• 1
    Suda T, Takahashi N, Martin JT 1992 Modulation of osteoclast differentiation Endocr Rev 13:6680.
  • 2
    Roodman DG 1996 Advances in bone biology: the osteoclast Endocr Rev 17:308332.
  • 3
    Baron R, Neff L, Tran Van P, Nefussi JR, Vignery A 1986 Kinetic and cytochemical identification of osteoclast precursors and their differentiation into multinucleated osteoclasts Am J Pathol 122:363378.
  • 4
    Burger EH, Van der Meer JW, van de Gevel JS, Gribnau JC, Thesingh GW, van Furth R 1982 In vitro formation of osteoclasts from long-term cultures of bone marrow mononuclear phagocytes J Exp Med 156:16041614.
  • 5
    Lucht U 1971 Acid phosphatase of osteoclasts demonstrated by electron microscopic histochemistry Histochemie 28:103117.
  • 6
    Ikegame M, Rakopoulos M, Zhou H, Houssami S, Martin TJ, Moseley JM, Findlay DM 1995 Calcitonin receptor isoforms in mouse and rat osteoclasts J Bone Miner Res 10:5965.
  • 7
    Okada Y, Naka K, Kawamura K, Matsumoto T, Nakanishi I, Fujimoto N, Sato H, Seiki M 1995 Localization of matrix metalloproteinase 9 (92-kilodalton gelatinase/type IV collagenase = gelatinase B) in osteoclasts: Implications for bone resorption Lab Invest 72:311322.
  • 8
    Horton MA, Lewis D, McNulty K, Pringle JA, Chambers TJ 1985 Monoclonal antibodies to osteoclastomas (giant cell bone tumors): Definition of osteoclast-specific cellular antigens Cancer Res 45:56635669.
  • 9
    Udagawa N, Takahashi N, Akatsu T, Sasaki T, Yamaguchi A, Kodama H, Martin TJ, Suda T 1989 The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells Endocrinology 125:18051813.
  • 10
    Takahashi N, Akatsu T, Udagawa N, Sasaki T, Yamaguchi A, Moseley JM, Martin TJ, Suda T 1988 Osteoblastic cells are involved in osteoclast formation Endocrinology 123:26002602.
  • 11
    Takahashi S, Reddy SV, Dallas M, Devlin R, Chou JY, Roodman GD 1995 Development and characterization of a human marrow stromal cell line that enhances osteoclast-like cell formation Endocrinology 136:14411449.
  • 12
    Kurihara N, Chenu C, Miller M, Civin C, Roodman GD 1990 Identification of committed mononuclear precursors for osteoclast-like cells formed in long term human marrow cultures Endocrinology 126:27332741.
  • 13
    Matayoshi A, Brown C, DiPersio JF, Haug J, Abu-Amer Y, Liapis H, Kuestner R, Pacifici R 1996 Human blood-mobilized hematopoietic precursors differentiate into osteoclasts in the absence of stromal cells Proc Natl Acad Sci USA 93:1078510790.
  • 14
    Yoshida H, Hayashi S, Kunisada T, Ogawa M, Nishikawa S, Okumura H, Sudo T, Schultz LD, Nishikawa Z 1990 The murine mutation osteopetrosis is in the coding region of the macrophage colony-stimulating factor gene Nature 345:442444.
  • 15
    Grigoriadis AE, Wang ZQ, Cecchini MG, Hofstetter W, Felix R, Fleisch HA, Wagner EF 1994 c-Fos: A key regulator of osteoclast-macrophage lineage determination and bone remodeling Science 266:443448.
  • 16
    Lesley J, Hyman R, Kincade PW 1993 CD44 and its interactions with the extracellular matrix Adv Immunol 54:271335.
  • 17
    Herrlich P, Zoller M, Pals ST, Ponta H 1993 CD44 splice variants: metastases meets lymphocytes Immunol Today 14:395399.
  • 18
    Knudson CB, Knudson W 1993 Hyaluronan-binding protein in development, tissue homeostasis, and disease FASEB J 7:12331241.
  • 19
    Goldstein LA, Zhou DF, Picker LJ, Minty CN, Bargatze RF, Ding JF, Butcher EC 1989 A human lymphocyte homing receptor, the hermes antigen, is related to cartilage proteoglycan core and link proteins Cell 56:10631072.
  • 20
    Jalkanen ST, Bargatze RF, Herron LR, Butcher EC 1986 A lymphoid cell surface glycoprotein involved in endothelial cell recognition and lymphocyte homing in man Eur J Immunol 16:11951202.
  • 21
    Miyake K, Medina KL, Hayashi S, Ono S, Hamaoka T, Kincade PW 1990 Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long-term bone marrow cultures J Exp Med 171:477488.
  • 22
    Birch M, Mitchell S, Hart IR 1991 Isolation and characterization of human melanoma cell variants expressing high and low levels of CD44 Cancer Res 51:66606667.
  • 23
    Arch R, Wirth K, Hofmann M, Ponta H, Matzku S, Herrlich P, Zoller M 1992 Participation in normal immune responses of a metastasis-inducing splice variant of CD44 Science 257:682685.
  • 24
    Tolg C, Hofmann M, Herrlich P, Ponta H 1993 Splicing choice from ten variant exons establishes CD44 variability Nucl Acids Res 21:12251229.
  • 25
    Screaton GR, Bell MV, Jackson DG, Cornelis FB, Gerth U, Bell JI 1992 Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons Proc Natl Acad Sci USA 89:1216012164.
  • 26
    Stamenkovic I, Amiot M, Pesando JM, Seed B 1989 A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family Cell 56:10571062.
  • 27
    Aruffo A, Stamenkovic I, Melnick M, Underhill CB, Seed B 1990 CD44 is the principal cell surface receptor for hyaluronate Cell 61:13031313.
  • 28
    Jalkanen S, Jalkanen M 1992 Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin J Cell Biol 116:817825.
  • 29
    Wayner EA, Carter WG 1987 Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing unique alpha and common beta subunits J Cell Biol 105:18731884.
  • 30
    Suda T, Takahashi N, Abe E 1992 Role of vitamin D in bone resorption J Cell Biochem 49:5358.
  • 31
    Nakamura K, Kenmotsu S, Sakai H, Ozawa H 1995 Localization of CD44, the hyaluronate receptor, on the plasma membrane of osteocytes and osteoclasts in rat tibiae Cell Tissue Res 280:225233.
  • 32
    Hughes DE, Salter DM, Simpson R 1994 CD44 expression in human bone: A novel marker of osteocytic differentiation J Bone Miner Res 9:3944.
  • 33
    Lakkakorpi PT, Horton MA, Helfrich MH, Karhukorpi EK, Vaananen HK 1991 Vitronectin receptor has a role in bone resorption but does not mediate tight sealing zone attachment of osteoclasts to the bone surface J Cell Biol 115:11791186.
  • 34
    Ross FP, Chappel J, Alvarez JI, Sander D, Butler WT, Farach-Carson MC, Mintz KA, Robey PG, Teitelbaum SL, Cheresh DA 1993 Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption J Biol Chem 268:99019907.
  • 35
    Takahashi N, Yamana H, Yoshiki S, Roodman GD, Mundy GR, Jones SJ, Boyde A, Suda T 1988 Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures Endocrinology 122:13731382.
  • 36
    Takahashi N, Akatsu T, Sasaki T, Nicholson GC, Moseley JM, Martin TJ, Suda T 1988 Induction of calcitonin receptors by 1α,25-dihydroxyvitamin D3 in osteoclast-like multinucleated cells formed from mouse bone marrow cells Endocrinology 123:15041510.
  • 37
    Boyde A, Ali NN, Jones SJ 1984 Resorption of dentine by isolated osteoclasts in vitro. Br Dent J 156:216220.
  • 38
    Dempster DW, Murrills RJ, Horbert WR, Arnett TR 1987 Biological activity of chicken calcitonin: Effects on neonatal rat and embryonic chick osteoclasts J Bone Miner Res 2:443448.
  • 39
    Lesley J, He Q, Miyake K, Hamann A, Hyman R, Kincade PW 1992 Requirements for hyaluronic acid binding by CD44: A role for the cytoplasmic domain and activation by antibody J Exp Med 175:257266.
  • 40
    Trowbridge IS, Lesley J, Schulte R, Hyman R, Trotter J 1982 Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues Immunogenetics 15:299312.
  • 41
    Murphy TL, Decker G, August JT 1983 Glycoproteins of coated pits, cell junctions, and the entire cell surface revealed by monoclonal antibodies and immunoelectron microscopy J Cell Biol 97:533541.
  • 42
    Jacobson K, O'Dell D, August JT 1984 Lateral diffusion of an 80,000-dalton glycoprotein in the plasma membrane of murine fibroblasts: Relationships to cell structure and function J Cell Biol 99:16241633.
  • 43
    Zheng Z, Katoh S, He Q, Oritani K, Miyake K, Lesley J, Hyman R, Hamik A, Parkhouse RM, Farr AG et al. 1995 Monoclonal antibodies to CD44 and their influence on hyaluronan recognition J Cell Biol 130:485495.
  • 44
    Perschl A, Lesley J, English N, Trowbridge I, Hyman R 1995 Role of CD44 cytoplasmic domain in hyaluronan binding Eur J Immunol 25:495501.
  • 45
    Lesley J, Kincade PW, Hyman R 1993 Antibody-induced activation of the hyaluronan receptor function of CD44 requires multivalent binding by antibody Eur J Immunol 23:19021909.
  • 46
    Lesley J, Hyman R 1992 CD44 can be activated to function as an hyaluronic acid receptor in normal murine T cells Eur J Immunol 22:27192723.
  • 47
    Biskobing DM, Fan X, Rubin J 1995 Characterization of MCSF-induced proliferation and subsequent osteoclast formation in murine marrow culture J Bone Miner Res 10:10251032.
  • 48
    Udagawa N, Findlay DM, Martin TJ 1996 CD44 involvement in osteoclast differentiation as well as bone resorption by mature osteoclasts J Bone Miner Res 11:S112 (abstract).
  • 49
    Kansas GS, Dailey MO 1989 Expression of adhesion structures during B cell development in man J Immunol 142:30583062.
  • 50
    Lesley J, Trotter J, Schulte R, Hyman R 1990 Phenotypic analysis of the early events during repopulation of the thymus by the bone marrow prothymocyte Cell Immunol 128:6378.
  • 51
    Petrie HT, Hugo P, Scollay R, Shortman K 1990 Lineage relationships and developmental kinetics of immature thymocytes: CD3, CD4, and CD8 acquisition in vivo and in vitro J Exp Med 172:15831588.
  • 52
    Hamann KJ, Dowling TL, Neeley SP, Grant JA, Leff AR 1995 Hyaluronic acid enhances cell proliferation during eosinopoiesis through the CD44 surface antigen J Immunol 154:40734080.
  • 53
    Miyake K, Underhill CB, Lesley J, Kincade PW 1990 Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition J Exp Med 172:6975.
  • 54
    Zahalka MA, Okon E, Gosslar U, Holzmann B, Naor D 1995 Lymph node (but not spleen) invasion by murine lymphoma is both CD44- and hyaluronate-dependent J Immunol 154:53455355.
  • 55
    Koopman G, van Kooyk Y, de Graaff M, Meyer CJ, Figdor CG, Pals ST 1990 Triggering of the CD44 antigen on T lymphocytes promotes T cell adhesion through the LFA-1 pathway J Immunol 145:35893593.
  • 56
    Pals ST, Hogervorst F, Keizer GD, Thepen T, Horst E, Figdor CC 1989 Identification of a widely distributed 90-kDa glycoprotein that is homologous to the Hermes-1 human lymphocyte homing receptor J Immunol 143:851857.
  • 57
    Horton MA, Rodan GA, 1995 Integrins as therapeutic target in bone disease. In: HortonMA, (ed.) Adhesion Receptors as Therapeutic Targets. CRC Press Inc., Boca Raton, LA, U.S.A., pp. 223245.
  • 58
    van der Pluijm G, Mouthaan H, Baas C, de Groot H, Papapoulos S, Lowik C 1994 Integrins and osteoclastic resorption in three bone organ cultures: Differential sensitivity to synthetic Arg-Gly-Asp peptides during osteoclast formation J Bone Miner Res 9:10211028.
  • 59
    Mbalaviele G, Chen H, Boyce BF, Mundy GR, Yoneda T 1995 The role of cadherin in the generation of multinucleated osteoclasts from mononuclear precursors in murine marrow J Clin Invest 95:27572765.
  • 60
    Weber GF, Ashkar S, Glimcher MJ, Cantor H 1996 Receptor-ligand interaction between CD44 and osteopontin (Eta-1) Science 271:509512.
  • 61
    Budd RC, Schumacher JH, Winslow G, Mosmann TR 1991 Elevated production of interferon-gamma and interleukin 4 by mature T cells from autoimmune lpr mice correlates with Pgp-1 (CD44) expression Eur J Immunol 21:10811084.
  • 62
    Noble PW, Lake FR, Henson PM, Riches DW 1993 Hyaluronate activation of CD44 induces insulin-like growth factor-1 expression by a tumor necrosis factor-alpha-dependent mechanism in murine macrophages J Clin Invest 91:23682377.
  • 63
    Kaufmann M, Heider KH, Sinn HP, von Minckwitz G, Ponta H, Herrlich P 1995 CD44 variant exon epitopes in primary breast cancer and length of survival Lancet 345:615619.