Research-Article

You have full text access to this OnlineOpen article

Accretion of Bone Mass and Strength with Parathyroid Hormone Prior to the Onset of Estrogen Deficiency Can Provide Temporary Beneficial Effects in Skeletally Mature Rats

  1. V. Shen1,2,*,
  2. R. Birchman1,
  3. X. G. Liang1,
  4. D. D. Wu1,
  5. D. W. Dempster1,2,
  6. R. Lindsay1,3

Article first published online: 1 MAY 1998

DOI: 10.1359/jbmr.1998.13.5.883

Issue

Journal of Bone and Mineral Research

Journal of Bone and Mineral Research

Volume 13, Issue 5, pages 883–890, May 1998

Additional Information

How to Cite

Shen, V., Birchman, R., Liang, X. G., Wu, D. D., Dempster, D. W. and Lindsay, R. (1998), Accretion of Bone Mass and Strength with Parathyroid Hormone Prior to the Onset of Estrogen Deficiency Can Provide Temporary Beneficial Effects in Skeletally Mature Rats. J Bone Miner Res, 13: 883–890. doi: 10.1359/jbmr.1998.13.5.883

Author Information

  1. 1

    Regional Bone Center, Helen Hayes Hospital, New York State Department of Health, West Haverstraw, New York, U.S.A.

  2. 2

    Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York, U.S.A.

  3. 3

    Departments of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, U.S.A.

*Address reprint requests to: Victor Shen, Ph.D., Regional Bone Center, Helen Hayes Hospital, Route 9W, West Haverstraw, NY 10993 U.S.A.

Publication History

  1. Issue published online: 4 DEC 2009
  2. Article first published online: 1 MAY 1998
  3. Manuscript Accepted: 27 DEC 1997
  4. Manuscript Revised: 10 NOV 1997
  5. Manuscript Received: 18 JUL 1997

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (217K)

References

  • 1
    Dempster DW, Cosman F, Parisien M, Shen V, Lindsay R 1993 Anabolic actions of parathyroid hormone on bone Endocr Rev 14:690–709.
  • 2
    Gunness M, Hock JM 1993 Anabolic effect of PTH on cancellous and cortical bone histology Bone 14:277–281.
  • 3
    Hock JM, Gera I, Fonseca J, Raisz LG 1988 Human PTH (1–34) increases bone in ovariectomized and orchidectomized rats Endocrinology 122:2899–2904.
  • 4
    Shen V, Dempster DW, Birchman R, Xu R, Lindsay R 1993 Loss of cancellous bone mass and connectivity in ovariectomized rats can be restored by combined treatment with PTH and estradiol J Clin Invest 91:2479–2487.
  • 5
    Tada K, Yamamuro T, Okumura H, Kasai R, Takahashi H 1990 Restoration of axial and appendicular bone volumes by hPTH (1–34) in parathyroidectomized and osteopenic rats Bone 11:163–169.
  • 6
    Liu CC, Kalu DN, Salerno E, Echon R, Hollis BW, Ray M 1991 Preexisting bone loss associated with ovariectomy in rats is reversed by PTH J Bone Miner Res 5:973–982.
  • 7
    Gunness-Hey M, Hock JM 1984 Increased trabecular bone mass in rats treated with synthetic human PTH Metab Bone Dis Rel Res 5:177–181.
  • 8
    Takahashi K, Tsuboyama T, Matsushita M, Kasai R, Okumura H, Yamamuro T, Okamoto Y, Kitagawa K, Takeda T 1994 Effective intervention of low peak bone mass and bone modeling in the spontaneous murine model of senile osteoporosis, SAM-P/6, by Ca and hormone treatment Bone 15:209–215.
  • 9
    Gunness-Hey M, Hock JM 1989 Loss of the anabolic effect of PTH on bone after discontinuation of hormone in rats Bone 10:447–452.
  • 10
    Yamamoto N, Takahashi HE, Tanizawa T, Fujimoto R, Hara T, Tanaka S 1993 Maintenance of bone mass by physical exercise after discontinuation of intermittent hPTH (1–34) administration Bone Miner 23:333–342.
  • 11
    Shen V, Birchman R, Xu R, Otter M, Wu DD, Lindsay R, Dempster DW 1995 Effects of reciprocal treatment with estrogen and estrogen plus PTH on bone structure and strength in ovariectomized rats J Clin Invest 96:2331–2338.
  • 12
    Aaron JE, Johnson DR, Kanis A, Oakley BA, O'Higgens P, Paxton SK 1992 An automated method for the analysis of trabecular bone structure Comput Biomed Res 25:1–16.
  • 13
    Parfitt AM, Drezner NH, Glorieus FH, Kanis JA, Malluche H, Meunier PG, Ott S, Recker RR 1987 Bone histomorphometry: Standardization of nomenclature, symbols, and units J Bone Miner Res 6:595–610.
  • 14
    Hvid I, Hansen SL 1985 Trabecular bone strength patterns at the proximal tibial epiphysis J Orthopaed Res 3:404–472.
  • 15
    Meng XW, Liang XG, Birchman R, Wu DD, Dempster DW, Lindsay R, Shen V 1996 Temporal expression of the anabolic action of PTH in cancellous bone of ovariectomized rats J Bone Miner Res 11:421–429.
  • 16
    Kalu DN 1991 The ovariectomized rat model of human postmenopausal bone loss Bone Miner 15:175–191.
  • 17
    Frost HM, Jee WSS 1992 On the rat model of human osteopenia and osteoporosis Bone Miner 18:227–236.
  • 18
    Liu CC, Kalu DN 1990 Human PTH(1–34) prevents bone loss and augments bone formation in sexually mature ovariectomized rats J Bone Miner Res 5:973–981.
  • 19
    Turner CH, Burr DB 1993 Basic biomechanical measurements of bone: A tutorial Bone 14:595–608.
  • 20
    Chow JWM, Fox S, Jagger CJ, Chambers TJ 1997 A role for PTH in the mechanical responsiveness of rat bone J Bone Miner Res 12 (Suppl 1):S316.
  • 21
    Gasser JA 1997 Preclinical studies of PTH and analogs J Bone Miner Res 17 (Suppl 1):S2.
  • 22
    Cheng PT, Aye LM, Vieth R, Muller K 1995 Estrogen dose required to maintain PTH mediated bone gain in osteopenic ovariectomized rats is probably higher than in preventive treatment with estrogen Bone 17 (Suppl 1):329S–334S.
  • 23
    Ma Y, Jee WSS, Chen Y, Gasser JA, Ke HZ, Li XJ, Kimmel DB 1995 Partial maintenance of extra cancellous bone mass by antiresorptive agents after discontinuation of human PTH in right hindlimb immobilized rats J Bone Miner Res 10:1726–1734.
  • 24
    Johnston CC, Slenmenda CW 1994 Peak bone mass, bone loss and risk of fracture Osteoporos Int 1 (Suppl):S43–S45.
  • 25
    Qi H, Li M, Wronski TJ 1995 A comparison of the anabolic effects of PTH at skeletal sites with moderate and severe osteopenia in aged ovariectomized rats J Bone Miner Res 10:948–955.
  • 26
    Tang LY, Jee WSS, Ke HZ, Kimmel DB 1992 Restoring and maintaining bone in osteopenic female rat skeleton: 1. Changes in bone mass and structure J Bone Miner Res 7:1093–1104.
  • 27
    Jee WSS, Tang L, Ke HZ, Setterberg RB, Kimmel DB 1993 Maintaining restored bone with bisphosphonate in the Ovx rat skeleton: Dynamic histomorphometry of changes in bone mass Bone 14:493–498.
  • 28
    Cheng PT, Chan C, Muller K 1994 Cyclical treatment of osteopenic ovariectomized adult rats with PTH(1–34) and pamidronate J Bone Miner Res 10:119–126.
View Full Article (HTML) Get PDF (217K)