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Low maternal vitamin D status and fetal bone development: Cohort study

  1. Pamela Mahon1,
  2. Nicholas Harvey1,
  3. Sarah Crozier1,
  4. Hazel Inskip1,
  5. Sian Robinson1,
  6. Nigel Arden1,
  7. Rama Swaminathan2,
  8. Cyrus Cooper1,
  9. Keith Godfrey1,*

Article first published online: 14 DEC 2009

DOI: 10.1359/jbmr.090701

Issue

Journal of Bone and Mineral Research

Journal of Bone and Mineral Research

Volume 25, Issue 1, pages 14–19, January 2010

Additional Information

How to Cite

Mahon, P., Harvey, N., Crozier, S., Inskip, H., Robinson, S., Arden, N., Swaminathan, R., Cooper, C. and Godfrey, K. (2010), Low maternal vitamin D status and fetal bone development: Cohort study. Journal of Bone and Mineral Research, 25: 14–19. doi: 10.1359/jbmr.090701

Author Information

  1. 1

    MRC Epidemiology Resource Centre, University of Southampton and NIHR Nutrition Biomedical Research Unit, Southampton General Hospital, Tremona Road, Southampton, Hampshire, United Kingdom

  2. 2

    Department of Chemical Pathology, St Thomas' Hospital, London, United Kingdom

*MRC Epidemiology Resource Centre, University of Southampton and NIHR Nutrition Biomedical Research Unit, Southampton General Hospital, Tremona Road, Southampton, Hampshire SO16 6YD, United Kingdom.

Publication History

  1. Issue published online: 20 JAN 2010
  2. Article first published online: 14 DEC 2009
  3. Manuscript Accepted: 1 JUL 2009
  4. Manuscript Revised: 10 APR 2009
  5. Manuscript Received: 17 JAN 2009

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References

  • 1
    Javaid MK, Crozier SR, Harvey NC, et al. Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study. Lancet. 2006; 367: 36–43.
  • 2
    Brooke OG, Brown IR, Bone CD, et al. Vitamin D supplements in pregnant Asian women: effects on calcium status and fetal growth. BMJ 1980; 280: 751–754.
  • 3
    Department of Health. Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. Report of the Panel on Dietary Reference Values of the Committee on Medical Aspects of Food Policy. London: HMSO; 1991.
  • 4
    Scientific Advisory Committee on Nutrition. Update on Vitamin D. Position statement by the Scientific Advisory Committee on Nutrition. London: HMSO; 2007.
  • 5
    Institute of Medicine. Dietary Reference Intakes for Calcium, Phosphorous, Magnesium, Vitamin D and Fluoride. Washington: National Academy Press; 1997.
  • 6
    Specker B. Vitamin D requirements during pregnancy. Am J Clin Nutr. 2004; 80: 1740S–1747S.
  • 7
    Harvey NC, Javaid MK, Poole JR, et al. and the Southampton Women's Survey Study Group. Paternal skeletal size predicts intrauterine bone mineral accrual. J Clin Endocrinol Metab. 2008; 93: 1676–1681.
  • 8
    Inskip H, Godfrey KM, Robinson SM, et al. and the SWS Study Group. Cohort profile: The Southampton Women's Survey. Int J Epidemiol. 2006; 35: 42–48.
  • 9
    Ruston D, Hoare J, Henderson L, et al. The National Diet and Nutrition Survey: Adults Aged 19-64 Years, Vol. 4: Nutritional Status (Anthropometry and Blood Analytes), Blood Pressure and Physical Activity. London: HMSO; 2004.
  • 10
    Chitty LS, Altman DG. Charts of fetal size: limb bones. Br J Obstet Gynaecol. 2002; 109: 919–929.
  • 11
    Endres LK, Cohen L. Reliability and validity of three-dimensional fetal brain volumes. J Ultrasound Med. 2001; 20: 1265–1269.
  • 12
    Prentice A, Schoenmakers I, Laskey MA, Debono S, Ginty F, Goldberg GR. Nutrition and bone growth and development. Proc Nutr Soc. 2006; 65: 348–360.
  • 13
    Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers and cardiovascular disease. Am J Clin Nutr. 2004; 80: 1678S–88S.
  • 14
    Holick MF. Resurrection of vitamin D deficiency and rickets. J Clin Invest. 2006; 116: 2062–2072.
  • 15
    Cashman KD. Vitamin D in childhood and adolescence. Postgrad Med J. 2007; 83: 230–235.
  • 16
    Reif S, Katzir Y, Eisenberg Z, Weisman Y. Serum 25-hydroxyvitamin D levels in congenital craniotabes. Acta Paediatr Scand. 1988; 77: 167–168.
    Direct Link:
  • 17
    Yorifuji J, Yorifuji T, Tachibana K, et al. Craniotabes in normal newborns: the earliest sign of subclinical vitamin D deficiency. J Clin Endocrinol Metab. 2008; 93: 1784–1788.
  • 18
    Abrams S. In utero physiology: role in nutrient delivery and fetal development for calcium, phosphorus, and vitamin D. Am J Clin Nutr. 2007; 85: 604S–607S.
  • 19
    Hypponen E, Laara E, Reunanen A, Järvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth cohort study. Lancet. 2001; 358: 1500–1503.
  • 20
    McGrath J, Saari K, Hakko H, et al. Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study. Schizophrenia Res. 2004; 67: 237–245.
  • 21
    Hypponen E, Turner S, Cumberland P, Power C, Gibb I. Serum 25-hydroxyvitamin D measurement in a large population survey with statistical harmonization of assay variation to an international standard. J Clin Endocrinol Metab. 2007; 92: 4615–4622.
  • 22
    National Institute for Health and Clinical Excellence. PH11 Maternal and child nutrition: guidance, March 26, 2008. Available from www.nice.org.uk/nicemedia/pdf/PH011guidance.pdf.
  • 23
    Harvey N, Cooper C. The developmental origins of osteoporotic fracture. J Br Menopause Soc. 2004; 10: 14–29.
  • 24
    Cooper C, Eriksson JG, Forsen T, Osmond C, Tuomilehto J, Barker DJ. Maternal height, childhood growth and risk of hip fracture in later life: a longitudinal study. Osteoporos Int. 2001; 12: 623–629.
  • 25
    Cooper C, Fall C, Egger P, Hobbs R, Eastell R, Barker D. Growth in infancy and bone mass in later life. Ann Rheum Dis. 1997; 56: 17–21.
  • 26
    Yarbrough DE, Barrett-Connor E, Morton DJ. Birth weight as a predictor of adult bone mass in postmenopausal women: the Rancho Bernardo Study. Osteoporos Int. 2000; 11: 626–630.
  • 27
    Javaid MK, Cooper C. Prenatal and childhood influences on osteoporosis. Best Pract Res Clin Endocrinol Metab. 2002; 16: 349–367.
  • 28
    Dennison EM, Arden NK, Keen RW, et al. Birthweight, vitamin D receptor genotype and the programming of osteoporosis. Paediatr Perinat Epidemiol. 2001; 15: 211–219.
    Direct Link:
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