Original Article
You have full text access to this OnlineOpen article
Differentiation-dependent association of phosphorylated extracellular signal-regulated kinase with the chromatin of osteoblast-related genes
Article first published online: 14 DEC 2009
DOI: 10.1359/jbmr.090705
Copyright © 2010 American Society for Bone and Mineral Research
Additional Information
How to Cite
Li, Y., Ge, C. and Franceschi, R. T. (2010), Differentiation-dependent association of phosphorylated extracellular signal-regulated kinase with the chromatin of osteoblast-related genes. J Bone Miner Res, 25: 154–163. doi: 10.1359/jbmr.090705
Publication History
- Issue published online: 20 JAN 2010
- Article first published online: 14 DEC 2009
- Manuscript Accepted: 1 JUL 2009
- Manuscript Revised: 19 MAY 2009
- Manuscript Received: 20 MAR 2009
References
- 1, , , , , . FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development. 2007; 134: 2895–2902.
- 2, , , et al. Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation. Proc Natl Acad Sci USA. 2003; 100: 12759–12764.
- 3, , , . Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2. J Biol Chem. 2002; 277: 36181–36187.
- 4, , , , , . Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells. J Bone Miner Res. 2002; 17: 101–110.Direct Link:
- 5, , , et al. Fluid shear-induced mechanical signaling in MC3T3-E1 osteoblasts requires cytoskeleton-integrin interactions. Am J Physiol. 1998; 275: C1591–1601.
- 6, , , . Changes in Runx2/Cbfa1 expression and activity during osteoblastic differentiation of human bone marrow stromal cells. J Bone Miner Res. 2003; 18: 213–221.Direct Link:
- 7, , , , , . Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase. J Biol Chem. 2000; 275: 9645–9652.
- 8, , , et al. ERK is essential for growth, differentiation, integrin expression, and cell function in human osteoblastic cells. J Biol Chem. 2001; 276: 14443–14450.
- 9, , , , . Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell. 2004; 6: 483–495.
- 10, , , . The regulation of osteogenesis by ECM rigidity in MC3T3-E1 cells requires MAPK activation. J Cell Physiol. 2007; 211: 661–672.Direct Link:
- 11, , . MAP kinase converts MyoD into an instructive muscle differentiation factor in Xenopus. Dev Biol. 2001; 240: 168–181.
- 12, , , , . Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site. J Biol Chem. 1997; 272: 5128–5132.
- 13, , , et al. MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1. J Biol Chem. 2000; 275: 4453–4459.
- 14, , , . Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway. Proc Natl Acad Sci USA. 2000; 97: 1113–1118.
- 15, , , . Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development. J Cell Biol. 2007; 176: 709–718.
- 16, , , , , . Differentiation and transforming growth factor-beta receptor down-regulation by collagen-α2β1 integrin interaction is mediated by focal adhesion kinase and its downstream signals in murine osteoblastic cells. J Biol Chem. 1997; 272: 29309–29316.
- 17, , , , . Transcriptional regulation of osteoblasts. Ann NY Acad Sci. 2007; 1116: 196–207.Direct Link:
- 18, , , et al. Functional interdependence at the chromatin level between the MKK6/p38 and IGF1/PI3K/AKT pathways during muscle differentiation. Mol Cell. 2007; 28: 200–213.
- 19, , , , . Activated signal transduction kinases frequently occupy target genes. Science. 2006; 313: 533–536.
- 20, , , , , . Isolation and characterization of MC3T3-E1 preosteoblast subclones with distinct in vitro and in vivo differentiation/mineralization potential. J Bone Miner Res. 1999; 14: 893–903.Direct Link:
- 21, , , . Mineralized bone nodules formed in vitro from enzymatically released rat calvaria cell populations. Calcif Tissue Int. 1986; 38: 143–154.
- 22, , , , . BMP signaling is required for RUNX2-dependent induction of the osteoblast phenotype. J Bone Miner Res. 2006; 21: 637–646.Direct Link:
- 23, . Analysis of transcription factor interactions in osteoblasts using competitive chromatin immunoprecipitation. Nucleic Acids Res. 2008; 36: 1723–1730.
- 24, , , , . Cooperative interactions between RUNX2 and homeodomain protein-binding sites are critical for the osteoblast-specific expression of the bone sialoprotein gene. J Biol Chem. 2005; 280: 30845–30855.
- 25, , , et al. Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2. Nature. 2007; 445: 442–446.
- 26, , , , , . Functional hierarchy between two OSE2 elements in the control of osteocalcin gene expression in vivo. J Biol Chem. 1998; 273: 30509–30516.
- 27, , , , , . In vitro and in vivo synergistic interactions between the Runx2/Cbfa1 transcription factor and bone morphogenetic protein-2 in stimulating osteoblast differentiation. J Bone Miner Res. 2003; 18: 705–715.Direct Link:
- 28, , , , . Role of the α2-integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor. J Biol Chem. 1998; 273: 32988–32994.
- 29, , , , , . Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites. Proc Natl Acad Sci USA. 2002; 99: 8048–8053.
- 30, , , , . Ascorbic acid–dependent activation of the osteocalcin promoter in MC3T3-E1 preosteoblasts: requirement for collagen matrix synthesis and the presence of an intact OSE2 sequence. Mol Endocrinol. 1997; 11: 1103–1113.
- 31, , . The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription. EMBO J. 2002; 21: 4632–4640.
- 32, , . Development expression of bone sialoprotein mRNA in rat mineralized connective tissues. J Bone Miner Res. 1992; 7: 987–997.Direct Link:
- 33, , . Control of MAP kinase signaling to the nucleus. Chromosoma. 2005; 114: 86–91.
- 34, . Relationship between collagen synthesis and expression of the osteoblast phenotype in MC3T3-E1 cells. J Bone Miner Res. 1992; 7: 235–246.Direct Link:
- 35, , , , . Mineralization of bone-like extracellular matrix in the absence of functional osteoblasts. J Bone Mineral Res. 1995; 10: 1635–1643.Direct Link:
- 36, , , , , . p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci.[see comments]. Nat Genet. 2004; 36: 738–743.
- 37, , , et al. Chromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in beta-cells. Proc Natl Acad Sci USA. 2008; 105: 13315–13320.
- 38, , , et al. Convergence on chromatin of nongenomic and genomic pathways of hormone signaling. J Steroid Biochem Mol Biol. 2008; 109: 344–349.
- 39, , , et al. DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: a link to histone acetylation. Mol Cell. 2007; 25: 297–308.
- 40, , , et al. Transcriptional induction of the osteocalcin gene during osteoblast differentiation involves acetylation of histones H3 and H4. Mol Endocrinol. 2003; 17: 743–756.

1523-4681/asset/olbannerleft.gif?v=1&s=d7e4c0e37904a489128d3a4e58ba94214db307a9)
1523-4681/asset/olbannerright.gif?v=1&s=854ee0e4d351ead9faaca8bfab3e50b1c7c9d03d)
