• 1
    Bouxsein ML, Marcus R 1994 Overview of exercise and bone mass Rheum Dis Clin North Am 20:787802.
  • 2
    Heinonen A, Oja P, Kannus P, Sievanen H, Haapasalo H, Manttari A, Vuori I 1995 Bone mineral density in female athletes representing sports with different loading characteristics of the skeleton Bone 17:197203.
  • 3
    Lanyon LE, Goodship AE, Pye CJ, MacFie JH 1982 Mechanically adaptive bone remodelling J Biomech 15:141154.
  • 4
    Rubin CT, Lanyon LE 1984 Regulation of bone formation by applied dynamic loads J Bone Joint Surg Am 66:397402.
  • 5
    Turner CH, Akhter MP, Raab DM, Kimmel DB, Recker RR 1991 A noninvasive, in vivo model for studying strain adaptive bone modeling Bone 12:7379.
  • 6
    Chow JW, Jagger CJ, Chambers TJ 1993 Characterization of osteogenic response to mechanical stimulation in cancellous bone of rat caudal vertebrae Am J Physiol 265:E340E347.
  • 7
    Duncan RL, Turner CH 1995 Mechanotransduction and the functional response of bone to mechanical strain Calcif Tissue Int 57:344358.
  • 8
    Binderman I, Shimshoni Z, Somjen D 1984 Biochemical pathways involved in the translation of physical stimulus into biological message Calcif Tissue Int 36(Suppl 1):S82S85.
  • 9
    Yeh CK, Rodan GA 1984 Tensile forces enhance prostaglandin E synthesis in osteoblastic cells grown on collagen ribbons Calcif Tissue Int 36(Suppl 1):S67S71.
  • 10
    Murray DW, Rushton N 1990 The effect of strain on bone cell prostaglandin E2 release: A new experimental method Calcif Tissue Int 47:3539.
  • 11
    Li XJ, Jee WS, Li YL, Buckendahl P 1990 Transient effects of subcutaneously administered prostaglandin E2 on cancellous and cortical bone in young adult dogs Bone 11:353364.
  • 12
    Tang LY, Cullen DM, Yee JA, Jee WS, Kimmel DB 1997 Prostaglandin E2 increases the skeletal response to mechanical loading J Bone Miner Res 12:276282.
  • 13
    Pead MJ, Lanyon LE 1989 Indomethacin modulation of load-related stimulation of new bone formation in vivo Calcif Tissue Int 45:3440.
  • 14
    Chow JW, Chambers TJ 1994 Indomethacin has distinct early and late actions on bone formation induced by mechanical stimulation Am J Physiol 267:E287E292.
  • 15
    Rawlinson SC, el Haj AJ, Minter SL, Tavares IA, Bennett A, Lanyon LE 1991 Loading-related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: A role for prostacyclin in adaptive bone remodeling? J Bone Miner Res 6:13451351.
  • 16
    Rawlinson SC, Mohan S, Baylink DJ, Lanyon LE 1993 Exogenous prostacyclin, but not prostaglandin E2, produces similar responses in both G6PD activity and RNA production as mechanical loading, and increases IGF-II release, in adult cancellous bone in culture Calcif Tissue Int 53:324329.
  • 17
    Zaman G, Suswillo RF, Cheng MZ, Tavares IA, Lanyon LE 1997 Early responses to dynamic strain change and prostaglandins in bone-derived cells in culture J Bone Miner Res 12:769777.
  • 18
    Reich KM, Mcallister TN, Gudi S, Frangos JA 1997 Activation of G proteins mediates flow-induced prostaglandin E (2) production in osteoblasts Endocrinology 138:10141018.
  • 19
    Frangos JA, Eskin SG, McIntire LV, Ives CL 1985 Flow effects on prostacyclin production by cultured human endothelial cells Science 227:14771479.
  • 20
    Kuchan MJ, Frangos JA 1994 Role of calcium and calmodulin in flow-induced nitric oxide production in endothelial cells Am J Physiol 266:C628C636.
  • 21
    Klein Nulend J, Semeins CM, Ajubi NE, Nijweide PJ, Burger EH 1995 Pulsating fluid flow increases nitric oxide (NO) synthesis by osteocytes but not periosteal fibroblasts—Correlation with prostaglandin upregulation Biochem Biophys Res Commun 217:640648.
  • 22
    Pitsillides AA, Rawlinson SC, Suswillo RF, Bourrin S, Zaman G, Lanyon LE 1995 Mechanical strain-induced NO production by bone cells: A possible role in adaptive bone (re) modeling? FASEB J 9:16141622.
  • 23
    Smalt R, Mitchell FT, Howard RL, Chambers TJ 1997 Induction of NO and prostaglandin E-2 in osteoblasts by wall-shear stress but not mechanical strain Am J Physiol 36:E751E758.
  • 24
    Fox SW, Chambers TJ, Chow JW 1996 Nitric oxide is an early mediator of the increase in bone formation by mechanical stimulation Am J Physiol 270:E955E960.
  • 25
    Turner CH, Takano Y, Owan I, Murrell GA 1996 Nitric oxide inhibitor L-NAME suppresses mechanically induced bone formation in rats Am J Physiol 270:E634E639.
  • 26
    Riancho JA, Salas E, Zarrabeitia MT, Olmos JM, Amado JA, Fernandez Luna JL, Gonzalez Macias J 1995 Expression and functional role of nitric oxide synthase in osteoblast-like cells J Bone Miner Res 10:439446.
  • 27
    Ralston SH, Todd D, Helfrich M, Benjamin N, Grabowski PS 1994 Human osteoblast-like cells produce nitric oxide and express inducible nitric oxide synthase Endocrinology 135:330336.
  • 28
    Hukkanen M, Hughes FJ, Buttery LDK, Gross SS, Evans TJ, Seddon S, Riverosmoreno V, MacIntyre I, Polak JM 1995 Cytokine-stimulated expression of inducible nitric oxide synthase by mouse, rat and human osteoblast-like cells and its functional role in osteoblast metabolic activity Endocrinology 136:54455453.
  • 29
    Torrance AG, Mosley JR, Suswillo RF, Lanyon LE 1994 Noninvasive loading of the rat ulna in vivo induces a strain-related modeling response uncomplicated by trauma or periostal pressure Calcif Tissue Int 54:241247.
  • 30
    Cheng MZ, Zaman G, Lanyon LE 1994 Estrogen enhances the stimulation of bone collagen synthesis by loading and exogenous prostacyclin, but not prostaglandin E2, in organ cultures of rat ulnae J Bone Miner Res 9:805816.
  • 31
    Rawlinson SC, Mosley JR, Suswillo RF, Pitsillides AA, Lanyon LE 1995 Calvarial and limb bone cells in organ and monolayer culture do not show the same early responses to dynamic mechanical strain J Bone Miner Res 10:12251232.
  • 32
    Jones SJ, Boyde A 1977 The migration of osteoblasts Cell Tissue Res 184:179193.
  • 33
    Marie PJ, Lomri A, Sabbagh A, Basle M 1989 Culture and behavior of osteoblastic oells Isolated from normal trabecular bone urfaces In Vitro Cell Dev Biol 25:373380.
  • 34
    Nijweide PJ, Mulder RJ 1986 Identification of osteocytes in osteoblast-like cell cultures using a monoclonal antibody specifically directed against osteocytes Histochemistry 84:342347.
  • 35
    van der Plas A, Nijweide PJ 1992 Isolation and purification of osteocytes J Bone Miner Res 7:389396.
  • 36
    Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Anal Biochem 162:156159.
  • 37
    Feinberg AP, Vogelstein B 1983 A technique for radiolabeling DNA estriction endonuclease fragments to high specific activity Anal Biochem 132:613.
  • 38
    Palmer RM, Ferrige AG, Moncada S 1987 Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor Nature 327:524526.
  • 39
    Walters CL, Gillatt PN, Palmer RC, Smith PL 1987 A rapid method for the determination of nitrate and nitrite by chemiluminescence Food Addit Contam 4:133140.
  • 40
    Ralston SH, Ho LP, Helfrich MH, Grabowski PS, Johnston PW, Benjamin N 1995 Nitric oxide: A cytokine-induced regulator of bone resorption J Bone Miner Res 10:10401049.
  • 41
    Weijerman PC, Zhang Y, Shen JC, Dubbink HJ, Romijin JC, Peehl DM, Schroder FH 1998 Expression of prosstatic factors measured by reverse transcription polymerase chain reaction in human papillomavirus type 18 deoxyribonucleic acid immortalized prostate cell lines Urology 51:657662.
  • 42
    Moudgil A, Toyoda M, Galfayan K, Jordan SC 1997 Selective expression of the interleukin-2 gene discrimination between the auto- and allo-mixed lymphocyte reaction Transplant Immunol 5:3538.
  • 43
    Fey MF, Moffat GJ, Vik DP, Meisenhelder J, Saris CJM, Hunter T, Tack BF 1996 The complete structure of the murine p36 (annexin II) gene: Identification of mRNAs for both the murine and human gene with alternatively spliced 5′ noncoding axons Biochim Biphys Acta 1306:160170.
  • 44
    Fujita M, Fujii H, Kanda T, Sato E, Hatakeyama K, Ono T 1995 Molecular-cloning, expression, and characterization, of a human intestinal 15-Kda protein Eur J Biochem 233:406413.
  • 45
    Siddiqui I, Funatomi H, Kobrin MS, Friess H, Buchler MW, Korc M 1995 Increased expression of keratinocyte growth factor in human pancreatic-cancer Biochem Biophys Res Commun 215:309315.
  • 46
    Frangos JA, Huang TY, Clark CB 1996 Steady shear stress and step changes in shear stimulate endothelium via independent mechanisms—Superposition of transient and sustained nitric oxide production Biochem Biophys Res Commun 224:660665.
  • 47
    Pitsillides AA, Rawlinson SCF, Suswillo RFL, Zaman G, Nijwiede PJ, Lanyon LE 1995 Mechanical strain-induced NO production by osteoblasts and osteocytes J Bone Miner Res 10:S217.
  • 48
    Rawlinson SCF, Pitsillides AA, Lanyon LE 1996 Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain Bone 19:609614.
  • 49
    Pitsillides AA, Rawlinson SCF, Suswillo RFL, Zaman G, Hukkanen M, Platt L, Polak Jm, Lanyon LE 1997 A putative role for osteocyte endothelial-nitric oxide synthase in adaptive bone (re)modelling Bone 20:16s.
  • 50
    Pitsillides AA, Rawlinson SCF, Suswillo RFL, Zaman G, Hukkanen M, Platt L, Polak Jm, Lanyon LE 1997 Aputative role for osteocyte eNOS derived No in adaptive bone remodelling: An extension to an endothelial paradigm Int J Exp Path 77:A40.
  • 51
    Fox SW, Chow JWM 1998 Nitric oxide expression in bone cell Bone 23:16.
  • 52
    Marotti G, Ferretti M, Muglia MA, Palumbo C, Palazzini S 1992 A quantitative evaluation of osteoblast-osteocyte relationships on growing endosteal surface of rabbit tibiae Bone 13:363368.
  • 53
    Dodds RA, Ali N, Pead MJ, Lanyon LE 1993 Early loading-related changes in the activity of glucose 6-phosphate dehydrogenase and alkaline phosphatase in osteocytes and periosteal osteoblasts in rat fibulae in vivo J Bone Miner Res 8:261267.