Original Article
You have full text access to this OnlineOpen article
Potential mediators of the mortality reduction with zoledronic acid after hip fracture
Article first published online: 14 DEC 2009
DOI: 10.1359/jbmr.090704
Copyright © 2010 American Society for Bone and Mineral Research
Additional Information
How to Cite
Colón-Emeric, C. S., Mesenbrink, P., Lyles, K. W., Pieper, C. F., Boonen, S., Delmas, P., Eriksen, E. F. and Magaziner, J. (2010), Potential mediators of the mortality reduction with zoledronic acid after hip fracture. J Bone Miner Res, 25: 91–97. doi: 10.1359/jbmr.090704
Publication History
- Issue published online: 20 JAN 2010
- Article first published online: 14 DEC 2009
- Manuscript Accepted: 1 JUL 2009
- Manuscript Revised: 6 MAY 2009
- Manuscript Received: 12 MAR 2009
References
- 1, , , , Excess mortality following hip fracture: the role of underlying health status. Osteoporos Int. 2007; 18: 1463–1472.
- 2, , Adjusted mortality after hip fracture: from the Cardiovascular Health Study. J Am Geriatr Soc. 2006; 54: 1885–1891.Direct Link:
- 3, , , et al. Excess mortality attributable to hip fracture in white women aged 70 years and older. Am J Public Health. 1997; 87: 1630–1636.
- 4, , Has mortality after a hip fracture increased? J Am Geriatr Soc. 2007; 55: 1720–1726.Direct Link:
- 5, , , et al. for the HORIZON Recurrent Fracture Trial. Zoledronic acid and clinical fracture and mortality after hip fracture. N Engl J Med. 2007; 357: 1799–1809.
- 6, , , , Risk of mortality following clinical fractures. Osteoporos Int. 2000; 11: 556–561.
- 7, , , et al. Cytokines and C-reactive protein production in hip-fracture-operated elderly patients. J Gerontol A Biol Sci Med Sci. 2007; 62: 420–426.
- 8, , , Central nervous system interleukin-8 production following neck of femur fracture. Aust NZ J Surg. 2005; 75: 813–816.Direct Link:
- 9, , , et al. Association between interleukin-6 and lower extremity function after hip fracture: the role of muscle mass and strength. J Am Geriatr Soc. 2008; 56: 1050–1056.Direct Link:
- 10, Elevation of plasma CGRP and SP levels in orthopedic patients with fracture of neck of femur. Neuropeptides. 2000; 34: 116–120.
- 11Vascular endothelial growth factor (VEGF) in plasma increases after hip surgery. J Clin Anesth. 2004; 16: 435–439.
- 12, , , , Increased expression of IL-6 and RANK mRNA in human trabecular bone from fragility fracture of the femoral neck. Bone. 2004; 35: 334–342.
- 13, , , , , Femoral neck fracture is accompanied by local changes in the content of transforming growth factor-beta1, interleukin-1β and collagenase activity. J Musculoskel Neuronal Interact. 2007; 7: 161–165.
- 14, , , et al. Reciprocal activating interaction between dentritic cells and pamidronate-stimulated γδ T cells: role of CD86 and inflammatory cytokines. J Immunol. 2005; 174: 252–260.
- 15
- 16, , , et al. Fever after zoledronic acid administration is due to increase in TNF-α and IL-6. J Interferon Cytokine Res. 2003; 23: 649–654.
- 17, , , et al. Pamidronate induces modifications of circulating angiogenetic factors in cancer patients. Clin Cancer Res. 2002; 8: 1080–1084.
- 18, Mortality associated with delay in operation after hip fracture. BMJ. 2006; 332: 947–951.
- 19, , , et al. Volumetric and areal bone mineral density measures are associated with cardiovascular disease in older men and women: the health, aging, and body composition study. Calcif Tissue Int. 2006; 79: 102–111.
- 20, , , , , Effects of bisphosphonates on prostaglandin E2 and thromboxane B2 production in human whole blood and monocytes stimulated by lipopolysaccharide and A23187. Methods Find Exp Clin Pharmacol. 2006; 28: 361–367.
- 21, , , et al. Assessment of mortality in patients enrolled in a risedronate clinical trial program: a retrospective cohort study. Regul Toxicol Pharmacol. 2002; 35: 320–326.
- 22, , , et al. Relationships between myocardial injury, all-cause mortality, vitamin D, PTH and biochemical bone turnover markers in older patients with hip fractures. Ann Clin Lab Sci. 2007; 37: 222–232.
- 23, , , et al., for the HORIZON Pivotal Fracture Trial. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med. 2007; 356: 1809–1822.
- 24, , , et al. Physiological and morphological effects of alendronate on rabbit esophageal epithelium. Am J Physiol Gastrointest Liver Physiol. 2002; 283: G576–G586.
- 25, , , , , Bisphosphonates stimulate an endogenous nonselective cation channel in Xenopus oocytes: potential mechanism of action. Am J Physiol Cell Physiol. 2005; 289: C248–256.
- 26, , , et al. Use of bisphosphonates among women and risk of atrial fibrillation and flutter: population based case-control study [see comment]. BMJ. 2008; 336: 813–816.
- 27, , , , , Gender differences in mortality after hip fracture: the role of infection. J Bone Miner Res. 2003; 18: 2231–2237.Direct Link:
- 28, , , Characterization of oxidized low-density lipoprotein-induced hormeses-like effects in osteoblastic cells. Am J Physiol. 2008; 294: C1021–1033.
- 29, , , et al. Persistent changes in interleukin-6 and lower extremity function following hip fracture. J Gerontol. 2006; 61: 1053–1058.
- 30, , , , , Inflammation in the nervous system: physiological and pathophysiological aspects. Physiol Behav. 2007; 92: 121–128.
- 31, , , et al. Interleukin-6 covaries inversely with cognitive performance among middle-aged community volunteers. Psychosom Med. 2006; 68: 895–903.

1523-4681/asset/olbannerleft.gif?v=1&s=d7e4c0e37904a489128d3a4e58ba94214db307a9)
1523-4681/asset/olbannerright.gif?v=1&s=854ee0e4d351ead9faaca8bfab3e50b1c7c9d03d)
