• 1
    Albright F, Smith PH, Richardson AM 1941 Postmenopausal osteoporosis JAMA 116:24652474.
  • 2
    Lindsay R, Aitkin JM, Anderson JB, Hart DM, MacDonald EB, Clarke AC 1976 Long-term prevention of postmenopausal osteoporosis by oestrogen Lancet i:10381040.
  • 3
    Genant HK, Cann CE, Ettinger B, Gordan GS 1982 Quantitative computed tomography of vertebral spongiosa: A sensitive method for detecting early bone loss after oophorectomy Ann Intern Med 97:699705.
  • 4
    Eriksen EF, Colvard DS, Berg NJ, Graham ML, Mann KG, Spelsberg TC, Riggs BL 1988 Evidence of estrogen receptors in normal human osteoblast-like cells Science 241:8486.
  • 5
    Komm BS, Terpening CM, Benz DJ, Graeme KA, O'Malley BW, Haussler MR 1988 Estrogen binding receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells Science 241:8184.
  • 6
    Oursler MJ, Osdoby P, Pyfferoen J, Riggs BL, Spelsberg TC 1991 Avian osteoclasts as estrogen target cells Proc Natl Acad Sci USA 88:66136617.
  • 7
    Eastell R, Yergey AL, Vieira N, Cedel SL, Kumar R, Riggs BL 1991 Interrelationship among vitamin D metabolism, true calcium absorption, parathyroid function, and age in women: Evidence of an age-related intestinal resistance to 1,25(OH)2D action J Bone Miner Res 6:125132.
  • 8
    Epstein S, Bryce G, Hinman JW, Miller ON, Riggs BL, Hui SL, Johnston CC Jr 1986 The influence of age on bone mineral regulating hormones Bone 7:421425.
  • 9
    Nicolas V, Prewett A, Bettica P, Mohan S, Finkelman RD, Baylink DJ, Farley JR 1994 Age-related decreases in insulin-like growth factor-I and transforming growth factor-β in femoral cortical bone from both men and women: Implications for bone loss with aging J Clin Endocrinol Metab 78:10111016.
  • 10
    Corpas E, Harman SM, Blackman MR 1993 Human growth hormone and human aging Endocr Rev 14:2039.
  • 11
    Landin-Wilhelmsen K, Wilhelmsen L, Lappas G, Rosen T, Lindstedt G, Lundberg P, Bengtsson B 1994 Serum insulin-like growth factor I in a random population sample of men and women: Relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin Clin Endocrinol 41:351357.
  • 12
    Chapuy MC, Arlot ME, Duboeuf F, Brun J, Crouzet B, Arnaud S, Delmas PD, Meunier PJ 1992 Vitamin D3 and calcium to prevent hip fractures in elderly women N Engl J Med 327:16371642.
  • 13
    Riggs BL, Melton LJ 1986 Medical progress series: Involutional osteoporosis N Engl J Med 314:16761686.
  • 14
    Slemenda C, Longcope C, Peacock M, Hui S, Johnston CC 1996 Sex steroids, bone mass and bone loss: A prospective study of pre-, peri-, and postmenopausal women J Clin Invest 97:1421.
  • 15
    Garnero P, Sornay-Rendu E, Chapuy M, Delmas PD 1996 Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis J Bone Miner Res 11:337349.
  • 16
    Cosman F, Shen V, Xie F, Seibel M, Ratcliffe A, Lindsay R 1993 Estrogen protection against bone resorbing effects of parathyroid hormone infusion Ann Intern Med 118:337343.
  • 17
    Heaney RP, Recker RR, Saville PD 1978 Menopausal changes in calcium balance performance J Lab Clin Med 92:953963.
  • 18
    McKane WR, Khosla S, Burritt MF, Kao PC, Wilson DM, Ory SJ, Riggs BL 1995 Mechanism of renal calcium conservation with estrogen replacement therapy in women in early postmenopause—A clinical research center study J Clin Endocrinol Metab 80:34583464.
  • 19
    Gennari C, Agnusdei D, Nardi P, Civitelli R 1990 Estrogen preserves a normal intestinal responsiveness to 1,25-dihydroxyvitamin D3 in oophorectomized women J Clin Endocrinol Metab 71:12881293.
  • 20
    Koh LKH, Bauer DC, Forsyth BA, Gore LR, Vogt MT, Cummings SR 1997 PTH in postmenopausal osteoporotic women J Bone Miner Res 12:S166.
  • 21
    Scharla SH, Minne HW, Waibel-Treber S, Schaible A, Lempert UG, Wuster C, Leyendecker G, Ziegler R 1990 Bone mass reduction after estrogen deprivation by long-acting gonadotropin-releasing hormone agonists and its relation to pretreatment serum concentrations of 1,25-dihydroxyvitamin D3 J Clin Endocrinol Metab 70:10551061.
  • 22
    Prince R, Dick I, Devine A, Price R, Gutteridge D, Kerr D, Criddle A, Garcia-Webb P, St. John A 1995 The effects of menopause and age on calcitropic hormones: A cross-sectional study of 655 healthy women aged 35–90 J Bone Miner Res 10:835842.
  • 23
    Prince RL, Schiff I, Neer RM 1990 Effects of transdermal estrogen replacement on parathyroid hormone secretion J Clin Endocrinol Metab 71:12841287.
  • 24
    Khosla S, Atkinson EJ, Melton LJ III, Riggs BL 1997 Effects of age and estrogen status on serum parathyroid hormone levels and biochemical markers of bone turnover in women: A population-based study J Clin Endocrinol Metab 82:15221527.
  • 25
    Ledger GA, Burritt MF, Kao PC, O'Fallon WM, Riggs BL, Khosla S 1995 Role of parathyroid hormone in mediating nocturnal and age-related increases in bone resorption J Clin Endocrinol Metab 80:33043310.
  • 26
    Khosla S, Melton LJ III, Atkinson EJ, Klee GG, O'Fallon WM, Riggs BL 1998 Relationship of serum sex steroid levels with bone mineral density in aging women and men: A key role for bioavailable estrogen. J Clin Endocrinol Metab (in press).
  • 27
    Arnaud CD, Wilson DM, Smith LH 1973 Primary hyperparathyroidism, renal lithiasis and the measurement of parathyroid hormone in serum by radioimmunoassay: Urinary Calculi. In: International Symposium on Renal Stone Research, Madrid, Spain, 1972. Karger, Basel, Switzerland, pp. 346353.
  • 28
    Avioli LV, McDonald JE, Lee SW 1965 The influence of age on the intestinal absorption of 47Ca in women and its relation to 47Ca absorption in postmenopausal osteoporosis J Clin Invest 44:19601967.
  • 29
    Bullamore JR, Gallagher JC, Wilkinson R, Nordin BEC, Marshall DH 1970 Effect of age on calcium absorption Lancet 2:535537.
  • 30
    Gallagher JC, Riggs BL, Eisman J, Hamstra A, Arnaud SB, DeLuca HF 1979 Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients: Effect of age and dietary calcium J Clin Invest 64:729736.
  • 31
    Ireland P, Fordtran JS 1973 Effect of dietary calcium and age on jejunal calcium absorption in humans studied by intestinal perfusion J Clin Invest 52:26722681.
  • 32
    Tsai K-S, Heath H III, Kumar R, Riggs BL 1984 Impaired vitamin D metabolism with aging in women: Possible role in pathogenesis of senile osteoporosis J Clin Invest 73:16681672.
  • 33
    Francis RM, Peacock M, Taylor GA, Storer JH, Nordin BEC 1984 Calcium malabsorption in elderly women with vertebral fractures: Evidence for resistance to the action of vitamin D metabolites on the bowel Clin Sci 66:103107.
  • 34
    Ebeling PR, Sandgren ME, DiMagno EP, Lane AW, DeLuca HF, Riggs BL 1992 Evidence of an age-related decrease in intestinal responsiveness to vitamin D: Relationship between serum 1,25-dihydroxyvitamin D3 and intestinal vitamin D receptor concentrations in normal women J Clin Endocrinol Metab 75:176182.
  • 35
    Looker AC, Harris TB, Madans JH, Sempos CT 1993 Dietary calcium and hip fracture risk: The NHANES I epidemiologic follow-up study Osteoporos Int 3:177184.
  • 36
    Reid IR, Ames RW, Evans MC, Gamble GD, Sharpe SJ 1995 Long-term effects of calcium supplementation on bone loss and fractures in postmenopausal women: A randomized controlled trial Am J Med 98:331335.
  • 37
    Prince R, Devine A, Dick I, Criddle A, Kerr D, Kent N, Price R, Randell A 1995 The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women J Bone Miner Res 10:10681075.
  • 38
    Elders PJM, Lips P, Netelenbos JC, Van Ginkel FC, Khoe E, Van Der Vijgh WJF, Van Der Stelt PF 1994 Long-term effect of calcium supplementation on bone loss in perimenopausal women J Bone Miner Res 9:963970.
  • 39
    Dawson-Hughes B, Harris SS, Krall EA, Dallal GE 1997 Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older N Engl J Med 337:670676.
  • 40
    McKane WR, Khosla S, Egan KS, Robins SP, Burritt MF, Riggs BL 1996 Role of calcium intake in modulating age-related increases in parathyroid function and bone resorption J Clin Endocrinol Metab 81:16991703.
  • 41
    Prestwood KM, Pilbeam CC, Burleson JA, Woodiel FN, Delmas PD, Deftos LJ, Raisz LG 1994 The short term effects of conjugated estrogen on bone turnover in older women J Clin Endocrinol Metab 79:366371.
  • 42
    McKane RW, Khosla S, Risteli J, Robins SP, Muhs JM, Riggs BL 1997 Role of estrogen deficiency in pathogenesis of secondary hyperparathyroidism and increased bone resorption in elderly women Proc Assoc Am Physicians 109:174180.
  • 43
    Heshmati HM, Khosla S, Robins SP, Geller N, McAlister CA, Riggs BL 1997 Endogenous residual estrogen levels determine bone resorption even in late postmenopausal women J Bone Miner Res 12:S121.
  • 44
    Richelson LS, Wahner HW, Melton LJ III, Riggs BL 1984 Relative contribution of aging and estrogen deficiency to postmenopausal bone loss N Engl J Med 311:12731275.
  • 45
    Prince RL 1994 Estrogen effects on calcitropic hormones and calcium homeostasis Endocr Rev 15:301309.
  • 46
    Bouillon R, Van Assche FA, Van Baelen H, Heyns W, DeMoor P 1981 Influence of the vitamin D-binding protein on the serum concentration of 1,25-dihydroxyvitamin D3: Significance of the free 1,25-dihydroxyvitamin D3 concentration J Clin Invest 67:589596.
  • 47
    Dick IM, Prince RL, Kelly JJ, Ho KKY 1995 Oestrogen effects on calcitriol levels in postmenopausal women: A comparison of oral versus transdermal administration Clin Endocrinol 43:219244.
  • 48
    Cheema C, Grant BF, Marcus R 1989 Effects of estrogen on circulating ‘free’ and total 1,25-dihydroxyvitamin D and on the parathyroid-vitamin D axis in postmenopausal women J Clin Invest 83:537542.
  • 49
    Bikle DD, Halloran BP, Harri ST, Portale AA 1992 Progestin antagonism of estrogen stimulated 1,25-dihydroxyvitamin D levels J Clin Endocrinol Metab 72:519523.
  • 50
    Nordin BEC, Need AG, Morris HA, Horowitz M, Robertson WG 1991 Evidence for a renal calcium leak in postmenopausal women J Clin Endocrinol Metab 72:401407.
  • 51
    Cosman F, Nieves J, Horton J, Shen V, Lindsay R 1994 Effects of estrogen on response to edetic acid infusion in postmenopausal osteoporotic women J Clin Endocrinol Metab 78:939943.
  • 52
    Naveh-Many T, Almogi G, Livni N, Silver J 1992 Estrogen receptors and biologic response in rat parathyroid tissue and C cells J Clin Invest 90:24342438.
  • 53
    Prince RL, MacLaughlin DT, Gaz RD, Neer RM 1991 Lack of evidence for estrogen receptors in human and bovine parathyroid tissue J Clin Endocrinol Metab 72:12261228.
  • 54
    Heaney RP, Recker RR, Saville PD 1978 Menopausal changes in bone remodeling J Lab Clin Med 92:964970.
  • 55
    Ivey JL, Baylink DJ 1981 Postmenopausal osteoporosis: Proposed roles of defective coupling and estrogen deficiency Metab Bone Dis Rel Res 3:38.
  • 56
    Lips P, Courpron P, Meunier PJ 1978 Mean wall thickness of trabecular bone packets in the human iliac crest: Changes with age Calcif Tissue Res 26:1317.
  • 57
    Marie PJ, Hott M, Launay JM, Graulet AM, Gueris J 1993 In vitro production of cytokines by bone surface-derived osteoblastic cells in normal and osteoporotic postmenopausal women: Relationship with cell proliferation J Clin Endocrinol Metab 77:824830.
  • 58
    Vermeulen A 1987 Nyctohemeral growth hormone profiles in young and aged men: Correlation with somatomedin-C levels J Clin Endocrinol Metab 64:884888.
  • 59
    Ernst M, Heath JK, Rodan GA 1989 Estradiol effects on proliferation, messenger ribonucleic acid for collagen and insulin-like growth factor-I, and parathyroid hormone-stimulated adenylate cyclase activity in osteoblastic cells from calvariae and long bones Endocrinology 125:825833.
  • 60
    Oursler MJ, Cortese C, Keeting PE, Anderson MA, Bonde SK, Riggs BL, Spelsberg TC 1991 Modulation of transforming growth factor-(production in normal human osteoblast-like cells by 17β-estradiol and parathyroid hormone Endocrinology 129:33133320.
  • 61
    Brincat M, Moniz CF, Kabalan S, Versi E, O'Dowd T, Magos AL, Montgomery J, Studd JWW 1987 Decline in skin collagen content and metacarpal index after the menopause and its prevention with sex hormone replacement Br J Obstet Gynaecol 94:126129.
  • 62
    Castelo-Branco C, Pons F, Gratacos E, Fortuny A, Vanrell JA, Gonzalez-Merlo J 1994 Relationship between skin collagen and bone changes during aging Maturitas 18:199206.
  • 63
    Chow J, Tobias JH, Colston KW, Chambers TJ 1992 Estrogen maintains trabecular bone volume in rats not only by suppression of bone resorption but also by stimulation of bone formation J Clin Invest 89:7478.
  • 64
    Westerlind KC, Wakley GK, Evans GL, Turner RT 1993 Estrogen does not increase bone formation in growing rats Endocrinology 133:29242934.
  • 65
    Armour KE, Houghton A, Russell RGG, Stringer BMJ 1996 Expression of estrogen receptors, and temporal viability responses to estrogen in conditionally imortalised human osteoprogenitor cells J Bone Miner Res 11:1586.
  • 66
    Kassem M, Okazaki R, DeLeon D, Harris SA, Robinson JA, Spelsberg TC, Conover CA, Riggs BL 1996 Potential mechanism of estrogen-mediated decrease in bone formation: Estrogen increases production of inhibitory insulin-like growth factor-binding protein-4 Proc Assoc Am Physicians 108:155164.
  • 67
    Stepan JJ, Lachman M, Zverina J, Pacovsky V 1989 Castrated men exhibit bone loss: Effect of calcitonin treatment on biochemical indices of bone remodeling J Clin Endocrinol Metab 69:523527.
  • 68
    Harman SM, Tsitouras PD 1980 Reproductive hormones in aging men. I. Measurement of sex steroids, basal luteinizing hormone, and leydig cell response to human chorionic gonadotropin J Clin Endocrinol Metab 51:3540.
  • 69
    Colvard DS, Eriksen EF, Keeting PE, Wilson EM, Lubahn DB, French FS, Riggs BL, Spelsberg TC 1989 Identification of androgen receptors in normal human osteoblast-like cells Proc Natl Acad Sci USA 86:854857.
  • 70
    Oursler MJ, Pederson L, Fitzpatrick L, Riggs BL 1994 Human giant cell tumors of the bone (osteoclastomas) are estrogen target cells Proc Natl Acad Sci USA 91:52275231.
  • 71
    Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Specker B, Williams TC, Lubahn DB, Korach KS 1994 Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man N Engl J Med 331:10561061.
  • 72
    Carani C, Qin K, Simoni M, Faustini-Fustini M, Serpente S, Boyd J, Korach KS, Simpson ER 1997 Effect of testosterone and estradiol in a man with aromatase deficiency N Engl J Med 337:9195.
  • 73
    Morishima A, Grumbach MM, Bilezikian JP 1997 Estrogen markedly increases bone mass in an estrogen deficient young man with aromatase deficiency J Bone Miner Res 12:S126.
  • 74
    Vanderschueren D, Van Herck E, Nijs J, Ederveen AGH, De Coster R, Bouillon R 1997 Aromatase inhibition impairs skeletal modeling and decreases bone mineral density in growing male rats Endocrinology 138:23012307.
  • 75
    Slemenda CW, Longcope C, Zhou L, Hui SL, Peacock M, Johnston C 1997 Sex steroids and bone mass in older men: Positive associations with serum estrogens and negative associations with androgens J Clin Invest 100:17551759.
  • 76
    Center JR, Nguyen TV, White CP, Eisman JA 1997 Male osteoporosis predictors: Sex hormones and calcitropic hormones J Bone Miner Res 12:S368.
  • 77
    Greendale GA, Edelstein S, Barrett-Connor E 1997 Endogenous sex steroids and bone mineral density in older women and men: The Rancho Bernardo study J Bone Miner Res 12:18331843.
  • 78
    Meier DE, Orwoll ES, Keenan EJ, Fagerstrom RM 1987 Marked decline in trabecular bone mineral content in healthy men with age: Lack of association with sex steroid levels J Am Geriatr Soc 35:189197.
  • 79
    Nankin HR, Calkins JH 1986 Decreased bioavailable testosterone in aging normal and impotent men J Clin Endocrinol Metab 63:14181420.
  • 80
    Bernecker PM, Willvonseder R, Resch H 1995 Decreased estrogen levels in male patients with primary osteoporosis J Bone Miner Res 10:S445.
  • 81
    Seeman E 1997 From density to structure: Growing up and growing old on the surfaces of bone J Bone Miner Res 12:509521.
  • 82
    Rodan GA 1997 Bone mass homeostasis and bisphosphonate action Bone 20:14.
  • 83
    Ledger GA, Burritt MF, Kao PC, O'Fallon WM, O'Fallon WM, Riggs BL, Khosla S 1994 Abnormalities of parathyroid hormone secretion in elderly women that are reversible by short term therapy with 1,25-dihydroxyvitamin D3 J Clin Endocrinol Metab 79:211216.
  • 84
    Akerstrom G, Rudberg C, Grimelius L, Bergstrom R, Johansson H, Ljunghall S, Rastad J 1986 Histologic parathyroid abnormalities in an autopsy series Hum Pathol 17:520527.
  • 85
    Parfitt AM, Mathews CHE, Villaneuva AR, Kleerekoper M, Frame B, Rao DS 1983 Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis J Clin Invest 72:13961409.
  • 86
    O'Neill TW, Felsenberg D, Varlow J, Cooper C, Kanis JA, Silman AJ, the European Vertebral Osteoporosis Study Group 1996 The prevalence of vertebral deformity in European men and women: The European Vertebral Osteoporosis Study J Bone Miner Res 11:10101018.
  • 87
    Vanderschueren D, Van Herck E, Nijs J, Ederveen AGH, De Coster R, Bouillon R 1997 Aromatase inhibition impairs skeletal modeling and decreases bone mineral density in growing male rats Endocrinology 138:23012307.
  • 88
    Riggs BL, Melton LJ III 1983 Evidence for two distinct syndromes of involutional osteoporosis Am J Med 75:899901.
  • 89
    Riggs BL, Melton LJ 1990 Clinical heterogeneity of involutional osteoporosis: Implications for preventive therapy J Clin Endocrinol Metab 70:12291232.
  • 90
    Davidson BJ, Riggs BL, Wahner HW, Judd HL 1983 Endogenous cortisol and sex steroids in patients with osteoporotic spinal fractures Obstet Gynecol 61:275278.
  • 91
    Manolagas SC, Jilka RL 1995 Bone marrow, cytokines, and bone remodeling: Emerging insights into the pathophysiology of osteoporosis N Engl J Med 332:305311.
  • 92
    Pacifici R, Rifas L, McCracken R, Vered I, McMurtry C, Avioli LV, Peck WA 1989 Ovarian steroid treatment blocks a postmenopausal increase in blood monocyte interleukin 1 release Proc Natl Acad Sci USA 86:23982402.
  • 93
    Kawaguchi H, Pilbeam CC, Vargas SJ, Morse EE, Lorenzo JA, Raisz LG 1995 Ovariectomy enhances and estrogen replacement inhibits the activity of bone marrow factors that stimulate prostaglandin production in cultured mouse calvariae J Clin Invest 96:539548.
  • 94
    Heshmati HM, Khosla S, Burritt MF, O'Fallon WM, Riggs BLA 1998 primary defect in renal calcium conservation may contribute to the pathogenesis of postmenopausal osteoporosis. J Clin Endocrinol Metal (in press).