Original Article
You have full text access to this OnlineOpen article
Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy
Article first published online: 14 DEC 2009
DOI: 10.1359/jbmr.090716
Copyright © 2010 American Society for Bone and Mineral Research
Additional Information
How to Cite
Kendler, D. L., Roux, C., Benhamou, C. L., Brown, J. P., Lillestol, M., Siddhanti, S., Man, H.-S., Martin, J. S. and Bone, H. G. (2010), Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy. J Bone Miner Res, 25: 72–81. doi: 10.1359/jbmr.090716
Publication History
- Issue published online: 20 JAN 2010
- Article first published online: 14 DEC 2009
- Manuscript Accepted: 6 JUL 2009
- Manuscript Revised: 22 MAY 2009
- Manuscript Received: 31 DEC 2008
References
- 1Anonymous. Who are candidates for prevention and treatment for osteoporosis? Osteoporos Int. 1997; 7: 1–6.
- 2Bone Health and Osteoporosis: A Report of the Surgeon General. US Department of Health and Human Services, Washington DC, 2004.
- 3NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. Osteoporosis prevention, diagnosis, and therapy. JAMA. 2001; 285: 785–795.
- 4, An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2006; 17: 1726–1733.
- 5, , , et al. The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts. J Cell Biol. 1999; 145: 527–538.
- 6, , , et al. Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo. Am J Pathol. 2000; 157: 435–448.
- 7, , , et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell. 1998; 93: 165–176.
- 8, , , et al. Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function. Endocrinology. 2000; 141: 3478–3484.
- 9, , , et al. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA. 1998; 95: 3597–3602.
- 10, , , , , , Effects of denosumab on bone mineral density and bone turnover in postmenopausal women. J Clin Endocrinol Metab. 2008; 93: 2149–2157.
- 11, , , et al. for the AMG 162 Bone Loss Study Group. Two-year treatment with denosumab (AMG 162) in a randomized phase 2 study of postmenopausal women with low BMD. J Bone Miner Res. 2007; 22: 1832–1841.Direct Link:
- 12, , , et al. Denosumab in postmenopausal women with low bone mineral density. N Engl J Med. 2006; 354: 821–831.
- 13, , , et al., for the AMG 162 Bone Loss Study Group. Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy: a randomized blinded phase 2 clinical trial. Bone. 2008; 43: 222–229.
- 14, , , et al. The effects of denosumab on fracture risk in women with osteoporosis. Osteoporos Int. 2009; 20: 167.
- 15Top 200 brand drugs by units in 2007. Drug Topics 2008.
- 16, , , Compliance with drug therapy for postmenopausal osteoporosis. Osteoporos Int. 2006; 17: 1645–1652.
- 17, , , Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy. Osteoporos Int. 2008; 19: 733–759.
- 18, , , et al. Comparison of the effect of denosumab and alendronate on bone mineral density and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, phase 3 trial. J Bone Miner Res. 2009; 24: 153–161.Direct Link:
- 19, Prediction of creatinine clearance from serum creatinine. Nephron. 1976; 16: 31–41.
- 20The International Society for Clinical Densitometry 2006 ISCD Understanding Bone Densitometry. http://www.iscd.org/visitors/pdfs/UnderstandingBMDTesting2006-Final.ppt. Accessed December 10, 2009.
- 21, , , et al. Increments in bone mineral density of the lumbar spine and hip and suppression of bone turnover are maintained after discontinuation of alendronate in postmenopausal women. Am J Med. 1997; 103: 291–297.
- 22, , , et al. Ten years' experience with alendronate for osteoporosis in postmenopausal women. N Engl J Med. 2004; 350: 1189–1199.
- 23, , , et al. Intravenous zoledronic acid 5 mg in the treatment of postmenopausal women with low bone density previously treated with alendronate. Bone. 2007; 41: 122–128.
- 24Mechanism of action, pharmacokinetic and pharmacodynamic profile, and clinical applications of nitrogen-containing bisphosphonates. J Dent Res. 2007; 86: 1022–1033.
- 25
- 26, , , et al. Compliance with osteoporosis medications. Arch Intern Med. 2005; 165: 2414–2419.
- 27, , , , The impact of compliance with osteoporosis therapy on fracture rates in actual practice. Osteoporos Int. 2004; 15: 1003–1008.
- 28, , Assessment of compliance with osteoporosis treatment and its consequences in a managed care population. Bone. 2006; 38: 922–928.
- 29, , , et al. Adherence to bisphosphonate therapy and fracture rates in osteoporotic women: relationship to vertebral and nonvertebral fractures from 2 US claims databases. Mayo Clin Proc. 2006; 81: 1013–1022.
- 30, , , Compliance with osteoporosis drug therapy and risk of fracture. Osteoporos Int. 2007; 18: 271–277.
- 31, , , et al. The use of placebo-controlled and non-inferiority trials for the evaluation of new drugs in the treatment of postmenopausal osteoporosis. Osteoporos Int. 2002; 13: 1–5.
- 32, , , et al. Study design in osteoporosis: a European perspective. J Bone Miner Res. 2003; 18: 1133–1138.Direct Link:
- 33, Considerations for development of surrogate endpoints for antifracture efficacy of new treatments in osteoporosis: a perspective. J Bone Miner Res. 2008; 23: 1155–1167.Direct Link:
- 34, , , , Change in lumbar spine BMD and vertebral fracture risk reduction in teriparatide-treated postmenopausal women with osteoporosis. J Bone Miner Res. 2006; 21: 1785–1790.Direct Link:
- 35, , , , , Changes in bone density and turnover explain the reductions in incidence of nonvertebral fractures that occur during treatment with antiresorptive agents. J Clin Endocrinol Metab. 2002; 87: 1586–1592.
- 36, , , et al. Larger increases in bone mineral density during alendronate therapy are associated with a lower risk of new vertebral fractures in women with postmenopausal osteoporosis. Fracture Intervention Trial Research Group. Arthritis Rheum. 1999; 42: 1246–1254.Direct Link:
- 37, , , , , Relationships between bone mineral density and incident vertebral fracture risk with raloxifene therapy. J Bone Miner Res. 2002; 17: 1–10.Direct Link:
- 38University of Sheffield Bone Marker Laboratory; available at www.shef.ac.uk/medicine/research/sections/musculoskeletal/bonemarkerlab/methodologies.html. Accessed March 3, 2009.

1523-4681/asset/olbannerleft.gif?v=1&s=d7e4c0e37904a489128d3a4e58ba94214db307a9)
1523-4681/asset/olbannerright.gif?v=1&s=854ee0e4d351ead9faaca8bfab3e50b1c7c9d03d)
