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Quantitative computed tomographic assessment of the effects of 24 months of teriparatide treatment on 3D femoral neck bone distribution, geometry, and bone strength: Results from the EUROFORS study

  1. Jan Borggrefe1,*,
  2. Christian Graeff1,
  3. Thomas N Nickelsen2,
  4. Fernando Marin2,
  5. Claus C Glüer2

Article first published online: 18 MAR 2010

DOI: 10.1359/jbmr.090820

Issue

Journal of Bone and Mineral Research

Journal of Bone and Mineral Research

Volume 25, Issue 3, pages 472–481, March 2010

Additional Information

How to Cite

Borggrefe, J., Graeff, C., Nickelsen, T. N., Marin, F. and Glüer, C. C. (2010), Quantitative computed tomographic assessment of the effects of 24 months of teriparatide treatment on 3D femoral neck bone distribution, geometry, and bone strength: Results from the EUROFORS study. J Bone Miner Res, 25: 472–481. doi: 10.1359/jbmr.090820

Author Information

  1. 1

    Medizinische Physik, Klinik für Diagnostische Radiologie, Universitätsklinikum Schleswig-Holstein, Kiel, Germany

  2. 2

    Department of Medical Research, Lilly Research Centre, Windlesham, United Kingdom

*Department of Diagnostic Radiology, Michaelisstr. 9, D-24105 Kiel, Germany.

Publication History

  1. Issue published online: 18 MAR 2010
  2. Article first published online: 18 MAR 2010
  3. Accepted manuscript online: 27 JAN 2010 12:00AM EST
  4. Manuscript Accepted: 27 AUG 2009
  5. Manuscript Revised: 13 AUG 2009
  6. Manuscript Received: 5 MAY 2009

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References

  • 1
    Kanis JA, Burlet N, Cooper C, et al. European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int. 2008; 19: 399–428.
  • 2
    Marshall D, Johnell O, Wedel H. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ. 1996; 312: 1254–1259.
  • 3
    Beck TJ, Looker AC, Ruff CB, Sievanen H, Wahner HW. Structural trends in the aging femoral neck and proximal shaft: analysis of the Third National Health and Nutrition Examination Survey dual-energy X-ray absorptiometry data. J Bone Miner Res. 2000; 15: 2297–2304.
    Direct Link:
  • 4
    Uusi-Rasi K, Semanick LM, Zanchetta JR, et al. Effects of teriparatide [rhPTH(1-34)] treatment on structural geometry of the proximal femur in elderly osteoporotic women. Bone. 2005; 36: 948–958.
  • 5
    Beck TJ, Ruff CB, Warden KE, Scott WW Jr, Rao GU. Predicting femoral neck strength from bone mineral data: a structural approach. Invest Radiol. 1990; 25: 6–18.
  • 6
    Beck TJ, Oreskovic TL, Stone KL, et al. Structural adaptation to changing skeletal load in the progression toward hip fragility: the Study of Osteoporotic Fractures. J Bone Miner Res. 2001; 16: 1108–1119.
    Direct Link:
  • 7
    Bolotin HH. DXA in vivo BMD methodology: an erroneous and misleading research and clinical gauge of bone mineral status, bone fragility, and bone remodeling. Bone. 2007; 41: 138–154.
  • 8
    Bouxsein ML, Karasik D. Bone geometry and skeletal fragility. Curr Osteoporos Rep. 2006; 4: 49–56.
  • 9
    Bauer JS, Kohlmann S, Eckstein F, Mueller D, Lochmuller EM, Link TM. Structural analysis of trabecular bone of the proximal femur using multislice computed tomography: a comparison with dual X-ray absorptiometry for predicting biomechanical strength in vitro. Calcif Tissue Int. 2006; 78: 78–89.
  • 10
    Duchemin L, Bousson V, Raossanaly C, et al. Prediction of mechanical properties of cortical bone by quantitative computed tomography. Med Eng Phys. 2008; 30: 321–328.
  • 11
    Graeff C, Timm W, Nickelsen TN, et al. Monitoring teriparatide-associated changes in vertebral microstructure by high-resolution CT in vivo: results from the EUROFORS Study. J Bone Miner Res. 2007; 22: 1426–1433.
    Direct Link:
  • 12
    Obermayer-Pietsch BM, Marin F, McCloskey EV, et al. Effects of two years of daily teriparatide treatment on BMD in postmenopausal women with severe osteoporosis with and without prior antiresorptive treatment. J Bone Miner Res. 2008; 23: 1591–1600.
    Direct Link:
  • 13
    Young W. Elastic stability formulas for stress and strain. In: CrawfordHTS, ed. Roark's Formulas for Stress and Strain. 6th ed. New York: McGraw-Hill, 1989; 688.
  • 14
    Zebaze RM, Jones A, Welsh F, Knackstedt M, Seeman E. Femoral neck shape and the spatial distribution of its mineral mass varies with its size: clinical and biomechanical implications. Bone. 2005; 37: 243–252.
  • 15
    Crabtree N, Loveridge N, Parker M, et al. Intracapsular hip fracture and the region-specific loss of cortical bone: analysis by peripheral quantitative computed tomography. J Bone Miner Res. 2001; 16: 1318–1328.
    Direct Link:
  • 16
    Crabtree N, Lunt M, Holt G, et al. Hip geometry, bone mineral distribution, and bone strength in European men and women: the EPOS Study. Bone. 2000; 27: 151–159.
  • 17
    Kuiper JW, Van Kuijk C, Grashuis JL. Distribution of trabecular and cortical bone related to geometry: a quantitative computed tomography study of the femoral neck. Invest Radiol. 1997; 32: 83–89.
  • 18
    McClung MR, San Martin J, Miller PD, et al. Opposite bone remodeling effects of teriparatide and alendronate in increasing bone mass. Arch Intern Med. 2005; 165: 1762–1768.
  • 19
    Boonen S, Marin F, Obermayer-Pietsch B, et al. Effects of previous antiresorptive therapy on the bone mineral density response to two years of teriparatide treatment in postmenopausal women with osteoporosis. J Clin Endocrinol Metab. 2008; 93: 852–860.
  • 20
    Burr DB. Does early PTH treatment compromise bone strength? The balance between remodeling, porosity, bone mineral, and bone size. Curr Osteoporos Rep. 2005; 3: 19–24.
  • 21
    Lindsay R, Zhou H, Cosman F, Nieves J, Dempster DW, Hodsman AB. Effects of a one-month treatment with PTH(1-34) on bone formation on cancellous, endocortical, and periosteal surfaces of the human ilium. J Bone Miner Res. 2007; 22: 495–502.
    Direct Link:
  • 22
    Jilka RL, O'Brien CA, Ali AA, Roberson PK, Weinstein RS, Manolagas SC. Intermittent PTH stimulates periosteal bone formation by actions on post-mitotic preosteoblasts. Bone. 2009; 44: 275–286.
  • 23
    Zanchetta JR, Bogado CE, Ferretti JL, et al. Effects of teriparatide [recombinant human parathyroid hormone (1-34)] on cortical bone in postmenopausal women with osteoporosis. J Bone Miner Res. 2003; 18: 539–543.
    Direct Link:
  • 24
    Kaptoge S, Dalzell N, Jakes RW, et al. Hip section modulus, a measure of bending resistance, is more strongly related to reported physical activity than BMD. Osteoporos Int. 2003; 14: 941–949.
  • 25
    Kaptoge S, Dalzell N, Loveridge N, Beck TJ, Khaw KT, Reeve J. Effects of gender, anthropometric variables, and aging on the evolution of hip strength in men and women aged over 65. Bone. 2003; 32: 561–570.
  • 26
    Kaptoge S, Jakes RW, Dalzell N, et al. Effects of physical activity on evolution of proximal femur structure in a younger elderly population. Bone. 2007; 40: 506–515.
  • 27
    Szulc P, Delmas PD. Bone loss in elderly men: increased endosteal bone loss and stable periosteal apposition. The prospective MINOS study. Osteoporos Int. 2007; 18: 495–503.
  • 28
    Power J, Loveridge N, Lyon A, Rushton N, Parker M, Reeve J. Osteoclastic cortical erosion as a determinant of subperiosteal osteoblastic bone formation in the femoral neck's response to BMU imbalance: effects of stance-related loading and hip fracture. Osteoporos Int. 2005; 16: 1049–1056.
  • 29
    Power J, Loveridge N, Rushton N, Parker M, Reeve J. Evidence for bone formation on the external “periosteal” surface of the femoral neck: a comparison of intracapsular hip fracture cases and controls. Osteoporos Int. 2003; 14: 141–145.
  • 30
    Burr DB, Hirano T, Turner CH, Hotchkiss C, Brommage R, Hock JM. Intermittently administered human parathyroid hormone (1-34) treatment increases intracortical bone turnover and porosity without reducing bone strength in the humerus of ovariectomized cynomolgus monkeys. J Bone Miner Res. 2001; 16: 157–165.
    Direct Link:
  • 31
    Sato M, Westmore M, Ma YL, et al. Teriparatide [PTH(1-34)] strengthens the proximal femur of ovariectomized nonhuman primates despite increasing porosity. J Bone Miner Res. 2004; 19: 623–629.
    Direct Link:
  • 32
    Mayhew PM, Thomas CD, Clement JG, et al. Relation between age, femoral neck cortical stability, and hip fracture risk. Lancet. 2005; 366: 129–135.
  • 33
    Frost HM, Bone “mass” and the “mechanostat”: a proposal. Anat Rec. 1987; 219: 1–9.
    Direct Link:
  • 34
    Frost HM. The mechanostat: a proposed pathogenic mechanism of osteoporoses and the bone mass effects of mechanical and nonmechanical agents. Bone Miner. 1987; 2: 73–85.
  • 35
    Ettinger B, San Martin J, Crans G, Pavo I. Differential effects of teriparatide on BMD after treatment with raloxifene or alendronate. J Bone Miner Res. 2004; 19: 745–751.
    Direct Link:
  • 36
    Rivadeneira F, Zillikens MC, De Laet CE, et al. Femoral neck BMD is a strong predictor of hip fracture susceptibility in elderly men and women because it detects cortical bone instability: the Rotterdam Study. J Bone Miner Res. 2007; 22: 1781–1790.
    Direct Link:
  • 37
    Lotz JC, Hayes WC. The use of quantitative computed tomography to estimate risk of fracture of the hip from falls. J Bone Joint Surg Am. 1990; 72: 689–700.
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