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References

  • 1
    Kasukawa Y, Miyakoshi N, Mohan S. The anabolic effects of GH/IGF system on bone. Curr Pharm Des, 2004; 10: 25772592.
  • 2
    Niu T, Rosen CJ. The insulin-like growth factor-1 gene and osteoporosis: a critical appraisal. Gene. 2005; 361: 3856.
  • 3
    Yakar S, Rosen CJ, Beamer WG, et al. Circulating levels of IGF-1 directly regulate bone growth and density. J Clin Invest. 2002; 110: 771781.
  • 4
    Adamo ML, Ma X, Ackert-Bicknell CL, Donahue LR, Beamer WG, Rosen CJ. Genetic increase in serum insulin-like growth factor-1 (IGF-1) in C3H/HeJ compared with C57BL/6J mice is associated with increased transcription from the IGF-1 exon 2 promoter. Endocrinology. 2006; 147: 29442955.
  • 5
    Jiang J, Lichtler AC, Gronowicz GA, et al. Transgenic mice with osteoblast-targeted insulin-like growth factor-1 show increased bone remodeling. Bone. 2006; 39: 494504.
  • 6
    Yakar S, Rosen CJ. From mouse to man: redefining the role of insulin-like growth factor-1 in the acquisition of bone mass. Exp Biol Med (Maywood). 2003; 228: 245252.
  • 7
    Rosen CJ, Ackert-Bicknell CL, Adamo ML, et al. Congenic mice with low serum IGF-1 have increased body fat, reduced bone mineral density, and an altered osteoblast differentiation program. Bone. 2004; 35: 10461058.
  • 8
    Hawse JR, Subramaniam M, Ingle JN, Oursler MJ, Rajamannan NM, Spelsberg TC. Estrogen-TGFβ cross-talk in bone and other cell types: role of TIEG, Runx2, and other transcription factors. J Cell Biochem. 2008; 103: 383392.
  • 9
    Seeman E. Estrogen, androgen, and the pathogenesis of bone fragility in women and men. Curr Osteoporos Rep. 2004; 2: 9096.
  • 10
    Syed FA, Modder UI, Fraser DG, et al. Skeletal effects of estrogen are mediated by opposing actions of classical and nonclassical estrogen receptor pathways. J Bone Miner Res. 2005; 20: 19922001.
  • 11
    Almeida M, Han L, Martin-Millan M, et al. Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J Biol Chem. 2007; 282: 2728527297.
  • 12
    Recker RR, Osteoporosis Bol Asoc Med PR. 1983; 75: 418420.
  • 13
    Falahati-Nini A, Riggs BL, Atkinson EJ, O'Fallon WM, Eastell R, Khosla S. Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men. J Clin Invest. 2000; 106: 15531560.
  • 14
    Riggs BL, Khosla S, Melton LJ. Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev. 2002; 23: 279302.
  • 15
    Zallone A. Direct and indirect estrogen actions on osteoblasts and osteoclasts. Ann NY Acad Sci. 2006; 1068: 173179.
  • 16
    Ernst M, Rodan GA. Estradiol regulation of insulin-like growth factor-I expression in osteoblastic cells: evidence for transcriptional control. Mol Endocrinol. 1991; 5: 10811089.
  • 17
    Leung KC, Johannsson G, Leong GM, Ho KK. Estrogen regulation of growth hormone action. Endocr Rev. 2004; 25: 693721.
  • 18
    Munzer T, Rosen CJ, Harman SM, et al. Effects of GH and/or sex steroids on circulating IGF-1 and IGFBPs in healthy, aged women and men. Am J Physiol Endocrinol Metab. 2006; 290: E1006E1013.
  • 19
    Meinhardt UJ, Ho KK. Modulation of growth hormone action by sex steroids. Clin Endocrinol (Oxf). 2006; 65: 413422.
  • 20
    Yakar S, Liu JL, Stannard B, et al. Normal growth and development in the absence of hepatic insulin-like growth factor 1. Proc Natl Acad Sci USA. 1999; 96: 73247329.
  • 21
    Silha JV, Gui Y, Mishra S, Leckstrom A, Cohen P, Murphy LJ. Overexpression of gly56/gly80/gly81-mutant insulin-like growth factor-binding protein-3 in transgenic mice. Endocrinology. 2005; 146: 15231531.
  • 22
    Bouxsein ML, Myers KS, Shultz KL, Donahue LR, Rosen CJ, Beamer WG. Ovariectomy-induced bone loss varies among inbred strains of mice. J Bone Miner Res. 2005; 20: 10851092.
  • 23
    Laib A, Hildebrand T, Hauselmann HJ, Ruegsegger P. Ridge number density: a new parameter for in vivo bone structure analysis. Bone. 1997; 21: 541546.
  • 24
    Parfitt AM, Drezner MK, Glorieux FH, et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res. 1987; 2: 595610.
  • 25
    Kawashima Y, Fritton JC, Yakar S, et al. Type 2 diabetic mice demonstrate slender long bones with increased fragility secondary to increased osteoclastogenesis. Bone. 2009; 44: 646653.
  • 26
    Jepsen KJ, Akkus OJ, Majeska RJ, Nadeau JH. Hierarchical relationship between bone traits and mechanical properties in inbred mice. Mamm Genome. 2003; 14: 97104.
  • 27
    Cardoso L, Herman BC, Verborgt O, Laudier D, Majeska RJ, Schaffler MB. Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue. J Bone Miner Res. 2009; 24: 597605.
  • 28
    Turyn D, Dominici FP, Sotelo AI, Bartke A. Growth hormone-binding protein enhances growth hormone activity in vivo. Am J Physiol Endocrinol Metab. 1997; 273: E549E556.
  • 29
    Coutant R, de Casson FB, Rouleau S, et al. Divergent effect of endogenous and exogenous sex steroids on the insulin-like growth factor 1 response to growth hormone in short normal adolescents. J Clin Endocrinol Metab. 2004; 89: 61856192.
  • 30
    Gibney J, Johannsson G, Leung KC, Ho KK. Comparison of the metabolic effects of raloxifene and oral estrogen in postmenopausal and growth hormone-deficient women. J Clin Endocrinol Metab. 2005; 90: 38973903.
  • 31
    Rooman RP, De Beeck LO, Martin M, van Doorn J, Mohan S, Du Caju MV. Ethinylestradiol and testosterone have divergent effects on circulating IGF system components in adolescents with constitutional tall stature. Eur J Endocrinol. 2005; 152: 597604.
  • 32
    Span JP, Pieters GF, Sweep CG, Hermus AR, Smals AG. Gender difference in insulin-like growth factor 1 response to growth hormone (GH) treatment in GH-deficient adults: role of sex hormone replacement. J Clin Endocrinol Metab. 2000; 85: 11211125.
  • 33
    Meinhardt UJ, Ho KK. Regulation of growth hormone action by gonadal steroids. Endocrinol Metab Clin North Am. 2007; 36: 5773.
  • 34
    Ahlborg HG, Johnell O, Turner CH, Rannevik G, Karlsson MK. Bone loss and bone size after menopause. N Engl J Med. 2003; 349: 327334.
  • 35
    Harris WH, Heaney RP. Effect of growth hormone on skeletal mass in adult dogs. Nature. 1969; 223: 403404.
  • 36
    Andreassen TT, Jorgensen PH, Flyvbjerg A, Orskov H, Oxlund H. Growth hormone stimulates bone formation and strength of cortical bone in aged rats. J Bone Miner Res. 1995; 10: 10571067.
  • 37
    Eschen C, Andreassen TT. Growth hormone normalizes vertebral strength in ovariectomized rats. Calcif Tissue Int. 1995; 57: 392396.
  • 38
    Verhaeghe J, van Bree R, Van Herck E, et al. Effects of recombinant human growth hormone and insulin-like growth factor-1, with or without 17β-estradiol, on bone and mineral homeostasis of aged ovariectomized rats. J Bone Miner Res. 1996; 11: 17231735.
  • 39
    Mosekilde L, Thomsen JS, Orhii PB, Kalu DN. Growth hormone increases vertebral and femoral bone strength in osteopenic, ovariectomized, aged rats in a dose-dependent and site-specific manner. Bone. 1998; 23: 343352.
  • 40
    Wilson ME. Regulation of the growth hormone-insulin-like growth factor I axis in developing and adult monkeys is affected by estradiol replacement and supplementation with insulin-like growth factor 1. J Clin Endocrinol Metab. 1998; 83: 20182028.
  • 41
    Sandstedt J, Tornell J, Norjavaara E, Isaksson OG, Ohlsson C. Elevated levels of growth hormone increase bone mineral content in normal young mice, but not in ovariectomized mice. Endocrinology. 1996; 137: 33683374.
  • 42
    Clark R. The somatogenic hormones and insulin-like growth factor-1: stimulators of lymphopoiesis and immune function. Endocr Rev. 1997; 18: 157179.
  • 43
    Walsh MC, Kim N, Kadono Y, et al. Osteoimmunology: interplay between the immune system and bone metabolism. Annu Rev Immunol. 2006; 24: 3363.
  • 44
    Ducy P, Amling M, Takeda S, et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell. 2000; 100: 197207.
  • 45
    Elefteriou F, Takeda S, Ebihara K, et al. Serum leptin level is a regulator of bone mass. Proc Natl Acad Sci USA. 2004; 101: 32583263.
  • 46
    Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature. 2003; 423: 337342.
  • 47
    Lorenzo J, Horowitz M, Choi Y. Osteoimmunology: interactions of the bone and immune system. Endocr Rev. 2008; 29: 403440.
  • 48
    Yakar S, Rosen CJ, Bouxsein ML, et al. Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism. FASEB J. 2009; 23: 709719.
  • 49
    Tomkinson A, Gevers EF, Wit JM, Reeve J, Noble BS. The role of estrogen in the control of rat osteocyte apoptosis. J Bone Miner Res. 1998; 13: 12431250.
  • 50
    Kogianni G, Mann V, Noble BS. Apoptotic bodies convey activity capable of initiating osteoclastogenesis and localized bone destruction. J Bone Miner Res. 2008; 23: 915927.
  • 51
    Verborgt O, Gibson GJ, Schaffler MB. Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo. J Bone Miner Res. 2000; 15: 6067.
  • 52
    Verborgt O, Tatton NA, Majeska RJ, Schaffler MB. Spatial distribution of Bax and Bcl-2 in osteocytes after bone fatigue: complementary roles in bone remodeling regulation? J Bone Miner Res. 2002; 17: 907914.
  • 53
    DiGirolamo DJ, Mukherjee A, Fulzele K, et al. Mode of growth hormone action in osteoblasts. J Biol Chem. 2007; 282: 3166631674.
  • 54
    Ruff CB, Hayes WC. Subperiosteal expansion and cortical remodeling of the human femur and tibia with aging. Science. 1982; 217: 945948.
  • 55
    Smith RW, Walker RR. Femoral expansion in aging women: Implications for osteoporosis and fractures. Science. 1964; 145: 156157.
  • 56
    Beck TJ, Looker AC, Ruff CB, Sievanen H, Wahner HW. Structural trends in the aging femoral neck and proximal shaft: analysis of the Third National Health and Nutrition Examination Survey dual-energy X-ray absorptiometry data. J Bone Miner Res. 2000; 15: 22972304.