Original Article
You have full text access to this OnlineOpen article
Bone turnover markers and prediction of fracture: A prospective follow-up study of 1040 elderly women for a mean of 9 years
Article first published online: 18 DEC 2009
DOI: 10.1359/jbmr.091006
Copyright © 2010 American Society for Bone and Mineral Research
Additional Information
How to Cite
Ivaska, K. K., Gerdhem, P., Väänänen, H. K., Åkesson, K. and Obrant, K. J. (2010), Bone turnover markers and prediction of fracture: A prospective follow-up study of 1040 elderly women for a mean of 9 years. J Bone Miner Res, 25: 393–403. doi: 10.1359/jbmr.091006
Publication History
- Issue published online: 19 FEB 2010
- Article first published online: 18 DEC 2009
- Manuscript Accepted: 9 OCT 2009
- Manuscript Revised: 17 AUG 2009
- Manuscript Received: 17 MAY 2009
References
- 1Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med. 1993; 94: 646–650.
- 2NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. JAMA. 2001; 285: 785–795.
- 3, . Epidemiology and outcomes of osteoporotic fractures. Lancet. 2002; 359: 1761–1767.
- 4Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: report of a WHO Study Group. WHO Tech Rep Ser 1994; 843: 1–129.
- 5, , . Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ. 1996; 312: 1254–1259.
- 6, , , et al. Predictive value of BMD for hip and other fractures. J Bone Miner Res. 2005; 20: 1185–1194.
- 7, , , et al. Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone. 2004; 34: 195–202.
- 8, , , et al. Hip fracture in women without osteoporosis. J Clin Endocrinol Metab. 2005; 90: 2787–2793.
- 9, , , et al. Half the burden of fragility fractures in the community occur in women without osteoporosis: when is fracture prevention cost-effective? Bone. 2006; 38: 694–700.
- 10, , , et al. The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int. 2007; 18: 1033–1046.
- 11, , , , . FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int. 2008; 19: 385–397.
- 12. Markers of bone turnover for the prediction of fracture risk. Osteoporos Int. 2000; 11: S55–S65.
- 13, , , et al. Biochemical markers of bone metabolism and prediction of fracture in elderly women. J Bone Miner Res. 2004; 19: 386–393.
- 14, , , et al. Markers of bone resorption predict hip fracture in elderly women: the EPIDOS Prospective Study. J Bone Miner Res. 1996; 11: 1531–1538.
- 15, , , et al. Interest of biochemical markers of bone turnover for long-term prediction of new vertebral fracture in postmenopausal osteoporotic women. Maturitas. 2003; 44: 259–265.
- 16, , , , , . Potential for bone turnover markers to cost-effectively identify and select post-menopausal osteopenic women at high risk of fracture for bisphosphonate therapy. Osteoporos Int. 2007; 18: 201–210.
- 17, , , , . Identification of osteopenic women at high risk of fracture: the OFELY study. J Bone Miner Res. 2005; 20: 1813–1819.
- 18. Biomarkers for osteoporosis management: utility in diagnosis, fracture risk prediction and therapy monitoring. Mol Diagn Ther. 2008; 12: 157–170.
- 19, , , et al. Development and evaluation of three immunofluorometric assays that measure different forms of osteocalcin in serum. Clin Chem. 2000; 46: 332–337.
- 20, , , , , . Urinary osteocalcin as a marker of bone metabolism. Clin Chem. 2005; 51: 618–628.
- 21, . Rates of fracture in participants and non-participants in the Osteoporosis Prospective Risk Assessment study. J Bone Joint Surg Br. 2007; 89: 1627–1631.
- 22, , , , . Relative contributions of bone density, bone turnover, and clinical risk factors to long-term fracture prediction. J Bone Miner Res. 2003; 18: 312–318.
- 23, . Preanalytical variability of biochemical markers of bone turnover. Osteoporos Int. 2000; 11: S30–S44.
- 24, , , , , . Serial assessment of serum bone metabolism markers identifies women with the highest rate of bone loss and osteoporosis risk. J Clin Endocrinol Metab. 2008; 93: 2622–2632.
- 25, , , . Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: the OFELY study. J Bone Miner Res. 2000; 15: 1526–1536.
- 26, , , et al. Hip and nonvertebral fracture prediction in nursing home patients: role of bone ultrasound and bone marker measurements. J Clin Endocrinol Metab. 2007; 92: 1678–1686.
- 27, , , et al. Biochemical markers of bone turnover predict bone loss in perimenopausal women but not in postmenopausal women: the Japanese Population-based Osteoporosis (JPOS) Cohort Study. Osteoporos Int. 2006; 17: 1086–1095.
- 28, , , , . Does follow-up duration influence the ultrasound and DXA prediction of hip fracture? The EPIDOS prospective study. Bone. 2004; 35: 357–363.
- 29, , , , . Fall severity and bone mineral density as risk factors for hip fracture in ambulatory elderly. JAMA. 1994; 271: 128–133.
- 30, , , , , . Effect of feeding on bone turnover markers and its impact on biological variability of measurements. Bone. 2002; 30: 886–890.

1523-4681/asset/olbannerleft.gif?v=1&s=d7e4c0e37904a489128d3a4e58ba94214db307a9)
1523-4681/asset/olbannerright.gif?v=1&s=854ee0e4d351ead9faaca8bfab3e50b1c7c9d03d)
