• 1
    Moncada S, Higgs A 1993 The L-Arginine nitric oxide pathway N Engl J Med 329:20022012.
  • 2
    Nathan C 1992 Nitric oxide as a secretory product of mammalian cells FASEB J 6:30513064.
  • 3
    Zhang X, Laubach VE, Alley EW, Edwards KA, Sherman PA, Russell SW, Murphy WJ 1996 Transcriptional basis for hyporesponsiveness of the human inducible nitric oxide synthase gene to lipopolysaccharide/interferon-gamma J Leukocyte Biol 59:575585.
  • 4
    Grabowski PS, Wright PK, Van't Hof RJ, Helfrich MH, Ohshima H, Ralston SH 1997 Immunolocalization of inducible nitric oxide synthase in synovium and cartilage in rheumatoid arthritis and osteoarthritis Br J Rheumatol 37:15.
  • 5
    Wei X, Charles IG, Smith A, Ure J, Feng G, Huang F, Xu D, Muller W, Moncada S, Liew FY 1995 Altered immune responses in mice lacking inducible nitric oxide synthase Nature 375:408411.
  • 6
    Ralston SH, Todd D, Helfrich MH, Benjamin N, Grabowski P 1994 Human osteoblast-like cells produce nitric oxide and express inducible nitric oxide synthase Endocrinology 135:330336.
  • 7
    Ralston SH, Ho LP, Helfrich MH, Grabowski PS, Johnston PW, Benjamin N 1995 Nitric oxide: A cytokine-induced regulator of bone resorption J Bone Miner Res 10:10401049.
  • 8
    Löwik CWGM, Nibbering PH, Van der Ruit M, Papapoulos SE 1994 Inducible production of nitric oxide in osteoblast like cells and in fetal bone explants is associated with supression of osteoclastic bone resorption J Clin Invest 93:14651472.
  • 9
    Klein-Nulend J, Semeins CM, Ajubi NE, Nijweide PJ, Burger EH 1995 Pulsating fluid flow increases nitric oxide (NO) synthesis by osteocytes but not periosteal fibroblasts—Correlation with prostaglandin upregulation Biochem Biophys Res Commun 217:640648.
  • 10
    Pitsillides AA, Rawlinson SC, Suswillo RF, Bourrin S, Zaman G, Lanyon LE 1995 Mechanical strain-induced NO production by bone cells: A possible role in adaptive bone (re)modeling? FASEB J 9:16141622.
  • 11
    Riancho JA, Salas E, Zarrabeitia MT, Olmos JM, Amado JA, Fernandez-Luna JL, Gonzalez-Macias J 1995 Expression and functional role of nitric oxide synthase in osteoblast-like cells J Bone Miner Res 10:439446.
  • 12
    Hukkanen M, Hughes FJ, Lee D, Buttery K, Gross SS, Evans TJ, Seddon S, Riveros-Moreno V, MacIntrye I, Polak JM 1995 Cytokine stimulated expression of inducible nitric oxide synthase by mouse, rat and human osteoblast-like cells and its functional role in osteoblast metabolic activity Endocrinology 136:54455453.
  • 13
    Ralston SH, Todd D, Helfrich M, Benjamin N, Grabowski PS 1994 Human osteoblast-like cells produce nitric oxide and express inducible nitric oxide synthase Endocrinology 135:330336.
  • 14
    Brandi ML, Hukkanen M, Umeda T, Moradi-Bidhendi N, Bianchi S, Gross SS, Polak JM, MacIntyre I 1995 Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms Proc Natl Acad Sci USA 92:29542958.
  • 15
    McSheehy PMJ, Chambers TJ 1986 Osteoblasts mediate interleukin-1 responsiveness of bone resorption by rat osteoclasts J Exp Med 164:104112.
  • 16
    Pollock JS, Nakane M, Buttery LDK, Martinez A, Springall D, Polak JM, Forstermann U, Murad F 1993 Characterization and localization of endothelial nitric oxide synthase using specific monoclonal antibodies Am J Physiol 265:C1379C1387.
  • 17
    Ohshima H, Brouet IM, Bandaletova T, Adachi H, Oguchi S, Iida S, Kurashima Y, Morishita Y, Sugimura T, Esumi H 1992 Polyclonal antibody against an inducible form of nitric oxide synthase purified from the liver of rats treated with Propionibacterium acnes and lipopolysaccharide Biochem Biophys Res Commun 187:12911297.
  • 18
    Bandaletova T, Brouet I, Bartsch H, Sugimura T, Esumi H, Ohshima H 1996 Immunohistochemical localization of an inducible form of nitric oxide synthase in various organs of rats treated with Propionibacterium acnes and lipopolysaccharide APMIS 101:330336.
  • 19
    Dijkstra CD, Dopp EA, Joling P, Kraal G 1985 The heterogenity of mononuclear phagocytes in lymphoid tissue: Distinct macrophage subpopulations in the rat recognized by mononuclear antibodies ED1, ED2 and ED3 Immunology 54:589.
  • 20
    Helfrich MH, Nesbitt SA, Horton MA 1992 Integrins on rat osteoclasts: Characterization of two monoclonal antibodies (F4 and F11) to rat β3 J Bone Miner Res 7:345351.
  • 21
    Hope BT, Vincent SR 1989 Histochemical characterisation of neuronal NADPH diaphorase J Histochem Cytochem 37:653661.
  • 22
    Schmidt HHW, Gagne GD, Nakane M, Pollock JS, Miller MF, Murad F 1992 Mapping of neural nitric oxide synthase in the rat suggests frequent co-localisation with HADPH diphorase but not with soluble guanylate cyclase and novel paraneural functions for signal transduction J Histochem Cytochem 40:14391456.
  • 23
    Ralston SH 1994 Analysis of gene expression in human bone biopsies by polymerase chain reaction: Evidence for enhanced cytokine expression in Postmenopausal osteoporosis J Bone Miner Res 9:883890.
  • 24
    Kasten TP, Collin-Osdoby P, Patel N, Osdoby P, Krukowski M, Misko TP, Settle SL, Currie MG, Nickols GA 1994 Potentiation of osteoclast bone resorbing activity by inhibition of nitric oxide synthase Proc Natl Acad Sci USA 91:35693573.
  • 25
    Knowles RG, Palacios M, Palmer RM, Moncada S 1989 Formation of nitric oxide from L-arginine in the central nervous system: A transduction mechanism for stimulation of the soluble guanylate cyclase Proc Natl Acad Sci USA 86:51595162.
  • 26
    Steinbeck MJ, Appel WH, Verhoeven AJ, Karnovsky MJ 1994 NADPH-oxidase expression and in situ production of superoxide by osteoclasts actively resorbing bone J Cell Biol 126:765772.
  • 27
    Dodds RA, Bradbeer JN, Pitsillides AA, Gowen M 1994 Activation of nitric oxide synthase or NADPH oxidase in osteoclasts at resorption sites Bone Miner 25:S42.
  • 28
    Evans DE, Ralston SH 1996 Nitric oxide and bone J Bone Miner Res 11:300305.
  • 29
    Stratman NC, Fici GJ, Sethy VH 1996 U-19451A: A selective inducible nitric oxide synthase inhibitor Life Sci 59:945951.
  • 30
    Wimalawansa SJ, DeMarco G, Gangula P, Yallampalli C 1996 Nitric Oxide donor alleviates ovariectomy induced bone loss Bone 18:301304.