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Ferritin ferroxidase activity: A potent inhibitor of osteogenesis
Article first published online: 14 DEC 2009
DOI: 10.1359/jbmr.091002
Copyright © 2010 American Society for Bone and Mineral Research
Additional Information
How to Cite
Zarjou, A., Jeney, V., Arosio, P., Poli, M., Zavaczki, E., Balla, G. and Balla, J. (2010), Ferritin ferroxidase activity: A potent inhibitor of osteogenesis. J Bone Miner Res, 25: 164–172. doi: 10.1359/jbmr.091002
Publication History
- Issue published online: 20 JAN 2010
- Article first published online: 14 DEC 2009
- Manuscript Accepted: 9 OCT 2009
- Manuscript Revised: 12 AUG 2009
- Manuscript Received: 30 JAN 2009
References
- 1, , , . Osteoporosis in HFE2 juvenile hemochromatosis: a case report and review of the literature. Osteoporosis Int. 2006; 17: 150–155.
- 2, , , et al. Bone mineral density in men with genetic hemochromatosis and HFE gene mutation. Osteoporosis Int. 2005; 16: 1809–1814.
- 3, , , , . Ascorbic acid deficiency, iron overload and alcohol abuse underlie the severe osteoporosis in black African patients with hip fractures: a bone histomorphometric study. Calcif Tissue Int. 2005; 76: 79–89.
- 4. Iron loading: a risk factor for osteoporosis. Biometals. 2006; 19: 633–635.
- 5, . The ferritins: molecular properties, iron storage function and cellular regulation. Biochim Biophys Acta. 1996; 1275: 161–203.
- 6. Ferritin: structure, gene regulation, and cellular function in animals, plants, and microorganisms. Annu Rev Biochem. 1996; 56: 289–315.
- 7, , . On ferritin heterogeneity: further evidence for heteropolymers. J Biol Chem. 1978; 253: 4451–4458.
- 8, , . Role of H and L subunits in mouse ferritin. J Biol Chem. 1996; 271: 33352–33357.
- 9, , , , , . A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron. Proc Natl Acad Sci USA. 1987; 84: 6730–6734.
- 10, , , et al. Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation. Science. 1988; 240: 924–928.
- 11, , , . Mutuated recombinant human heavy-chain ferritins and myelosuppression in vitro and in vivo: a link between ferritin ferroxidase activity and biological function. Proc Natl Acad Sci USA. 1991; 88: 770–774.
- 12, , , . Reaction paths of iron oxidation and hydrolysis in horse spleen and recombinant human ferritins. Biochemistry. 1998; 37: 9743–9750.
- 13, , , . Oxidative stress modulates osteoblastic differentiation of vascular and bone cells. Free Radicals Biol Med. 2001; 31: 509–519.
- 14
- 15
- 16, , , , , . Concentration of bone elements in osteoporosis. J Bone Miner Res. 1990; 5: 41–47.
- 17, , , , . Does iron affect osteoblast function? Studies in vitro and in patients with chronic liver disease. Calcif Tissue Int. 1991; 48: 373–379.
- 18, , , et al. Spontaneous multiple vertebral fractures revealed primary haemochromatosis. Osteoporosis Int. 1996; 6: 338–340.
- 19, , , et al. Bone and joint involvement in genetic hemochromatosis: role of cirrhosis and iron overload. J Rheumatol. 1997; 24: 1809–1813.
- 20, , , et al. Serum ferritin as a guide for iron stores in chronic hemodialysis patients. Kidney Int. 1984; 26: 451–458.
- 21, , , et al. Effects of iron overload on bone remodeling in pigs. Am J Pathol. 1984; 116: 377–384.
- 22, , , , . Iron lactate–induced osteopenia in male Sprague-Dawley rats. Toxicol Pathol. 2001; 29: 623–629.
- 23, , , et al. Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo. Endocrinology. 2004; 145: 4366–4374.
- 24
- 25, , , , . Green tea catechin enhances osteogenesis in a bone marrow mesenchymal stem cell line. Osteoporosis Int. 2005; 16: 2039–2045.
- 26, , , et al. Normal lumbar bone mineral density in optimally treated children and young adolescents with beta-thalassaemia major. Hormones. 2007; 6: 334–340.
- 27, , , , . The radiological appearances of thalassaemia. Clin Radiol. 2006; 61: 40–52.
- 28, , , . Bone disease in children with homozygous beta-thalassemia. Bone Miner. 1990; 8: 69–86.
- 29, , , , , . Low bone mineral density in adolescents with beta-thalassemia. Ann NY Acad Sci. 2005; 1054: 462–466.Direct Link:
- 30, , , . Deferoxamine-induced bone dysplasia in patients with thalassemia major. AJR, Am J Roentgenol. 1991; 156: 561–565.
- 31, , , et al. Ferritin: a cytoprotective antioxidant strategem of endothelium. J Biol Chem. 1992; 267: 18148–18153.
- 32, , , . Corneal epithelial nuclear ferritin: developmental regulation of ferritin and its nuclear transporter ferritoid. Dev Dyn. 2008; 237: 2529–2541.Direct Link:
- 33, , , , . Characterization of nuclear ferritin and mechanism of translocation. Biochem J. 2005; 388: 731–740.
- 34, , , , . Regulation, mechanisms and proposed function of ferritin translocation to cell nuclei. J Cell Sci. 2002; 5: 2165–2177.
- 35, , , et al. Specific repression of beta-globin promoter activity by nuclear ferritin. Proc Natl Acad Sci USA. 2001; 98: 9145–9150.
- 36, , . Iron(II) and hydrogen peroxide detoxification by human H-chain ferritin: an EPR spin-trapping study. Biochemistry. 2006; 45: 3429–3436.
- 37, . Discovering mechanisms of signaling-mediated cysteine oxidation. Curr Opin Chem Biol. 2008; 12: 18–24.
- 38, , , et al. Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. Arterioscler Thromb Vasc Biol. 1997; 17: 680–687.
- 39, , , et al. Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling. J Biol Chem. 2008; 283: 15319–15327.
- 40, , , et al. Ferritin prevents calcification and osteoblastic differentiation of vascular smooth muscle cells. J Am Soc Nephrol. 2009; 20: 1254–1263.

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