Original Article

You have full text access to this OnlineOpen article

Age-dependence of femoral strength in white women and men

  1. Tony M Keaveny1,2,*,
  2. David L Kopperdahl2,
  3. L Joseph Melton III3,5,
  4. Paul F Hoffmann2,
  5. Shreyasee Amin3,4,
  6. B Lawrence Riggs5,
  7. Sundeep Khosla5

Article first published online: 14 DEC 2009

DOI: 10.1359/jbmr.091033

Issue

Journal of Bone and Mineral Research

Journal of Bone and Mineral Research

Volume 25, Issue 5, pages 994–1001, May 2010

Additional Information

How to Cite

Keaveny, T. M., Kopperdahl, D. L., Melton, L. J., Hoffmann, P. F., Amin, S., Riggs, B. L. and Khosla, S. (2010), Age-dependence of femoral strength in white women and men. J Bone Miner Res, 25: 994–1001. doi: 10.1359/jbmr.091033

Author Information

  1. 1

    Departments of Mechanical Engineering and Bioengineering, University of California–Berkeley, Berkeley, CA, USA

  2. 2

    O. N. Diagnostics, Berkeley, CA, USA

  3. 3

    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN, USA

  4. 4

    Division of Rheumatology, Department of Internal Medicine, College of Medicine, Mayo Clinic, Rochester, MN, USA

  5. 5

    Division of Endocrinology, Department of Internal Medicine, College of Medicine, Mayo Clinic, Rochester, MN, USA

*6175 Etcheverry Hall, MC 1740, University of California, Berkeley, CA 94720-1740, USA.

Publication History

  1. Issue published online: 30 APR 2010
  2. Article first published online: 14 DEC 2009
  3. Accepted manuscript online: 27 JAN 2010 12:00AM EST
  4. Manuscript Accepted: 22 OCT 2009
  5. Manuscript Revised: 5 OCT 2009
  6. Manuscript Received: 31 JUL 2009

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (365K)

References

  • 1
    U.S. Department of Health and Human Services. Bone Health and Osteoporosis: A Report of the Surgeon General. Rockville, MD: USDHH; 2004.
  • 2
    Cummings SR, Bates D, Black DM. Clinical use of bone densitometry: scientific review. JAMA. 2002; 288: 1889–1897.
  • 3
    Kanis JA. Diagnosis of osteoporosis and assessment of fracture risk. Lancet. 2002; 359: 1929–1936 .
  • 4
    Cranney A, Jamal SA, Tsang JF, Josse RG, Leslie WD. Low bone mineral density and fracture burden in postmenopausal women. Can Med Assoc J. 2007; 177: 575–580.
  • 5
    Pasco JA, Seeman E, Henry MJ, Nicholson GC, Kotowicz MA. The population burden of fractures originates in women with osteopenia, not osteoporosis. Osteoporos Int. 2006; 17: 1404–1409.
  • 6
    Stone KL, Seeley DG, Lui LY, et al. BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic Fractures. J Bone Miner Res. 2003; 18: 1947–1954.
    Direct Link:
  • 7
    Wainwright SA, Marshall LM, Ensrud KE, et al. Hip fracture in women without osteoporosis. J Clin Endocrinol Metab. 2005; 90: 2787–2793.
  • 8
    Seeman E, Delmas PD. Bone quality: the material and structural basis of bone strength and fragility. N Engl J Med. 2006; 354: 2250–2261.
  • 9
    Kleerekoper M. Osteoporosis prevention and therapy: preserving and building strength through bone quality. Osteoporos Int. 2006; 17: 1707–1715.
  • 10
    Keyak JH. Improved prediction of proximal femoral fracture load using nonlinear finite element models. Med Eng Phys. 2001; 23: 165–173.
  • 11
    Cody DD, Gross GJ, Hou FJ, Spencer HJ, Goldstein SA, Fyhrie DP. Femoral strength is better predicted by finite element models than QCT and DXA. J Biomech. 1999; 32: 1013–1020.
  • 12
    Roberts BJ, Kopperdahl DL, Thrall E, Muller JA, Keaveny TM, Bouxsein ML. Prediction of femoral strength in a sideways fall configuration using QCT-based finite element analysis. Bone. 2009; 44: S72.
  • 13
    Lian KC, Lang TF, Keyak JH, et al. Differences in hip quantitative computed tomography (QCT) measurements of bone mineral density and bone strength between glucocorticoid-treated and glucocorticoid-naive postmenopausal women. Osteoporos Int. 2005; 16: 642–650.
  • 14
    Keaveny TM, Bouxsein ML. Theoretical implications of the biomechanical fracture threshold. J Bone Miner Res. 2008; 23: 1541–1547.
    Direct Link:
  • 15
    Keaveny TM, Hoffmann PF, Singh M, et al. Femoral bone strength and its relation to cortical and trabecular changes after treatment with PTH, alendronate, and their combination as assessed by finite element analysis of quantitative CT scans. J Bone Miner Res. 2008; 23: 1974–1982.
    Direct Link:
  • 16
    Lewiecki EM, Keaveny TM, Kopperdahl DL, et al. Once-monthly oral ibandronate improves biomechanical determinants of bone strength in women with postmenopausal osteoporosis. J Clin Endocrinol Metab. 2009; 94: 171–180.
  • 17
    Orwoll ES, Marshall LM, Nielson CM, et al. Finite element analysis of the proximal femur and hip fracture risk in older men. J Bone Miner Res. 2009; 24: 475–483.
    Direct Link:
  • 18
    Riggs BL, Melton LJ III, Robb RA, et al. Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites. J Bone Miner Res. 2004; 19: 1945–1954.
    Direct Link:
  • 19
    Melton LJ III. History of the Rochester Epidemiology Project. Mayo Clin Proc. 1996; 71: 266–274.
  • 20
    Morgan EF, Keaveny TM. Dependence of yield strain of human trabecular bone on anatomic site. J Biomech. 2001; 34: 569–577.
  • 21
    Morgan EF, Bayraktar HH, Keaveny TM. Trabecular bone modulus-density relationships depend on anatomic site. J Biomech. 2003; 36: 897–904.
  • 22
    Bayraktar HH, Morgan EF, Niebur GL, Morris GE, Wong EK, Keaveny TM. Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue. J Biomech. 2004; 37: 27–35.
  • 23
    Kanis JA, McCloskey EV, Johansson H, Oden A, Melton LJ III, Khaltaev N. A reference standard for the description of osteoporosis. Bone. 2008; 42: 467–475.
  • 24
    Bonnick SL. Bone Densitometry in Clinical Practice 2nd ed. Totowa, NJ: Humana Press, 2004.
  • 25
    Looker AC, Wahner HW, Dunn WL, et al. Updated data on proximal femur bone mineral levels of US adults. Osteoporos Int. 1998; 8: 468–489.
  • 26
    Bousson V, Le Bras A, Roqueplan F, et al. Volumetric quantitative computed tomography of the proximal femur: relationships linking geometric and densitometric variables to bone strength. Role for compact bone. Osteoporos Int. 2006; 17: 855–864.
  • 27
    Hayes WC, Myers ER, Morris JN, Gerhart TN, Yett HS, Lipsitz LA. Impact near the hip dominates fracture risk in elderly nursing home residents who fall. Calcif Tissue Int. 1993; 52: 192–198.
  • 28
    Nevitt MC, Cummings SR. Type of fall and risk of hip and wrist fractures: the study of osteoporotic fractures. The Study of Osteoporotic Fractures Research Group. J Am Geriatr Soc. 1993; 41: 1226–1234.
  • 29
    De Laet CE, van Hout BA, Burger H, Hofman A, Pols HA. Bone density and risk of hip fracture in men and women: cross sectional analysis. BMJ. 1997; 315: 221–225.
  • 30
    Looker AC, Orwoll ES, Johnston CC Jr, et al. Prevalence of low femoral bone density in older U.S. adults from NHANES III. J Bone Miner Res. 1997; 12: 1761–1768.
    Direct Link:
  • 31
    Melton LJ III, Atkinson EJ, O'Connor MK, O'Fallon WM, Riggs BL. Bone density and fracture risk in men. J Bone Miner Res. 1998; 13: 1915–1923.
    Direct Link:
  • 32
    Melton LJ III, Khosla S, Atkinson EJ, O'Connor MK, O'Fallon WM, Riggs BL. Cross-sectional versus longitudinal evaluation of bone loss in men and women. Osteoporos Int. 2000; 11: 592–599.
  • 33
    Riggs BL, Melton LJ, Robb RA, et al. A population-based assessment of rates of bone loss at multiple skeletal sites: Evidence for substantial trabecular bone loss in young adult women and men. J Bone Miner Res. 2008; 23: 205–214.
    Direct Link:
  • 34
    Lewiecki EM, Miller PD, McClung MR, et al. Two-year treatment with denosumab (AMG 162) in a randomized phase 2 study of postmenopausal women with low BMD. J Bone Miner Res. 2007; 22: 1832–1841.
    Direct Link:
  • 35
    Pols HA, Felsenberg D, Hanley DA, et al. Multinational, placebo-controlled, randomized trial of the effects of alendronate on bone density and fracture risk in postmenopausal women with low bone mass: results of the FOSIT study. Fosamax International Trial Study Group. Osteoporos Int. 1999; 9: 461–468.
  • 36
    Keaveny TM, Pinilla TP, Crawford RP, Kopperdahl DL, Lou A. Systematic and random errors in compression testing of trabecular bone. J Orthop Res. 1997; 15: 101–110.
    Direct Link:
  • 37
    Li W, Kornak J, Harris T, et al. Identify fracture-critical regions inside the proximal femur using statistical parametric mapping. Bone. 2009; 44: 596–602.
  • 38
    Marshall LM, Lang TF, Lambert LC, Zmuda JM, Ensrud KE, Orwoll ES. Dimensions and volumetric BMD of the proximal femur and their relation to age among older U.S. men. J Bone Miner Res. 2006; 21: 1197–1206.
    Direct Link:
  • 39
    Melton LJ III, Marquez MA. Opportunities in population-specific osteoporosis research and management. Osteoporos Int. 2008; 19: 1679–1681.
  • 40
    Hernandez CJ, Keaveny TM. A biomechanical perspective on bone quality. Bone. 2006; 39: 1173–1181.
  • 41
    Kanis JA, Johnell O, Oden A, et al. The use of multiple sites for the diagnosis of osteoporosis. Osteoporos Int. 2006; 17: 527–534.
  • 42
    Kanis JA, Oden A, Johnell O, et al. The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int. 2007; 18: 1033–1046.
View Full Article (HTML) Get PDF (365K)