. Osteoporos Int 20 : 445453.
  • 7
    Beck TJ, Looker AC, Ruff CB, Sievanen H, Wahner HW 2000 Structural trends in the ageing femoral neck and proximal shaft: Analysis of the third national health and nutrition examination survey dual-energy X-ray absorptiometry data. J Bone Miner Res 15 : 22972308.
  • 8
    Riggs BL, Melton LJ III, Robb RA, Camp JJ, Atkinson EJ, Oberg AL, Rouleau PA, McCullough CH, Khosla S, Bouxsein ML 2006 Population-based analysis of the relationship of whole bone strength indices and fall-related loads to age- and sex-specific patterns of hip and wrist fractures. J Bone Miner Res 21 : 315323.
  • 9
    Nevitt MC, Cummings SR 1993 Type of fall and risk of hip and wrist fractures: The study of osteoporotic fractures. The Study of Osteoporotic Fractures Research Group. J Am Geriatr Soc 42 : 797798.
  • 10
    Lotz JC, Cheal EJ, Hayes WC 1995 Stress distributions within the proximal femur during gait and falls: Implications for osteoporotic fracture. Osteoporos Int 5 : 252261.
  • 11
    Lovejoy CO 1988 Evolution of human walking. Sci Am 259 : 118125.
  • 12
    van Rietbergen B, Huiskes R, Eckstein F, Ruegsegger P 2003 Trabecular bone tissue strains in the healthy and osteoporotic human femur. J Bone Miner Res 18 : 17811788.
  • 13
    Mayhew PM, Thomas CDL, Clement JG, Loveridge N, Beck TJ, Bonfield W, Burgoyne CJ, Reeve J 2005 Relation between age, femoral neck cortical stability, and hip fracture risk. Lancet 366 : 129135.
  • 14
    Carpenter RD, Beaupré GS, Lang TF, Orwoll ES, Carter DR, MrOS Study Group 2005 New QCT analysis approach shows the importance of fall orientation on femoral neck strength. J Bone Miner Res. 20 : 15331542.
  • 15
    Hetenyi M 1946 Beams on Elastic Foundation: Theory With Applications in the Fields of Civil and Mechanical Engineering. University of Michigan Press, Detroit, MI.
  • 16
    Thomas CD, Stein MS, Feik SA, Wark JD, Clement JG 2000 Determination of age at death using combined morphology and histology of the femur. J Anat 196 : 463471.
  • 17
    Mayhew P, Kaptoge S, Loveridge N, Power J, Kroger HPJ, Parker M, Reeve J 2004 Discrimination between cases of hip fracture and controls is improved by hip structural analysis compared to areal bone mineral density. An ex vivo study of the femoral neck. Bone 34 : 352361.
  • 18
    Kuiper J, Van Kuijk C, Grashuis J 1997 Distribution of trabecular and cortical bone related to geometry. A quantitative computed tomography study of the femoral neck. Invest Radiol 32 : 8389.
  • 19
    Crabtree N, Loveridge N, Parker M, Rushton N, Power J, Bell KL, Beck TJ, Reeve J 2001 Intracapsular hip fracture and the region-specific loss of cortical bone: Analysis by quantitative computed tomography (pQCT). J Bone Miner Res 16 : 13181328.
  • 20
    Bell K, Garrahan N, Kneissel M, Loveridge N, Grau E, Stanton M, Reeve J 1996 Cortical and cancellous bone in the human femoral neck: Evaluation of an interactive image analysis system. Bone 19 : 541548.
  • 21
    Hangartner TN, Gilsanz V 1996 Evaluation of cortical bone by computed tomography. J Bone Miner Res 11 : 15181525.
  • 22
    Hangartner TN, Overton TR 1982 Quantitative measurement of bone density using gamma-ray computed tomography. J Comput Assist Tomogr 6 : 11561162.
  • 23
    Burstein AH, Reilly DT, Martins M 1976 Ageing of bone tissue: Mechanical properties. J Bone Joint Surg Am 58 : 8286.
  • 24
    Carter DR, Hayes WC 1977 The compressive behavior of bone as a two-phase porous structure. J Bone Joint Surg Am 59 : 954962.
  • 25
    Crabtree N, Lunt M, Holt G, Kröger H, Burger H, Grazio S, Lorenc R, Nijs J, Stepan JJ, Falch JA, Miazgowski T, Raptou P, Pols HAP, Dequeker J, Havelka S, Hoszowski K, Jajic I, Czekalski S, Lyritis G, Silman AJ, Reeve J 2000 Hip geometry, bone mineral distribution and bone strength in European men and women: The EPOS study. Bone 27 : 151160.
  • 26
    Nakamura T, Turner CH, Yoshikawa T, Slemenda CW, Peacock M, Burr DB, Mizuno Y, Orimo H, Ouchi Y, Johnston CCJ 1994 Do variations in hip geometry explain differences in hip fracture risk between Japanese and white Americans ? J Bone Miner Res 9 : 10711076.
  • 27
    Bell K, Loveridge N, Power J, Garrahan N, Stanton M, Lunt M, Meggitt B, Reeve J 1999 Structure of the femoral neck in hip fracture: Cortical bone loss in the inferoanterior to superoposterior axis. J Bone Miner Res 14 : 112120.
  • 28
    Power J, Loveridge N, Rushton N, Parker M, Reeve J 2003 Intracapsular bone formation on the external “periosteal” surface of the femoral neck: An investigation in cases of hip fracture and controls. Osteoporos Int 14 : 146151.
  • 29
    Kaptoge S, Dalzell N, Loveridge N, Beck TJ, Khaw KT, Reeve J 2003 Effects of gender, anthropometric variables and aging on the evolution of hip strength in men and women aged over 65. Bone 32 : 561570.
  • 30
    Melton LJ III 1990 A Gompertzian view of osteoporosis. Calcif Tissue Int 46 : 285286.
  • 31
    Keaveny TM, Bouxsein ML 2008 Theoretical implications of the biomechanical fracture threshold. J Bone Miner Res 23 : 15411547.
  • 32
    Meta M, Lu Y, Keyak JH, Lang T 2006 Young-elderly differences in bone density, geometry and strength indices depend on proximal femur sub-region: A cross sectional study in Caucasian-American women. Bone 39 : 152158.
  • 33
    Black DM, Bouxsein ML, Marshall LM, Cummings SR, Lang TF, Cauley JA, Ensrud KE, Nielson CM, Orwoll ES, MrOS Research Group 2008 Proximal femoral structure and the prediction of hip fracture in men: A large prospective study using QCT. J Bone Miner Res. 23 : 13261333.
  • 34
    Keaveny TM, Hoffmann PF, Singh M, Palermo L, Bilezikian JP, Greenspan SL, Black DM 2008 Femoral bone strength and its relation to cortical and trabecular changes after treatment with PTH, alendronate, and their combination as assessed by finite element analysis of quantitative CT scans. J Bone Miner Res 23 : 19741982.
  • 35
    Verhulp E, van Rietbergen B, Huiskes R 2008 Load distribution in the healthy and osteoporotic human proximal femur durng a fall to the side. Bone 42 : 3035.
  • 36
    Yoshikawa T, Turner CH, Peacock M, Slemenda CW, Weaver CM, Teegarden D, Markwardt P, Burr DB 1994 Geometric structure of the femoral neck measured using dual-energy X-ray absorptiometry. J Bone Miner Res 9 : 10531064.
  • 37
    Beck TJ, Oreskovic TL, Stone KL, Ruff CB, Ensrud K, Nevitt MC, Genant HK, Cummings SR 2001 Structural adaptation to changing skeletal load in the progression towards hip fragility: The Study of Osteoporotic Fractures. J Bone Miner Res 16 : 11081119.
  • 38
    Kaptoge S, Dalzell N, Jakes R, Wareham N, Khaw KT, Beck TJ, Day NE, Loveridge N, Reeve J 2003 Hip section modulus, a measure of bending resistance, is more strongly related to physical activity than BMD. Osteoporos Int 14 : 941949.
  • 39
    Duboeuf F, Hans D, Schott AM, Kotzki PO, Favier F, Marcelli C, Meunier PJ, Delmas PD 1997 Different morphometric and densitometric parameters predict cervical and trochanteric hip fracture: The EPIDOS Study. J Bone Miner Res 12 : 18951902.
  • 40
    Tsangari H, Findlay DM, Fazzalari NL 2007 Structural and remodeling indices in the cancellous bone of the proximal femur across adulthood. Bone 40 : 211217.
  • 41
    Tsangari H, Kuliwaba JS, Fazzalari N 2007 Trabecular bone remodelling and subcapital femoral fracture. J Musculoskelet Neuronal Interact 7 : 6973.
  • 42
    Kaptoge S, Beck TJ, Reeve J, Stone KL, Hillier TA, Cauley JA, Cummings SR 2008 Prediction of incident hip fracture risk by femur geometry variables measured by hip structural analysis in the Study of Osteoporotic Fractures. J Bone Miner Res 23 : 18921904.
  • 43
    Crabtree NJ, Kroger H, Martin A, Pols HAP, Lorenc R, Nijs J, Stepan JJ, Falch JA, Miazgowski T, Grazio S, Raptou P, Adams J, Collings A, Khaw KT, Rushton N, Lunt M, Dixon AK, Reeve J 2002 Improving risk assessment: Hip geometry, bone mineral distribution and bone strength in hip fracture cases and controls. The EPOS Study. Osteoporos Int 13 : 4854.
  • 44
    Johnston CC Jr, Norton J, Khairi MR, Kernek C, Edouard C, Arlot M, Meunier PJ 1985 Heterogeneity of fracture syndromes in postmenopausal women. J Clin Endocrinol Metab 61 : 551556.
  • 45
    Power J, Loveridge N, Lyon A, Rushton N, Parker M, Reeve J 2005 Osteoclastic cortical erosion as a determinant of sub-periosteal osteoblastic bone formation in the femoral neck's response to BMU imbalance. Effects of stance-related loading and hip fracture. Osteoporos Int 6 : 10491056.
  • 46
    Power J, Loveridge N, Lyon A, Rushton N, Parker MA, Reeve J 2003 Bone remodelling at the endocortical surface of the human femoral neck: A mechanism for regional cortical thinning in cases of hip fracture. J Bone Miner Res 18 : 17751780.
  • 47
    Nikander R, Kannus P, Dastidar P, Hannula M, Harrison L, Cervinka T, Narra NG, Aktour R, Arola T, Eskola H, Soimakallio S, Heinonen A, Hyttinen J, Sievanen H 2008 Targeted exercise against hip fragility. Osteoporos Int 20 : 13211328.
  • 48
    Zioupos P, Currey JD 1998 Changes in the stiffness, strength and toughness of human cortical bone with age. Bone 22 : 5766.
  • 49
    Vashishth D, Tanner KE, Bonfield W 2003 Experimental validation of a microcracking-based toughening mechanism for cortical bone. J Biomech 36 : 121124.
  • 50
    Bell KL, Loveridge N, Jordan GR, Power J, Constant CR, Reeve J 2000 A novel mechanism for the induction of the increased cortical porosity in cases of intra-capsular hip fracture. Bone 27 : 297304.
  • 51
    Wand JS, Hill ID, Reeve J 1990 Coxarthrosis and femoral neck fracture. Clin Orthop Relat Res 278 : 8894.
  • 52
    Dequeker J, Johnell O 1993 Osteoarthritis protects against femoral neck fracture. Bone 14 (Suppl 1) : s51s56.
  • 53
    Dretakis EK, Steriopoulos KA, Kontakis GM, Giaourakis G, Economakis G, Dretakis KE 1998 Cervical hip fractures do not occur in arthrotic joints. A clinicoradiological study of 256 patients. Acta Orthop Scand 69 : 384386.
  • 54
    Blain H, Chavassieux P, Portero-Muzy N, Bonnel F, Canovas F, Chammas M, Maury P, Delmas PD 2008 Cortical and trabecular bone distribution in the femoral neck in osteoporosis and osteoarthritis. Bone 43 : 862868.
  • 55
    Jordan GR, Loveridge N, Power J, Clarke MT, Reeve J 2003 Increased cancellous bone in the femoral neck of patients with coxarthrosis (hip osteoarthritis): A positive remodelling imbalance favouring bone formation. Osteoporos Int 14 : 160165.
  • 56
    Hernandez CJ, Beaupre GS, Keller TS, Carter DR 2001 The influence of bone volume fraction and ash fraction on bone strength and modulus. Bone 29 : 7478.
  • 57
    Loveridge N, Power J, Reeve J, Boyde A 2004 Bone mineralization density and femoral neck fragility. Bone 35 : 929941.