Original Article

You have full text access to this OnlineOpen article

Risedronate reduces intracortical porosity in women with osteoporosis

  1. Babul Borah1,*,
  2. Tom Dufresne1,
  3. Joe Nurre1,
  4. Roger Phipps1,2,
  5. Paula Chmielewski1,
  6. Leigh Wagner1,
  7. Mark Lundy1,
  8. Mary Bouxsein3,
  9. Roger Zebaze4,
  10. Ego Seeman4

Article first published online: 18 DEC 2009

DOI: 10.1359/jbmr.090711

Issue

Journal of Bone and Mineral Research

Journal of Bone and Mineral Research

Volume 25, Issue 1, pages 41–47, January 2010

Additional Information

How to Cite

Borah, B., Dufresne, T., Nurre, J., Phipps, R., Chmielewski, P., Wagner, L., Lundy, M., Bouxsein, M., Zebaze, R. and Seeman, E. (2010), Risedronate reduces intracortical porosity in women with osteoporosis. J Bone Miner Res, 25: 41–47. doi: 10.1359/jbmr.090711

Author Information

  1. 1

    New Drug Development, Procter & Gamble Pharmaceuticals, Mason, OH, USA

  2. 2

    Maine Institute for Human Genetics and Health, Brewer, ME, USA

  3. 3

    Ortho Biomechanics Laboratory, Harvard Medical School, Boston, MA, USA

  4. 4

    Austin Health, University of Melbourne, Australia

*Procter & Gamble Pharmaceuticals, MBC SB3-3J8, 8700 Mason Montgomery Road, Mason, OH 45040, USA.

Publication History

  1. Issue published online: 20 JAN 2010
  2. Article first published online: 18 DEC 2009
  3. Manuscript Accepted: 1 JUL 2009
  4. Manuscript Revised: 24 APR 2009
  5. Manuscript Received: 19 JAN 2009

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (389K)

References

  • 1
    Albright F, Smith PH, Richardson AM. Postmenopausal osteoporosis. JAMA. 1941; 116: 2465–2474.
  • 2
    Riggs BL, Wahner HW, Melton LJ, Richelson LS, Judd HL, Offord KP. Rates of bone loss in the appendicular and axial skeletons of women: evidence of substantial vertebral bone loss before menopause. J Clin Invest. 1986; 77: 1487–1491.
  • 3
    Riggs BL, Melton LJ 3rd, Robb RA. et al. Population-based study of age and sex differences in bone volumetric density, size, geometry and structure at different skeletal sites. J Bone Miner Res. 2004; 19: 1945–1954
    Direct Link:
  • 4
    Riggs BL, Melton LJ, Robb R. et al. A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men. J Bone Miner Res. 2008; 23: 205–214.
    Direct Link:
  • 5
    Kanis JA, Johnell O, Oden A, Dawson A, De Laet C, Jonsson B. Ten year probabilities of osteoporotic fractures according to BMD and diagnostic thresholds. Osteoporos Int. 2001; 12: 989–995.
  • 6
    Zebaze R, Ghasem A, Bohte A, et al. The neglected role of intracortical remodeling in age-related bone loss. J Bone Miner Res. 2008; 23: S29.
  • 7
    Parfitt AM. Surface specific bone remodeling in health and disease. In: KleerekoperM, KraneS, eds. Clinical Disorders of Bone and Mineral Metabolism. New York: Mary Ann Liebert; 1989: 7–14.
  • 8
    Han Z-H, Palnitkar S, Rao DS, Nelson D, Parfitt AM. Effect of ethnicity and age or menopause on the structure and geometry of iliac bone. J Bone Miner Res. 1996; 11: 1967–1975.
  • 9
    Harris ST, Watts NB, Genant HK, et al. Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized, controlled trial. Vertebral Efficacy with Risedronate Therapy (VERT) Study Group. JAMA. 1999; 282: 1344–1352.
  • 10
    Eriksen EF, Melsen F, Sod E, Barton I, Chines A. Effects of long-term risedronate on bone quality and bone turnover in women with postmenopausal osteoporosis. Bone. 2002; 31: 620–625.
  • 11
    Ste-Marie L-G, Sod E, Johnson T, Chines A. Five years of treatment with risedronate and its effects on bone safety in women with postmenopausal osteoporosis. Calcif Tissue Int. 2004; 75: 469–476.
  • 12
    Compston JE, Vedi S, Stellon AJ. Inter-observer and intra-observer variation in bone histomorphometry. Calcif Tissue Int. 1986; 38: 67–70.
  • 13
    Power J, Loveridge N, Lyon A, Rushton N, Parker M, Reeve J. Bone remodeling at the endocortical surface of the human femoral neck: a mechanism for regional cortical thinning in cases of hip fracture. J Bone Miner Res. 2003; 18: 1775–1780.
    Direct Link:
  • 14
    Keshawarz NM, Recker RB. Expansion of the medullary cavity at the expense of cortex in postmenopausal osteoporosis. Metab Bone Dis Relat Res. 1984; 5: 223–228.
  • 15
    Bousson V, Meunier A, Bergot C, et al. Distribution of intracortical porosity in human midfemoral cortex by age and gender. J Bone Miner Res. 2001; 16: 1308–1317.
    Direct Link:
  • 16
    Harlick RM, Shapiro LG. Computer and Robot Vision. Vol. 1 Reading, MA: Addison-Wesley; 1992.
  • 17
    Parfitt AM. The physiologic and clinical significance of bone histomorphometric data. In: ReckerRR, ed. Bone Histomorphometry: Techniques and Interpretation. Boca Raton, FL: CRC Press; 1983: 143–223.
  • 18
    Martin RB, Burr DB. The microscopic structure of bone. In: Structure, Function, and Adaptation of Compact Bone. New York: Raven Press; 1989: 18–56.
  • 19
    Brockstedt H, Kassem M, Eriksen EF, Mosekilde L, Melsen F. Age- and sex-related changes in iliac cortical bone mass and remodeling. Bone. 1993; 14: 681–691.
  • 20
    Barth RW, Williams JL, Kaplan FS. Osteon morphometry in females with femoral neck fractures. Clin Orthop Relat Res. 1992; 283: 178–186.
  • 21
    Parfitt AM. Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone. J Cell Biochem. 1994; 55: 273–286.
    Direct Link:
  • 22
    Qiu S, Fyhrie DP, Palnitkar S, Rao DS. Histomorphometric assessment of haversian canal and osteocyte lacunae in different-sized osteons in human rib. Anat Rec A Discov Mol Cell Evol Biol. 2003; 272: 520–525.
    Direct Link:
  • 23
    Broulik P, Kragstrup J, Moskilde L, Melsen F. Osteon cross-sectional size in the iliac crest: variation in normals and patients with osteoporosis, hyperparathyroidism, acromegaly, hypothyroidism and treated epilepsia. Acta Pathol Microbiol Immunol Scand [A]. 1982; 90: 339–344.
  • 24
    Bell KL, Loveridge N, Jordan GR, Power J, Constant CR, Reeve J. A novel mechanism for induction of increased cortical porosity in cases of intracapsular hip fracture. Bone 2000; 27: 297–304.
  • 25
    The Mathworks, Inc. Image Processing Toolbox for Use with Matlab: User's Guide. Natick, MA: Mathworks Inc.; 2004.
  • 26
    Parfitt AM. Skeletal heterogeneity and the purposes of bone remodeling: implications for the understanding of osteoporosis. In: MarcusR, FeldmanD, KelseyJ, eds. Osteoporosis. San Diego: Academic Press; 1996: 315–339.
  • 27
    Mödder UI, Khosla S. Skeletal stem/osteoprogenitor cells: current concepts, alternate hypotheses, and relationship to the bone remodeling compartment. J Cell Biochem. 2008; 103: 393–400.
    Direct Link:
  • 28
    Yeni YN, Brown CU, Wang Z, Norman TL. The influence of bone morphology on fracture toughness of the human femur and tibia. Bone. 1997; 21: 453–459.
  • 29
    Martin RB, Boardman DL. The effects of collagen fiber orientation, porosity, density, and mineralization on bovine cortical bone bending properties. J Biomech. 1993; 26: 1047–1054.
  • 30
    Martin RB, Ishida J. The relative effects of collagen fiber orientation, porosity, density, and mineralization on bone strength. J Biomech. 1989; 22: 419–426.
  • 31
    Schaffler MB, Burr DB. Stiffness of compact bone: effects of porosity and density. J Biomech. 1988; 21: 13–16.
  • 32
    Delmas PD. Treatment of postmenopausal osteoporosis. Lancet. 2002; 359: 2018–2026.
  • 33
    Lips P, Courpron P, Meunier PJ. Mean wall thickness of trabecular bone packets in the human iliac crest: changes with age. Calcif Tissue Res. 1978; 26: 13–17.
  • 34
    Croucher PI, Garrahan NJ, Mellish RWE, Compston JE. Age-related changes in resorption cavity characteristics in human trabecular bone. Osteoporos Int. 1991; 1: 257–261.
  • 35
    Power J, Loveridge N, Lyon A, Rushton N, Parker M, Reeve J. Osteoclastic cortical erosion as a determinant of subperiosteal osteoblastic bone formation in the femoral neck's response to BMU imbalance: effects of stance-related loading and hip fracture. Osteoporos Int. 2005; 16: 1049–1056.
  • 36
    Mayhew PM, Thomas CD, Clement JG. et al. Relation between age, femoral neck cortical stability, and hip fracture risk. Lancet 2005; 366: 129–135.
View Full Article (HTML) Get PDF (389K)