• 1
    Albright F, Smith PH, Richardson AM. Postmenopausal osteoporosis. JAMA. 1941; 116: 24652474.
  • 2
    Riggs BL, Wahner HW, Melton LJ, Richelson LS, Judd HL, Offord KP. Rates of bone loss in the appendicular and axial skeletons of women: evidence of substantial vertebral bone loss before menopause. J Clin Invest. 1986; 77: 14871491.
  • 3
    Riggs BL, Melton LJ 3rd, Robb RA. et al. Population-based study of age and sex differences in bone volumetric density, size, geometry and structure at different skeletal sites. J Bone Miner Res. 2004; 19: 19451954
    Direct Link:
  • 4
    Riggs BL, Melton LJ, Robb R. et al. A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men. J Bone Miner Res. 2008; 23: 205214.
  • 5
    Kanis JA, Johnell O, Oden A, Dawson A, De Laet C, Jonsson B. Ten year probabilities of osteoporotic fractures according to BMD and diagnostic thresholds. Osteoporos Int. 2001; 12: 989995.
  • 6
    Zebaze R, Ghasem A, Bohte A, et al. The neglected role of intracortical remodeling in age-related bone loss. J Bone Miner Res. 2008; 23: S29.
  • 7
    Parfitt AM. Surface specific bone remodeling in health and disease. In: KleerekoperM, KraneS, eds. Clinical Disorders of Bone and Mineral Metabolism. New York: Mary Ann Liebert; 1989: 714.
  • 8
    Han Z-H, Palnitkar S, Rao DS, Nelson D, Parfitt AM. Effect of ethnicity and age or menopause on the structure and geometry of iliac bone. J Bone Miner Res. 1996; 11: 19671975.
  • 9
    Harris ST, Watts NB, Genant HK, et al. Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized, controlled trial. Vertebral Efficacy with Risedronate Therapy (VERT) Study Group. JAMA. 1999; 282: 13441352.
  • 10
    Eriksen EF, Melsen F, Sod E, Barton I, Chines A. Effects of long-term risedronate on bone quality and bone turnover in women with postmenopausal osteoporosis. Bone. 2002; 31: 620625.
  • 11
    Ste-Marie L-G, Sod E, Johnson T, Chines A. Five years of treatment with risedronate and its effects on bone safety in women with postmenopausal osteoporosis. Calcif Tissue Int. 2004; 75: 469476.
  • 12
    Compston JE, Vedi S, Stellon AJ. Inter-observer and intra-observer variation in bone histomorphometry. Calcif Tissue Int. 1986; 38: 6770.
  • 13
    Power J, Loveridge N, Lyon A, Rushton N, Parker M, Reeve J. Bone remodeling at the endocortical surface of the human femoral neck: a mechanism for regional cortical thinning in cases of hip fracture. J Bone Miner Res. 2003; 18: 17751780.
  • 14
    Keshawarz NM, Recker RB. Expansion of the medullary cavity at the expense of cortex in postmenopausal osteoporosis. Metab Bone Dis Relat Res. 1984; 5: 223228.
  • 15
    Bousson V, Meunier A, Bergot C, et al. Distribution of intracortical porosity in human midfemoral cortex by age and gender. J Bone Miner Res. 2001; 16: 13081317.
  • 16
    Harlick RM, Shapiro LG. Computer and Robot Vision. Vol. 1 Reading, MA: Addison-Wesley; 1992.
  • 17
    Parfitt AM. The physiologic and clinical significance of bone histomorphometric data. In: ReckerRR, ed. Bone Histomorphometry: Techniques and Interpretation. Boca Raton, FL: CRC Press; 1983: 143223.
  • 18
    Martin RB, Burr DB. The microscopic structure of bone. In: Structure, Function, and Adaptation of Compact Bone. New York: Raven Press; 1989: 1856.
  • 19
    Brockstedt H, Kassem M, Eriksen EF, Mosekilde L, Melsen F. Age- and sex-related changes in iliac cortical bone mass and remodeling. Bone. 1993; 14: 681691.
  • 20
    Barth RW, Williams JL, Kaplan FS. Osteon morphometry in females with femoral neck fractures. Clin Orthop Relat Res. 1992; 283: 178186.
  • 21
    Parfitt AM. Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone. J Cell Biochem. 1994; 55: 273286.
  • 22
    Qiu S, Fyhrie DP, Palnitkar S, Rao DS. Histomorphometric assessment of haversian canal and osteocyte lacunae in different-sized osteons in human rib. Anat Rec A Discov Mol Cell Evol Biol. 2003; 272: 520525.
  • 23
    Broulik P, Kragstrup J, Moskilde L, Melsen F. Osteon cross-sectional size in the iliac crest: variation in normals and patients with osteoporosis, hyperparathyroidism, acromegaly, hypothyroidism and treated epilepsia. Acta Pathol Microbiol Immunol Scand [A]. 1982; 90: 339344.
  • 24
    Bell KL, Loveridge N, Jordan GR, Power J, Constant CR, Reeve J. A novel mechanism for induction of increased cortical porosity in cases of intracapsular hip fracture. Bone 2000; 27: 297304.
  • 25
    The Mathworks, Inc. Image Processing Toolbox for Use with Matlab: User's Guide. Natick, MA: Mathworks Inc.; 2004.
  • 26
    Parfitt AM. Skeletal heterogeneity and the purposes of bone remodeling: implications for the understanding of osteoporosis. In: MarcusR, FeldmanD, KelseyJ, eds. Osteoporosis. San Diego: Academic Press; 1996: 315339.
  • 27
    Mödder UI, Khosla S. Skeletal stem/osteoprogenitor cells: current concepts, alternate hypotheses, and relationship to the bone remodeling compartment. J Cell Biochem. 2008; 103: 393400.
  • 28
    Yeni YN, Brown CU, Wang Z, Norman TL. The influence of bone morphology on fracture toughness of the human femur and tibia. Bone. 1997; 21: 453459.
  • 29
    Martin RB, Boardman DL. The effects of collagen fiber orientation, porosity, density, and mineralization on bovine cortical bone bending properties. J Biomech. 1993; 26: 10471054.
  • 30
    Martin RB, Ishida J. The relative effects of collagen fiber orientation, porosity, density, and mineralization on bone strength. J Biomech. 1989; 22: 419426.
  • 31
    Schaffler MB, Burr DB. Stiffness of compact bone: effects of porosity and density. J Biomech. 1988; 21: 1316.
  • 32
    Delmas PD. Treatment of postmenopausal osteoporosis. Lancet. 2002; 359: 20182026.
  • 33
    Lips P, Courpron P, Meunier PJ. Mean wall thickness of trabecular bone packets in the human iliac crest: changes with age. Calcif Tissue Res. 1978; 26: 1317.
  • 34
    Croucher PI, Garrahan NJ, Mellish RWE, Compston JE. Age-related changes in resorption cavity characteristics in human trabecular bone. Osteoporos Int. 1991; 1: 257261.
  • 35
    Power J, Loveridge N, Lyon A, Rushton N, Parker M, Reeve J. Osteoclastic cortical erosion as a determinant of subperiosteal osteoblastic bone formation in the femoral neck's response to BMU imbalance: effects of stance-related loading and hip fracture. Osteoporos Int. 2005; 16: 10491056.
  • 36
    Mayhew PM, Thomas CD, Clement JG. et al. Relation between age, femoral neck cortical stability, and hip fracture risk. Lancet 2005; 366: 129135.