Original Article
You have full text access to this OnlineOpen article
Bone mineralization defects and vitamin D deficiency: Histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients
Article first published online: 14 DEC 2009
DOI: 10.1359/jbmr.090728
Copyright © 2010 American Society for Bone and Mineral Research
Additional Information
How to Cite
Priemel, M., von Domarus, C., Klatte, T. O., Kessler, S., Schlie, J., Meier, S., Proksch, N., Pastor, F., Netter, C., Streichert, T., Püschel, K. and Amling, M. (2010), Bone mineralization defects and vitamin D deficiency: Histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients. J Bone Miner Res, 25: 305–312. doi: 10.1359/jbmr.090728
Publication History
- Issue published online: 19 FEB 2010
- Article first published online: 14 DEC 2009
- Manuscript Accepted: 8 JUL 2009
- Manuscript Revised: 11 MAR 2009
- Manuscript Received: 11 AUG 2008
References
- 1. Bone health. Am J Clin Nutr. 2007; 85: 300S–303S.
- 2, , , , , . The role of calcium and vitamin D in the management of osteoporosis. Bone. 2008; 42: 246–249.
- 3, , , , , . New insights into the role of vitamin D and calcium in osteoporosis management: an expert roundtable discussion. Curr Med Res Opin. 2008; 24: 1363–1370.
- 4, Involutional osteoporosis. N Engl J Med. 1986; 314: 1676–1686.
- 5Epidemiology worldwide. Endocrinol Metab Clin North Am. 2003; 32: 1–13.
- 6, , , , , . Relationship of early changes in bone resorption to the reduction in fracture risk with risedronate. J Bone Miner Res. 2003; 18: 1051–1056.
- 7, , , . Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med. 1997; 337: 670–676.
- 8, , , et al. Vitamin D3 and calcium to prevent hip fractures in the elderly women. N Engl J Med. 1992; 327: 1637–1642.
- 9, , . Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomized, double-blind, controlled trial. BMJ. 2003; 326: 469.
- 10, , , , , . Effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderly women. J Bone Miner Res. 2000; 15: 1113–1118.
- 11, , , et al. Effects of vitamin D and calcium supplementation on falls: a randomized, controlled trial. J Bone Miner Res. 2003; 18: 343–351.
- 12, , , , , , . Effect of vitamin D on falls: a meta-analysis. JAMA. 2004; 291: 1999–2006.
- 13, , , , , . Fracture prevention with vitamin D supplementation: a meta-analysis of randomized, controlled trials. JAMA. 2005; 293: 2257–2264.
- 14, , , , , . Estimates of optimal vitamin D status. Osteoporos Int. 2005; 16: 713–716.
- 15, , , et al. Combined calcium and vitamin D3 supplementation in elderly women: confirmation of reversal of secondary hyperparathyroidism and hip fracture risk: the Decalyos II study. Osteoporos Int. 2002; 13: 257–264.
- 16, , , , , . The relationship between vitamin D and parathyroid hormone: calcium homeostasis, bone turnover, and bone mineral density in postmenopausal women with established osteoporosis. Bone. 2004; 35: 312–319.
- 17, , , , , . Need for additional calcium to reduce the risk of hip fracture with vitamin D supplementation: evidence from a comparative metaanalysis of randomized, controlled trials. J Clin Endocrinol Metab. 2007; 92: 1415–1423.
- 18, , , , . Vitamin D status and health correlates among German adults. Eur J Clin Nutr. 2008; 62: 1079–1089.
- 19, , , , . Higher prevalence of vitamin D deficiency is associated with immigrant background among children and adolescents in Germany. J Nutr. 2008; 138: 1482–1490.
- 20, , , . Histological measure of the volume and resorption of bone joints. Pathol Biol (Paris). 1964; 12: 1238–1243.
- 21, , , et al. Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses. Endocrinology. 1999; 140: 4982–4987.
- 22, , , et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res. 1987; 2: 595–610.
- 23. Endokrine osteopathien: morphologie, histomorphometrie und differenzialdiagnose. In: BüngelerW, EderM, LennertK, PetersG, SandritterW, SeifertG, eds. Veröffentlichungen aus der Pathologie. H98. Stuttgart: Gustav Fischer Verlag; 1975.
- 24. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev. 2001; 22: 477–501.
- 25, , . Vitamin D and health: perspectives from mice and man. J Bone Miner Res. 2008; 23: 974–979.
- 26, , , et al. Vitamin D status and sex hormone–binding globulin: determinants of bone turnover and bone mineral density in elderly women. J Bone Miner Res. 1995; 10: 1177–1184.
- 27, , , et al. A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial. J Clin Endocrinol Metab. 2001; 86: 1212–1221.
- 28, , , . Positive association between 25-hydroxyvitamin D levels and bone mineral density: a population-based study of younger and older adults. Am J Med. 2004; 116: 634–639.
- 29, , , , . Thirteenth workshop consensus for vitamin D nutritional guidelines. J Steroid Biochem Mol Biol. 2007; 103: 204–205.
- 30, , , , , . New insights into the role of vitamin D and calcium in osteoporosis management: an expert roundtable discussion. Curr Med Res Opin. 2008; 24: 1363–1370.
- 31. Bone morphology in primary hyperparathyroidism: a qualitative and quantitative study of 391 cases. Appl Pathol. 1987; 5: 147–159.
- 32, , , , . Three-dimensional analysis of the spine in autopsy cases with renal osteodystrophy. Kidney Int. 1994; 46: 733–743.
- 33, , , . Bone response to phosphate salts, ergocalciferol, and calcitriol in hypophosphatemic vitamin D–resistant rickets. N Engl J Med. 1980; 303: 1023–1031.
- 34, , , et al. Paget's disease of bone: histologic analysis of 754 patients. J Bone Miner Res. 2009; 24: 62–69.
- 35, , , et al. Seasonal variation of biochemical indexes of bone turnover: results of a population-based study. J Clin Endocrinol Metab. 1998; 83: 68–75.
- 36, , , , . Vitamin D status, parathyroid function, bone turnover and bone mineral density in postmenopausal women with osteoporosis in global perspective. J Bone Miner Res. [Epub ahead of print], 2008.
- 37, , , , , , . A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial. J Clin Endocrinol Metab. 2001; 86: 1212–1221.
- 38, , , , . Polyostotic heterogeneity of the spine in osteoporosis: quantitative analysis and three-dimensional morphology. Bone Miner. 1994; 27: 193–208.
- 39, , , , , . Heterogeneity of the skeleton: comparison of the trabecular microarchitecture of the spine, the iliac crest, the femur, and the calcaneus. J Bone Miner Res. 1996; 11: 36–45.
- 40, , . Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab. 1988; 67: 373–378.

1523-4681/asset/olbannerleft.gif?v=1&s=d7e4c0e37904a489128d3a4e58ba94214db307a9)
1523-4681/asset/olbannerright.gif?v=1&s=854ee0e4d351ead9faaca8bfab3e50b1c7c9d03d)
