Original Article

You have full text access to this OnlineOpen article

Bone mineralization defects and vitamin D deficiency: Histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients

  1. Matthias Priemel1,2,
  2. Christoph von Domarus1,
  3. Till Orla Klatte1,
  4. Steffen Kessler1,
  5. Julia Schlie1,
  6. Simon Meier1,
  7. Nils Proksch1,
  8. Frederic Pastor1,
  9. Clemens Netter1,
  10. Thomas Streichert3,
  11. Klaus Püschel4,
  12. Michael Amling1,2,*

Article first published online: 14 DEC 2009

DOI: 10.1359/jbmr.090728

Issue

Journal of Bone and Mineral Research

Journal of Bone and Mineral Research

Volume 25, Issue 2, pages 305–312, February 2010

Additional Information

How to Cite

Priemel, M., von Domarus, C., Klatte, T. O., Kessler, S., Schlie, J., Meier, S., Proksch, N., Pastor, F., Netter, C., Streichert, T., Püschel, K. and Amling, M. (2010), Bone mineralization defects and vitamin D deficiency: Histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients. Journal of Bone and Mineral Research, 25: 305–312. doi: 10.1359/jbmr.090728

Author Information

  1. 1

    Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  2. 2

    Department of Trauma, Hand, and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  3. 3

    Department of Clinical Chemistry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  4. 4

    Department of Forensic Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

*Department of Osteology and Biomechanics, Department of Trauma, Hand, and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

Publication History

  1. Issue published online: 19 FEB 2010
  2. Article first published online: 14 DEC 2009
  3. Manuscript Accepted: 8 JUL 2009
  4. Manuscript Revised: 11 MAR 2009
  5. Manuscript Received: 11 AUG 2008

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (398K)

References

  • 1
    Heaney RP. Bone health. Am J Clin Nutr. 2007; 85: 300S–303S.
  • 2
    Rizzoli R, Boonen S, Brandi ML, Burlet N, Delmas P, Register JY. The role of calcium and vitamin D in the management of osteoporosis. Bone. 2008; 42: 246–249.
  • 3
    Roux C, Bischoff-Ferrari HA, Papapoulos SE, de Papp AE, West JA, Bouillon R. New insights into the role of vitamin D and calcium in osteoporosis management: an expert roundtable discussion. Curr Med Res Opin. 2008; 24: 1363–1370.
  • 4
    Riggs BL, Melton LJ III. Involutional osteoporosis. N Engl J Med. 1986; 314: 1676–1686.
  • 5
    Melton LJ III. Epidemiology worldwide. Endocrinol Metab Clin North Am. 2003; 32: 1–13.
  • 6
    Eastell R, Barton I, Hannon RA, Chines A, Garnero P, Delmas PD. Relationship of early changes in bone resorption to the reduction in fracture risk with risedronate. J Bone Miner Res. 2003; 18: 1051–1056.
  • 7
    Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med. 1997; 337: 670–676.
  • 8
    Chapuy MC, Arlot ME, Duboeuf F, et al. Vitamin D3 and calcium to prevent hip fractures in the elderly women. N Engl J Med. 1992; 327: 1637–1642.
  • 9
    Trivedi DP, Doll R, Khaw KT. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomized, double-blind, controlled trial. BMJ. 2003; 326: 469.
  • 10
    Pfeifer M, Begerow B, Minne HW, Abrams C, Nachtigall D, Hansen C. Effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderly women. J Bone Miner Res. 2000; 15: 1113–1118.
  • 11
    Bischoff HA, Stähelin HB, Dick W, et al. Effects of vitamin D and calcium supplementation on falls: a randomized, controlled trial. J Bone Miner Res. 2003; 18: 343–351.
  • 12
    Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC, Staehelin HB, Bazemore MG, Zee RY, Wong JB. Effect of vitamin D on falls: a meta-analysis. JAMA. 2004; 291: 1999–2006.
  • 13
    Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized, controlled trials. JAMA. 2005; 293: 2257–2264.
  • 14
    Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R. Estimates of optimal vitamin D status. Osteoporos Int. 2005; 16: 713–716.
  • 15
    Chapuy MC, Pamphile R, Paris E, et al. Combined calcium and vitamin D3 supplementation in elderly women: confirmation of reversal of secondary hyperparathyroidism and hip fracture risk: the Decalyos II study. Osteoporos Int. 2002; 13: 257–264.
  • 16
    Sahota O, Mundey MK, San P, Godber IM, Lawson N, Hosking DJ. The relationship between vitamin D and parathyroid hormone: calcium homeostasis, bone turnover, and bone mineral density in postmenopausal women with established osteoporosis. Bone. 2004; 35: 312–319.
  • 17
    Boonen S, Lips P, Bouillon R, Bischoff-Ferrari HA, Vanderschueren D, Haentjens P. Need for additional calcium to reduce the risk of hip fracture with vitamin D supplementation: evidence from a comparative metaanalysis of randomized, controlled trials. J Clin Endocrinol Metab. 2007; 92: 1415–1423.
  • 18
    Hintzpeter B, Mensink GB, Thierfelder W, Müller MJ, Scheidt-Nave C. Vitamin D status and health correlates among German adults. Eur J Clin Nutr. 2008; 62: 1079–1089.
  • 19
    Hinzpeter B, Scheidt-Nave C, Müller MJ, Schenk L, Mensink GB. Higher prevalence of vitamin D deficiency is associated with immigrant background among children and adolescents in Germany. J Nutr. 2008; 138: 1482–1490.
  • 20
    Bordier P, Matrajt H, Miravet L, Hioco D. Histological measure of the volume and resorption of bone joints. Pathol Biol (Paris). 1964; 12: 1238–1243.
  • 21
    Amling M, Priemel M, Holzmann T, et al. Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses. Endocrinology. 1999; 140: 4982–4987.
  • 22
    Parfitt AM, Drezner MK, Glorieux FH, et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res. 1987; 2: 595–610.
  • 23
    Delling G. Endokrine osteopathien: morphologie, histomorphometrie und differenzialdiagnose. In: BüngelerW, EderM, LennertK, PetersG, SandritterW, SeifertG, eds. Veröffentlichungen aus der Pathologie. H98. Stuttgart: Gustav Fischer Verlag; 1975.
  • 24
    Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev. 2001; 22: 477–501.
  • 25
    Boullion R, Bischoff-Ferrari H, Willett W. Vitamin D and health: perspectives from mice and man. J Bone Miner Res. 2008; 23: 974–979.
  • 26
    Ooms ME, Lips P, Roos JC, et al. Vitamin D status and sex hormone–binding globulin: determinants of bone turnover and bone mineral density in elderly women. J Bone Miner Res. 1995; 10: 1177–1184.
  • 27
    Lips P, Duong T, Oleksik A, et al. A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial. J Clin Endocrinol Metab. 2001; 86: 1212–1221.
  • 28
    Bischoff-Ferrari HA, Dietrich T, Orav EJ, Dawson-Hughes B. Positive association between 25-hydroxyvitamin D levels and bone mineral density: a population-based study of younger and older adults. Am J Med. 2004; 116: 634–639.
  • 29
    Norman AW, Bouillon R, Whiting SJ, Vieth R, Lips P. Thirteenth workshop consensus for vitamin D nutritional guidelines. J Steroid Biochem Mol Biol. 2007; 103: 204–205.
  • 30
    Roux C, Bischoff-Ferrari HA, Papapoulos SE, de Papp AE, West JA, Bouillon R. New insights into the role of vitamin D and calcium in osteoporosis management: an expert roundtable discussion. Curr Med Res Opin. 2008; 24: 1363–1370.
  • 31
    Delling G. Bone morphology in primary hyperparathyroidism: a qualitative and quantitative study of 391 cases. Appl Pathol. 1987; 5: 147–159.
  • 32
    Amling M, Grote HJ, Vogel M, Hahn M, Delling G. Three-dimensional analysis of the spine in autopsy cases with renal osteodystrophy. Kidney Int. 1994; 46: 733–743.
  • 33
    Glorieux FH, Marie PJ, Pettifor JM, Delvin EE. Bone response to phosphate salts, ergocalciferol, and calcitriol in hypophosphatemic vitamin D–resistant rickets. N Engl J Med. 1980; 303: 1023–1031.
  • 34
    Seitz S, Priemel M, Zustin J, et al. Paget's disease of bone: histologic analysis of 754 patients. J Bone Miner Res. 2009; 24: 62–69.
  • 35
    Woitge HW, Scheidt-Nave C, Kissling C, et al. Seasonal variation of biochemical indexes of bone turnover: results of a population-based study. J Clin Endocrinol Metab. 1998; 83: 68–75.
  • 36
    Kuchuk NO, van Schoor NM, Pluijm SM, Chines A, Lips P. Vitamin D status, parathyroid function, bone turnover and bone mineral density in postmenopausal women with osteoporosis in global perspective. J Bone Miner Res. [Epub ahead of print], 2008.
  • 37
    Lips P, Duong T, Oleksik A, Black D, Cummings S, Cox D, Nickelsen T. A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial. J Clin Endocrinol Metab. 2001; 86: 1212–1221.
  • 38
    Amling M, Grote HJ, Posl M, Hahn M, Delling G. Polyostotic heterogeneity of the spine in osteoporosis: quantitative analysis and three-dimensional morphology. Bone Miner. 1994; 27: 193–208.
  • 39
    Amling M, Herden S, Posl M, Hahn M, Ritzel H, Delling G. Heterogeneity of the skeleton: comparison of the trabecular microarchitecture of the spine, the iliac crest, the femur, and the calcaneus. J Bone Miner Res. 1996; 11: 36–45.
  • 40
    Webb AR, Kline L, Holick MF. Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab. 1988; 67: 373–378.
View Full Article (HTML) Get PDF (398K)