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Dependence of bone yield (volume of bone formed per unit of cement surface area) on resorption cavity size during osteonal remodeling in human rib: implications for osteoblast function and the pathogenesis of age-related bone loss

  1. Shijing Qiu1,*,
  2. D Sudhaker Rao1,
  3. Saroj Palnitkar1,
  4. A Michael Parfitt2

Article first published online: 14 DEC 2009

DOI: 10.1359/jbmr.091003

Issue

Journal of Bone and Mineral Research

Journal of Bone and Mineral Research

Volume 25, Issue 2, pages 423–430, February 2010

Additional Information

How to Cite

Qiu, S., Rao, D. S., Palnitkar, S. and Parfitt, A. M. (2010), Dependence of bone yield (volume of bone formed per unit of cement surface area) on resorption cavity size during osteonal remodeling in human rib: implications for osteoblast function and the pathogenesis of age-related bone loss. J Bone Miner Res, 25: 423–430. doi: 10.1359/jbmr.091003

Author Information

  1. 1

    Bone and Mineral Research Laboratory, Henry Ford Hospital, Detroit, MI, USA

  2. 2

    Division of Endocrinology and Center for Osteoporosis and Metabolic Bone Disease, University of Arkansas for Medical Sciences, Little Rock, AR, USA

*Bone and Mineral Research Laboratory, E&R Building 7071, Henry Ford Hospital, 2799 W Grand Blvd., Detroit, MI 48202, USA.

Publication History

  1. Issue published online: 19 FEB 2010
  2. Article first published online: 14 DEC 2009
  3. Manuscript Accepted: 9 OCT 2009
  4. Manuscript Revised: 16 JUN 2009
  5. Manuscript Received: 17 MAR 2009

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References

  • 1
    Parfitt AM. Osteoporosis: 50 years of change, mostly in the right direction. In: CompstonJ, RalstonSH, eds. Osteoporosis and Bone Biology: The State of the Art. London: International Medical Press, 2000; 1–13.
  • 2
    Perzigian AJ. Osteoporotic bone loss in two prehistoric Indian populations. Am J Phys Anthropol. 1973; 39: 87–95.
  • 3
    Parfitt AM. Bone “densitometry”: so easy to order, so difficult to interpret. 3rd Congress of Nephrology in Internet, 2003. Available at www.uninet.edu/cin2003/conf/parfitt.html.
  • 4
    Frost HM. The Bone Dynamics in Osteoporosis and Osteomalacia. Springfield, IL: CC Thomas, 1966.
  • 5
    Parfitt AM. Surface specific bone remodeling in health and disease. In: KleerekoperM, KraneSM, eds. Clinical Disorders of Bone and Mineral Metabolism. New York: Mary Ann Liebert Publishers, 1989; 7–14.
  • 6
    Parfitt AM. New concepts of bone remodeling: a unified spatial and temporal model with physiological and pathophysiologic implications. In: AgarwalSC, StoutSD, eds. Bone Loss and Osteoporosis: An Anthropological Perspective. New York: Kluwer Academic/Plenum Publishers, 2003; 3–17.
  • 7
    Heaney RP. The bone-remodeling transient: implications for the interpretation of clinical studies of bone mass change. J Bone Miner Res. 1994; 9: 1515–1523.
  • 8
    Han ZH, Palnitkar S, Rao DS, Nelson D, Parfitt AM. Effects of ethnicity and age or menopause on the remodeling and turnover of iliac bone: implications for mechanisms of bone loss. J Bone Miner Res. 1997; 12: 498–508.
  • 9
    Parfitt AM, Mundy GR, Roodman GD, Hughes DE, Boyce BF. A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates. J Bone Miner Res. 1996; 11: 150–159.
  • 10
    Han ZH, Palnitkar S, Rao DS, Nelson D, Parfitt AM. Effect of ethnicity and age or menopause on the structure and geometry of iliac bone. J Bone Miner Res. 1996; 11: 1967–1675.
  • 11
    Wu K, Schubeck KE, Frost HM, Villanueva A. Haversian bone formation rates determined by a new method in a mastodon, and in human diabetes mellitus and osteoporosis. Calcif Tissue Res. 1970; 6: 204–219.
  • 12
    Brockstedt H, Kassem M, Eriksen EF, Mosekilde L, Melsen F. Age- and sex-related changes in iliac cortical bone mass and remodeling. Bone. 1993; 14: 681–691.
  • 13
    Jowsey J. Age changes in human bone. Clin Orthop. 1960; 17: 210–218.
  • 14
    Jowsey J. Studies of haversian systems in man and some animals. J Anat. 1966; 100: 857–864.
  • 15
    Landeros O, Frost HM. The cross section size of the osteon. Henry Ford Hosp Med Bull. 1964; 12: 517–525.
  • 16
    Parfitt AM. The stereologic basis of bone histomorphometry: theory of quantitative microscopy and reconstruction of the 3rd dimension. In: ReckerR, ed. Bone Histomorphometry: Techniques and Interpretations. Boca Raton, FL: CRC Press, 1983; 53–87.
  • 17
    Parfitt AM. Bone-forming cells in clinical conditions. In: HallBK, ed. Bone, Vol. 1: Osteoblast and Osteocyte. Calwell, NJ: Telford Press, 1990; 351–429.
  • 18
    Jones SJ. Secretory territories and rate of matrix production of osteoblasts. Calcif Tissue Res. 1974; 14: 309–315.
  • 19
    Qiu S, Fyhrie DP, Palnitkar S, Rao DS. Histomorphometric assessment of haversian canal and osteocyte lacunae in different-sized osteons in human rib. Anat Rec. 2003; 272A: 520–525.
  • 20
    Frost HM. Tetracycline bone labeling in anatomy. Am J Phys Anthropol. 1968; 29: 183–195.
  • 21
    Frost HM. Presence of microscopic cracks in vivo in bone. Bull Henry Ford Hosp. 1960; 8: 25–35.
  • 22
    Oldham PD. A note on the analysis of repeated measurements of the same subjects. J Chronic Dis. 1962; 15: 969–977.
  • 23
    Cohen-Solal ME, Shih MS, Lundy MW, Parfitt AM. A new method for measuring cancellous bone erosion depth: application to the cellular mechanisms of bone loss in postmenopausal osteoporosis. J Bone Miner Res. 1991; 6: 1331–1338.
  • 24
    Croucher PI, Garrahan NJ, Mellish RW, Compston JE. Age-related changes in resorption cavity characteristics in human trabecular bone. Osteoporos Int. 1991; 1: 257–261.
  • 25
    Hert J, Fiala P, Petrtyl M. Osteon orientation of the diaphysis of the long bones in man. Bone. 1994; 15: 269–277.
  • 26
    Marotti G. Decrement in volume of osteoblast during osteon formation and its effect on the size of the corresponding osteocytes. In: MeunierPJ, ed. Bone Histomorphometry: Second International Workshop. Paris: Armour Montague, 1977; 299–310.
  • 27
    Schen S, Villanueva AR, Frost HM. Number of osteoblasts per unit area of osteoid seam in cortical human bone. Can J Physiol Pharmacol. 1965; 43: 319–325.
  • 28
    Dempster DW, Zhou H. New concepts in bone remodeling. In: SeibelMJ, RobinsSP, BilezikianJP, eds. Dynamics of Bone and Cartelage Metabolism: Principles and Clinical Applications 2nd ed. New York: Academic Press, 2006; 377–389.
  • 29
    Hulley P, Russell G, Croucher P. Growth factors. In: SeibelMJ, RobinsSP, BilezikianJP, eds. Dynamics of Bone and Cartilage Metabolism 2nd ed. New York: Academic Press, 2006; 99–113.
  • 30
    Pivonka P, Zimak J, Smith DW, et al. Model structure and control of bone remodeling: a theoretical study. Bone. 2006; 43: 249–263.
  • 31
    Parfitt AM. Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone. J Cell Biochem. 1994; 55: 273–286.
  • 32
    Parfitt AM. The mechanism of coupling: a role for the vasculature. Bone. 2000; 26: 319–323.
  • 33
    Parfitt AM. The bone remodeling compartment: a circulatory function for bone lining cells. J Bone Miner Res. 2001; 16: 1583–1585.
  • 34
    Parfitt AM. Misconceptions V: activation of osteoclasts is the first step in the bone remodeling cycle. Bone. 2006; 39. 1170–1172.
  • 35
    Zhao C, Irie N, Takada Y, et al. Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell Metab. 2006; 4: 111–121.
  • 36
    Bonewald LF. Osteocytes as dynamic multifunctional cells. Ann NY Acad Sci. 2007; 1116: 281–290.
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