Original Article
You have full text access to this OnlineOpen article
Candidate gene analysis of femoral neck trabecular and cortical volumetric bone mineral density in older men
Article first published online: 14 DEC 2009
DOI: 10.1359/jbmr.090729
Copyright © 2010 American Society for Bone and Mineral Research
Additional Information
How to Cite
Yerges, L. M., Klei, L., Cauley, J. A., Roeder, K., Kammerer, C. M., Ensrud, K. E., Nestlerode, C. S., Lewis, C., Lang, T. F., Barrett-Connor, E., Moffett, S. P., Hoffman, A. R., Ferrell, R. E., Orwoll, E. S. and Zmuda, J. M. (2010), Candidate gene analysis of femoral neck trabecular and cortical volumetric bone mineral density in older men. J Bone Miner Res, 25: 330–338. doi: 10.1359/jbmr.090729
Publication History
- Issue published online: 19 FEB 2010
- Article first published online: 14 DEC 2009
- Manuscript Accepted: 8 JUL 2009
- Manuscript Revised: 10 MAY 2009
- Manuscript Received: 22 DEC 2008
References
- 1, , , et al. Volumetric quantitative computed tomography of the proximal femur: precision and relation to bone strength. Bone. 1997; 21: 101–108.
- 2, , , et al. Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using quantitative computed tomography. J Bone Miner Res. 2008; 23: 1326–1333.
- 3, . Genetic regulation of bone mass and susceptibility to osteoporosis. Genes Dev. 2006; 20: 2492–2506.
- 4, , , , . Site and gender specificity of inheritance of bone mineral density. J Bone Miner Res. 2003; 18: 1531–1538.
- 5, , , et al. Identification of genetic loci that regulate bone adaptive response to mechanical loading in C57BL/6J and C3H/HeJ mice intercross. Bone. 2006; 39: 634–643.
- 6, , , , , . Variability in skeletal mass, structure, and biomechanical properties among inbred strains of rats. J Bone Miner Res. 2001; 16: 1532–1539.
- 7, , , , . Genetically based influences on the site-specific regulation of trabecular and cortical bone morphology. J Bone Miner Res. 2004; 19: 600–606.
- 8, , , et al. Mapping quantitative trait loci for vertebral trabecular bone volume fraction and microarchitecture in mice. J Bone Miner Res. 2004; 19: 587–599.
- 9, , , . Effects of genes, sex, age, and activity on BMC, bone size, and areal and volumetric BMD. J Bone Miner Res. 2007; 22: 737–746.
- 10, , , , , . Genetic and environmental determinants of volumetric and areal BMD in multi-generational families of African ancestry: the Tobago Family Health Study. J Bone Miner Res. 2007; 22: 527–536.
- 11, , , , , . Pleiotropy and heterogeneity in the expression of bone strength-related phenotypes in extended pedigrees. J Bone Miner Res. 2007; 22: 1766–1772.
- 12, , , et al. Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study: a large observational study of the determinants of fracture in older men. Contemp Clin Trials. 2005; 26: 569–585.
- 13, , , et al. Overview of recruitment for the osteoporotic fractures in men study (MrOS). Contemp Clin Trials. 2005; 26: 557–568.
- 14, , , , , . Dimensions and volumetric BMD of the proximal femur and their relation to age among older US men. J Bone Miner Res, 2006; 21: 1197–1206.
- 15, , , . Automated registration of hip and spine for longitudinal QCT studies: integration with 3D densitometric and structural analysis. Bone. 2006; 38: 273–279.
- 16International HapMap Project. Nature. 2003; 426: 789–796.
- 17, , , , . Analysis of single-locus tests to detect gene/disease associations. Genet Epidemiol. 2005; 28: 207–219.
- 18, , , . PromoLign: a database for upstream region analysis and SNPs. Hum Mutat. 2004; 23: 534–539.
- 19, , , et al. PupaSNP Finder: a web tool for finding SNPs with putative effect at transcriptional level. Nucleic Acids Res. 2004; 32: W242–W248.
- 20, , . Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Genetics. 2003; 164: 1567–1587.
- 21, , , , , . Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet. 2006; 38: 904–909.
- 22, , , et al. TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro. Mol Cell Biol. 2005; 25: 1191–1199.
- 23, , , et al. Overexpression of a nuclear protein, TIEG, mimics transforming growth factor-beta action in human osteoblast cells. J Biol Chem. 2000; 275: 20255–20259.
- 24, , , et al. TGFβ inducible early gene-1 knockout mice display defects in bone strength and microarchitecture. Bone. 2006; 39: 1244–1251.
- 25, , , et al. Developmental profiles of phosphorylated and unphosphorylated CREBs in murine calvarial MC3T3-E1 cells. J Biochem. 1998; 123: 399–407.
- 26, , , . Activating transcription factor-2 affects skeletal growth by modulating pRb gene expression. Mech Dev. 2008; 125: 843–856.
- 27, , , et al. Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice. Nature. 1996; 379: 262–265.
- 28, , , et al. Bone morphogenetic protein-3 is a negative regulator of bone density. Nat Genet. 2001; 27: 84–88.
- 29, , , et al. Purification and partial amino acid sequence of osteogenin, a protein initiating bone differentiation. J Biol Chem. 1989; 264: 13377–13380.
- 30, , , et al. Possible involvement of the vascular endothelial growth factor-Flt-1-focal adhesion kinase pathway in chemotaxis and the cell proliferation of osteoclast precursor cells in arthritic joints. J Immunol. 2002; 168: 5824–5831.
- 31, , , et al. Vascular endothelial growth factor (VEGF) directly enhances osteoclastic bone resorption and survival of mature osteoclasts. FEBS Lett. 2000; 473: 161–164.
- 32, , , et al. Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption. J Exp Med. 1999; 190: 293–298.
- 33, , , et al. Association between UHMWPE particle-induced inflammatory osteoclastogenesis and expression of RANKL, VEGF, and Flt-1 in vivo. Biomaterials. 2006; 27: 5161–5169.
- 34, , , , , . Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation. Endocrinology. 2000; 141: 1667–1674.
- 35, , , et al. Flt-1 tyrosine kinase-deficient homozygous mice result in decreased trabecular bone volume with reduced osteogenic potential. Bone. 2007; 40: 1494–1501.
- 36, . Critical role of the hypothalamic-pituitary-thyroid axis in bone. Bone. 2008; 43: 418–426.
- 37. A WNT canon orchestrating osteoblastogenesis. Trends Cell Biol. 2006; 16: 151–158.
- 38, , . Regulation of bone mass by WNT signaling. J Clin Invest. 2006; 116: 1202–1209.
- 39, , . WNT signaling in osteoblasts and bone diseases. Gene. 2004; 341: 19–39.
- 40, , , , . Adenomatous polyposis coli (APC), beta-catenin, and cadherin are expressed in human bone and cartilage. Histopathology. 2001; 39: 611–619.
- 41, , , et al. Essential role of beta-catenin in postnatal bone acquisition. J Biol Chem. 2005; 280: 21162–21168.
- 42, , , . Molecular analysis of the APC gene in 205 families: extended genotype-phenotype correlations in FAP and evidence for the role of APC amino acid changes in colorectal cancer predisposition. J Med Genet. 1999; 36: 14–20.
- 43, , , , . Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc Natl Acad Sci USA. 1995; 92: 3046–3050.
- 44, , , et al. Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study. PLoS Med. 2006; 3: e90.
- 45, , , et al. Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density and fracture risk in women: a meta-analysis. J Bone Miner Res. 2002; 17: 2048–2060.
- 46, , , et al. Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis. JAMA. 2008; 299: 1277–1290.
- 47, , , et al. The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis. Ann Intern Med. 2006; 145: 255–264.
- 48, , , et al. Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet. 2008; 371: 1505–1512.
- 49, , , et al. Multiple genetic loci for bone mineral density and fractures. N Engl J Med. 2008; 358: 2355–2365.
- 50, , , et al. Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet. 2008; 40: 575–583.

1523-4681/asset/olbannerleft.gif?v=1&s=d7e4c0e37904a489128d3a4e58ba94214db307a9)
1523-4681/asset/olbannerright.gif?v=1&s=854ee0e4d351ead9faaca8bfab3e50b1c7c9d03d)
