• 1
    Shai I, Schwarzfuchs D, Henkin Y, et al. Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. N Engl J Med 2008; 359: 229241.
  • 2
    Reddy ST, Wang CY, Sakhaee K, Brinkley L, Pak CY. Effect of low-carbohydrate, high-protein diets on acid-base balance, stone-forming propensity, and calcium metabolism. Am J Kidney Dis 2002; 40: 265274.
  • 3
    Carter JD, Vasey FB, Valeriano J. The effect of a low-carbohydrate diet on bone turnover. Osteoporos Int 2006; 17: 13981403.
  • 4
    Porta N, Vallee L, Boutry E, et al. Comparison of seizure reduction and serum fatty acid levels after receiving the ketogenic and modified Atkins diet. Seizure 2009; 18: 359364.
  • 5
    Neal EG, Chaffe HM, Edwards N, Lawson MS, Schwartz RH, Cross JH. Growth of children on classical and medium-chain triglyceride ketogenic diets. Pediatrics 2008; 122: e334e340.
  • 6
    Bergqvist AG, Schall JI, Stallings VA, Zemel BS. Progressive bone mineral content loss in children with intractable epilepsy treated with the ketogenic diet. Am J Clin Nutr 2008; 88: 16781684.
  • 7
    Zernicke RF, Salem GJ, Barnard RJ, Schramm E. Long-term, high-fat-sucrose diet alters rat femoral neck and vertebral morphology, bone mineral content, and mechanical properties. Bone 1995; 16: 2531.
  • 8
    Lac G, Cavalie H, Ebal E, Michaux O. Effects of a high fat diet on bone of growing rats: correlations between visceral fat, adiponectin and bone mass density. Lipids Health Dis 2008; 7: 16.
  • 9
    Mardon J, Habauzit V, Trzeciakiewicz A, et al. Influence of high and low protein intakes on age-related bone loss in rats submitted to adequate or restricted energy conditions. Calcif Tissue Int 2008; 82: 373382.
  • 10
    Hamrick MW, Ding KH, Ponnala S, Ferrari SL, Isales CM. Caloric restriction decreases cortical bone mass but spares trabecular bone in the mouse skeleton: implications for the regulation of bone mass by body weight. J Bone Miner Res 2008; 23: 870878.
  • 11
    Caton SJ, Yinglong B, Burget L, Spangler LJ, Tschop MH, Bidlingmaier M. Low-carbohydrate high-fat diets: Regulation of energy balance and body weight regain in rats. Obesity (Silver Spring) 2009; 17: 283289.
  • 12
    Malluche HH, Koszewski N, Monier-Faugere MC, Williams JP, Mawad H. Influence of the parathyroid glands on bone metabolism. Eur J Clin Invest 2006; 36: S23S33.
  • 13
    Riggs BL, Khosla S, Melton LJ III. Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev. 2002; 23: 279302.
  • 14
    Laviola L, Natalicchio A, Perrini S, Giorgino F. Abnormalities of IGF-I signaling in the pathogenesis of diseases of the bone, brain, and fetoplacental unit in humans. Am J Physiol Endocrinol Metab 2008; 295: E991E999.
  • 15
    Wang Y, Nishida S, Sakata T, et al. Insulin-like growth factor I is essential for embryonic bone development. Endocrinology 2006; 147: 47534761.
  • 16
    Boudignon BM, Bikle DD, Kurimoto P, et al. Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloading. J Appl Physiol 2007; 103: 125131.
  • 17
    Tanaka H, Quarto R, Williams S, Barnes J, Liang CT. In vivo and in vitro effects of insulin-like growth factor I (IGF-I) on femoral mRNA expression in old rats. Bone 1994; 15: 647653.
  • 18
    Isgaard J, Nilsson A, Lindahl A, Jansson JO, Isaksson OG. Effects of local administration of GH and IGF-1 on longitudinal bone growth in rats. Am J Physiol 1986; 250: E367E372.
  • 19
    Isaksson OG, Lindahl A, Nilsson A, Isgaard J. Mechanism of the stimulatory effect of growth hormone on longitudinal bone growth. Endocr Rev 1987; 8: 426438.
  • 20
    Ohlsson C, Bengtsson BA, Isaksson OG, Andreassen TT, Slootweg MC. Growth hormone and bone. Endocr Rev 1998; 19: 5579.
  • 21
    Eckstein F, Pavicic T, Nedbal S, et al. Insulin-like growth factor binding protein 2 (IGFBP-2) overexpression negatively regulates bone size and mass, but not density, in the absence and presence of growth hormone/IGF-I excess in transgenic mice. Anat Embryol (Berl) 2002; 206: 139148.
  • 22
    Hoeflich A, Gotz W, Lichanska AM, Bielohuby M, Tonshoff B, Kiepe D. Effects of insulin-like growth factor binding proteins in bone: a matter of cell and site. Arch Physiol Biochem 2007; 113: 142153.
  • 23
    Lee NK, Karsenty G. Reciprocal regulation of bone and energy metabolism. Trends Endocrinol Metab 2008; 19: 161166.
  • 24
    Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284: 143147.
  • 25
    Ziros PG, Basdra EK, Papavassiliou AG. Runx2: of bone and stretch. Int J Biochem Cell Biol 2008; 40: 16591663.
  • 26
    Tominaga H, Maeda S, Hayashi M, et al. CCAAT/enhancer-binding protein beta promotes osteoblast differentiation by enhancing Runx2 activity with ATF4. Mol Biol Cell 2008; 19: 53735386.
  • 27
    National. Research Council. Nutritional Requiremnets of Laboratory Animals. 4th ed. Washington: National Academy of Sciences; 1995.
  • 28
    Hoeflich A, Weber MM, Fisch T, et al. Insulin-like growth factor binding protein 2 (IGFBP-2) separates hypertrophic and hyperplastic effects of growth hormone (GH)/IGF-I excess on adrenocortical cells in vivo. FASEB J 2002; 16: 17211731.
  • 29
    Hunt JR, Hunt CD, Zito CA, Idso JP, Johnson LK. Calcium requirements of growing rats based on bone mass, structure, or biomechanical strength are similar. J Nutr 2008; 138: 14621468.
  • 30
    Williams EA, Perkins SN, Smith NC, Hursting SD, Lane MA. Carbohydrate versus energy restriction: effects on weight loss, body composition and metabolism. Ann Nutr Metab 2007; 51: 232243.
  • 31
    Ward WE, Kim S, Robert Bruce W. A western-style diet reduces bone mass and biomechanical bone strength to a greater extent in male compared with female rats during development. Br J Nutr 2003; 90: 589595.
  • 32
    Salem GJ, Zernicke RF, Barnard RJ. Diet-related changes in mechanical properties of rat vertebrae. Am J Physiol 1992; 262: R318R321.
  • 33
    Smith EE, Ferguson VL, Simske SJ, Gayles EC, Pagliassotti MJ. Effects of high fat or high sucrose diets on rat femora mechanical and compositional properties. Biomed Sci Instrum 2000; 36: 385390.
  • 34
    Karsenty G. Convergence between bone and energy homeostases: leptin regulation of bone mass. Cell Metab 2006; 4: 341348.
  • 35
    Thomas T. The complex effects of leptin on bone metabolism through multiple pathways. Curr Opin Pharmacol 2004; 4: 295300.
  • 36
    Hamrick MW, Della-Fera MA, Choi YH, Pennington C, Hartzell D, Baile CA. Leptin treatment induces loss of bone marrow adipocytes and increases bone formation in leptin-deficient ob/ob mice. J Bone Miner Res 2005; 20: 9941001.
  • 37
    Stevenson AE, Evans BA, Gevers EF, et al. Does adiposity status influence femoral cortical strength in rodent models of growth hormone deficiency? Am J Physiol Endocrinol Metab 2009; 296: E147E156.
  • 38
    Elefteriou F, Takeda S, Ebihara K, et al. Serum leptin level is a regulator of bone mass. Proc Natl Acad Sci USA 2004; 101: 32583263.
  • 39
    Takeda S, Elefteriou F, Levasseur R, et al. Leptin regulates bone formation via the sympathetic nervous system. Cell 2002; 111: 305317.
  • 40
    Martin A, David V, Malaval L, Lafage-Proust MH, Vico L, Thomas T. Opposite effects of leptin on bone metabolism: a dose-dependent balance related to energy intake and insulin-like growth factor I pathway. Endocrinology 2007; 148: 34193425.
  • 41
    Li R, Svenson KL, Donahue LR, Peters LL, Churchill GA. Relationships of dietary fat, body composition, and bone mineral density in inbred mouse strain panels. Physiol Genom 2008; 33: 2632.
  • 42
    Meunier P, Aaron J, Edouard C, Vignon G. Osteoporosis and the replacement of cell populations of the marrow by adipose tissue: a quantitative study of 84 iliac bone biopsies. Clin Orthop Relat Res 1971; 80: 147154.
  • 43
    Burkhardt R, Kettner G, Bohm W, et al. Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: a comparative histomorphometric study. Bone 1987; 8: 157164.
  • 44
    Nuttall ME, Gimble JM. Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis? Bone 2000; 27: 177184.
  • 45
    Scariano JK, Glew RH, Bou-Serhal CE, Clemens JD, Garry PJ, Baumgartner RN. Serum levels of cross-linked N-telopeptides and aminoterminal propeptides of type I collagen indicate low bone mineral density in elderly women. Bone 1998; 23: 471477.
  • 46
    Ziros PG, Georgakopoulos T, Habeos I, Basdra EK, Papavassiliou AG. Growth hormone attenuates the transcriptional activity of Runx2 by facilitating its physical association with Stat3β. J Bone Miner Res 2004; 19: 18921904 .
  • 47
    Celil AB, Campbell PG. BMP-2 and insulin-like growth factor I mediate Osterix (Osx) expression in human mesenchymal stem cells via the MAPK and protein kinase D signaling pathways. J Biol Chem 2005; 280: 3135331359.
  • 48
    Ito S, Suzuki N, Kato S, Takahashi T, Takagi M. Glucocorticoids induce the differentiation of a mesenchymal progenitor cell line, ROB-C26 into adipocytes and osteoblasts, but fail to induce terminal osteoblast differentiation. Bone 2007; 40: 8492.
  • 49
    Kanemaru K, Seya K, Miki I, Motomura S, Furukawa K. Calcification of aortic smooth muscle cells isolated from spontaneously hypertensive rats. J Pharmacol Sci 2008; 106: 280286.
  • 50
    Chen J, Kunos G, Gao B. Ethanol rapidly inhibits IL-6-activated STAT3 and C/EBP mRNA expression in freshly isolated rat hepatocytes. FEBS Lett 1999; 457: 162168.