• 1
    Kishimoto T, Taga T, Akira S 1994 Cytokine signal transduction Cell 76:253262.
  • 2
    Kishimoto T, Akira S, Narazaki M, Taga T 1995 Interleukin-6 family of cytokines and gp130 Blood 86:12431254.
  • 3
    Kurihara N, Bertolini D, Suda T, Akiyama Y, Roodman GD 1990 IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release J Immunol 144:42264230.
  • 4
    Ishimi Y, Miyaura C, Jin CH, Akatsu T, Abe E, Nakamura Y, Yamaguchi A, Yoshiki S, Matsuda T, Hirano T, Kishimoto T, Suda T 1990 IL-6 is produced by osteoblasts and induced bone resorption J Immunol 145:32973303.
  • 5
    Jilka RL, Hangoc G, Girasole G, Passeri G, Williams DC, Abrams JS, Boyce B, Broxmeyer H, Manolagas SC 1992 Increased osteoclast development after estrogen loss: Mediation by interleukin-6 Science 257:8891.
  • 6
    Poli V, Balena R, Fattori E, Markatos A, Yamamoto A, Tanaka H, Ciliberto G, Rodan GA, Costantini F 1994 Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion EMBO J 13:11891196.
  • 7
    Manolagas SC, Jilka RL 1995 Bone marrow, cytokines, and bone remodeling-emerging insights into the pathophysiology of osteoporosis N Engl J Med 332:305311.
  • 8
    Roodman GD, Kurihara N, Ohsaki Y, Kukita A, Hosking D, Demulder A, Smith JF, Singer FR 1992 Interleukin-6, a potent autocrine/paracrine factor in Paget's disease of bone J Clin Invest 89:4652.
  • 9
    Devlin RD, Bone HG, Roodman GD 1996 Interleukin-6: A potential mediator of the massive osteolysis in patients with Gorhan-Stout disease J Clin Endocrinol Metab 81:18931897.
  • 10
    Roodman GD 1992 Interleukin-6: An osteotropic factor? J Bone Miner Res 7:475478.
  • 11
    Linkhart TA, Linkhart SG, MacCharles DC, Long DL, Strong DD 1991 Interleukin-6 messenger RNA expression and interleukin-6 protein secretion in cells isolated from normal human bone: Regulation by interleukin-1 J Bone Miner Res 6:12851294.
  • 12
    Rifas L, Kenny JS, Marcelli M, Pacifici R, Cheng SL, Dawson LL, Avioli LV 1995 Production of interleukin-6 in human osteoblasts and human bone marrow stromal cells: Evidence that induction by interleukin-1 and tumor necrosis factor-α is not regulated by ovarian steroids Endocrinology 136:40564067.
  • 13
    Taichman RS, Reily MJ, Verma RS, Emerson SG 1997 Augmented production of interleukin-6 by normal human osteoblasts in response to CD34+ hematopoietic bone marrow cells in vitro Blood 89:11651172.
  • 14
    Greenfield EM, Shaw SM, Gornik SA, Banks MA 1993 Adenyl cyclase and interleukin-6 are downstream effectors of parathyroid hormone resulting in stimulation of bone resorption J Clin Invest 96:12381244.
  • 15
    Littlewood AJ, Russell J, Harvey GR, Hughes DE, Russell RGG, Gowen M 1991 The modulation of the expression of IL-6 and its receptor in human osteoblasts in vitro Endocrinology 129:15131520.
  • 16
    Littlewood AJ, Aarden LA, Evans DB, Russell RGG, Gowen M 1991 Human osteoblastlike cells do not respond to interleukin-6 J Bone Miner Res 6:141148.
  • 17
    Fang MA, Hohn TJ 1991 Effects of interleukin-6 on cellular function in UMR-106-01 osteoblastlike cells J Bone Miner Res 6:133139.
  • 18
    Murakami M, Hibi M, Nakagawa N, Nakagawa T, Yasukawa K, Yamanishi K, Taga T, Kishimoto T 1993 IL-6 induced homodimerization of gp130 and associated activation of a tyrosine kinase Science 260:18081810.
  • 19
    Rose-John S, Heinrich PC 1994 Soluble receptors for cytokines and growth factors: Generation and biological function Biochem J 300:281290.
  • 20
    Tamura T, Udagawa N, Takahashi N, Miyaura C, Tanaka S, Yamada Y, Koishihara Y, Ohsugi Y, Kumaki K, Taga T, Kishimoto T, Suda T 1993 Soluble interleukin-6 receptor triggers osteoclast formation by interleukin-6 Proc Natl Acad Sci USA 90:1192411928.
  • 21
    Narazaki M, Witthuhn BA, Yoshida K, Silvennoinen O, Yasukawa K, Ihre JN, Kishimoto T, Taga T 1994 Activation of JAK2 kinase mediated by the interleukin-6 signal transducer gp130 Proc Natl Acad Sci USA 91:22852289.
  • 22
    Bonewald L, Kester MB, Schwartz Z, Swain LD, Khare A, Johnson TL, Leach RJ, Boyan BD 1992 Effects of combining transforming growth factor b and 1,25-dihydroxyvitamin D3 on differentiation of a human osteosarcoma (MG-63) J Biol Chem 267:89438949.
  • 23
    Hibi M, Murakami M, Saito M, Hirano T, Tag T, Kishimoto T 1990 Molecular cloning and expression of an IL-6 signal transducer, gp130 Cell 63:11491157.
  • 24
    Thomas SM, De Marco M, D'Arcangelo G, Halegoua S, Brugge JS 1992 Ras is essential for nerve growth factor and phorbol ester-reduced tyrosine phosphorylation of MAP kinase Cell 68:10311040.
  • 25
    Daeipour M, Kumar G, Amaral MC, Nel AE 1993 Recombinant IL-6 activates p42 and p44 mitogen-activated protein kinases in the IL-6 responsive B cell line, AF-10 J Immunol 150:47434753.
  • 26
    Yasukawa K, Saito T, Fukunaga T, Sekimori Y, Koishihara Y, Fukui H, Ohsugi Y, Matsuda T, Yawata H, Hirano T, Taga T, Kishimoto T 1990 Purification and characterization of soluble human IL-6 receptor expressed in CHO cells J Biochem 108:673676.
  • 27
    Saito T, Taga T, Miki D, Futatsugi K, Yawata H, Kishimoto T, Yasukawa K 1993 Preparation of monoclonal antibodies against the IL-6 signal transducer, gp130, that can inhibit IL-6-mediated functions J Immunol Meth 163:217223.
  • 28
    Nishimura R, Li W, Kashishian A, Mondino A, Zhou M, Cooper J, Schlessinger J 1993 Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor Mol Cell Biol 13:68896896.
  • 29
    Li W, Nishimura R, Kashishian A, Batzer AG, Kim WJH, Cooper JA, Schlessinger J 1994 A new function for a phosphotyrosine phosphatase: Linking Grb2-SOS to a receptor tyrosine kinase Mol Cell Biol 14:509517.
  • 30
    Zhong Z, Wen Z, Darnell J Jr 1994 A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6 Science 264:9598.
  • 31
    Akira S, Nishio Y, Inoue M, Wang X, Wei S, Matsusaka T, Yoshida K, Sudo T, Naruto M, Kishimoto T 1994 Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved on the gp130-mediated signaling pathway Cell 77:6371.
  • 32
    Gomez N, Cohen P 1991 Dissection of the protein kinase cascade by which nerve growth activates MAP kinase Nature 253:170173.
  • 33
    Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, Hirano T, Kishimoto T 1989 Interleukin-6 triggers the association of its receptor with a possible signal transducer Cell 58:573581.
  • 34
    Sadowski HB, Shuai K, Darnell JER, Gilman MZ 1993 A common nuclear signal transduction pathway activated by growth factor and cytokine receptors Science 261:17391744.
  • 35
    Silvennoinen O, Schindler C, Schlessinger J, Levy D 1993 Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation Science 261:17361738.
  • 36
    Bellido T, Borba VZC, Stahl N, Yancopoulous G, Jilka RL, Manolagas SC 1995 Ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF) stimulate cell proliferation and increase alkaline phosphatase and interleukin-6 production by osteoblastic cells J Bone Miner Res 10 (Suppl 1):M267.
  • 37
    Moriyama K, Williams P, Niewolna M, Dallas MR, Uehara Y, Mundy GR, Yoneda T 1996 Herbimycin A, a tyrosine kinase inhibitor, impairs hypercalcemia associated with a human squamous cancer producing interleukin-6 in nude mice J Bone Miner Res 11:905911.
  • 38
    Bellido T, Stahl N, Farruggella TJ, Borba V, Yancopoulos GD, Manolagas SC 1996 Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neutrophic factor in bone marrow stroma/osteoblastic cells J Clin Invest 97:431437.
  • 39
    David M, Petricoin E, Benjamin C, Pine R, Weber MJ, Larner AC 1995 Requirement for MAP kinase (ERK2) activity in interferon α– and interferon β–stimulated gene expression through STAT proteins Science 269:17211723.
  • 40
    Wen Z, Zhong Z, Darnell J Jr 1995 Maximal activation of transcription by Stat 1 and Stat 3 requires both tyrosine and serine phosphorylation Cell 82:241250.