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REFERENCES

  • 1
    Einhorn TA 1998 The cell and molecular biology of fracture healing Clin Orthop 355S:S7S21.
  • 2
    Brighton CT, Hunt T 1991 Early histological and ultrastructural changes in medullary fracture callus J Bone Joint Surg Am 73:832847.
  • 3
    Bolander ME 1998 Regulation of fracture repair by growth factors Proc Soc Exp Biol Med 200:165170.
  • 4
    Einhorn TA, Majeska RJ, Rush EB, Levine PM, Horowitz MC 1995 The expression of cytokine activity by fracture callus J Bone Miner Res 10:12721281.
  • 5
    Iwaki A, Jingushi S, Oda Y, Izumi T, Shida JI, Tsuneyoshi M, Sugioka Y 1997 Localization and quantification of proliferating cells during rat fracture repair: Detection of proliferating cell nuclear antigen by immunohistochemistry J Bone Miner Res 12:96102.
  • 6
    McKibbin B 1978 The biology of fracture healing in long bones J Bone Joint Surg Br 60-B:150162.
  • 7
    Sandberg M, Aro HT, Multimaki P, Aho H, Vuorio E 1989 In situ localization of collagen production by chondrocytes and osteblasts in fracture callus J Bone Joint Surg Am 71:6977.
  • 8
    Einhorn TA, Hirschman A, Kaplan C, Nashed R, Devlin VJ, Warman J 1989 Neutral protein-degrading enzymes in experimental fracture callus: A preliminary report J Orthop Res 7:792805.
  • 9
    Nakagawa Y, Shimizu K, Hamamoto T, Suzuki K, Ueda R, Yamamuro T 1994 Calcium-dependent neutral protease (Calpain) in fracture healing in rats J Orthop Res 12:5869.
  • 10
    Linkhart TA, Mohan S, Baylink DJ 1996 Growth factors for bone growth and repair: IGF, TGF-β, and BMP Bone 19:1S12S.
  • 11
    Trippel SB, Coutts RD, Einhorn TA, Mundy GR, Rosenfeld RG 1996 Growth factors as therapeutic agents J Bone Joint Surg Am 78:12721286.
  • 12
    Wang JS 1996 Basic fibroblast growth factor for stimulation of bone formation in osteinductive or conductive implants Acta Orthop Scand 67:133.
  • 13
    Hauschka PV, Mavrakos AE, Iafrati MD, Doleman SE, Klagsburn M 1986 Growth factors in bone matrix: Isolation of multiple types by affinity chromatography on heparin-sepharose J Biol Chem 261:1266512674.
  • 14
    Baird A, Walicke PA 1989 Fibroblast growth factors Br Med Bull 45:438452.
  • 15
    Vlodavsky I, Fuks Z, Ishai-Michaeli R, Bashkin P, Korner G, Bar-Shavit R, Klagsburn M 1991 Extracellular matrix-resident basic fibroblast growth factor: Implication for the control of angiogenesis J Cell Biochem 45:167176.
  • 16
    Dionne CA, Jaye M, Schlessinger J 1991 Structural diversity and binding of FGF receptors Ann NY Acad Sci 638:161166.
  • 17
    Givol D, Yayon A 1992 Complexity of FGF receptors: Genetic basis for structural diversity and functional specificity FASEB J 6:33623369.
  • 18
    Jingushi S, Heydemann A, Kana SK, Macey LR, Bolander ME 1990 Acidic fibroblast growth factor (aFGF) injection stimulates cartilage enlargement and inhibits cartilage gene expression in rat fracture healing J Orthop Res 8:364371.
  • 19
    Canalis E, Centrella M, McCarthy TL 1988 Effects of basic fibroblast growth factor on bone formation in vitro J Clin Invest 81:15721577.
  • 20
    Rodan SB, Weolowski G, Thomas K, Rodan GA 1987 Growth stimulation of rat calvaria osteoblastic cells by acidic fibroblast growth factor Endocrinology 121:19171923.
  • 21
    Canalis E, McCarthy TL, Centrella M 1991 Growth factors and cytokines in bone cell metabolism Ann Rev Med 42:1724.
  • 22
    Nakamura T, Hara Y, Tagawa M, Tamura M, Yuge T, Fukuda H, Nigi H 1998 Recombinant human basic fibroblast growth factor accelerates fracture healing by enhancing callus remodeling in experimental dog tibial fractures J Bone Miner Res 13:942949.
  • 23
    Kawaguchi H, Kurokawa T, Hanada K, Hiyama Y, Tamura M, Ogata E, Matsumoto T 1994 Stimulation of fracture repair by recombinant human basic fibroblast growth factor in normal and streptozotocin-diabetic rats Endocrinology 135:774781.
  • 24
    Radomsky ML, Aufdemorte TB, Swain LD, Fox WC, Spiro RC, Poser JW 1999 A novel formulation of FGF-2 in a hyaluronan gel accelerates fracture healing in non-human primates J Orthop Res 17:607614.
  • 25
    Bland YS, Critchlow MA, Ashhurts DE 1995 Exogenous fibroblast growth factors-1 and -2 do not accelerate fracture healing in the rabbit Acta Orthop Scand 66:543548.
  • 26
    Radomsky ML, Thompson AY, Spiro RC, Poser JW 1998 Potential role of fibroblast growth factor in enhancement of fracture healing Clin Orthop 355(Supp):S283S293.
  • 27
    Nakamura K, Kawaguchi H, Aoyama I, Hanada K, Hiyama Y, Awa T, Tamura M, Kurokawa T 1997 Stimulation of bone formation by intraosseous application of recombinant basic fibroblast growth factor in normal and ovariectomized rabbits J Orthop Res 15:307313.
  • 28
    Heldin CH, Ostman A, Ronnstrand L 1998 Signal transduction via platelet-derived growth factor receptors Biochim Biophys Acta 1378:F79F113.
  • 29
    Andrew JG, Hoyland J, Freemont AJ, Marsh D 1995 Platelet-derived growth factor expression in normally healing human fractures Bone 16:455460.
  • 30
    Shimokado K, Raines EW, Madtes DK, Barrett T, Benditt EP, Ross R 1985 A significant part of macrophage derived growth factor consists of at least two forms of PDGF Cell 43:277286.
  • 31
    Nash TJ, Howlett CR, Martin C, Steele J, Johnson KA, Hicklin DJ 1994 Effect of platelt-derived growth factor on tibial osteotomies in rabbits Bone 15:203208.
  • 32
    Marden LJ, Fan RSP, Pierce GF, Reddi AH, Hollinger JO 1993 Platelet derived growth factor inhibits bone regeneration induced by osteogenin, a bone morphogenetic protein, in rat craniotomy defects J Clin Invest 92:28972905.
  • 33
    Kingsley DM 1994 The TGFβ superfamily: New members, new receptors, and new genetic tests of function in different organisms Genes Dev 8:133146.
  • 34
    Massague J, Attisano L, Wrana JL 1994 The TGF-β family and its composite receptors Trends Cell Biol 4:172178.
  • 35
    Massague J 1990 The transforming growth factor-beta family Ann Rev Cell Biol 6:597641.
  • 36
    Massague J 1992 Receptors for the TGF-beta family Cell 69:10671070.
  • 37
    Dernyck R, Zhang Y, Feng XH 1998 Smads: Transcriptional activators of TGF-β responses Cell 95:737740.
  • 38
    Joyce ME, Jingushi S, Bolander ME 1990 Transforming growth factor-β in the regulation of fracture repair Orthop Clin North Am 21:199209.
  • 39
    Beck LS, Deguzman L, Lee WP, Xu Y, McFatridge LA, Gillett NA, Amento EP 1991 TGF-β1 induces bone closure of skull defects J Bone Miner Res 6:12571265.
  • 40
    Lind M, Schumacker B, Soballe K, Keller J, Melsen F, Bunger C 1993 Transforming growth factor-β enhances fracture healing in rabbit tibiae Acta Orthop Scand 64:553556.
  • 41
    Nielsen HM, Andreassen TT, Ledet T, Oxlund H 1994 Local injection of TGF-β increases the strength of tibial fractures in the rat Acta Orthop Scand 65:3741.
  • 42
    Critcholow MA, Bland YS, Ashhurts DE 1995 The effect of exogenous transforming growth factor-β2 on healing fractures in the rabbit Bone 16:521527.
  • 43
    Ripamonti U, Bosch C, van den Heever B, Duneas N, Melsen B, Ebner R 1996 Limited chondro-osteogenesis by recombinant human transforming growth factor-β1 in calvarial defects of adult baboons (Papio ursinus) J Bone Miner Res 11:938945.
  • 44
    Ongipattanakul B, Nguyen T, Zioncheck T, Wong R, Osaka G, Deguzman L, Lee WP, Beck LS 1997 Development of tricalcium phosphate/amylopectin paste combined with recombinant human transforming growth factor beta 1 as a bone defect filler J Biomed Mater Res 36:293305.
  • 45
    Hogan BLM 1996 Bone morphogenetic proteins: Multifunctional regulators of veretebrate development Genes Dev 10:15801594.
  • 46
    Sakou T 1998 Bone morphogenetic proteins: From basic studies to clinical approaches Bone 22:591603.
  • 47
    Urist MR 1965 Bone formation by autoinduction Science 150:893899.
  • 48
    Heldin CH, Miyazono K, Dijke PT 1997 TGF-β signalling from cell membrane to nucleus through SMAD proteins Nature 390:465471.
  • 49
    Brunet LJ, McMahon JA, McMahon AP, Harland RM 1998 Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton Science 280:14551457.
  • 50
    Gazzero E, Gnagji V, Canalis E 1998 Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts J Clin Invest 102:21062114.
  • 51
    Ishidou Y, Kitajima I, Obama H, Maruyama I, Murata F, Imamura T, Yamada N, Dijke PT, Miyazono K, Sakou T 1995 Enhanced expression of type I receptors for bone morphogenetic proteins during bone formation J Bone Miner Res 10:16511659.
  • 52
    Onishi T, Ishidou Y, Nagamine T, Yone K, Imamura T, Kato M, Sampath TK, Dijke PT, Sakou T 1998 Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats Bone 22:605612.
  • 53
    Nakase T, Nomura S, Yoshikawa H, Hashimoto J, Hirota S, Kitamura Y, Oikawa S, Ono K, Takaoka K 1994 Transient and localized expression of bone morphogenetic protein 4 messenger RNA during fracture healing J Bone Miner Res 9:651659.
  • 54
    Bostrom MPG 1998 Expression of bone morphogenetic proteins in fracture healing Clin Orthop 355(Supp):S116S123.
  • 55
    Einhorn TA, Lane JM, Burstein AH, Kopman CR, Vigorita VJ 1984 The healing of segmental bone defects induced by demineralized bone matrix J Bone Joint Surg AM 66:274279.
  • 56
    Johnson EE, Urist MR, Finerman GAM 1988 Repair of segmental defects of the tibia with cancellous bone grafts augmented with human bone morphogenetic protein Clin Orthop 236:249257.
  • 57
    Johnson EE, Urist MR, Finerman GAM 1988 Bone morphogenetic protein augmentation grafting of resistant femoral nonunions Clin Orthop 230:257265.
  • 58
    Johnson EE, Urist MR, Finerman GAM 1992 Resistant nonunions and partial or complete segmental defects of long bones Clin Orthop 277:229237.
  • 59
    Heckman JD, Boyan BD, Aufdemorte TB, Abbott JT 1991 The use of bone morphogenetic protein in the treatment of non-union in a canine model J Bone Joint Surg Am 730:750764.
  • 60
    Cook SD, Baffes GC, Wolfe MW, Sampath TK, Rueger DC 1994 Recombinant human bone morphogenetic protein-7 induces healing in a canine long-bone segmental defect model Clin Orthop 301:302312.
  • 61
    Cook SD, Baffes GC, Wolfe MW, Sampath TK, Rueger DC, Whitecloud TS 1994 The effect of recombinant human osteogenic protein-1 on healing of large segmental bone defects J Bone Joint Surg Am 76:827838.
  • 62
    Yasko AW, Lane JM, Fellinger EJ, Rosen V, Wozney JM, Wang EA 1992 The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2) J Bone Joint Surg Am 74:659671.
  • 63
    Gerhart TN, Kirker-Head CA, Kriz MJ, Holtrop ME, Hennig GE, Hipp JA, Schelling SH, Wang EA 1993 Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein Clin Orthop 293:317326.
  • 64
    Bostrom M, Lane JM, Tomin E, Browne M, Berberian W, Turek T, Smith J, Wozney J, Schildhauer T 1996 The use of bone morphogenetic protein-2 in the rabbit ulnar non-union model Clin Orthop 327:272282.
  • 65
    Stevenson S, Cunningham N, Toth J, Davy D, Reddi AH 1994 The effect of osteogenin (a bone morphogenetic protein) on the formation of bone in orthotopic segmental defects in rats J Bone Joint Surg Am 76:16761687.
  • 66
    Ripamonti U, Ma S, Cunningham NS, Yeates L, Reddie AH 1992 Initiation of bone regeneration in adult baboons by osteogenin, a bone morphogenetic protein Matrix 12:369380.
  • 67
    Massague J, Hata A, Liu F 1997 TGF-β signalling through the Smad pathway Trends Cell Biol 7:187192.
  • 68
    Shimizu T, Mehdi R, Yoshimura Y, Yoshikawa A, Nomura S, Miyazono K, Takaoka K 1998 Sequential expression of bone morphogenetic protein, tumor necrosis factor, and their receptors in bone-forming reaction after mouse femoral marrow ablation Bone 23:127133.
  • 69
    Darnell JE, Kerr IM, Stark GM 1994 Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signalling proteins Science 257:803806.
  • 70
    Schindler C, Darnell JE 1995 Transcriptional responses to polypeptide ligands: The JAK-STAT pathway Ann Rev Biochem 64:621651.
  • 71
    Janknecht R, Hunter T 1999 Nuclear fusion of signaling pathways Science 284:443444.
  • 72
    Nakashima K, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T, Kawabata M, Miyazono K, Taga T 1999 Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300 Science 284:479482.
  • 73
    Zhang M, Tracey KJ 1998 Tumor necrosis factor. In: ThomsonA (ed.) The Cytokine Handbook, 3rd Ed. Academic Press Limited, San Diego, CA, U.S.A., pp. 517548.
  • 74
    Dinarello CA 1998 Interleukin-1. In: ThomsonA (ed.) The Cytokine Handbook, 3rd Ed. Academic Press Limited, San Diego, CA, U.S.A., pp. 3672.