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Mineralization density distribution of postmenopausal osteoporotic bone is restored to normal after long-term alendronate treatment: qBEI and sSAXS data from the fracture intervention trial long-term extension (FLEX)
Article first published online: 14 DEC 2009
DOI: 10.1359/jbmr.090702
Copyright © 2010 American Society for Bone and Mineral Research
Additional Information
How to Cite
Roschger, P., Lombardi, A., Misof, B., Maier, G., Fratzl-Zelman, N., Fratzl, P. and Klaushofer, K. (2010), Mineralization density distribution of postmenopausal osteoporotic bone is restored to normal after long-term alendronate treatment: qBEI and sSAXS data from the fracture intervention trial long-term extension (FLEX). J Bone Miner Res, 25: 48–55. doi: 10.1359/jbmr.090702
Publication History
- Issue published online: 20 JAN 2010
- Article first published online: 14 DEC 2009
- Manuscript Accepted: 1 JUL 2009
- Manuscript Revised: 1 APR 2009
- Manuscript Received: 5 FEB 2009
References
- 1Alendronate in the treatment of osteoporosis: a review of the clinical trials. J Womens Health Gender-Based Med. 2000; 9: 599–606.
- 2, , , et al. Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial. JAMA. 1998; 280: 2077–2082.
- 3, , , et al. Multinational, placebo-controlled, randomized trial of the effects of alendronate on bone density and fracture risk in postmenopausal women with low bone mass: results from the FOSIT study. Osteoporosis Int. 1999; 9: 461–468.
- 4, , , , Meta-analysis of the efficacy of alendronate for the prevention of hip fractures in postmenopausal women. Osteoporosis Int. 2005; 16: 468–474.
- 5, , , et al. Effect of oral alendronate on the bone mineral density and the incidence of fractures in postmenopausal osteoporosis. N Engl J Med. 1995; 333: 1437–1443.
- 6
- 7, , , , , Bone fragility and collagen cross-links. J Bone Miner Res. 2004; 19: 2000–2004.Direct Link:
- 8, , , , , Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women. Bone. 2001; 29: 185–191.
- 9, , , Bone mineralization density and femoral neck fragility. Bone. 2004; 35: 929–941.
- 10, , , et al. Effects of 3- and 5-year treatment with risedronate on the bone mineral density distribution of cancellous bone in human iliac crest biopsies. J Bone Miner Res. 2006; 21: 1106–1112.Direct Link:
- 11, , , Age-related change in the damage morphology of human cortical bone and its role in bone fragility. Bone. 2006; 38: 427–431.
- 12, , , Structure and mechanical quality of the collagen-mineral nano-composite in bone. J Mater Chem. 2004; 14: 2115–2123.
- 13, , , , Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women. Bone. 2000; 27: 687–694.
- 14
- 15, , , et al. Long-term risedronate treatment normalizes mineralization and continues to preserve trabecular architecture: sequential triple biopsy studies with micro-computed tomography. Bone. 2006; 39: 345–352.
- 16Bones: Structure and Mechanics. Princeton, NJ: Princeton University Pres; 2002: 436.
- 17, , , et al. The role of mineralization and organic matrix in the microhardness of bone tissue from controls and osteoporotic patients. Bone. 2008; 43: 532–538.
- 18, , , et al. Synchrotron radiation microtomography allows the analysis of three-dimensional microarchitecture and degree of mineralization of human iliac crest biopsy specimens: effect of etidronate treatment. J Bone Miner Res. 2002; 17: 1372–1382.Direct Link:
- 19, , , Bone mineralization density distribution in health and disease. Bone. 2008; 42: 456–466.
- 20, Backscattered electron imaging of skeletal tissues. Metab Bone Dis Relat Res. 1983; 5: 145–150.
- 21, , , , The bone mineralization density distribution as a fingerprint of the mineralization process. Bone. 2007; 40: 1308–1319.
- 22, , , et al. Constant mineralization density distribution in cancellous human bone. Bone. 2003; 32: 316–323.
- 23, , , Long-term treatment with oral bisphosphonates in postmenopausal women: effects on the degree of mineralization and microhardness of bone [abstract 1029]. ASBMR 30th Annual Meeting, Montreal, Canada, September 12–16, 2008.
- 24, , , et al. Effects of continuing or stopping alendronate after 5 years of treatment: the fracture intervention trial long-term extension (FLEX)—a randomized trial. JAMA. 2006; 296: 2927–2938.
- 25, , , et al. Ten years' experience with alendronate for osteoporosis in postmenopausal women. N Engl J Med. 2004; 350: 1189–1199.
- 26, , , et al. Randomized trial of effects of alendronate continuation versus discontinuation in women with low BMD: results from the Fracture Intervention Trial Long-Term Extension. J Bone Miner Res. 2004; 19: 1259–1269.Direct Link:
- 27, , , A theoretical analysis of long-term bisphosphonate effects on trabecular bone volume and microdamage. Bone. 2004; 35: 296–305.
- 28, , , et al. Long-term treatment of incadronate disodium accumulates microdamage but improves the trabecular bone microarchitecture in dog vertebra. J Bone Miner Res. 2003; 18: 512–520.Direct Link:
- 29, Three years of alendronate treatment results in similar levels of vertebral microdamage as after one year of treatment. J Bone Miner Res. 2007; 22: 1759–1765.Direct Link:
- 30, , , et al. Low bone mineral density is associated with bone microdamage accumulation in postmenopausal women with osteoporosis. Bone. 2007; 41: 378–385.
- 31, , , et al. Microcrack frequency and bone remodeling in postmenopausal osteoporotic women in long-term bisphosphonates: a bone biopsy study. J Bone Miner Res. 2007; 22: 1502–1509.Direct Link:
- 32, , , , , Histomorphometric assessment of the long-term effects of alendronate on bone quality and remodeling in patients with osteoporosis. J Clin Invest. 1997; 100: 1475–1480.
- 33, , , et al. Characteristics of mineral particles in the human bone/cartilage interface. J Struct Biol. 2003; 141: 208–217.
- 34, , , Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies. Bone. 1998; 23: 319–26.
- 35, , , , , Scanning small angle X-ray scattering analysis of human bone sections. Calcif Tissue Int. 1999; 64: 422–429.
- 36, , , A new scanning electron microscopy approach to the quantification of bone mineral distribution: backscattered electron image grey-levels correlated to calcium K alpha-line intensities. Scanning Microsc. 1995; 9: 75–86; discussion 86–88.
- 37
- 38, The prevention and treatment of osteoporosis. N Engl J Med. 1992; 327: 620–627.
- 39, , , , , Effect of temporal changes in bone turnover on the bone mineralization density distribution: a computer simulation study. J Bone Miner Res. 2008; 23: 1905–1914.Direct Link:
- 40, , , , , Evidence that treatment with risedronate in women with postmenopausal osteoporosis affects bone mineralization and bone volume. Calcif Tissue Int. 2007; 81: 73–80.
- 41, , , Trabecular architecture in iliac crest bone biopsies: infra-individual variability in structural parameters and changes with age. Bone. 1988; 9: 289–295.
- 42, , , et al. Bone material properties in trabecular bone from human iliac crest biopsies after 3- and 5-year treatment with risedronate. J Bone Miner Res. 2006; 21: 1581–1590.Direct Link:
- 43, , , , , Severely suppressed bone turnover: a potential complication of alendronate therapy. J Clin Endocrinol Metab. 2005; 90: 1294–1301.
- 44, Positive effects of intravenous zoledronic acid on bone remodeling and structure: are different effects on osteoblast activity to other oral bisphosphonates responsible? J Bone Miner Res. 2008; 23: 2–5.Direct Link:
- 45
- 46, , , et al. Effects of intravenous zoledronic acid once yearly on bone remodeling and bone structure. J Bone Miner Res. 2008; 23: 6–16.Direct Link:

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